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Guan Zhu

Professor

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Phone: (979) 845-6981

Mailstop: 4467

Department: VTPB

Photo of Zhu, Guan

Web Presence

Education

  • Ph.D. Parasitology, University of Georgia 1993
  • M.S. Zoology and Parasitology, Zhejiang (formerly Hangzhou) University, China 1986
  • B.S. Biology, Zhejiang (formerly Hangzhou) University, China 1983

Scholarly Interests

Our laboratory conducts translational research with an ultimate goal to discover new anti-parasitic therapeutics by targeting metabolic enzymes and other molecules critical or essential to the parasite infection, survival and development, such as those involved in the lipid and energy metabolisms and interacting with host cells in Cryptosporidium and other protozoan parasites. Other research areas include functional genomics and molecular evolution of apicomplexan parasites, and parasitic diseases important to the conservation of wild animals. Please also see additional lab information at http://www.guanzhulab.com .

Publications

A Unique Hexokinase in Cryptosporidium parvum, an Apicomplexan Pathogen Lacking the Krebs Cycle and Oxidative Phosphorylation.
Yu Y, Zhang H, Guo F, Sun M, Zhu G.
Protist. ; 165: 701-714.
A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.
Checkley W, White AC Jr, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, Petri WA Jr, Priest JW, Roos DS, Striepen B, Thompson RC, Ward HD, Van Voorhis WA, Xiao L, Zhu G, Houpt ER.
Lancet Infect Dis. ; .
Amelioration of Cryptosporidium parvum infection in vitro and in vivo by targeting parasite fatty acyl-coenzyme A syntheses.
Guo F, Zhang H, Fritzler JM, Rider SD Jr, Xiang L, McNair NN, Mead JR, Zhu G.
J Infect Dis. ; 209: 1279-87.
Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics
Zhang H, Guo F & Zhu G.
PLoS Pathogens. ; 11: e1005250.
Differential Gene Expression and Protein Localization of Cryptosporidium parvum Fatty Acyl-CoA Synthetase Isoforms
Guo F, Zhang H, Payne HR & Zhu G.
Journal of Eukaryotic Microbiology. ; 63: 233-46.
Silk Fibroin Scaffolds Facilitating the Repair of Rat Abdominal Wall Defect
He K, Wu Z, Wen JC, Xu B, Shao YK, Qian JM, Zhu G & Yao QY.
Journal of Biomaterials and Tissue Engineering. ; 6: 665-71.
Molecular and biochemical characterization of Eimeria tenella hexokinase
Sun M, Liao S, Zhang L, Wu C, Qi N, Lv M, Li J, Lin X, Zhang J, Xie M, Zhu G & Cai J.
Parasitology Research. ; 115: 3425-33.
Giardia fatty acyl-CoA synthetases as potential drug targets.
Guo F, Ortega-Pierres G, Argüello-García R, Zhang H, Zhu G.
Front. Microbiol.. ; .
Quantitative RT-PCR assay for high-throughput screening (HTS) of drugs against the growth of Cryptosporidium parvum in vitro
Zhang H & Zhu G .
Frontier in Microbiology. ; 63: 233-46.


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