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Robert Burghardt

Associate Dean for Research and Graduate Studies

Curriculum Vitae

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Phone: (979) 862-4083

Mailstop: 4458

Department: DCVM

Photo of Burghardt, Robert

Education

  • Ph.D. Biology, Wayne State University 1976
  • M.S. Biology, Wayne State University 1973
  • B.S. Zoology, University of Michigan 1969

Credentials

  • 1991 - present, Professor, Veterinary Integrative Biosciences; 1987 - present, Director, Image Analysis Laboratory; 2010 - present, Chair, Interdisciplinary Faculty of Reproductive Biology

Research

  • Cell Biology
  • Environmental Health
  • Toxicology
  • Reproductive Biology

Interdisciplinary Activities

  • Toxicology
  • Reproductive Biology

Scholarly Interests

My laboratory has research interests in reproductive biology and toxicology/environmental health. The major reproductive biology focus involves uterine biology and cellular adaptive responses to mechanical forces of pregnancy. The toxicology focus includes functional analysis of cellular signaling and signal transduction and mechanisms of cellular injury using non-invasive cellular/tissue imaging technologies.

Publications

Mechanistic mammalian target of rapamycin (MTOR) cell signaling: Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses.
Bazer FW, Song G, Kim J, Erikson DW, Johnson GA, Burghardt RC, Gao H, Carey Satterfield M, Spencer TE, Wu G.
Mol Cell Endocrinol. 2011 Sep; .
PMID: 21907263 [PubMed - as supplied by publisher]
Cationic polyfluorenes for intracellular delivery of proteins.
Kamkaew A, Barhoumi R, Burghardt RC, Burgess K.
Org Biomol Chem. 2011 Sep; 9(19):6513-8.
PMID: 21845277 [PubMed - in process]
Energy transfer cassettes in silica nanoparticles target intracellular organelles.
Jose J, Loudet A, Ueno Y, Wu L, Chen HY, Son DH, Barhoumi R, Burghardt R, Burgess K.
Org Biomol Chem. 2011 May; 9(10):3871-7.
PMID: 21455504 [PubMed - indexed for MEDLINE]
Organelle-selective energy transfer: a fluorescent indicator of intracellular environment.
Loudet A, Ueno Y, Wu L, Jose J, Barhoumi R, Burghardt R, Burgess K.
Bioorg Med Chem Lett. 2011 Mar; 21(6):1849-51.
PMID: 21316231 [PubMed - indexed for MEDLINE]
Select nutrients in the ovine uterine lumen. IX. Differential effects of arginine, leucine, glutamine, and glucose on interferon tau, ornithine decarboxylase, and nitric oxide synthase in the ovine conceptus.
Kim J, Burghardt RC, Wu G, Johnson GA, Spencer TE, Bazer FW.
Biol Reprod. 2011 Jun; 84(6):1139-47.
PMID: 21293034 [PubMed - indexed for MEDLINE]
Uterine receptivity to implantation of blastocysts in mammals.
Bazer FW, Spencer TE, Johnson GA, Burghardt RC.
Front Biosci (Schol Ed). 2011 Jan; 3:745-67.
PMID: 21196409 [PubMed - indexed for MEDLINE]
Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration.
Kim JY, Burghardt RC, Wu G, Johnson GA, Spencer TE, Bazer FW.
Biol Reprod. 2011 Jan; 84(1):62-9.
PMID: 20844282 [PubMed - indexed for MEDLINE]
Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines.
Kim JY, Burghardt RC, Wu G, Johnson GA, Spencer TE, Bazer FW.
Biol Reprod. 2011 Jan; 84(1):70-8.
PMID: 20844281 [PubMed - indexed for MEDLINE]
Proline and hydroxyproline metabolism: implications for animal and human nutrition.
Wu G, Bazer FW, Burghardt RC, Johnson GA, Kim SW, Knabe DA, Li P, Li X, McKnight JR, Satterfield MC, Spencer TE.
Amino Acids. 2011 Apr; 40(4):1053-63.
PMID: 20697752 [PubMed - indexed for MEDLINE]
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line.
Barhoumi R, Mouneimne Y, Ramos E, Morisseau C, Hammock BD, Safe S, Parrish AR, Burghardt RC.
Toxicol Appl Pharmacol. 2011 May; 253(1):45-56.
PMID: 21420996 [PubMed - indexed for MEDLINE]
Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53.
Banu SK, Stanley JA, Lee J, Stephen SD, Arosh JA, Hoyer PB, Burghardt RC.
Toxicol Appl Pharmacol. 2011 Mar; 251(3):253-66.
PMID: 21262251 [PubMed - indexed for MEDLINE]
Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and production.
Wu G, Bazer FW, Johnson GA, Knabe DA, Burghardt RC, Spencer TE, Li XL, Wang JJ.
J Anim Sci. 2011 Jul; 89(7):2017-30.
PMID: 21169511 [PubMed - in process]
MDM2 regulates estrogen receptor a and estrogen responsiveness in breast cancer cells.
Kim K, Burghardt R, Barhoumi R, Lee SO, Liu X, Safe S.
J Mol Endocrinol. 2011 ; 46(2):67-79.
PMID: 21169420 [PubMed - indexed for MEDLINE]
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.
Vanderlaag K, Su Y, Frankel AE, Burghardt RC, Barhoumi R, Chadalapaka G, Jutooru I, Safe S.
BMC Cancer. 2010 Dec; 10:669.
PMID: 21129193 [PubMed - indexed for MEDLINE]
Embryo production and possible species preservation by nuclear transfer of somatic cells isolated from bovine semen.
Liu J, Westhusin M, Long C, Johnson G, Burghardt R, Kraemer D.
Theriogenology. 2010 Dec; 74(9):1629-35.
PMID: 20708234 [PubMed - indexed for MEDLINE]
Effects of long-term progesterone exposure on porcine uterine gene expression: progesterone alone does not induce secreted phosphoprotein 1 (osteopontin) in glandular epithelium.
Bailey DW, Dunlap KA, Erikson DW, Patel AK, Bazer FW, Burghardt RC, Johnson GA.
Reproduction. 2010 Oct; 140(4):595-604.
PMID: 20705772 [PubMed - indexed for MEDLINE]
Effects of long-term progesterone on developmental and functional aspects of porcine uterine epithelia and vasculature: progesterone alone does not support development of uterine glands comparable to that of pregnancy.
Bailey DW, Dunlap KA, Frank JW, Erikson DW, White BG, Bazer FW, Burghardt RC, Johnson GA.
Reproduction. 2010 Oct; 140(4):583-94.
PMID: 20634388 [PubMed - indexed for MEDLINE]
Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth.
Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S.
Exp Cell Res. 2010 Aug; 316(13):2174-88.
PMID: 20435036 [PubMed - indexed for MEDLINE]
Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.
Chadalapaka G, Jutooru I, Burghardt R, Safe S.
Mol Cancer Res. 2010 May; 8(5):739-50.
PMID: 20407012 [PubMed - indexed for MEDLINE]
Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae.
Song G, Bailey DW, Dunlap KA, Burghardt RC, Spencer TE, Bazer FW, Johnson GA.
Biol Reprod. 2010 May; 82(5):854-64.
PMID: 20107207 [PubMed - indexed for MEDLINE]
Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus-maternal interface.
Massuto DA, Kneese EC, Johnson GA, Burghardt RC, Hooper RN, Ing NH, Jaeger LA.
Reproduction. 2010 Feb; 139(2):465-78.
PMID: 19920116 [PubMed - indexed for MEDLINE]
Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine production.
Wu G, Bazer FW, Burghardt RC, Johnson GA, Kim SW, Li XL, Satterfield MC, Spencer TE.
J Anim Sci. 2010 Apr; 88(13 Suppl):E195-204.
PMID: 19854987 [PubMed - indexed for MEDLINE]
Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model.
Black SG, Arnaud F, Burghardt RC, Satterfield MC, Fleming JA, Long CR, Hanna C, Murphy L, Biek R, Palmarini M, Spencer TE.
J Virol. 2010 Sep; 84(18):9078-85.
PMID: 20610723 [PubMed - indexed for MEDLINE]
Intracellular imaging of organelles with new water-soluble benzophenoxazine dyes.
Jose J, Loudet A, Ueno Y, Barhoumi R, Burghardt RC, Burgess K.
Org Biomol Chem. 2010 May; 8(9):2052-9.
PMID: 20401381 [PubMed - indexed for MEDLINE]
Dietary supplementation with 0.8% L-arginine between days 0 and 25 of gestation reduces litter size in gilts.
Li X, Bazer FW, Johnson GA, Burghardt RC, Erikson DW, Frank JW, Spencer TE, Shinzato I, Wu G.
J Nutr. 2010 Jun; 140(6):1111-6.
PMID: 20392885 [PubMed - indexed for MEDLINE]
Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells.
Kim J, Erikson DW, Burghardt RC, Spencer TE, Wu G, Bayless KJ, Johnson GA, Bazer FW.
Matrix Biol. 2010 Jun; 29(5):369-82.
PMID: 20385232 [PubMed - indexed for MEDLINE]
Morphologic and cytokine profile characterization of Salmonella enterica serovar typhimurium infection in calves with bovine leukocyte adhesion deficiency.
Nunes JS, Lawhon SD, Rossetti CA, Khare S, Figueiredo JF, Gull T, Burghardt RC, Bäumler AJ, Tsolis RM, Andrews-Polymenis HL, Adams LG.
Vet Pathol. 2010 Mar; 47(2):322-33.
PMID: 20118318 [PubMed - indexed for MEDLINE]
The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep.
Dunlap KA, Kwak HI, Burghardt RC, Bazer FW, Magness RR, Johnson GA, Bayless KJ.
Biol Reprod. 2010 May; 82(5):876-87.
PMID: 20107206 [PubMed - indexed for MEDLINE]
Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.
Bazer FW, Wu G, Spencer TE, Johnson GA, Burghardt RC, Bayless K.
Mol Hum Reprod. 2010 Mar; 16(3):135-52.
PMID: 19880575 [PubMed - indexed for MEDLINE]
Image analysis of Ca2+ signals as a basis for neurotoxicity assays: promises and challenges.
Barhoumi R, Qian Y, Burghardt RC, Tiffany-Castiglioni E.
Neurotoxicol Teratol. 2010 Jan; 32(1):16-24.
PMID: 19555758 [PubMed - indexed for MEDLINE]
Comparative aspects of implantation.
Bazer FW, Spencer TE, Johnson GA, Burghardt RC, Wu G.
Reproduction. 2009 Aug; 138(2):195-209.
PMID: 19502456 [PubMed - indexed for MEDLINE]
Salmonella enterica serovar Typhimurium-induced internalization and IL-8 expression in HeLa cells does not have a direct relationship with intracellular Ca(2+) levels.
Figueiredo JF, Barhoumi R, Raffatellu M, Lawhon SD, Rousseau B, Burghardt RC, Tsolis RM, Bäumler AJ, Adams LG.
Microbes Infect. 2009 Sep; 11(10-11):850-8.
PMID: 19450704 [PubMed - indexed for MEDLINE]
Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.
Papineni S, Chintharlapalli S, Abdelrahim M, Lee SO, Burghardt R, Abudayyeh A, Baker C, Herrera L, Safe S.
Carcinogenesis. 2009 Jul; 30(7):1193-201.
PMID: 19406933 [PubMed - indexed for MEDLINE]
The influence of estrogen on hepatobiliary osteopontin (SPP1) expression in a female rodent model of alcoholic steatohepatitis.
Banerjee A, Rose R, Johnson GA, Burghardt RC, Ramaiah SK.
Toxicol Pathol. 2009 ; 37(4):492-501.
PMID: 19387089 [PubMed - indexed for MEDLINE]
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines.
Barhoumi R, Catania JM, Parrish AR, Awooda I, Tiffany-Castiglioni E, Safe S, Burghardt RC.
J Toxicol Sci. 2009 Feb; 34(1):13-25.
PMID: 19182432 [PubMed - indexed for MEDLINE]
Evaluation of culture systems for attachment and proliferation of epithelial cells cultured from ovine semen.
Liu J, Westhusin M, Johnson G, Raudsepp T, Chowdhary B, Burghardt R, Long C, Kraemer D.
Anim Reprod Sci. 2009 Oct; 115(1-4):49-57.
PMID: 19108960 [PubMed - indexed for MEDLINE]
Enhanced focal adhesion assembly reflects increased mechanosensation and mechanotransduction at maternal-conceptus interface and uterine wall during ovine pregnancy.
Burghardt RC, Burghardt JR, Taylor JD 2nd, Reeder AT, Nguen BT, Spencer TE, Bayless KJ, Johnson GA.
Reproduction. 2009 Mar; 137(3):567-82.
PMID: 19060096 [PubMed - indexed for MEDLINE]
Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans.
Banu SK, Starzinski-Powitz A, Speights VO, Burghardt RC, Arosh JA.
Fertil Steril. 2009 May; 91(5 Suppl):2199-209.
PMID: 18722604 [PubMed - indexed for MEDLINE]
Select nutrients and glucose transporters in pig uteri and conceptuses.
Bazer FW, Gao H, Johnson GA, Wu G, Bailey DW, Burghardt RC.
Soc Reprod Fertil Suppl. 2009 ; 66:335-6.
PMID: 19848301 [PubMed - indexed for MEDLINE]
Serum brain-derived neurotrophic factor and peripheral indicators of the serotonin system in underweight and weight-recovered adolescent girls and women with anorexia nervosa.
Ehrlich S, Salbach-Andrae H, Eckart S, Merle JV, Burghardt R, Pfeiffer E, Franke L, Uebelhack R, Lehmkuhl U, Hellweg R.
J Psychiatry Neurosci. 2009 Jul; 34(4):323-9.
PMID: 19568484 [PubMed - indexed for MEDLINE]
Fluorescent cassettes for monitoring three-component interactions in vitro and in living cells.
Wu L, Loudet A, Barhoumi R, Burghardt RC, Burgess K.
J Am Chem Soc. 2009 Jul; 131(26):9156-7.
PMID: 19566090 [PubMed - indexed for MEDLINE]
Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation.
Simmons RM, Erikson DW, Kim J, Burghardt RC, Bazer FW, Johnson GA, Spencer TE.
Endocrinology. 2009 Sep; 150(9):4295-305.
PMID: 19497977 [PubMed - indexed for MEDLINE]
The role of leptin and cortisol in hyperactivity in patients with acute and weight-recovered anorexia nervosa.
Ehrlich S, Burghardt R, Schneider N, Broecker-Preuss M, Weiss D, Merle JV, Craciun EM, Pfeiffer E, Mann K, Lehmkuhl U, Hebebrand J.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun; 33(4):658-62.
PMID: 19296912 [PubMed - indexed for MEDLINE]
Use of multiple singular value decompositions to analyze complex intracellular calcium ion signals.
Martinez JG, Huang JZ, Burghardt RC, Barhoumi R, Carroll RJ.
Ann Appl Stat. 2009 ; 3(4):1467-1492.
PMID: 20428493 [PubMed]
Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses.
Johnson GA, Bazer FW, Burghardt RC, Spencer TE, Wu G, Bayless KJ.
Soc Reprod Fertil Suppl. 2009 ; 66:321-32.
PMID: 19848299 [PubMed - indexed for MEDLINE]
Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase.
Parrish AR, Chen G, Burghardt RC, Watanabe T, Morisseau C, Hammock BD.
Cell Biol Toxicol. 2009 Jun; 25(3):217-25.
