Cardiology

Canine Study 1 (Closed to new patients)

Title:	EPIC Study
Contact Person:	Kathy Glaze Phone: 979-845-2351 Email: kglaze@cvm.tamu.edu (put Heart Studies in the subject line)
Species:	Canines
Study Summary:	EPIC Study Summary This study will evaluate if pimobendan (Vetmedin®) can prolong the asymptomatic stage of chronic leaky mitral valve disease (i.e. delay the onset of heart failure/pulmonary edema). It is a placebo controlled study that is fully funded (no cost to the owner). The study requires screening to determine if all entry criteria are met and then follow-up appointments (approximately every 4 months) at TAMU.
Eligibility for EPIC free screening including a physical exam and echocardiogram at TAMU	Relatively healthy dogs greater or equal to 6 year of age Weight between 9 and 33.1 lbs (must weigh at least 9 lbs) Heart murmur from leaky mitral valve greater than or equal to 3/6 Willing to come to Texas A & M approximately every 4 months for 4-5 years Fulfill the rest of the screening criteria which can be determined during a free screening visit to Texas A & M. Not taking enalapril, benazepril, furosemide, pimobendan or a beta-blocker such as atenolol or carvedilol Client willing to consider taking part in a placebo controlled clinical study

Title:	Biologic Variability Study for Cardiac Biomarkers in Dogs
Contact	If you, your staff or clients would like more information or to set up appointments for screening, please contact Kathy Glaze Phone: 979-845-2351 Email: kglaze@cvm.tamu.edu (put Heart Studies in the subject line)
Species	Canines
Study Summary	This study will evaluate how much the concentrations of certain molecules (NTproBNP and cardiac troponin I) change in the blood stream of dogs with chronic leaky mitral valve disease Screening tests will ensure each dog is healthy, other than their heart disease All screening tests will be paid for ONLY IF all eligibility requirements are met This study is funded by the American Kennel Club (AKC) Only 2 visits are required for the study, exactly 7 days apart
Eligibility	Relatively healthy dogs weighing between 11 and 33 lbs Dogs with somewhat advanced leaky mitral valve disease (i.e they have heart enlargement, and some will have been in congestive heart failure previously) Willing to come to Texas A&M 2 times, exactly 7 days apart No significant other diseases Client pays for the exam fee (~$30) if the patient qualifies for the study, then all screening tests are free If the patient doesn't qualify for the study, then the client pays for the exam and all screening tests performed