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Stephen Safe

Distinguished Professor

Curriculum Vitae

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Phone: (979) 845-5988

Mailstop: 4466

Department: VTPP

Photo of Safe, Stephen

Education

  • D.Phil. Bioorganic Chemistry, Oxford University, Great Britain 1965
  • M.S. Chemistry, Queen's University, Canada 1963
  • B.S. Chemistry, Queen's University, Canada 1962

Scholarly Interests

Toxicology and molecular biology of estrogenic and antiestrogenic compounds; molecular mechanisms of estrogen receptor and Ah receptor action and their crosstalk in breast cancer; NR4A1 and Sp proteins as drug targets; long non-coding RNAs

Publications

Unifying Mechanisms of Action of the Anticancer Activities of Triterpenoids and Synthetic Analogs.
Safe SH, Prather PL, Brents LK, Chadalapaka G, Jutooru I.
Anticancer Agents Med Chem. 2012 May; .
PMID: 22583404 [PubMed - as supplied by publisher]
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.
Zhuang G, Meng C, Guo X, Cheruku PS, Shi L, Xu H, Li H, Wang G, Evans AR, Safe S, Wu C, Zhou B.
Circulation. 2012 Jun; 125(23):2892-903.
PMID: 22580331 [PubMed - in process]
Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer.
Liu X, Jutooru I, Lei P, Kim K, Lee SO, Brents LK, Prather PL, Safe S.
Mol Cancer Ther. 2012 Jul; 11(7):1421-31.
PMID: 22553354 [PubMed - in process]
Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells.
Chadalapaka G, Jutooru I, Safe S.
Carcinogenesis. 2012 Apr; 33(4):886-94.
PMID: 22334592 [PubMed - indexed for MEDLINE]
Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.
Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S.
Nutr Cancer. 2011 ; 63(7):1133-42.
PMID: 21919647 [PubMed - indexed for MEDLINE]
Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.
Chintharlapalli S, Papineni S, Lei P, Pathi S, Safe S.
BMC Cancer. 2011 Aug; 11:371.
PMID: 21864401 [PubMed - in process]
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line.
Barhoumi R, Mouneimne Y, Ramos E, Morisseau C, Hammock BD, Safe S, Parrish AR, Burghardt RC.
Toxicol Appl Pharmacol. 2011 May; 253(1):45-56.
PMID: 21420996 [PubMed - indexed for MEDLINE]
MDM2 regulates estrogen receptor a and estrogen responsiveness in breast cancer cells.
Kim K, Burghardt R, Barhoumi R, Lee SO, Liu X, Safe S.
J Mol Endocrinol. 2011 ; 46(2):67-79.
PMID: 21169420 [PubMed - indexed for MEDLINE]
GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.
Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S.
Mol Cancer Res. 2011 Feb; 9(2):195-202.
PMID: 21156786 [PubMed - indexed for MEDLINE]
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.
Vanderlaag K, Su Y, Frankel AE, Burghardt RC, Barhoumi R, Chadalapaka G, Jutooru I, Safe S.
BMC Cancer. 2010 Dec; 10:669.
PMID: 21129193 [PubMed - indexed for MEDLINE]
3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters.
Safe S.
Toxicol Sci. 2010 Sep; 117(1):1-3.
PMID: 20651249 [PubMed - indexed for MEDLINE]
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.
Jutooru I, Chadalapaka G, Lei P, Safe S.
J Biol Chem. 2010 Aug; 285(33):25332-44.
PMID: 20538607 [PubMed - indexed for MEDLINE]
Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.
Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S.
Mol Pharmacol. 2010 Aug; 78(2):226-36.
PMID: 20488920 [PubMed - indexed for MEDLINE]
Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth.
Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S.
Exp Cell Res. 2010 Aug; 316(13):2174-88.
PMID: 20435036 [PubMed - indexed for MEDLINE]
Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.
Chadalapaka G, Jutooru I, Burghardt R, Safe S.
Mol Cancer Res. 2010 May; 8(5):739-50.
PMID: 20407012 [PubMed - indexed for MEDLINE]
MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.
Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J, Safe S.
Endocrinology. 2010 Jun; 151(6):2462-73.
PMID: 20382698 [PubMed - indexed for MEDLINE]
1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells.
Sreevalsan S, Jutooru I, Chadalapaka G, Walker M, Safe S.
Int J Oncol. 2009 Nov; 35(5):1191-9.
PMID: 19787275 [PubMed - indexed for MEDLINE]
Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.
Papineni S, Chintharlapalli S, Abdelrahim M, Lee SO, Burghardt R, Abudayyeh A, Baker C, Herrera L, Safe S.
Carcinogenesis. 2009 Jul; 30(7):1193-201.
PMID: 19406933 [PubMed - indexed for MEDLINE]
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines.
Barhoumi R, Catania JM, Parrish AR, Awooda I, Tiffany-Castiglioni E, Safe S, Burghardt RC.
J Toxicol Sci. 2009 Feb; 34(1):13-25.
PMID: 19182432 [PubMed - indexed for MEDLINE]
Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative.
Jutooru I, Chadalapaka G, Chintharlapalli S, Papineni S, Safe S.
Mol Carcinog. 2009 Aug; 48(8):692-702.
PMID: 19125423 [PubMed - indexed for MEDLINE]
Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways.
Safe S, Kim K.
J Mol Endocrinol. 2008 Nov; 41(5):263-75.
PMID: 18772268 [PubMed - indexed for MEDLINE]
Curcumin decreases specificity protein expression in bladder cancer cells.
Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R 3rd, Li X, Safe S.
Cancer Res. 2008 Jul; 68(13):5345-54.
PMID: 18593936 [PubMed - indexed for MEDLINE]
Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.
Safe S, Papineni S, Chintharlapalli S.
Cancer Lett. 2008 Oct; 269(2):326-38.
PMID: 18501502 [PubMed - indexed for MEDLINE]
Absorption and biological activity of phytochemical-rich extracts from açai (Euterpe oleracea Mart.) pulp and oil in vitro.
Pacheco-Palencia LA, Talcott ST, Safe S, Mertens-Talcott S.
J Agric Food Chem. 2008 May; 56(10):3593-600.
PMID: 18442253 [PubMed - indexed for MEDLINE]
Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives.
Chadalapaka G, Jutooru I, McAlees A, Stefanac T, Safe S.
Bioorg Med Chem Lett. 2008 Apr; 18(8):2633-9.
PMID: 18359628 [PubMed - indexed for MEDLINE]
Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay.
Zhang S, Rowlands C, Safe S.
Toxicol Appl Pharmacol. 2008 Mar; 227(2):196-206.
PMID: 18048071 [PubMed - indexed for MEDLINE]
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways.
Vanderlaag K, Su Y, Frankel AE, Grage H, Smith R 3rd, Khan S, Safe S.
Breast Cancer Res Treat. 2008 May; 109(2):273-83.
PMID: 17624585 [PubMed - indexed for MEDLINE]
Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins.