PMID: 18386137 [PubMed - indexed for MEDLINE]
Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estradiol.
Song G, Dunlap KA, Kim J, Bailey DW, Spencer TE, Burghardt RC, Wagner GF, Johnson GA, Bazer FW.
Endocrinology. 2009 Feb; 150(2):936-45.
PMID: 18845628 [PubMed - indexed for MEDLINE]
Insulin-like growth factor II activates phosphatidylinositol 3-kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell Signaling pathways, and stimulates migration of ovine trophectoderm cells.
Kim J, Song G, Gao H, Farmer JL, Satterfield MC, Burghardt RC, Wu G, Johnson GA, Spencer TE, Bazer FW.
Endocrinology. 2008 Jun; 149(6):3085-94.
PMID: 18339715 [PubMed - indexed for MEDLINE]
Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney.
Akintola AD, Crislip ZL, Catania JM, Chen G, Zimmer WE, Burghardt RC, Parrish AR.
Am J Physiol Renal Physiol. 2008 Jan; 294(1):F170-6.
PMID: 17959753 [PubMed - indexed for MEDLINE]
Galectin 15 (LGALS15) functions in trophectoderm migration and attachment.
Farmer JL, Burghardt RC, Jousan FD, Hansen PJ, Bazer FW, Spencer TE.
FASEB J. 2008 Feb; 22(2):548-60.
PMID: 17890287 [PubMed - indexed for MEDLINE]
Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats.
Banu SK, Samuel JB, Arosh JA, Burghardt RC, Aruldhas MM.
Toxicol Appl Pharmacol. 2008 Oct; 232(2):180-9.
PMID: 18602937 [PubMed - indexed for MEDLINE]
Using quantitative structure-activity relationships (QSAR) to predict toxic endpoints for polycyclic aromatic hydrocarbons (PAH).
Bruce ED, Autenrieth RL, Burghardt RC, Donnelly KC, McDonald TJ.
J Toxicol Environ Health A. 2008 ; 71(16):1073-84.
PMID: 18569619 [PubMed - indexed for MEDLINE]
Integrin activation in bovine placentomes and in caruncular epithelial cells isolated from pregnant cows.
Bridger PS, Haupt S, Leiser R, Johnson GA, Burghardt RC, Tinneberg HR, Pfarrer C.
Biol Reprod. 2008 Aug; 79(2):274-82.
PMID: 18417711 [PubMed - indexed for MEDLINE]
Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.
Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R, Safe S.
J Steroid Biochem Mol Biol. 2008 May; 110(1-2):104-15.
PMID: 18400491 [PubMed - indexed for MEDLINE]
Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways.
Bazer FW, Burghardt RC, Johnson GA, Spencer TE, Wu G.
Reprod Biol. 2008 Nov; 8(3):179-211.
PMID: 19092983 [PubMed - indexed for MEDLINE]
Non-covalent delivery of proteins into mammalian cells.
Loudet A, Han J, Barhoumi R, Pellois JP, Burghardt RC, Burgess K.
Org Biomol Chem. 2008 Dec; 6(24):4516-22.
PMID: 19039359 [PubMed - indexed for MEDLINE]
Uterine MHC class I molecules and beta 2-microglobulin are regulated by progesterone and conceptus interferons during pig pregnancy.
Joyce MM, Burghardt JR, Burghardt RC, Hooper RN, Bazer FW, Johnson GA.
J Immunol. 2008 Aug; 181(4):2494-505.
PMID: 18684940 [PubMed - indexed for MEDLINE]
Progesterone and placentation increase secreted phosphoprotein one (SPP1 or osteopontin) in uterine glands and stroma for histotrophic and hematotrophic support of ovine pregnancy.
Dunlap KA, Erikson DW, Burghardt RC, White FJ, Reed KM, Farmer JL, Spencer TE, Magness RR, Bazer FW, Bayless KJ, Johnson GA.
Biol Reprod. 2008 Nov; 79(5):983-90.
PMID: 18667748 [PubMed - indexed for MEDLINE]
Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2.
Laffin B, Wellberg E, Kwak HI, Burghardt RC, Metz RP, Gustafson T, Schedin P, Porter WW.
Mol Cell Biol. 2008 Mar; 28(6):1936-46.
PMID: 18160708 [PubMed - indexed for MEDLINE]
Pig conceptuses secrete estrogen and interferons to differentially regulate uterine STAT1 in a temporal and cell type-specific manner.
Joyce MM, Burghardt RC, Geisert RD, Burghardt JR, Hooper RN, Ross JW, Ashworth MD, Johnson GA.
Endocrinology. 2007 Sep; 148(9):4420-31.
PMID: 17525118 [PubMed - indexed for MEDLINE]
Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells.
Barhoumi R, Burghardt RC, Qian Y, Tiffany-Castiglioni E.
Brain Res. 2007 May; 1145:11-8.
PMID: 17328872 [PubMed - indexed for MEDLINE]
Cloning of GJA1 (connexin43) and its expression in canine ovarian follicles throughout the estrous cycle.
Willingham-Rocky LA, Golding MC, Wright JM, Kraemer DC, Westhusin ME, Burghardt RC.
Gene Expr Patterns. 2007 Jan; 7(1-2):66-71.
PMID: 16829210 [PubMed - indexed for MEDLINE]
Galectin 15 (LGALS15): a gene uniquely expressed in the uteri of sheep and goats that functions in trophoblast attachment.
Lewis SK, Farmer JL, Burghardt RC, Newton GR, Johnson GA, Adelson DL, Bazer FW, Spencer TE.
Biol Reprod. 2007 Dec; 77(6):1027-36.
PMID: 17855730 [PubMed - indexed for MEDLINE]
Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction.
Chen G, Bridenbaugh EA, Akintola AD, Catania JM, Vaidya VS, Bonventre JV, Dearman AC, Sampson HW, Zawieja DC, Burghardt RC, Parrish AR.
Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1272-81.
PMID: 17670906 [PubMed - indexed for MEDLINE]
Fetal-maternal interactions during the establishment of pregnancy in ruminants.
Spencer TE, Johnson GA, Bazer FW, Burghardt RC.
Soc Reprod Fertil Suppl. 2007 ; 64:379-96.
PMID: 17491160 [PubMed - indexed for MEDLINE]
Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone.
Satterfield MC, Dunlap KA, Hayashi K, Burghardt RC, Spencer TE, Bazer FW.
Endocrinology. 2007 Aug; 148(8):3922-31.
PMID: 17478549 [PubMed - indexed for MEDLINE]
Pig conceptuses increase uterine interferon-regulatory factor 1 (IRF1), but restrict expression to stroma through estrogen-induced IRF2 in luminal epithelium.
Joyce MM, Burghardt JR, Burghardt RC, Hooper RN, Jaeger LA, Spencer TE, Bazer FW, Johnson GA.
Biol Reprod. 2007 Aug; 77(2):292-302.
PMID: 17475929 [PubMed - indexed for MEDLINE]
WNTs in the ovine uterus: potential regulation of periimplantation ovine conceptus development.
Hayashi K, Burghardt RC, Bazer FW, Spencer TE.
Endocrinology. 2007 Jul; 148(7):3496-506.
PMID: 17431004 [PubMed - indexed for MEDLINE]
Regulation of expression of fibroblast growth factor 7 in the pig uterus by progesterone and estradiol.
Ka H, Al-Ramadan S, Erikson DW, Johnson GA, Burghardt RC, Spencer TE, Jaeger LA, Bazer FW.
Biol Reprod. 2007 Jul; 77(1):172-80.
PMID: 17392499 [PubMed - indexed for MEDLINE]
Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses.
Spencer TE, Johnson GA, Bazer FW, Burghardt RC, Palmarini M.
Reprod Fertil Dev. 2007 ; 19(1):65-78.
PMID: 17389136 [PubMed - indexed for MEDLINE]
Rescuing valuable genomes by animal cloning: a case for natural disease resistance in cattle.
Westhusin ME, Shin T, Templeton JW, Burghardt RC, Adams LG.
