Phone: (979) 845-7910
Our studies focus on the molecular and biochemical aspects of viruses, interactions of viral proteins with host cell moieties and intracellular transport. The overall goal of our work is to identify unique therapeutic targets for viral intervention. We employ a multitude of techniques such as yeast two-hybrid assays, laser-scanning confocal microscopic techniques (single and multiphoton), synthetic peptide chemistry, protein analyses and mutagenesis studies. Our primary interest is rotavirus, the single most important cause of pediatric, life-threatening gastroenteritis that annually claims ~610,000 young lives worldwide and results in hospitalization of 1 in 60 children in the U.S. at an annual cost of one billion dollars. We also study other viral systems that impact human and animal health with a focus on dissecting the association viral proteins with plasma membrane microdomains, such as caveolae.
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