Higgins KJ, Liu S, Abdelrahim M, Vanderlaag K, Liu X, Porter W, Metz R, Safe S.
Mol Endocrinol. 2008 Feb; 22(2):388-402.
PMID: 18006642 [PubMed - indexed for MEDLINE]
Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells.
Khan S, Wu F, Liu S, Wu Q, Safe S.
J Mol Endocrinol. 2007 Oct; 39(4):289-304.
PMID: 17909268 [PubMed - indexed for MEDLINE]
Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells.
Khan S, Liu S, Stoner M, Safe S.
Toxicol Appl Pharmacol. 2007 Aug; 223(1):28-38.
PMID: 17599377 [PubMed - indexed for MEDLINE]
Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150).
Lee J, Safe S.
Arch Biochem Biophys. 2007 May; 461(2):200-10.
PMID: 17306756 [PubMed - indexed for MEDLINE]
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.
Mertens-Talcott SU, Chintharlapalli S, Li X, Safe S.
Cancer Res. 2007 Nov; 67(22):11001-11.
PMID: 18006846 [PubMed - indexed for MEDLINE]
The role of xenoestrogenic compounds in the development of breast cancer.
Safe S, Papineni S.
Trends Pharmacol Sci. 2006 Aug; 27(8):447-54.
PMID: 16822555 [PubMed - indexed for MEDLINE]
Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes.
Khan S, Konstantinov A, Chittim B, McAlees A, Yeo B, Safe S.
Toxicol In Vitro. 2006 Oct; 20(7):1234-7.
PMID: 16759834 [PubMed - indexed for MEDLINE]
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways.
Chintharlapalli S, Papineni S, Safe S.
Mol Cancer Ther. 2006 May; 5(5):1362-70.
PMID: 16731770 [PubMed - indexed for MEDLINE]
Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.
Khan S, Barhoumi R, Burghardt R, Liu S, Kim K, Safe S.
Mol Endocrinol. 2006 Sep; 20(9):2199-214.
PMID: 16675542 [PubMed - indexed for MEDLINE]
17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways.
Ru Lee W, Chen CC, Liu S, Safe S.
J Cell Biochem. 2006 Sep; 99(1):209-20.
PMID: 16598773 [PubMed - indexed for MEDLINE]
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.
Barhoumi R, Awooda I, Mouneimne Y, Safe S, Burghardt RC.
Toxicol Lett. 2006 Aug; 165(2):133-41.
PMID: 16567066 [PubMed - indexed for MEDLINE]
Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds.
Li X, Zhang S, Safe S.
J Steroid Biochem Mol Biol. 2006 Feb; 98(2-3):122-32.
PMID: 16413991 [PubMed - indexed for MEDLINE]
Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM.
Vanderlaag K, Samudio I, Burghardt R, Barhoumi R, Safe S.
Cancer Lett. 2006 May; 236(2):198-212.
PMID: 16051428 [PubMed - indexed for MEDLINE]
Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells.
Zhang S, Li X, Burghardt R, Smith R 3rd, Safe SH.
J Mol Endocrinol. 2005 Dec; 35(3):433-47.
PMID: 16326831 [PubMed - indexed for MEDLINE]
Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins.
Abdelrahim M, Safe S.
Mol Pharmacol. 2005 Aug; 68(2):317-29.
PMID: 15883203 [PubMed - indexed for MEDLINE]
Clinical correlates of environmental endocrine disruptors.
Safe S.
Trends Endocrinol Metab. 2005 May; 16(4):139-44.
PMID: 15860409 [PubMed - indexed for MEDLINE]
Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer.
Kim K, Barhoumi R, Burghardt R, Safe S.
Mol Endocrinol. 2005 Apr; 19(4):843-54.
PMID: 15637147 [PubMed - indexed for MEDLINE]
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.
Lee JE, Kim K, Sacchettini JC, Smith CV, Safe S.
J Biol Chem. 2005 Mar; 280(10):8819-30.
PMID: 15625066 [PubMed - indexed for MEDLINE]
Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins.
Wu Q, Burghardt R, Safe S.
J Biol Chem. 2004 Dec; 279(51):53602-12.
PMID: 15471764 [PubMed - indexed for MEDLINE]
Endocrine disruptors and human health: is there a problem.
Safe S.
Toxicology. 2004 Dec; 205(1-2):3-10.
PMID: 15458784 [PubMed - indexed for MEDLINE]
Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1.
Chen CC, Lee WR, Safe S.
J Cell Biochem. 2004 Nov; 93(5):1063-74.
PMID: 15449318 [PubMed - indexed for MEDLINE]
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells.
Abdelrahim M, Smith R 3rd, Burghardt R, Safe S.
Cancer Res. 2004 Sep; 64(18):6740-9.
PMID: 15374992 [PubMed - indexed for MEDLINE]
Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways.
Qin C, Samudio I, Ngwenya S, Safe S.
Mol Carcinog. 2004 Jul; 40(3):160-70.
PMID: 15224348 [PubMed - indexed for MEDLINE]
Nuclear receptor-mediated transactivation through interaction with Sp proteins.
Safe S, Kim K.
Prog Nucleic Acid Res Mol Biol. 2004 ; 77:1-36.
PMID: 15196889 [PubMed - indexed for MEDLINE]
Comparative in vitro and in vivo genotoxicities of 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions.
Cizmas L, Zhou GD, Safe SH, McDonald TJ, Zhu L, Donnelly KC.
Environ Mol Mutagen. 2004 ; 43(3):159-68.
PMID: 15065203 [PubMed - indexed for MEDLINE]
Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.
Morrow D, Qin C, Smith R 3rd, Safe S.
J Steroid Biochem Mol Biol. 2004 Jan; 88(1):27-36.
PMID: 15026081 [PubMed - indexed for MEDLINE]
Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins.
Stoner M, Wormke M, Saville B, Samudio I, Qin C, Abdelrahim M, Safe S.
Oncogene. 2004 Feb; 23(5):1052-63.
PMID: 14647449 [PubMed - indexed for MEDLINE]
Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action.
Safe S, Wormke M.
Chem Res Toxicol. 2003 Jul; 16(7):807-16.
PMID: 12870882 [PubMed - indexed for MEDLINE]
Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells.
Abdelrahim M, Smith R 3rd, Safe S.
Mol Pharmacol. 2003 Jun; 63(6):1373-81.
PMID: 12761348 [PubMed - indexed for MEDLINE]
Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells.
Khan S, Abdelrahim M, Samudio I, Safe S.
Endocrinology. 2003 Jun; 144(6):2325-35.
PMID: 12746293 [PubMed - indexed for MEDLINE]
17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context.
Castro-Rivera E, Safe S.
J Steroid Biochem Mol Biol. 2003 Jan; 84(1):23-31.
PMID: 12648521 [PubMed - indexed for MEDLINE]
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.
Qin C, Burghardt R, Smith R, Wormke M, Stewart J, Safe S.
Cancer Res. 2003 Mar; 63(5):958-64.