J Anim Sci. 2007 Jan; 85(1):138-42.
PMID: 17179549 [PubMed - indexed for MEDLINE]
Ischemia-induced cleavage of cadherins in NRK cells is not sufficient for beta-catenin transcriptional activity.
Chen G, Akintola AD, Catania JM, Covington MD, Dean DD, Trzeciakowski JP, Burghardt RC, Parrish AR.
Cell Commun Adhes. 2007 Oct; 14(4):111-23.
PMID: 17957528 [PubMed - indexed for MEDLINE]
Transmission electron microscopy.
Burghardt RC, Droleskey R.
Curr Protoc Microbiol. 2006 Dec; Chapter 2:Unit 2B.1.
PMID: 18770588 [PubMed - indexed for MEDLINE]
Endogenous retroviruses regulate periimplantation placental growth and differentiation.
Dunlap KA, Palmarini M, Varela M, Burghardt RC, Hayashi K, Farmer JL, Spencer TE.
Proc Natl Acad Sci U S A. 2006 Sep; 103(39):14390-5.
PMID: 16980413 [PubMed - indexed for MEDLINE]
The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: a potential biomarker.
Banerjee A, Burghardt RC, Johnson GA, White FJ, Ramaiah SK.
Toxicol Pathol. 2006 ; 34(4):373-84.
PMID: 16844665 [PubMed - indexed for MEDLINE]
3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha.
Abdelrahim M, Ariazi E, Kim K, Khan S, Barhoumi R, Burghardt R, Liu S, Hill D, Finnell R, Wlodarczyk B, Jordan VC, Safe S.
Cancer Res. 2006 Feb; 66(4):2459-67.
PMID: 16489053 [PubMed - indexed for MEDLINE]
Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14).
Covington MD, Burghardt RC, Parrish AR.
Am J Physiol Renal Physiol. 2006 Jan; 290(1):F43-51.
PMID: 16077081 [PubMed - indexed for MEDLINE]
Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.
Vanderlaag K, Samudio I, Burghardt R, Barhoumi R, Safe S.
Cancer Lett. 2006 May; 236(2):198-212.
PMID: 16051428 [PubMed - indexed for MEDLINE]
Secreted phosphoprotein 1 (osteopontin) is expressed by stromal macrophages in cyclic and pregnant endometrium of mice, but is induced by estrogen in luminal epithelium during conceptus attachment for implantation.
White FJ, Burghardt RC, Hu J, Joyce MM, Spencer TE, Johnson GA.
Reproduction. 2006 Dec; 132(6):919-29.
PMID: 17127752 [PubMed - indexed for MEDLINE]
Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.
Khan S, Barhoumi R, Burghardt R, Liu S, Kim K, Safe S.
Mol Endocrinol. 2006 Sep; 20(9):2199-214.
PMID: 16675542 [PubMed - indexed for MEDLINE]
Glycosylation dependent cell adhesion molecule 1-like protein and L-selectin expression in sheep interplacentomal and placentomal endometrium.
Muniz JJ, Joyce MM, Taylor JD 2nd, Burghardt JR, Burghardt RC, Johnson GA.
Reproduction. 2006 Apr; 131(4):751-61.
PMID: 16595726 [PubMed - indexed for MEDLINE]
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.
Barhoumi R, Awooda I, Mouneimne Y, Safe S, Burghardt RC.
Toxicol Lett. 2006 Aug; 165(2):133-41.
PMID: 16567066 [PubMed - indexed for MEDLINE]
Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells.
Zhang S, Li X, Burghardt R, Smith R 3rd, Safe SH.
J Mol Endocrinol. 2005 Dec; 35(3):433-47.
PMID: 16326831 [PubMed - indexed for MEDLINE]
Steroid regulation of cell specific secreted phosphoprotein 1 (osteopontin) expression in the pregnant porcine uterus.
White FJ, Ross JW, Joyce MM, Geisert RD, Burghardt RC, Johnson GA.
Biol Reprod. 2005 Dec; 73(6):1294-301.
PMID: 16120824 [PubMed - indexed for MEDLINE]
Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep.
Joyce MM, White FJ, Burghardt RC, Muñiz JJ, Spencer TE, Bazer FW, Johnson GA.
Endocrinology. 2005 Feb; 146(2):675-84.
PMID: 15528302 [PubMed - indexed for MEDLINE]
Galectin-15 in ovine uteroplacental tissues.
Gray CA, Dunlap KA, Burghardt RC, Spencer TE.
Reproduction. 2005 Aug; 130(2):231-40.
PMID: 16049161 [PubMed - indexed for MEDLINE]
FIA/MS analysis of temporally ozonated benzo[a]pyrene and pyrene and their reaction products: inhibition of gap junction-mediated intercellular communication.
Ottinger S, Barhoumi R, McKenzie KS, McDonald T, Burghardt R, Huebner HJ, Phillips TD.
Chemosphere. 2005 Aug; 60(8):1025-33.
PMID: 15993149 [PubMed - indexed for MEDLINE]
Functional effects of transforming growth factor beta on adhesive properties of porcine trophectoderm.
Jaeger LA, Spiegel AK, Ing NH, Johnson GA, Bazer FW, Burghardt RC.
Endocrinology. 2005 Sep; 146(9):3933-42.
PMID: 15961561 [PubMed - indexed for MEDLINE]
Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.
Kim K, Barhoumi R, Burghardt R, Safe S.
Mol Endocrinol. 2005 Apr; 19(4):843-54.
PMID: 15637147 [PubMed - indexed for MEDLINE]
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Chintharlapalli S, Burghardt R, Papineni S, Ramaiah S, Yoon K, Safe S.
J Biol Chem. 2005 Jul; 280(26):24903-14.
PMID: 15871945 [PubMed - indexed for MEDLINE]
Ischemia-induced cleavage of cadherins in NRK cells: evidence for a role of metalloproteinases.
Covington MD, Bayless KJ, Burghardt RC, Davis GE, Parrish AR.
Am J Physiol Renal Physiol. 2005 Aug; 289(2):F280-8.
PMID: 15769936 [PubMed - indexed for MEDLINE]
The IGF system in the neonatal ovine uterus.
Hayashi K, Carpenter KD, Welsh TH Jr, Burghardt RC, Spicer LJ, Spencer TE.
Reproduction. 2005 Mar; 129(3):337-47.
PMID: 15749960 [PubMed - indexed for MEDLINE]
Caprine uterine and placental osteopontin expression is distinct among epitheliochorial implanting species.
Joyce MM, González JF, Lewis S, Woldesenbet S, Burghardt RC, Newton GR, Johnson GA.
Placenta. 2005 Feb; 26(2-3):160-70.
PMID: 15708117 [PubMed - indexed for MEDLINE]
An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosis.
Sanders LM, Henderson CE, Hong MY, Barhoumi R, Burghardt RC, Wang N, Spinka CM, Carroll RJ, Turner ND, Chapkin RS, Lupton JR.
J Nutr. 2004 Dec; 134(12):3233-8.
PMID: 15570018 [PubMed - indexed for MEDLINE]
Conceptus signals for establishment and maintenance of pregnancy.
Spencer TE, Burghardt RC, Johnson GA, Bazer FW.
Anim Reprod Sci. 2004 Jul; 82-83:537-50.
PMID: 15271478 [PubMed - indexed for MEDLINE]
Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells.
Li X, Qin C, Burghardt R, Safe S.
Biochem Biophys Res Commun. 2004 Jul; 320(3):625-34.
PMID: 15240094 [PubMed - indexed for MEDLINE]
Loss of N-cadherin and alpha-catenin in the proximal tubules of aging male Fischer 344 rats.
Jung KY, Dean D, Jiang J, Gaylor S, Griffith WH, Burghardt RC, Parrish AR.
Mech Ageing Dev. 2004 Jun; 125(6):445-53.
PMID: 15178134 [PubMed - indexed for MEDLINE]
Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm.
Gray CA, Adelson DL, Bazer FW, Burghardt RC, Meeusen EN, Spencer TE.
Proc Natl Acad Sci U S A. 2004 May; 101(21):7982-7.
PMID: 15148380 [PubMed - indexed for MEDLINE]
Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility.
Sanders LM, Henderson CE, Hong MY, Barhoumi R, Burghardt RC, Carroll RJ, Turner ND, Chapkin RS, Lupton JR.
Cancer Lett. 2004 May; 208(2):155-61.
PMID: 15142673 [PubMed - indexed for MEDLINE]
Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity.
Jiang J, Dean D, Burghardt RC, Parrish AR.
Toxicol Sci. 2004 Jul; 80(1):170-82.
PMID: 15084754 [PubMed - indexed for MEDLINE]
Progesterone and placental hormone actions on the uterus: insights from domestic animals.
Spencer TE, Johnson GA, Burghardt RC, Bazer FW.
Biol Reprod. 2004 Jul; 71(1):2-10.
PMID: 14973264 [PubMed - indexed for MEDLINE]
Implantation mechanisms: insights from the sheep.
Spencer TE, Johnson GA, Bazer FW, Burghardt RC.
Reproduction. 2004 Dec; 128(6):657-68.
PMID: 15579583 [PubMed - indexed for MEDLINE]
Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins.
Wu Q, Burghardt R, Safe S.
J Biol Chem. 2004 Dec; 279(51):53602-12.
PMID: 15471764 [PubMed - indexed for MEDLINE]
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells.
Abdelrahim M, Smith R 3rd, Burghardt R, Safe S.
Cancer Res. 2004 Sep; 64(18):6740-9.
PMID: 15374992 [PubMed - indexed for MEDLINE]
Osteopontin: roles in implantation and placentation.
Johnson GA, Burghardt RC, Bazer FW, Spencer TE.
Biol Reprod. 2003 Nov; 69(5):1458-71.
PMID: 12890718 [PubMed - indexed for MEDLINE]
A comparison of two methods for fractionating complex mixtures in preparation for toxicity analysis.
Cizmas L, Barhoumi R, Burghardt RC, Reeves WR, He L, McDonald TJ, Donnelly KC.
J Toxicol Environ Health A. 2003 Jul; 66(14):1351-70.
PMID: 12851116 [PubMed - indexed for MEDLINE]
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.
Qin C, Burghardt R, Smith R, Wormke M, Stewart J, Safe S.
Cancer Res. 2003 Mar; 63(5):958-64.
PMID: 12615709 [PubMed - indexed for MEDLINE]
The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes.
Wormke M, Stoner M, Saville B, Walker K, Abdelrahim M, Burghardt R, Safe S.
Mol Cell Biol. 2003 Mar; 23(6):1843-55.
PMID: 12612060 [PubMed - indexed for MEDLINE]
Osteopontin expression in uterine stroma indicates a decidualization-like differentiation during ovine pregnancy.
Johnson GA, Burghardt RC, Joyce MM, Spencer TE, Bazer FW, Pfarrer C, Gray CA.
Biol Reprod. 2003 Jun; 68(6):1951-8.
PMID: 12606396 [PubMed - indexed for MEDLINE]
Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds.
Hong MS, Hong SJ, Barhoumi R, Burghardt RC, Donnelly KC, Wild JR, Venkatraj V, Tiffany-Castiglioni E.
Toxicol Appl Pharmacol. 2003 Jan; 186(2):110-8.
PMID: 12639502 [PubMed - indexed for MEDLINE]
Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy.
Johnson GA, Burghardt RC, Joyce MM, Spencer TE, Bazer FW, Gray CA, Pfarrer C.
Biol Reprod. 2003 Jul; 69(1):92-8.
PMID: 12606367 [PubMed - indexed for MEDLINE]
Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes.
Hong MY, Chapkin RS, Barhoumi R, Burghardt RC, Turner ND, Henderson CE, Sanders LM, Fan YY, Davidson LA, Murphy ME, Spinka CM, Carroll RJ, Lupton JR.
Carcinogenesis. 2002 Nov; 23(11):1919-25.
PMID: 12419841 [PubMed - indexed for MEDLINE]
Evidence that absence of endometrial gland secretions in uterine gland knockout ewes compromises conceptus survival and elongation.
Gray CA, Burghardt RC, Johnson GA, Bazer FW, Spencer TE.
Reproduction. 2002 Aug; 124(2):289-300.
PMID: 12141942 [PubMed - indexed for MEDLINE]
Analysis of osteopontin at the maternal-placental interface in pigs.
Garlow JE, Ka H, Johnson GA, Burghardt RC, Jaeger LA, Bazer FW.
Biol Reprod. 2002 Mar; 66(3):718-25.
PMID: 11870079 [PubMed - indexed for MEDLINE]
Integrins and extracellular matrix proteins at the maternal-fetal interface in domestic animals.
Burghardt RC, Johnson GA, Jaeger LA, Ka H, Garlow JE, Spencer TE, Bazer FW.
Cells Tissues Organs. 2002 ; 172(3):202-17.
PMID: 12476049 [PubMed - indexed for MEDLINE]
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells.
Stoner M, Saville B, Wormke M, Dean D, Burghardt R, Safe S.
Mol Endocrinol. 2002 Oct; 16(10):2231-42.
PMID: 12351689 [PubMed - indexed for MEDLINE]
Rb localization and phosphorylation kinetics correlate with the cellular phenotype of cultured breast adenocarcinoma cells.
Botos J, Barhoumi R, Burghardt R, Kochevar DT.
In Vitro Cell Dev Biol Anim. 2002 Apr; 38(4):235-41.
PMID: 12197776 [PubMed - indexed for MEDLINE]
Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells.
Barhoumi R, Mouneimne Y, Awooda I, Safe SH, Donnelly KC, Burghardt RC.
Toxicol Sci. 2002 Aug; 68(2):444-50.
PMID: 12151640 [PubMed - indexed for MEDLINE]
Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex.
Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R, Safe S.
Mol Endocrinol. 2002 Aug; 16(8):1793-809.
PMID: 12145335 [PubMed - indexed for MEDLINE]
Production of nuclear transfer horse embryos by Piezo-driven injection of somatic cell nuclei and activation with stallion sperm cytosolic extract.
Choi YH, Love CC, Chung YG, Varner DD, Westhusin ME, Burghardt RC, Hinrichs K.
Biol Reprod. 2002 Aug; 67(2):561-7.
PMID: 12135896 [PubMed - indexed for MEDLINE]
Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells.
Abdelrahim M, Samudio I, Smith R 3rd, Burghardt R, Safe S.
J Biol Chem. 2002 Aug; 277(32):28815-22.
PMID: 12052832 [PubMed - indexed for MEDLINE]
Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function.
Chapkin RS, Hong MY, Fan YY, Davidson LA, Sanders LM, Henderson CE, Barhoumi R, Burghardt RC, Turner ND, Lupton JR.
Lipids. 2002 Feb; 37(2):193-9.
PMID: 11908911 [PubMed - indexed for MEDLINE]
Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells.
Mealey KL, Barhoumi R, Burghardt RC, Safe S, Kochevar DT.
Antimicrob Agents Chemother. 2002 Mar; 46(3):755-61.
PMID: 11850258 [PubMed - indexed for MEDLINE]
A study of 2,4,6-trinitrotoluene inhibition of benzo[a]pyrene uptake and activation in a microbial mutagenicity assay.
Washburn KS, Donnelly KC, Huebner HJ, Burghardt RC, Sewall TC, Claxton LD.
Chemosphere. 2001 Sep; 44(8):1703-9.
PMID: 11534902 [PubMed - indexed for MEDLINE]
Mares with delayed uterine clearance have an intrinsic defect in myometrial function.
Rigby SL, Barhoumi R, Burghardt RC, Colleran P, Thompson JA, Varner DD, Blanchard TL, Brinsko SP, Taylor T, Wilkerson MK, Delp MD.
Biol Reprod. 2001 Sep; 65(3):740-7.
PMID: 11514336 [PubMed - indexed for MEDLINE]
Bovine nuclear transfer embryo development using cells derived from a cloned fetus.
Hill JR, Winger QA, Burghardt RC, Westhusin ME.
