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Neurology

Neuro Gait Analysis Study

TitleNeuro Gait Analysis Study
Contact Person Small Animal Neurology Service (979) 845-2351
Species Dogs
Inclusion Criteria and General Background Information

Monday – Thursday; 8a-5p ONLY

20 Dachshunds total

  • 10 Dachshunds with moderate SCIs- non-ambulatory paraparesis
  • MFS - 3
  • <7 day duration of clinical signs consistent with spinal cord injury
  • Lesion localized to T10-L2 intervertebral disc spaces
  • Advanced imaging and surgery to treat IVDH
  • 2-6 years of age
  • BCS <6 (0-9 scale)
  • 10 Dachshunds with severe SCIs – parapelegia
  • MFS – 0-2
  • <7 day duration of clinical signs consistent with spinal cord injury
  • Lesion localized to T10-L2 intervertebral disc spaces
  • Advanced imaging and surgery to treat IVDH
  • 2-6 years of age
  • BCS <6 (0-9 scale)

Kinetic/kinematic analysis:

  • Dogs with SCI (4 total): Days 3, 7, 30, 90
Exclusion Criteria
  • Disseminated neoplasia or systemic inflammation
  • History of recent breeding/pregnancy
  • Detectable orthopedic disease
  • Unsuitable temperament for repeated behavioral evaluation
Owner Commitments
Financial Incentives

$3750 package pricing and a $750.00 rebate at the completion of the Day 90 recheck.

Effect of LUNAR-301 on Dogs with Glial Brain Tumors-Phase II Efficacy Study

TitleEffect of LUNAR-301 on Dogs with Glial Brain Tumors-Phase II Efficacy Study
Contact Person

Elizabeth Scanlin, BS

Cindy Schocke, CST

Beth Boudreau, DVM, PhD, DACVIM-Neurology

Species Dogs
Inclusion Criteria and General Background Information
  • Dogs at least one year of age
  • Weight >25 kgs
  • Diagnosed with a high-grade glioma
    • Presumptively (based on MRI characteristics) OR
    • Definitively (based on biopsy)
  • Normal organ and bonne marrow function
    • Determined by pre-treatment CBC/Chemistry/UA/Coag panel
  • MRI must be performed at Texas A&M University

MRI+/-biopsy and clinicopathological testing must be complete and reviewed before patient can be enrolled in the study

Exclusion Criteria
  • Dogs with severe signs of brain disease on the Modified Glasgow Coma Scale
    • MGCS<14
  • Dogs with no discrete mass identified on MRI
  • Dogs that previously received chemotherapy
    • Chemotherapy for unrelated tumors OK
    • Corticosteroids are OK
Owner Commitments

Study drug administration and collection of study and diagnostic blood samples will occur for 19 study days.

Dogs must remain hospitalized for 24 hours after each drug administration period.

Required Rechecks

6-8 weeks: Recheck with optional MRI (MRI would require general anesthesia)

3, 6, 9, 12 months: Recheck MRI (requires general anesthesia)

Further details on the study procedures can be obtained by contacting the Neurology Staff at 979-845-2351

Financial Incentives
  • Costs of hospitalization, drug administration and diagnostic monitoring between enrollment and completion of the study will be covered by the study
  • Costs of the brain biopsy (if elected by the owner) will be covered by the study
  • Up to $2,500 for the treatment of adverse events related to the study drug will be covered by the study

Initial Peripheral Blood Collection in Dogs with SCI

TitleInitial Peripheral Blood Collection in Dogs with SCI
Contact Person Neurology Service
(979) 845-2351
Species
Inclusion Criteria and General Background Information

Enrollment is Mon.-Fri. 8a-5pm; Closed for enrollment Sept. 19-Oct. 2, 2016

Blood draws of 10 mLs-12 mLs will be collected in EDTA coated plastic tubes, provided for the study. Dogs enrolled in this study will have blood draws at 4 time points: day 0 (day of surgery), and days 3, 7, 42, 90 post-surgeries.

Inclusion Criteria for SCI Dogs

  1. Affected dogs will have IVDH treated with surgical decompression
  2. Lesions must be localized to the T3-L3 spinal cord segments
  3. ≤ 2 day history of non-ambulatory status compatible with SCI
  4. Can have back pain prior to non-ambulatory status
  5. Minimum weight of 4 kg (9 lbs)

Inclusion Criteria for Peripheral Injury Dogs

  1. Affected dogs will have acute long bone fracture treated with surgery.
  2. ≤ 2 day history of cruciate rupture
  3. Minimum weight of 4 kg (9 lbs)

NOTE: If a Dachshund, the patient can be co-enrolled in the Dachshund

Exclusion Criteria
  1. Additional neurologic disease that is unrelated to the spinal cord
  2. Pregnant
  3. Uncooperative dogs
  4. Illness or disease in which the immune system is functioning abnormally (e.g.: cancer, inflammatory bowel disease, atopy, immune-mediated diseases)
  5. Inflammation unrelated to SCI (e.g.: clinically significant skin infections)
  6. NSAIDS given within 30 days
  7. Glucocorticoids given within 30 days
  8. No history of vaccination within 2 weeks
Owner Commitments
Financial Incentives

$3,750 package pricing for research