PMID: 12615709 [PubMed - indexed for MEDLINE]
The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes.
Wormke M, Stoner M, Saville B, Walker K, Abdelrahim M, Burghardt R, Safe S.
Mol Cell Biol. 2003 Mar; 23(6):1843-55.
PMID: 12612060 [PubMed - indexed for MEDLINE]
Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
Zhang S, Qin C, Safe SH.
Environ Health Perspect. 2003 Dec; 111(16):1877-82.
PMID: 14644660 [PubMed - indexed for MEDLINE]
Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells.
Kim K, Thu N, Saville B, Safe S.
Mol Endocrinol. 2003 May; 17(5):804-17.
PMID: 12576490 [PubMed - indexed for MEDLINE]
Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells.
Vyhlidal C, Li X, Safe S.
J Mol Endocrinol. 2002 Dec; 29(3):305-17.
PMID: 12459033 [PubMed - indexed for MEDLINE]
Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells.
Stoner M, Saville B, Wormke M, Dean D, Burghardt R, Safe S.
Mol Endocrinol. 2002 Oct; 16(10):2231-42.
PMID: 12351689 [PubMed - indexed for MEDLINE]
Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells.
Barhoumi R, Mouneimne Y, Awooda I, Safe SH, Donnelly KC, Burghardt RC.
Toxicol Sci. 2002 Aug; 68(2):444-50.
PMID: 12151640 [PubMed - indexed for MEDLINE]
Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex.
Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R, Safe S.
Mol Endocrinol. 2002 Aug; 16(8):1793-809.
PMID: 12145335 [PubMed - indexed for MEDLINE]
Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells.
Abdelrahim M, Samudio I, Smith R 3rd, Burghardt R, Safe S.
J Biol Chem. 2002 Aug; 277(32):28815-22.
PMID: 12052832 [PubMed - indexed for MEDLINE]
Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells.
Duan R, Xie W, Li X, McDougal A, Safe S.
Biochem Biophys Res Commun. 2002 Jun; 294(2):384-94.
PMID: 12051724 [PubMed - indexed for MEDLINE]
Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review).
Safe S, McDougal A.
Int J Oncol. 2002 Jun; 20(6):1123-8.
PMID: 12011988 [PubMed - indexed for MEDLINE]
Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells.
Mealey KL, Barhoumi R, Burghardt RC, Safe S, Kochevar DT.
Antimicrob Agents Chemother. 2002 Mar; 46(3):755-61.
PMID: 11850258 [PubMed - indexed for MEDLINE]
Environmental estrogens: roles in male reproductive tract problems and in breast cancer.
Safe S.
Rev Environ Health. 2002 Oct; 17(4):253-62.
PMID: 12611468 [PubMed - indexed for MEDLINE]
Problems for risk assessment of endocrine-active estrogenic compounds.
Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, McDonnell D.
Environ Health Perspect. 2002 Dec; 110 Suppl 6:925-9.
PMID: 12634121 [PubMed - indexed for MEDLINE]
Toxicology of environmental estrogens.
Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, Saville B, McDonnellc D.
Reprod Fertil Dev. 2001 ; 13(4):307-15.
PMID: 11800169 [PubMed - indexed for MEDLINE]
Transcriptional activation of rat creatine kinase B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites.
Wang F, Samudio I, Safe S.
J Cell Biochem. 2001 ; 84(1):156-72.
PMID: 11746525 [PubMed - indexed for MEDLINE]
Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells.
Lee JE, Safe S.
Biochem Pharmacol. 2001 Oct; 62(8):1113-24.
PMID: 11597580 [PubMed - indexed for MEDLINE]
Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements.
Yoon K, Pallaroni L, Stoner M, Gaido K, Safe S.
J Steroid Biochem Mol Biol. 2001 Jul; 78(1):25-32.
PMID: 11530281 [PubMed - indexed for MEDLINE]
Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats.
McDougal A, Gupta MS, Morrow D, Ramamoorthy K, Lee JE, Safe SH.
Breast Cancer Res Treat. 2001 Mar; 66(2):147-57.
PMID: 11437101 [PubMed - indexed for MEDLINE]
Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements.
Castro-Rivera E, Samudio I, Safe S.
J Biol Chem. 2001 Aug; 276(33):30853-61.
PMID: 11410592 [PubMed - indexed for MEDLINE]
Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator.
McDougal A, Wormke M, Calvin J, Safe S.
Cancer Res. 2001 May; 61(10):3902-7.
PMID: 11358803 [PubMed - indexed for MEDLINE]
Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk.
Xie W, Duan R, Safe S.
J Mol Endocrinol. 2001 Jun; 26(3):217-28.
PMID: 11357058 [PubMed - indexed for MEDLINE]
Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions.
Safe S.
Vitam Horm. 2001 ; 62:231-52.
PMID: 11345900 [PubMed - indexed for MEDLINE]
Molecular biology of the Ah receptor and its role in carcinogenesis.
Safe S.
Toxicol Lett. 2001 Mar; 120(1-3):1-7.
PMID: 11323156 [PubMed - indexed for MEDLINE]
Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis.
Qin C, Wilson C, Blancher C, Taylor M, Safe S, Harris AL.
Clin Cancer Res. 2001 Apr; 7(4):818-23.
PMID: 11309328 [PubMed - indexed for MEDLINE]
Transcriptional activation of deoxyribonucleic acid polymerase alpha gene expression in MCF-7 cells by 17 beta-estradiol.
Samudio I, Vyhlidal C, Wang F, Stoner M, Chen I, Kladde M, Barhoumi R, Burghardt R, Safe S.
Endocrinology. 2001 Mar; 142(3):1000-8.
PMID: 11181512 [PubMed - indexed for MEDLINE]
Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization.
Chen I, Hsieh T, Thomas T, Safe S.
Gene. 2001 Jan; 262(1-2):207-14.
PMID: 11179685 [PubMed - indexed for MEDLINE]
Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists.
Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Kim K, Safe S.
J Mol Endocrinol. 2001 Feb; 26(1):31-42.
PMID: 11174852 [PubMed - indexed for MEDLINE]
Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.
Wang F, Samudio I, Safe S.
Mol Cell Endocrinol. 2001 Feb; 172(1-2):91-103.
PMID: 11165043 [PubMed - indexed for MEDLINE]
Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1.
Duan R, Xie W, Burghardt RC, Safe S.
J Biol Chem. 2001 Apr; 276(15):11590-8.
PMID: 11145955 [PubMed - indexed for MEDLINE]
Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells.
Stewart MD, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE.
Endocrinology. 2001 Jan; 142(1):98-107.
PMID: 11145571 [PubMed - indexed for MEDLINE]
3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells.
Lee JE, Safe S.
Toxicol Sci. 2000 Dec; 58(2):235-42.
PMID: 11099636 [PubMed - indexed for MEDLINE]
Bisphenol A and related endocrine disruptors.
Safe S.
Toxicol Sci. 2000 Aug; 56(2):251-2.