Anim Reprod Sci. 2001 Jul; 67(1-2):17-26.
PMID: 11408110 [PubMed - indexed for MEDLINE]
Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures.
Reeves WR, Barhoumi R, Burghardt RC, Lemke SL, Mayura K, McDonald TJ, Phillips TD, Donnelly KC.
Environ Sci Technol. 2001 Apr; 35(8):1630-6.
PMID: 11329713 [PubMed - indexed for MEDLINE]
Transcriptional activation of deoxyribonucleic acid polymerase alpha gene expression in MCF-7 cells by 17 beta-estradiol.
Samudio I, Vyhlidal C, Wang F, Stoner M, Chen I, Kladde M, Barhoumi R, Burghardt R, Safe S.
Endocrinology. 2001 Mar; 142(3):1000-8.
PMID: 11181512 [PubMed - indexed for MEDLINE]
Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1.
Duan R, Xie W, Burghardt RC, Safe S.
J Biol Chem. 2001 Apr; 276(15):11590-8.
PMID: 11145955 [PubMed - indexed for MEDLINE]
Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells.
Stewart MD, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE.
Endocrinology. 2001 Jan; 142(1):98-107.
PMID: 11145571 [PubMed - indexed for MEDLINE]
Potential for cloning dogs.
Westhusin ME, Burghardt RC, Ruglia JN, Willingham LA, Liu L, Shin T, Howe LM, Kraemer DC.
J Reprod Fertil Suppl. 2001 ; 57:287-93.
PMID: 11787163 [PubMed - indexed for MEDLINE]
Interferon regulatory factor-two restricts expression of interferon-stimulated genes to the endometrial stroma and glandular epithelium of the ovine uterus.
Choi Y, Johnson GA, Burghardt RC, Berghman LR, Joyce MM, Taylor KM, Stewart MD, Bazer FW, Spencer TE.
Biol Reprod. 2001 Oct; 65(4):1038-49.
PMID: 11566724 [PubMed - indexed for MEDLINE]
Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep.
Johnson GA, Bazer FW, Jaeger LA, Ka H, Garlow JE, Pfarrer C, Spencer TE, Burghardt RC.
Biol Reprod. 2001 Sep; 65(3):820-8.
PMID: 11514347 [PubMed - indexed for MEDLINE]
Effects of the estrous cycle, pregnancy, and interferon tau on 2',5'-oligoadenylate synthetase expression in the ovine uterus.
Johnson GA, Stewart MD, Gray CA, Choi Y, Burghardt RC, Yu-Lee LY, Bazer FW, Spencer TE.
Biol Reprod. 2001 May; 64(5):1392-9.
PMID: 11319143 [PubMed - indexed for MEDLINE]
Functional analysis of autocrine and paracrine signalling at the uterine-conceptus interface in pigs.
Jaeger LA, Johnson GA, Ka H, Garlow JG, Burghardt RC, Spencer TE, Bazer FW.
Reprod Suppl. 2001 ; 58:191-207.
PMID: 11980190 [PubMed - indexed for MEDLINE]
2,3,7,8-Tetrachlorodibenzo-p-dioxin alters hippocampal astroglia-neuronal gap junctional communication.
Legare ME, Hanneman WH, Barhoumi R, Burghardt RC, Tiffany-Castiglioni E.
Neurotoxicology. 2000 Dec; 21(6):1109-16.
PMID: 11233757 [PubMed - indexed for MEDLINE]
Cellular mechanisms of implantation in domestic farm animals.
Bowen JA, Burghardt RC.
Semin Cell Dev Biol. 2000 Apr; 11(2):93-104.
PMID: 10873706 [PubMed - indexed for MEDLINE]
Prolactin receptor and uterine milk protein expression in the ovine endometrium during the estrous cycle and pregnancy.
Stewart MD, Johnson GA, Gray CA, Burghardt RC, Schuler LA, Joyce MM, Bazer FW, Spencer TE.
Biol Reprod. 2000 Jun; 62(6):1779-89.
PMID: 10819783 [PubMed - indexed for MEDLINE]
Progesterone modulation of osteopontin gene expression in the ovine uterus.
Johnson GA, Spencer TE, Burghardt RC, Taylor KM, Gray CA, Bazer FW.
Biol Reprod. 2000 May; 62(5):1315-21.
PMID: 10775182 [PubMed - indexed for MEDLINE]
Interferon-tau and progesterone regulate ubiquitin cross-reactive protein expression in the ovine uterus.
Johnson GA, Spencer TE, Burghardt RC, Joyce MM, Bazer FW.
Biol Reprod. 2000 Mar; 62(3):622-7.
PMID: 10684803 [PubMed - indexed for MEDLINE]
Expression of carbohydrate antigens in the goat uterus during early pregnancy and on steroid-treated polarized uterine epithelial cells in vitro.
Powell JK, Glasser SR, Woldesenbet S, Burghardt RC, Newton GR.
Biol Reprod. 2000 Feb; 62(2):277-84.
PMID: 10642563 [PubMed - indexed for MEDLINE]
Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses.
Hill JR, Burghardt RC, Jones K, Long CR, Looney CR, Shin T, Spencer TE, Thompson JA, Winger QA, Westhusin ME.
Biol Reprod. 2000 Dec; 63(6):1787-94.
PMID: 11090450 [PubMed - indexed for MEDLINE]
Adsorption of Salmonella enteritidis by cetylpyridinium-exchanged montmorillonite clays.
Herrera P, Burghardt RC, Phillips TD.
Vet Microbiol. 2000 Jun; 74(3):259-72.
PMID: 10808094 [PubMed - indexed for MEDLINE]
Phenotypic profiles of cultured glomerular cells following repeated cycles of hydrocarbon injury.
Alejandro NF, Parrish AR, Bowes RC, Burghardt RC, Ramos KS.
Kidney Int. 2000 Apr; 57(4):1571-80.
PMID: 10760092 [PubMed - indexed for MEDLINE]
Analysis of benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line.
Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC.
Toxicol Sci. 2000 Feb; 53(2):264-70.
PMID: 10696774 [PubMed - indexed for MEDLINE]
Effect of cholesterol on the motility and plasma membrane integrity of frozen equine spermatozoa after thawing.
Combes GB, Varner DD, Schroeder F, Burghardt RC, Blanchard TL.
J Reprod Fertil Suppl. 2000 ; (56):127-32.
PMID: 20681124 [PubMed - indexed for MEDLINE]
Immunosuppressant inhibition of P-glycoprotein function is independent of drug-induced suppression of peptide-prolyl isomerase and calcineurin activity.
Mealey KL, Barhoumi R, Burghardt RC, McIntyre BS, Sylvester PW, Hosick HL, Kochevar DT.
Cancer Chemother Pharmacol. 1999 ; 44(2):152-8.
PMID: 10412950 [PubMed - indexed for MEDLINE]
Expression of the interferon tau inducible ubiquitin cross-reactive protein in the ovine uterus.
Johnson GA, Spencer TE, Hansen TR, Austin KJ, Burghardt RC, Bazer FW.
Biol Reprod. 1999 Jul; 61(1):312-8.
PMID: 10377064 [PubMed - indexed for MEDLINE]
Oxytocin-induced Ca2+ responses in human myometrial cells.
Burghardt RC, Barhoumi R, Sanborn BM, Andersen J.
Biol Reprod. 1999 Apr; 60(4):777-82.
PMID: 10084948 [PubMed - indexed for MEDLINE]
Development and characterization of immortalized ovine endometrial cell lines.
Johnson GA, Burghardt RC, Newton GR, Bazer FW, Spencer TE.
Biol Reprod. 1999 Nov; 61(5):1324-30.
PMID: 10529281 [PubMed - indexed for MEDLINE]
Ovine osteopontin: II. Osteopontin and alpha(v)beta(3) integrin expression in the uterus and conceptus during the periimplantation period.
Johnson GA, Burghardt RC, Spencer TE, Newton GR, Ott TL, Bazer FW.
Biol Reprod. 1999 Oct; 61(4):892-9.
PMID: 10491621 [PubMed - indexed for MEDLINE]
Ovine osteopontin: I. Cloning and expression of messenger ribonucleic acid in the uterus during the periimplantation period.
Johnson GA, Spencer TE, Burghardt RC, Bazer FW.
