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Gloria Conover

Research Assistant Professor

Curriculum Vitae

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Phone: (979) 845-4240

Mailstop: 4467

Department: VTPB

Photo of Conover, Gloria

Education

  • Ph.D. Molecular Biology and Microbiology, Tufts University School of Medicine 2003
  • B.A. Biological Sciences, Wellesley College 1996

Scholarly Interests

Our research is focused on the cell biology of muscle disease. Mutations in desmin identified in humans cause severe muscle atrophies and cardiomyopathies. Our goal is to decipher how inherited desmin mutations lead to muscle dysfunction. Specifically, we are interested in the effects of these mutations on sarcomere protein assembly and actin cytoskeletal dynamics. We are also interested in defining the ultrastructural impact of desmin mutations on sarcomere architecture by using a combination of genetic, molecular, biophysical and biochemical approaches.

Publications

Nebulin binding impedes mutant desmin filament assembly
Baker LK, Gillis DC, Sharma S, Ambrus A, Herrmann H, Conover GM..
Mol Biol Cell. 2013 Apr; .
PMID: 23615443 []
The desmin coil 1B impairs C-terminal nebulin assembly and destabilizes actin thin filaments
Conover, G.M.*, and Gregorio C.C..
Journal of Cell Science. 2011 Oct; 124 (20): 3464-3476.
PMID: 21984811 []
A myopathy-linked desmin mutation perturbs striated muscle actin filament architecture.
Conover, G.M., Henderson, S.N. and Gregorio C.C..
Molecular Biology of the Cell. 2009 Feb; 1 (20): 834-845.
PMID: 19005210 []
Legionella pneumophila EnhC is required for efficient replication in tumor necrosis factor alpha-stimulated macrophages.
Liu, M., Conover, G.M. and Isberg R.R. .
Cellular Microbiology. 2008 Jun; 10 (10): 1906-1923.
PMID: 18549456 []
Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants
Conover, G.M., Martinez, F., Heidtman, M, I., Luo, Z., Tang, M., Chen, C., Geiger, O. and Isberg R.R.
Cellular Microbiology. 2008 Feb; 10 (2): 514-528.
PMID: 17979985 []
The DotL protein, a member of the TraG-coupling protein family, is essential for viability of Legionella pneumophila strain Lp02
Buscher B.A.*, Conover G.M.*, Miller J.L., Vogel S.A., Meyers S.N., Isberg R.R. and Vogel J. P. .
Journal of Bacteriology. 2005 May; 187, p.2927-2938.
PMID: 15838018 []
The Legionella pneumophila LidA protein: a translocated effector required for bacterial integrity and efficient replication vacuole formation
Conover, G.M., Derre I., Vogel, J.P. and Isberg, R.R.,.
Molecular Microbiology. 2003 Apr; 48 (2): 305-321.
PMID: 12675793 []