PMID: 10910979 [PubMed - indexed for MEDLINE]
Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells.
Xie W, Duan R, Chen I, Samudio I, Safe S.
Endocrinology. 2000 Jul; 141(7):2439-49.
PMID: 10875244 [PubMed - indexed for MEDLINE]
Endocrine disruptors and human health--is there a problem? An update.
Safe SH.
Environ Health Perspect. 2000 Jun; 108(6):487-93.
PMID: 10856020 [PubMed - indexed for MEDLINE]
Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines.
Yoon K, Pellaroni L, Ramamoorthy K, Gaido K, Safe S.
Mol Cell Endocrinol. 2000 Apr; 162(1-2):211-20.
PMID: 10854714 [PubMed - indexed for MEDLINE]
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells.
Wormke M, Castro-Rivera E, Chen I, Safe S.
J Steroid Biochem Mol Biol. 2000 Apr; 72(5):197-207.
PMID: 10822009 [PubMed - indexed for MEDLINE]
Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.
Stoner M, Wang F, Wormke M, Nguyen T, Samudio I, Vyhlidal C, Marme D, Finkenzeller G, Safe S.
J Biol Chem. 2000 Jul; 275(30):22769-79.
PMID: 10816575 [PubMed - indexed for MEDLINE]
Transcriptional activation of cathepsin D gene expression by growth factors.
Wang F, Duan R, Chirgwin J, Safe SH.
J Mol Endocrinol. 2000 Apr; 24(2):193-202.
PMID: 10750020 [PubMed - indexed for MEDLINE]
Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane.
McDougal A, Sethi Gupta M, Ramamoorthy K, Sun G, Safe SH.
Cancer Lett. 2000 Apr; 151(2):169-79.
PMID: 10738111 [PubMed - indexed for MEDLINE]
Analysis of benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line.
Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC.
Toxicol Sci. 2000 Feb; 53(2):264-70.
PMID: 10696774 [PubMed - indexed for MEDLINE]
Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.
Saville B, Wormke M, Wang F, Nguyen T, Enmark E, Kuiper G, Gustafsson JA, Safe S.
J Biol Chem. 2000 Feb; 275(8):5379-87.
PMID: 10681512 [PubMed - indexed for MEDLINE]
Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells.
Safe S, Wormke M, Samudio I.
J Mammary Gland Biol Neoplasia. 2000 Jul; 5(3):295-306.
PMID: 14973392 [PubMed - indexed for MEDLINE]
Symposium on mechanisms of action of naturally occurring anticarcinogens.
Safe S, Wargovich MJ, Lamartiniere CA, Mukhtar H.
Toxicol Sci. 1999 Nov; 52(1):1-8.
PMID: 10568692 [PubMed - indexed for MEDLINE]
Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells.
Dong L, Wang W, Wang F, Stoner M, Reed JC, Harigai M, Samudio I, Kladde MP, Vyhlidal C, Safe S.
J Biol Chem. 1999 Nov; 274(45):32099-107.
PMID: 10542244 [PubMed - indexed for MEDLINE]
Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.
Duan R, Porter W, Samudio I, Vyhlidal C, Kladde M, Safe S.
Mol Endocrinol. 1999 Sep; 13(9):1511-21.
PMID: 10478842 [PubMed - indexed for MEDLINE]
Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex.
Wang F, Wang W, Safe S.
Biochemistry. 1999 Aug; 38(35):11490-500.
PMID: 10471301 [PubMed - indexed for MEDLINE]
Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer.
Safe S, Qin C, McDougal A.
Expert Opin Investig Drugs. 1999 Sep; 8(9):1385-96.
PMID: 15992156 [PubMed]
3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells.
Ramamoorthy K, Gupta MS, Sun G, McDougal A, Safe SH.
Carcinogenesis. 1999 Jan; 20(1):115-23.
PMID: 9934858 [PubMed - indexed for MEDLINE]
Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions.
Xie W, Duan R, Safe S.
Endocrinology. 1999 Jan; 140(1):219-27.
PMID: 9886828 [PubMed - indexed for MEDLINE]
Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions.
Wang W, Dong L, Saville B, Safe S.
Mol Endocrinol. 1999 Aug; 13(8):1373-87.
PMID: 10446910 [PubMed - indexed for MEDLINE]
Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells.
Castro-Rivera E, Wormke M, Safe S.
Mol Cell Endocrinol. 1999 Apr; 150(1-2):11-21.
PMID: 10411295 [PubMed - indexed for MEDLINE]
Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes.
Qin C, Singh P, Safe S.
Endocrinology. 1999 Jun; 140(6):2501-8.
PMID: 10342835 [PubMed - indexed for MEDLINE]
Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells.
Gupta M, McDougal A, Safe S.
J Steroid Biochem Mol Biol. 1998 Dec; 67(5-6):413-9.
PMID: 10030690 [PubMed - indexed for MEDLINE]
Methods for xenoestrogen testing.
Safe S, Connor K, Gaido K.
Toxicol Lett. 1998 Dec; 102-103:665-70.
PMID: 10022332 [PubMed - indexed for MEDLINE]
Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms.
Safe S, Wang F, Porter W, Duan R, McDougal A.
Toxicol Lett. 1998 Dec; 102-103:343-7.
PMID: 10022276 [PubMed - indexed for MEDLINE]
Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses.
Wilson CL, Safe S.
Toxicol Pathol. 1998 Sep; 26(5):657-71.
PMID: 9789953 [PubMed - indexed for MEDLINE]
Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane.
Chen I, McDougal A, Wang F, Safe S.
Carcinogenesis. 1998 Sep; 19(9):1631-9.
PMID: 9771935 [PubMed - indexed for MEDLINE]
Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach.
Safe SH.
Environ Health Perspect. 1998 Aug; 106 Suppl 4:1051-8.
PMID: 9703492 [PubMed - indexed for MEDLINE]
Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex.
Sun G, Porter W, Safe S.
Mol Endocrinol. 1998 Jun; 12(6):882-90.
PMID: 9626663 [PubMed - indexed for MEDLINE]
Estrogen- and antiestrogen-responsiveness of HEC1A endometrial adenocarcinoma cells in culture.
Castro-Rivera E, Safe S.
J Steroid Biochem Mol Biol. 1998 Mar; 64(5-6):287-95.
PMID: 9618030 [PubMed - indexed for MEDLINE]
Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes.
Wang F, Hoivik D, Pollenz R, Safe S.
Nucleic Acids Res. 1998 Jun; 26(12):3044-52.
PMID: 9611253 [PubMed - indexed for MEDLINE]
Interactions between hormones and chemicals in breast cancer.
Safe SH.
Annu Rev Pharmacol Toxicol. 1998 ; 38:121-58.
PMID: 9597151 [PubMed - indexed for MEDLINE]
Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene.
Willett KL, Randerath K, Zhou GD, Safe SH.
Biochem Pharmacol. 1998 Mar; 55(6):831-9.
PMID: 9586956 [PubMed - indexed for MEDLINE]
Altered phenotypic characteristics of T47d human breast cancer cells after prolonged growth in estrogen-deficient medium.