Biol Reprod. 1999 Oct; 61(4):884-91.
PMID: 10491620 [PubMed - indexed for MEDLINE]
Antagonism of CD95 signaling blocks butyrate induction of apoptosis in young adult mouse colonic cells.
Fan YY, Zhang J, Barhoumi R, Burghardt RC, Turner ND, Lupton JR, Chapkin RS.
Am J Physiol. 1999 Aug; 277(2 Pt 1):C310-9.
PMID: 10444408 [PubMed - indexed for MEDLINE]
Analysis of Pb2+ entry into cultured astroglia.
Legare ME, Barhoumi R, Hebert E, Bratton GR, Burghardt RC, Tiffany-Castiglioni E.
Toxicol Sci. 1998 Nov; 46(1):90-100.
PMID: 9928672 [PubMed - indexed for MEDLINE]
Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut adult rat liver and kidney slices.
Parrish AR, Fisher R, Bral CM, Burghardt RC, Gandolfi AJ, Brendel K, Ramos KS.
Toxicol Appl Pharmacol. 1998 Oct; 152(2):302-8.
PMID: 9852999 [PubMed - indexed for MEDLINE]
Effects of the estrous cycle and early pregnancy on uterine expression of Mx protein in sheep (Ovis aries).
Ott TL, Yin J, Wiley AA, Kim HT, Gerami-Naini B, Spencer TE, Bartol FF, Burghardt RC, Bazer FW.
Biol Reprod. 1998 Oct; 59(4):784-94.
PMID: 9746726 [PubMed - indexed for MEDLINE]
Regulation of protein and prostaglandin secretion in polarized primary cultures of caprine uterine epithelial cells.
Newton GR, Weise DW, Bowen JA, Woldesenbet S, Burghardt RC.
In Vitro Cell Dev Biol Anim. 1998 Jul; 34(7):578-84.
PMID: 9719418 [PubMed - indexed for MEDLINE]
Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays.
Thompson DC, Barhoumi R, Burghardt RC.
Toxicol Appl Pharmacol. 1998 Mar; 149(1):55-63.
PMID: 9512727 [PubMed - indexed for MEDLINE]
Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells.
Hutchinson RW, Ing NH, Burghardt RC.
Cell Biol Toxicol. 1998 Dec; 14(6):391-9.
PMID: 9879931 [PubMed - indexed for MEDLINE]
Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line.
Hutchinson RW, Barhoumi R, Miles JM, Burghardt RC.
Toxicol Appl Pharmacol. 1998 Aug; 151(2):311-8.
PMID: 9707507 [PubMed - indexed for MEDLINE]
Endometrial connexin expression in the mare and pig: evidence for the suppression of cell-cell communication in uterine luminal epithelium.
Day WE, Bowen JA, Barhoumi R, Bazer FW, Burghardt RC.
Anat Rec. 1998 Jul; 251(3):277-85.
PMID: 9669753 [PubMed - indexed for MEDLINE]
17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects.
Wang W, Smith R 3rd, Burghardt R, Safe SH.
Mol Cell Endocrinol. 1997 Sep; 133(1):49-62.
PMID: 9359472 [PubMed - indexed for MEDLINE]
Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Wang WL, Porter W, Burghardt R, Safe SH.
Carcinogenesis. 1997 May; 18(5):925-33.
PMID: 9163677 [PubMed - indexed for MEDLINE]
Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vitro.
Bowen JA, Bazer FW, Burghardt RC.
Biol Reprod. 1997 Feb; 56(2):409-15.
PMID: 9116140 [PubMed - indexed for MEDLINE]
Extracellular matrix and the implantation cascade in pigs.
Burghardt RC, Bowen JA, Newton GR, Bazer FW.
J Reprod Fertil Suppl. 1997 ; 52:151-64.
PMID: 9602726 [PubMed - indexed for MEDLINE]
Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells.
Hoivik D, Wilson C, Wang W, Willett K, Barhoumi R, Burghardt R, Safe S.
Arch Biochem Biophys. 1997 Dec; 348(1):174-82.
PMID: 9390189 [PubMed - indexed for MEDLINE]
Diet and carcinogen alter luminal butyrate concentration and intracellular pH in isolated rat colonocytes.
Zoran DL, Barhoumi R, Burghardt RC, Chapkin RS, Lupton JR.
Nutr Cancer. 1997 ; 27(3):222-30.
PMID: 9101550 [PubMed - indexed for MEDLINE]
Alteration of oxytocin-induced calcium oscillations in clone 9 cells by toxin exposure.
Barhoumi R, Mouneimne Y, Phillips TD, Safe SH, Burghardt RC.
Fundam Appl Toxicol. 1996 Oct; 33(2):220-8.
PMID: 8921340 [PubMed - indexed for MEDLINE]
Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vivo.
Bowen JA, Bazer FW, Burghardt RC.
Biol Reprod. 1996 Nov; 55(5):1098-106.
PMID: 8902223 [PubMed - indexed for MEDLINE]
Characterization of a polarized porcine uterine epithelial model system.
Bowen JA, Newton GR, Weise DW, Bazer FW, Burghardt RC.
Biol Reprod. 1996 Sep; 55(3):613-9.
PMID: 8862779 [PubMed - indexed for MEDLINE]
Correlation between connexin43 expression, cell-cell communication, and oxytocin-induced Ca2+ responses in an immortalized human myometrial cell line.
Burghardt RC, Barhoumi R, Stickney M, Monga M, Ku CY, Sanborn BM.
Biol Reprod. 1996 Aug; 55(2):433-8.
PMID: 8828851 [PubMed - indexed for MEDLINE]
Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Hanneman WH, Legare ME, Barhoumi R, Burghardt RC, Safe S, Tiffany-Castiglioni E.
Toxicology. 1996 Aug; 112(1):19-28.
PMID: 8792845 [PubMed - indexed for MEDLINE]
Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro.
Barhoumi R, Burghardt RC.
Fundam Appl Toxicol. 1996 Apr; 30(2):290-7.
PMID: 8812278 [PubMed - indexed for MEDLINE]
Cyclic AMP induces rapid increases in gap junction permeability and changes in the cellular distribution of connexin43.
Burghardt RC, Barhoumi R, Sewall TC, Bowen JA.
J Membr Biol. 1995 Dec; 148(3):243-53.
PMID: 8747556 [PubMed - indexed for MEDLINE]
Developmental toxicity and structure-activity relationships of chlorophenols using human embryonic palatal mesenchymal cells.
Zhao F, Mayura K, Hutchinson RW, Lewis RP, Burghardt RC, Phillips TD.
Toxicol Lett. 1995 Jun; 78(1):35-42.
PMID: 7604397 [PubMed - indexed for MEDLINE]
Oxidative injury of coronary venular endothelial cells depletes intracellular glutathione and induces HSP 70 mRNA.
Aucoin MM, Barhoumi R, Kochevar DT, Granger HJ, Burghardt RC.
Am J Physiol. 1995 Apr; 268(4 Pt 2):H1651-8.
PMID: 7733367 [PubMed - indexed for MEDLINE]
Enhancement of melphalan toxicity by octanol in ovarian adenocarcinoma cell lines: effects of altered cell-cell communication, glutathione levels, and plasma membrane fluidity.
Barhoumi R, Bailey HR, Hutchinson RW, Bowen JA, Burghardt RC.
Fundam Appl Toxicol. 1995 Apr; 25(1):70-9.
PMID: 7601329 [PubMed - indexed for MEDLINE]
Kinetic analysis of glutathione in anchored cells with monochlorobimane.
Barhoumi R, Bailey RH, Burghardt RC.
Cytometry. 1995 Mar; 19(3):226-34.
PMID: 7736868 [PubMed - indexed for MEDLINE]
Laser cytometric analysis of FIV-induced injury in astroglia.
Zenger E, Collisson EW, Barhoumi R, Burghardt RC, Danave IR, Tiffany-Castiglioni E.
Glia. 1995 Feb; 13(2):92-100.
PMID: 7649618 [PubMed - indexed for MEDLINE]
Feline immunodeficiency virus decreases cell-cell communication and mitochondrial membrane potential.
Danave IR, Tiffany-Castiglioni E, Zenger E, Barhoumi R, Burghardt RC, Collisson EW.
