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Patricia Holman

Research Associate Professor

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Phone: (979) 845-4202

Mailstop: 4467

Department: VTPB

Photo of Holman, Patricia


  • PhD Veterinary Microbiology, Texas A&M University 1994
  • MS Microbiology, University of Nebraska 1976
  • BA Biology, Winthrop College 1974

Scholarly Interests

Molecular mechanisms driving interactions between Babesia spp. and their hosts; characterization of potential vaccine or drug targets for babesiosis; molecular phylogeny of the hemoparasites; genetic basis of bovine resistance/susceptibility to ectoparasitism; development of molecular diagnostic tests for piroplasms.


Expression of bovine genes associated with local and systemic immune response to infestation with the Lone Star tick, Amblyomma americanum
58. Brannan, JL, P K Riggs, P M Olafson, I Ivanov, PJ Holman
Ticks and Tick-borne Diseases . 2014 5(6):676-688.
Sika deer carrying Babesia parasites closely related to B. divergens, Japan
Zamoto-Niikura A, Tsuji M, Imaoka K, Kimura M, Morikawa S, Holman PJ, Hirata H, Ishihara C
Emerg Infect Dis. 2014 20(8):1398-1400.
Molecular characterization of Trypanosoma (Megatrypanum) spp. infecting cattle (Bos taurus), white-tailed deer (Odocoileus virginianus), and elk (Cervus elaphus canadensis) in the United States
Fisher, AC, G Schuster, WJ Cobb, AJ James, SM Cooper, AA Peréz de León, PJ Holman
Veterinary Parasitology. 2013 197(197):29-42.
Babesia odocoilei infection in a North American elk (Cervus elaphus canadensis)
Ameri, M, WI Anderson, PJ Holman, GW Palmer.
Comparative Clinical Pathology. 2012 21(21):3.
Canine hepatozoonosis and babesiosis, and feline cytauxzoonosis.
Holman PJ, Snowden KF
Vet Clin North Am Small Anim Pract. 2009 39(6):1035-53.
Detection of a large unnamed Babesia piroplasm originally identified in dogs in North Carolina in a dog with no history of travel to that state.
Holman PJ, Backlund BB, Wilcox AL, Stone R, Stricklin AL, Bardin KE
J Am Vet Med Assoc. 2009 235(7):851-4.
Anthelmintic resistant Haemonchus contortus in a giraffe (Giraffa camelopardalis) in Florida.
Garretson PD, Hammond EE, Craig TM, Holman PJ
J Zoo Wildl Med. 2009 40(1):131-9.
In vitro cultivation of a newly recognized Babesia sp. in dogs in North Carolina.
Lehtinen LE, Birkenheuer AJ, Droleskey RE, Holman PJ
Vet Parasitol. 2008 151(2-4):150-7.
A new species of coccidia (Apicomplexa: Sarcocystidae) from the slender-tailed meerkat Suricata suricatta (Scheber, 1776) from South Africa
El-Gayar, A.K., P.J. Holman, T.M. Craig, T.W. deMaar, S.C. Wilson, P. Chung, K.M. Woods, C. Norris, S.J. Upton.
Acta Protozoologica 47: 69-76 . 2008 47(47):69-76.
Sequence polymorphism in the ribosomal DNA internal transcribed spacers differs among Theileria species.
Aktas, M., K.G. Bendele, K. Altay, N. Dumanli, M. Tsuji, P.J. Holman
Veterinary Parasitology. 2007 147(147):221-230.
New ruminant hosts and wider geographic range identified for Babesia odocoilei (Emerson and Wright 1970).
Schoelkopf L, Hutchinson CE, Bendele KG, Goff WL, Willette M, Rasmussen JM, Holman PJ
J Wildl Dis. 2005 41(4):683-90.
In vitro cultivation of a zoonotic Babesia sp. isolated from eastern cottontail rabbits (Sylvilagus floridanus) on Nantucket Island, Massachusetts.
Holman PJ, Spencer AM, Droleskey RE, Goethert HK, Telford SR 3rd
J Clin Microbiol. 2005 43(8):3995-4001.
Molecular cloning of a phospholipid-hydroperoxide glutathione peroxidase gene from the tick, Boophilus microplus (Acari: Ixodidae)
Cossío-Bayúgar, R., E. Miranda, P.J. Holman
Insect Biochemistry and Molecular Biology . 2005 35(12):1378-1387.
Detection of Theileria ovis in infected sheep by nested PCR
Altay, K., N. Dumanli, P.J. Holman, M. Aktas
Veterinary Parasitology. 2005 127(127):99-104.
Naturally-acquired babesiosis in a reindeer (Rangifer tarandus tarandus) herd in Great Britain.
Langton, C., J. Gray, P.F. Waters, P.J. Holman.
Parasitology Research. 2003 89(89):194-198.
Babesia odocoilei in elk (Cervus elaphus canadensis) in Indiana. Journal of the
Gallatin, L., A.R. Irizarry Rovira, M.Renninger, P.J. Holman, G.G. Wagner, J. Sojka, J.A. Christian
American Veterinary Medical Association . 2003 223(223):1027-1032.
Babesiosis and heartwater: threats without boundaries.
Wagner GG, Holman P, Waghela S
Vet Clin North Am Food Anim Pract. 2002 18(3):417-30.
Genotypically unique Babesia spp. isolated from reindeer (Rangifer tarandus tarandus) in the United States.
Holman PJ, Swift PK, Frey RE, Bennett J, Cruz D, Wagner GG
Parasitol Res. 2002 88(5):405-11.