Fernandez P, Wilson C, Hoivik D, Safe SH.
Cell Biol Int. 1998 ; 22(9-10):623-33.
PMID: 10452832 [PubMed - indexed for MEDLINE]
Ah receptor-independent induction of CYP1A2 gene expression in genetically inbred mice.
Gupta M, Miggens J, Parrish A, Womack J, Ramos KS, Rodriguez LV, Goldstein LS, Holtzapple C, Stanker L, Safe SH.
Environ Toxicol Pharmacol. 1998 May; 5(3):205-13.
PMID: 21781866 [PubMed - in process]
Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation.
Duan R, Porter W, Safe S.
Endocrinology. 1998 Apr; 139(4):1981-90.
PMID: 9528985 [PubMed - indexed for MEDLINE]
Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens.
McDougal A, Safe S.
Environ Health Perspect. 1998 Apr; 106(4):203-6.
PMID: 9494123 [PubMed - indexed for MEDLINE]
Halogenated aromatic hydrocarbons suppress CA1 field excitatory postsynaptic potentials in rat hippocampal slices.
Hong SJ, Grover CA, Safe SH, Tiffany-Castiglioni E, Frye GD.
Toxicol Appl Pharmacol. 1998 Jan; 148(1):7-13.
PMID: 9465258 [PubMed - indexed for MEDLINE]
Development validation and problems with the toxic equivalency factor approach for risk assessment of dioxins and related compounds.
Safe SH.
J Anim Sci. 1998 Jan; 76(1):134-41.
PMID: 9464894 [PubMed - indexed for MEDLINE]
17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects.
Wang W, Smith R 3rd, Burghardt R, Safe SH.
Mol Cell Endocrinol. 1997 Sep; 133(1):49-62.
PMID: 9359472 [PubMed - indexed for MEDLINE]
Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol.
Ramamoorthy K, Vyhlidal C, Wang F, Chen I, Safe S, McDonnell DP, Leonard LS, Gaido KW.
Toxicol Appl Pharmacol. 1997 Nov; 147(1):93-100.
PMID: 9356311 [PubMed - indexed for MEDLINE]
Functional synergy between the transcription factor Sp1 and the estrogen receptor.
Porter W, Saville B, Hoivik D, Safe S.
Mol Endocrinol. 1997 Oct; 11(11):1569-80.
PMID: 9328340 [PubMed - indexed for MEDLINE]
Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein.
Wilson CL, Thomsen J, Hoivik DJ, Wormke MT, Stanker L, Holtzapple C, Safe SH.
Arch Biochem Biophys. 1997 Oct; 346(1):65-73.
PMID: 9328285 [PubMed - indexed for MEDLINE]
Human exposure to endocrine-active chemicals: hazard assessment problems.
Safe S, Connor K, Ramamoorthy K, Gaido K, Maness S.
Regul Toxicol Pharmacol. 1997 Aug; 26(1 Pt 1):52-8.
PMID: 9339480 [PubMed - indexed for MEDLINE]
Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships.
Connor K, Ramamoorthy K, Moore M, Mustain M, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P.
Toxicol Appl Pharmacol. 1997 Jul; 145(1):111-23.
PMID: 9221830 [PubMed - indexed for MEDLINE]
Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene.
Wang F, Porter W, Xing W, Archer TK, Safe S.
Biochemistry. 1997 Jun; 36(25):7793-801.
PMID: 9201922 [PubMed - indexed for MEDLINE]
Characterization of the H4IIE rat hepatoma cell bioassay for evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs).
Willett KL, Gardinali PR, Sericano JL, Wade TL, Safe SH.
Arch Environ Contam Toxicol. 1997 May; 32(4):442-8.
PMID: 9175514 [PubMed - indexed for MEDLINE]
Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Wang WL, Porter W, Burghardt R, Safe SH.
Carcinogenesis. 1997 May; 18(5):925-33.
PMID: 9163677 [PubMed - indexed for MEDLINE]
Is there an association between exposure to environmental estrogens and breast cancer?
Safe SH.
Environ Health Perspect. 1997 Apr; 105 Suppl 3:675-8.
PMID: 9168013 [PubMed - indexed for MEDLINE]
Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism.
Ramamoorthy K, Wang F, Chen IC, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S.
Endocrinology. 1997 Apr; 138(4):1520-7.
PMID: 9075711 [PubMed - indexed for MEDLINE]
Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced fetal cleft palate and immunotoxicity in C57BL/6 mice by 2,2',4,4',5,5'-hexachlorobiphenyl.
Zhao F, Mayura K, Harper N, Safe SH, Phillips TD.
Chemosphere. 1997 Mar; 34(5-7):1605-13.
PMID: 9134691 [PubMed - indexed for MEDLINE]
Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds.
Safe S.
Teratog Carcinog Mutagen. 1997 199; 17(4-5):285-304.
PMID: 9508738 [PubMed - indexed for MEDLINE]
Organochlorine exposure and risk for breast cancer.
Safe SH, Zacharewski T.
Prog Clin Biol Res. 1997 ; 396:133-45.
PMID: 9108595 [PubMed - indexed for MEDLINE]
Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl.
Zhao F, Mayura K, Kocurek N, Edwards JF, Kubena LF, Safe SH, Phillips TD.
Fundam Appl Toxicol. 1997 Jan; 35(1):1-8.
PMID: 9024668 [PubMed - indexed for MEDLINE]
Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum.
Moore M, Mustain M, Daniel K, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P.
Toxicol Appl Pharmacol. 1997 Jan; 142(1):160-8.
PMID: 9007045 [PubMed - indexed for MEDLINE]
Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists.
McDougal A, Wilson C, Safe S.
Cancer Lett. 1997 Nov; 120(1):53-63.
PMID: 9570386 [PubMed - indexed for MEDLINE]
Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression.
Porter W, Wang F, Wang W, Duan R, Safe S.
Mol Endocrinol. 1996 Nov; 10(11):1371-8.
PMID: 8923463 [PubMed - indexed for MEDLINE]
Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring.
Wilker C, Johnson L, Safe S.
Toxicol Appl Pharmacol. 1996 Nov; 141(1):68-75.
PMID: 8917677 [PubMed - indexed for MEDLINE]
Atypical cytochrome P450 induction profiles in glomerular mesangial cells at the mRNA and enzyme level. Evidence for CYP1A1 and CYP1B1 expression and their involvement in benzo[a]pyrene metabolism.
Bowes RC 3rd, Parrish AR, Steinberg MA, Willett KL, Zhao W, Savas U, Jefcoate CR, Safe SH, Ramos KS.
Biochem Pharmacol. 1996 Aug; 52(4):587-95.
PMID: 8759031 [PubMed - indexed for MEDLINE]
Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells.
Lu YF, Sun G, Wang X, Safe S.
Arch Biochem Biophys. 1996 Aug; 332(1):35-40.