J Virol. 1994 Oct; 68(10):6745-50.
PMID: 8084006 [PubMed - indexed for MEDLINE]
High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness.
Fernandez P, Burghardt R, Smith R, Nodland K, Safe S.
Eur J Pharmacol. 1994 Jan; 270(1):53-65.
PMID: 8157081 [PubMed - indexed for MEDLINE]
c-Ha-rasEJ transfection of rat aortic smooth muscle cells induces epidermal growth factor responsiveness and characteristics of a malignant phenotype.
Sadhu DN, Lundberg MS, Burghardt RC, Ramos KS.
J Cell Physiol. 1994 Dec; 161(3):490-500.
PMID: 7962130 [PubMed - indexed for MEDLINE]
Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone.
Moore M, Wang X, Lu YF, Wormke M, Craig A, Gerlach JH, Burghardt R, Barhoumi R, Safe S.
J Biol Chem. 1994 Apr; 269(16):11751-9.
PMID: 7909315 [PubMed - indexed for MEDLINE]
An in vitro model of ovarian epithelial carcinogenesis: changes in cell-cell communication and adhesion occurring during neoplastic progression.
Hoffman AG, Burghardt RC, Tilley R, Auersperg N.
Int J Cancer. 1993 Jul; 54(5):828-38.
PMID: 8325708 [PubMed - indexed for MEDLINE]
Low-level lead exposure in cultured astroglia: identification of cellular targets with vital fluorescent probes.
Legare ME, Barhoumi R, Burghardt RC, Tiffany-Castiglioni E.
Neurotoxicology. 1993 Sum; 14(2-3):267-72.
PMID: 8247400 [PubMed - indexed for MEDLINE]
Concurrent analysis of intracellular glutathione content and gap junctional intercellular communication.
Barhoumi R, Bowen JA, Stein LS, Echols J, Burghardt RC.
Cytometry. 1993 Oct; 14(7):747-56.
PMID: 8243203 [PubMed - indexed for MEDLINE]
Concomitant alterations of desmosomes, adhesiveness, and diffusion through gap junction channels in a rat ovarian transformation model system.
Stein LS, Stein DW, Echols J, Burghardt RC.
Exp Cell Res. 1993 Jul; 207(1):19-32.
PMID: 8319770 [PubMed - indexed for MEDLINE]
Gap junctions in myometrial cell cultures: evidence for modulation by cyclic adenosine 3':5'-monophosphate.
Dookwah HD, Barhoumi R, Narasimhan TR, Safe SH, Burghardt RC.
Biol Reprod. 1992 Sep; 47(3):397-407.
PMID: 1324745 [PubMed - indexed for MEDLINE]
Cell-to-cell communication competence in simian virus 40-transfected rat ovarian cells is reduced following tumor selection.
Stein LS, Welsh TH Jr, Wilson VG, Burghardt RC.
In Vitro Cell Dev Biol. 1992 Jun; 28A(6):436-44.
PMID: 1321806 [PubMed - indexed for MEDLINE]
Patulin-induced cellular toxicity: a vital fluorescence study.
Burghardt RC, Barhoumi R, Lewis EH, Bailey RH, Pyle KA, Clement BA, Phillips TD.
Toxicol Appl Pharmacol. 1992 Feb; 112(2):235-44.
PMID: 1539161 [PubMed - indexed for MEDLINE]
Reduced cell-cell communication between mitotic and nonmitotic coupled cells.
Stein LS, Boonstra J, Burghardt RC.
Exp Cell Res. 1992 Jan; 198(1):1-7.
PMID: 1727042 [PubMed - indexed for MEDLINE]
Rat ovarian granulosa cell culture: a model system for the study of cell-cell communication during multistep transformation.
Stein LS, Stoica G, Tilley R, Burghardt RC.
Cancer Res. 1991 Jan; 51(2):696-706.
PMID: 1845958 [PubMed - indexed for MEDLINE]
Viability and ultrastructure of equine embryos following culture in a static or dynamic system.
Pruitt JA, Forrest DW, Burghardt RC, Evans JW, Kraemer DC.
J Reprod Fertil Suppl. 1991 ; 44:405-10.
PMID: 1795284 [PubMed - indexed for MEDLINE]
Serum immunoreactive erythropoietin of children in health and disease.
Eckardt KU, Hartmann W, Vetter U, Pohlandt F, Burghardt R, Kurtz A.
Eur J Pediatr. 1990 Apr; 149(7):459-64.
PMID: 2347340 [PubMed - indexed for MEDLINE]
Gap junction modulation in rat uterus. III. Structure-activity relationships of estrogen receptor-binding ligands on myometrial and serosal cells.
Burghardt RC, Gaddy-Kurten D, Burghardt RL, Kurten RC, Mitchell PA.
Biol Reprod. 1987 Apr; 36(3):741-51.
PMID: 3593845 [PubMed - indexed for MEDLINE]
The ontogeny of nexuses (gap junctions) in the ovary of the fetal mouse.
Mitchell PA, Burghardt RC.
Anat Rec. 1986 Mar; 214(3):283-8.
PMID: 3963423 [PubMed - indexed for MEDLINE]
[Long-term study of various immunologic functions in children with chronic nonspecific lung diseases].
Wiersbitzky S, Ballke EH, Burghardt R, Spangenberg U, Joswig T, Baufeld W, Ordt HA, Paul W.
Z Erkr Atmungsorgane. 1985 ; 164(3):241-53.
PMID: 3874493 [PubMed - indexed for MEDLINE]
Gap junction modulation in rat uterus. I. Effects of estrogens on myometrial and serosal cells.
Burghardt RC, Matheson RL, Gaddy D.
Biol Reprod. 1984 Feb; 30(1):239-48.
PMID: 6696964 [PubMed - indexed for MEDLINE]
Gap junction modulation in rat uterus. II. Effects of antiestrogens on myometrial and serosal cells.
Burghardt RC, Mitchell PA, Kurten R.
Biol Reprod. 1984 Feb; 30(1):249-55.
PMID: 6421335 [PubMed - indexed for MEDLINE]
Gap junction amplification in rat ovarian granulosa cells. I. A direct response to follicle-stimulating hormone.
Burghardt RC, Matheson RL.
Dev Biol. 1982 Nov; 94(1):206-15.
PMID: 6818064 [PubMed - indexed for MEDLINE]
Histone-like protein and chromatin structure in the wall-less dinoflagellate Gymnodinium nelsoni.
Rizzo PJ, Burghardt RC.
Biosystems. 1982 ; 15(1):27-34.
PMID: 7200816 [PubMed - indexed for MEDLINE]
Light-induced division and genomic synchrony in phototrophically growing cultures of Rhodopseudomonas sphaeroides.
Lueking DR, Campbell TB, Burghardt RC.
J Bacteriol. 1981 May; 146(2):790-7.
PMID: 7012139 [PubMed - indexed for MEDLINE]
Hormonal modulation of gap junctions in rat ovarian follicles.
Burghardt RC, Anderson E.
Cell Tissue Res. 1981 ; 214(1):181-93.
PMID: 7471172 [PubMed - indexed for MEDLINE]
Intercellular junctions and exocytosis in the vas deferens of Ascaris.
Burghardt RC.
J Ultrastruct Res. 1980 May; 71(2):162-72.
PMID: 7381989 [PubMed - indexed for MEDLINE]
Chromatin structure in the unicellular algae Olisthodiscus luteus, Crypthecodinium cohnii and Peridiniun balticum.
Rizzo PJ, Burghardt RC.
Chromosoma. 1980 ; 76(1):91-9.
PMID: 7358010 [PubMed - indexed for MEDLINE]
Hormonal modulation of ovarian interstitial cells with particular reference to gap junctions.
Burghardt RC, Anderson E.
J Cell Biol. 1979 Apr; 81(1):104-14.
PMID: 479284 [PubMed - indexed for MEDLINE]
Membrane fusion during spermiogenesis in Ascaris.
Burghardt RC, Foor WE.
J Ultrastruct Res. 1978 Feb; 62(2):190-202.
PMID: 650734 [PubMed - indexed for MEDLINE]
Rapid morphological transformations of spermatozoa in the uterus of Brugia pahangi (Nematoda, Filarioidea).
Burghardt RC, Foor WE.
J Parasitol. 1975 Apr; 61(2):343-50.
PMID: 1127564 [PubMed - indexed for MEDLINE]