Theileria buffeli infection of a Michigan cow confirmed by small subunit ribosomal RNA gene analysis.
Cossio-Bayugar R, Pillars R, Schlater J, Holman PJ
Vet Parasitol. 2002 105(2):105-10.
In vitro generation of organophosphate resistant boophilus microplus (Acari: Ixodidae) cell lines.
Cossio-Bayugar R, Wagner GG, Holman PJ
J Med Entomol. 2002 39(2):278-84.
A cathepsin L-like cysteine protease is conserved among Babesia equi isolates.
Holman PJ, Hsieh MM, Nix JL, Bendele KG, Wagner GG, Ball JM
Mol Biochem Parasitol. 2002 119(2):295-300.
Basal cellular alterations of esterase, glutathione, glutathione-S-transferase, intracellular calcium, and membrane potentials in coumaphos-resistant Boophilus microplus (Acari: Ixodidae) cell lines
Cossío-Bayúgar, R., R. Barhoumi, R.C. Burghardt, G.G. Wagner, P.J. Holman
Pesticide Biochemistry and Physiology. 2002 72(72):1-9.
Acute babesiosis caused by Babesia divergens in a resident of Kentucky.
Beattie, J.F, M.L. Michelson, P.J. Holman
The New England Journal of Medicine . 2002 347(347):697-698.
Antigenic, phenotypic and molecular characterization confirms Babesia odocoilei isolated from three cervids.
Holman PJ, Madeley J, Craig TM, Allsopp BA, Allsopp MT, Petrini KR, Waghela SD, Wagner GG
J Wildl Dis. 2000 36(3):518-30.
A common high molecular weight antigen of Babesia bovis isolates from Mexico.
Sahagun Ruiz A, Waghela SD, Romany MM, Holman PJ, Melendy D, Cruz D, Wagner GG
Int J Parasitol. 2000 30(1):59-64.
Restriction-fragment-length polymorphism analysis of small-subunit rRNA genes of Blastocystis isolates from animal hosts.
Snowden K, Logan K, Blozinski C, Hoevers J, Holman P
Parasitol Res. 2000 86(1):62-6.
Theileria sp. Infections associated with bovine fatalities in the United States confirmed by small-subunit rRNA gene analyses of blood and tick samples.
Chae J, Levy M, Hunt J Jr, Schlater J, Snider G, Waghela SD, Holman PJ, Wagner GG
J Clin Microbiol. 1999 37(9):3037-40.
Two Theileria cervi SSU RRNA gene sequence types found in isolates from white-tailed deer and elk in North America.
Chae JS, Waghela SD, Craig TM, Kocan AA, Wagner GG, Holman PJ
J Wildl Dis. 1999 35(3):458-65.
A study of the systematics of Theileria spp. based upon SSU rRNA gene sequences
Chae, J.S., B.A. Allsopp, S.D. Waghela, J.H. Park, T. Kukuda, C. Sugimoto, M. Allsopp, G.G.Wagner, P.J. Holman
Parasitology Research . 1999 85(85):877-883.
Babesia equi field isolates cultured from horse blood using a microcentrifuge method.
Holman PJ, Becu T, Bakos E, Polledo G, Cruz D, Wagner GG
J Parasitol. 1998 84(4):696-9.
Identical small subunit ribosomal RNA gene nucleotide sequence of bovine Theileria isolates (Korea and Japan) and Theileria buffeli (Marula, Kenya).
Chae JS, Kwon OD, Holman PJ, Waghela SD, Wagner GG, Lee JM
Korean J Parasitol. 1998 36(1):47-53.
Identification and sequence analysis of SSU rRNA gene of bovine Theileria isolates from Korea and Japan.
Chae, J.S. O.D. Kwon, S.D. Waghela, P.J. Holman, G.G.Wagner, J.M. Lee
Korean Journal of Parasitology . 1998 38(38):909-917.
Biotin-labeled DNA probe in a PCR-based assay increases detection sensitivity for the equine hemoparasite Babesia caballi.
Sahagun-Ruiz A, Waghela SD, Holman PJ, Chieves LP, Wagner GG
Vet Parasitol. 1997 73(1-2):53-63.
Culture isolation and partial characterization of a Babesia sp. from a North American elk (Cervus elaphus).
Holman PJ, Craig TM, Crider DL, Petrini KR, Rhyan J, Wagner GG
J Wildl Dis. 1994 30(3):460-5.
Babesia equi erythrocytic stage continuously cultured in an enriched medium.
Holman PJ, Chieves L, Frerichs WM, Olson D, Wagner GG
J Parasitol. 1994 80(2):232-6.
In vitro isolation and cultivation of a Babesia from an American woodland caribou (Rangifer tarandus caribou).
Holman PJ, Petrini K, Rhyan J, Wagner GG
J Wildl Dis. 1994 30(2):195-200.
In vitro growth of Babesia bovis in white-tailed deer (Odocoileus virginianus) erythrocytes.
Holman PJ, Waldrup KA, Droleskey RE, Corrier DE, Wagner GG
J Parasitol. 1993 79(2):233-7.
Culture confirmation of the carrier status of Babesia caballi-infected horses.
Holman PJ, Frerichs WM, Chieves L, Wagner GG
J Clin Microbiol. 1993 31(3):698-701.
In vitro cultivation of a Babesia isolated from a white-tailed deer (Odocoileus virginianus).
Holman PJ, Waldrup KA, Wagner GG
J Parasitol. 1988 74(1):111-5.
Expression of bovine genes associated with local and systemic immune response to infestation with the Lone Star tick, Amblyomma americanum
Brannan, JL, Penny K. Riggs, Pia M. Olafson, Ivan Ivanov, Patricia J. Holman
Ticks and Tick-Borne Diseases.

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