PMID: 8806706 [PubMed - indexed for MEDLINE]
Stimulation of calcium uptake in cultured rat hippocampal neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Hanneman WH, Legare ME, Barhoumi R, Burghardt RC, Safe S, Tiffany-Castiglioni E.
Toxicology. 1996 Aug; 112(1):19-28.
PMID: 8792845 [PubMed - indexed for MEDLINE]
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-induced responses in MCF-7 human breast cancer cells.
Liu H, Safe S.
Toxicol Appl Pharmacol. 1996 Jun; 138(2):242-50.
PMID: 8658525 [PubMed - indexed for MEDLINE]
Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists.
Lu YF, Santostefano M, Cunningham BD, Threadgill MD, Safe S.
Biochem Pharmacol. 1996 Apr; 51(8):1077-87.
PMID: 8866830 [PubMed - indexed for MEDLINE]
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells.
Chen I, Safe S, Bjeldanes L.
Biochem Pharmacol. 1996 Apr; 51(8):1069-76.
PMID: 8866829 [PubMed - indexed for MEDLINE]
Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro.
Connor K, Howell J, Chen I, Liu H, Berhane K, Sciarretta C, Safe S, Zacharewski T.
Fundam Appl Toxicol. 1996 Mar; 30(1):93-101.
PMID: 8812239 [PubMed - indexed for MEDLINE]
Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells.
Wang WL, Thomsen JS, Porter W, Moore M, Safe S.
Br J Cancer. 1996 Feb; 73(3):316-22.
PMID: 8562336 [PubMed - indexed for MEDLINE]
Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: structure-activity studies.
Dickerson R, Keller LH, Safe S.
Toxicol Appl Pharmacol. 1995 Dec; 135(2):287-98.
PMID: 8545839 [PubMed - indexed for MEDLINE]
Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells.
Krishnan V, Porter W, Santostefano M, Wang X, Safe S.
Mol Cell Biol. 1995 Dec; 15(12):6710-9.
PMID: 8524236 [PubMed - indexed for MEDLINE]
Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats.
Connor K, Safe S, Jefcoate CR, Larsen M.
Biochem Pharmacol. 1995 Nov; 50(11):1913-20.
PMID: 8615872 [PubMed - indexed for MEDLINE]
Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines.
Wang X, Thomsen JS, Santostefano M, Rosengren R, Safe S, Perdew GH.
Eur J Pharmacol. 1995 Oct; 293(3):191-205.
PMID: 8666036 [PubMed - indexed for MEDLINE]
Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum.
Safe S, Washburn K, Zacharewski T, Phillips T.
Chemosphere. 1995 Aug; 31(4):3017-23.
PMID: 7552046 [PubMed - indexed for MEDLINE]
Environmental and dietary estrogens and human health: is there a problem?
Safe SH.
Environ Health Perspect. 1995 Apr; 103(4):346-51.
PMID: 7607134 [PubMed - indexed for MEDLINE]
Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells.
Lu YF, Santostefano M, Cunningham BD, Threadgill MD, Safe S.
Arch Biochem Biophys. 1995 Jan; 316(1):470-7.
PMID: 7840652 [PubMed - indexed for MEDLINE]
Human chorionic gonadotropin protects Leydig cell function against 2,3,7,8-tetrachlorodibenzo-p-dioxin in adult rats: role of Leydig cell cytoplasmic volume.
Wilker CE, Welsh TH Jr, Safe SH, Narasimhan TR, Johnson L.
Toxicology. 1995 Jan; 95(1-3):93-102.
PMID: 7825193 [PubMed - indexed for MEDLINE]
Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity.
Liu H, Wormke M, Safe SH, Bjeldanes LF.
J Natl Cancer Inst. 1994 Dec; 86(23):1758-65.
PMID: 7966413 [PubMed - indexed for MEDLINE]
Development of an in vitro model for investigating the formation of the nuclear Ah receptor complex in mouse Hepa 1c1c7 cells.
Wang X, Safe S.
Arch Biochem Biophys. 1994 Dec; 315(2):285-92.
PMID: 7986070 [PubMed - indexed for MEDLINE]
Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice.
Narasimhan TR, Craig A, Arellano L, Harper N, Howie L, Menache M, Birnbaum L, Safe S.
Fundam Appl Toxicol. 1994 Nov; 23(4):598-607.
PMID: 7867912 [PubMed - indexed for MEDLINE]
2-Phenylphenanthridinone and related compounds: aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1.
Liu H, Santostefano M, Safe S.
Arch Biochem Biophys. 1994 Sep; 313(2):206-14.
PMID: 8080264 [PubMed - indexed for MEDLINE]
Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists.
Harper N, Wang X, Liu H, Safe S.
Mol Cell Endocrinol. 1994 Aug; 104(1):47-55.
PMID: 7821706 [PubMed - indexed for MEDLINE]
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in MCF-7 human breast cancer cells.
Lu Y, Wang X, Safe S.
Toxicol Appl Pharmacol. 1994 Jul; 127(1):1-8.
PMID: 8048042 [PubMed - indexed for MEDLINE]
Effect of ligand structure on formation and DNA binding properties of the transformed rat cytosolic aryl hydrocarbon receptor.
Santosfefano M, Liu H, Wang X, Chaloupka K, Safe S.
Chem Res Toxicol. 1994 Jul; 7(4):544-50.
PMID: 7981419 [PubMed - indexed for MEDLINE]
Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.
Krishnan V, Wang X, Safe S.
J Biol Chem. 1994 Jun; 269(22):15912-7.
PMID: 8195246 [PubMed - indexed for MEDLINE]
Biphasic modulation of protein kinase C (PKC) activity by polychlorinated dibenzo-p-dioxins (PCDDs) in serum-deprived rat aortic smooth muscle cells.
Weber TJ, Ou X, Merchant M, Wang X, Safe SH, Ramos KS.
J Biochem Toxicol. 1994 Jun; 9(3):113-20.
PMID: 7983676 [PubMed - indexed for MEDLINE]
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor.
Thomsen JS, Wang X, Hines RN, Safe S.
Carcinogenesis. 1994 May; 15(5):933-7.
PMID: 8200098 [PubMed - indexed for MEDLINE]
Benzo[a]pyrene-resistant MCF-7 human breast cancer cells. A unique aryl hydrocarbon-nonresponsive clone.
Moore M, Wang X, Lu YF, Wormke M, Craig A, Gerlach JH, Burghardt R, Barhoumi R, Safe S.
J Biol Chem. 1994 Apr; 269(16):11751-9.
PMID: 7909315 [PubMed - indexed for MEDLINE]
2,3,7,8-Tetrachlorodibenzo-p-dioxin reduces the number, size, and organelle content of Leydig cells in adult rat testes.
Johnson L, Wilker CE, Safe SH, Scott B, Dean DD, White PH.
Toxicology. 1994 Mar; 89(1):49-65.
PMID: 8178322 [PubMed - indexed for MEDLINE]
Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.
Safe SH.
Crit Rev Toxicol. 1994 ; 24(2):87-149.
PMID: 8037844 [PubMed - indexed for MEDLINE]
Immunosuppressive effects of highly chlorinated biphenyls and diphenyl ethers on T-cell dependent and independent antigens in mice.
Harper N, Howie L, Connor K, Dickerson R, Safe S.
Toxicology. 1993 Dec; 85(2-3):123-35.
PMID: 8303708 [PubMed - indexed for MEDLINE]
Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists.
Chaloupka K, Harper N, Krishnan V, Santostefano M, Rodriguez LV, Safe S.
Chem Biol Interact. 1993 Dec; 89(2-3):141-58.
PMID: 8269543 [PubMed - indexed for MEDLINE]
Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells.
Wang X, Porter W, Krishnan V, Narasimhan TR, Safe S.
Mol Cell Endocrinol. 1993 Oct; 96(1-2):159-66.
PMID: 8276131 [PubMed - indexed for MEDLINE]
6-substituted 3,4-benzocoumarins: a new structural class of inducers and inhibitors of CYP1A1-dependent activity.
Liu H, Santostefano M, Lu Y, Safe S.
Arch Biochem Biophys. 1993 Oct; 306(1):223-31.
PMID: 8215408 [PubMed - indexed for MEDLINE]
Development of bioassays and approaches for the risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Safe S.
Environ Health Perspect. 1993 Oct; 101 Suppl 3:317-25.
PMID: 8143638 [PubMed - indexed for MEDLINE]
Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate.
Moore M, Narasimhan TR, Steinberg MA, Wang X, Safe S.
Arch Biochem Biophys. 1993 Sep; 305(2):483-8.
PMID: 8396892 [PubMed - indexed for MEDLINE]
Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-p-dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice.
Harper N, Connor K, Safe S.
Toxicology. 1993 Jun; 80(2-3):217-27.
PMID: 8328002 [PubMed - indexed for MEDLINE]
Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.
Merchant M, Krishnan V, Safe S.
Toxicol Appl Pharmacol. 1993 Jun; 120(2):179-85.
PMID: 8390116 [PubMed - indexed for MEDLINE]
Immunosuppressive and monooxygenase induction activities of highly chlorinated diphenyl ether congeners in C57BL/6 and DBA/2 mice.
Harper N, Howie L, Connor K, Arellano L, Craig A, Dickerson R, Safe S.
Fundam Appl Toxicol. 1993 May; 20(4):496-502.
PMID: 8314464 [PubMed - indexed for MEDLINE]
Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs).
Harris M, Zacharewski T, Safe S.
Fundam Appl Toxicol. 1993 May; 20(4):456-63.
PMID: 8314461 [PubMed - indexed for MEDLINE]
Characterization of the aryl hydrocarbon receptor and aryl hydrocarbon responsiveness in human ovarian carcinoma cell lines.
Rowlands C, Krishnan V, Wang X, Santostefano M, Safe S, Miller WR, Langdon S.
Cancer Res. 1993 Apr; 53(8):1802-7.
PMID: 8385571 [PubMed - indexed for MEDLINE]
Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems.
Safe S.
Environ Health Perspect. 1993 Apr; 100:259-68.
PMID: 8354174 [PubMed - indexed for MEDLINE]
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells.
Moore M, Narasimhan TR, Wang X, Krishnan V, Safe S, Williams HJ, Scott AI.
J Steroid Biochem Mol Biol. 1993 Mar; 44(3):251-61.
PMID: 8384872 [PubMed - indexed for MEDLINE]
Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines.
Arellano LO, Wang X, Safe S.
Carcinogenesis. 1993 Feb; 14(2):219-22.
PMID: 8382112 [PubMed - indexed for MEDLINE]
alpha-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation.
Santostefano M, Merchant M, Arellano L, Morrison V, Denison MS, Safe S.
Mol Pharmacol. 1993 Feb; 43(2):200-6.
PMID: 8381508 [PubMed - indexed for MEDLINE]
Teratogenicity and immunotoxicity of 3,3',4,4',5-pentachlorobiphenyl in C57BL/6 mice.
Mayura K, Spainhour CB, Howie L, Safe S, Phillips TD.
Toxicology. 1993 Jan; 77(1-2):123-31.
PMID: 8442008 [PubMed - indexed for MEDLINE]
Modulation of protooncogene expression in rat aortic smooth muscle cells by benzo[a]pyrene.
Sadhu DN, Merchant M, Safe SH, Ramos KS.
Arch Biochem Biophys. 1993 Jan; 300(1):124-31.
PMID: 8424644 [PubMed - indexed for MEDLINE]
Reduced Leydig cell volume and function in adult rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin without a significant effect on spermatogenesis.
Johnson L, Dickerson R, Safe SH, Nyberg CL, Lewis RP, Welsh TH Jr.
Toxicology. 1992 Nov; 76(2):103-18.
PMID: 1462355 [PubMed - indexed for MEDLINE]
Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: role of the Ah receptor.
Chaloupka K, Krishnan V, Safe S.
Carcinogenesis. 1992 Dec; 13(12):2233-9.
PMID: 1335374 [PubMed - indexed for MEDLINE]
A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis.
Wang X, Santostefano M, Lu Y, Safe S.
Chem Biol Interact. 1992 Nov; 85(1):79-93.
PMID: 1333892 [PubMed - indexed for MEDLINE]
Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Merchant M, Morrison V, Santostefano M, Safe S.
Arch Biochem Biophys. 1992 Nov; 298(2):389-94.
PMID: 1329656 [PubMed - indexed for MEDLINE]
Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Liu H, Biegel L, Narasimhan TR, Rowlands C, Safe S.
Mol Cell Endocrinol. 1992 Sep; 87(1-3):19-28.
PMID: 1332906 [PubMed - indexed for MEDLINE]
Gap junctions in myometrial cell cultures: evidence for modulation by cyclic adenosine 3':5'-monophosphate.
Dookwah HD, Barhoumi R, Narasimhan TR, Safe SH, Burghardt RC.
Biol Reprod. 1992 Sep; 47(3):397-407.
PMID: 1324745 [PubMed - indexed for MEDLINE]
The interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in chick embryo hepatocytes.
Yao C, Safe S.
Toxicol In Vitro. 1992 Jul; 6(4):373-80.
PMID: 20732135 [PubMed - in process]
Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells.
Krishnan V, Narasimhan T, Safe S.
Anal Biochem. 1992 Jul; 204(1):137-42.
PMID: 1381155 [PubMed - indexed for MEDLINE]
Growth inhibitory and antimitogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in T47D human breast cancer cells.
Fernandez P, Safe S.
Toxicol Lett. 1992 Jul; 61(2-3):185-97.
PMID: 1322575 [PubMed - indexed for MEDLINE]
Kinetics of the association of several tritiated polychlorinated dibenzo-p-dioxin and dibenzofuran congeners with hepatic cytosolic Ah receptor from the Wistar rat.
Rosengren R, Safe S, Bunce NJ.
Chem Res Toxicol. 1992 May; 5(3):376-82.
PMID: 1324021 [PubMed - indexed for MEDLINE]
Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line.
Wang X, Rosengren R, Morrison V, Santostefano M, Safe S.
Biochem Pharmacol. 1992 Apr; 43(7):1635-42.
PMID: 1314608 [PubMed - indexed for MEDLINE]
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor.
Zacharewski T, Harris M, Biegel L, Morrison V, Merchant M, Safe S.
Toxicol Appl Pharmacol. 1992 Apr; 113(2):311-8.
PMID: 1313996 [PubMed - indexed for MEDLINE]
The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus.
Dickerson R, Howie L, Safe S.
Toxicol Appl Pharmacol. 1992 Mar; 113(1):55-63.
PMID: 1313194 [PubMed - indexed for MEDLINE]
Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins.
Merchant M, Wang X, Kamps C, Rosengren R, Morrison V, Safe S.
Arch Biochem Biophys. 1992 Jan; 292(1):250-7.
PMID: 1309295 [PubMed - indexed for MEDLINE]
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action.
Safe S, Astroff B, Harris M, Zacharewski T, Dickerson R, Romkes M, Biegel L.
Pharmacol Toxicol. 1991 Dec; 69(6):400-9.
PMID: 1766914 [PubMed - indexed for MEDLINE]
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced glucose metabolism in MCF-7 human breast cancer cells: 13C nuclear magnetic resonance spectroscopy studies.
Narasimhan TR, Safe S, Williams HJ, Scott AI.
Mol Pharmacol. 1991 Dec; 40(6):1029-35.
PMID: 1758438 [PubMed - indexed for MEDLINE]
DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells.
Piskorska-Pliszczynska J, Morrison V, Zacharewski T, Safe S.
Arch Biochem Biophys. 1991 Nov; 290(2):362-8.
PMID: 1656877 [PubMed - indexed for MEDLINE]
Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells.
Zacharewski T, Harris M, Safe S.
Biochem Pharmacol. 1991 Jun; 41(12):1931-9.
PMID: 1645554 [PubMed - indexed for MEDLINE]
In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon receptor from transformed rodent and human cell lines.
Wang X, Narasimhan TR, Morrison V, Safe S.
Arch Biochem Biophys. 1991 May; 287(1):186-94.
PMID: 1654803 [PubMed - indexed for MEDLINE]
Neonatal exposure to Aroclor 1254: effects on adult hepatic testosterone hydroxylase activities.
Haake-McMillan JM, Safe SH.
Xenobiotica. 1991 Apr; 21(4):481-9.
PMID: 1897248 [PubMed - indexed for MEDLINE]
6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats.
Astroff B, Safe S.
Toxicology. 1991 ; 69(2):187-97.
PMID: 1949047 [PubMed - indexed for MEDLINE]
Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes.
Piskorska-Pliszczynska J, Astroff B, Zacharewski T, Harris M, Rosengren R, Morrison V, Safe L, Safe S.
Arch Biochem Biophys. 1991 Jan; 284(1):193-200.
PMID: 1846513 [PubMed - indexed for MEDLINE]
Effects of hydroxylated polychlorinated biphenyls on mouse liver mitochondrial oxidative phosphorylation.
Narasimhan TR, Kim HL, Safe SH.
J Biochem Toxicol. 1991 Fal; 6(3):229-36.
PMID: 1837567 [PubMed - indexed for MEDLINE]
Development and validation of bioassays for polychlorinated dibenzo-p-dioxins and dibenzofurans.
Safe S, Harris M, Zacharewski T.
IARC Sci Publ. 1991 ; (108):147-59.
PMID: 1817094 [PubMed - indexed for MEDLINE]
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells.
Biegel L, Safe S.
J Steroid Biochem Mol Biol. 1990 Dec; 37(5):725-32.
PMID: 2278856 [PubMed - indexed for MEDLINE]
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of 17 beta-estradiol-induced increases in rat uterine epidermal growth factor receptor binding activity and gene expression.
Astroff B, Rowlands C, Dickerson R, Safe S.
Mol Cell Endocrinol. 1990 Sep; 72(3):247-52.
PMID: 2289633 [PubMed - indexed for MEDLINE]
Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies.
Harris M, Zacharewski T, Piskorska-Pliszczynska J, Rosengren R, Safe S.
Toxicol Appl Pharmacol. 1990 Sep; 105(2):243-53.
PMID: 2219118 [PubMed - indexed for MEDLINE]
Immunosuppressive and monooxygenase induction activities of polychlorinated diphenyl ether congeners in C57BL/6N mice: quantitative structure-activity relationships.
Howie L, Dickerson R, Davis D, Safe S.
Toxicol Appl Pharmacol. 1990 Sep; 105(2):254-63.
PMID: 2120796 [PubMed - indexed for MEDLINE]
The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.
Merchant M, Arellano L, Safe S.
Arch Biochem Biophys. 1990 Aug; 281(1):84-9.
PMID: 2166479 [PubMed - indexed for MEDLINE]
The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: immunotoxicity and monooxygenase enzyme induction.
Dickerson R, Howie L, Davis D, Safe S.
Fundam Appl Toxicol. 1990 Aug; 15(2):298-307.
PMID: 2227157 [PubMed - indexed for MEDLINE]
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
Kelley M, Womack J, Safe S.
Biochem Pharmacol. 1990 Jun; 39(12):1991-8.
PMID: 2353939 [PubMed - indexed for MEDLINE]
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells.
Harris M, Zacharewski T, Safe S.
Cancer Res. 1990 Jun; 50(12):3579-84.
PMID: 2340506 [PubMed - indexed for MEDLINE]
2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity.
Astroff B, Safe S.
Biochem Pharmacol. 1990 Feb; 39(3):485-8.
PMID: 2154986 [PubMed - indexed for MEDLINE]
Neonatal modulation of adult rat hepatic microsomal benzo[a]pyrene hydroxylase activities by Aroclor 1254 or phenobarbital.
Haake-McMillan JM, Safe SH.
J Biochem Toxicol. 1990 Win; 5(4):203-10.
PMID: 2096216 [PubMed - indexed for MEDLINE]
6-substituted-1,3,8-trichlorodibenzofurans as 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists in the rat: structure activity relationships.
Astroff B, Safe S.
Toxicology. 1989 Dec; 59(3):285-96.
PMID: 2631297 [PubMed - indexed for MEDLINE]
Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review.
Safe S, Mason G, Sawyer T, Zacharewski T, Harris M, Yao C, Keys B, Farrell K, Holcomb M, Davis D.
Toxicol Ind Health. 1989 Oct; 5(5):757-75.
PMID: 2683222 [PubMed - indexed for MEDLINE]
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies.
Yao C, Safe S.
Toxicol Appl Pharmacol. 1989 Sep; 100(2):208-16.
PMID: 2781554 [PubMed - indexed for MEDLINE]
Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor.
Harris M, Piskorska-Pliszczynska J, Zacharewski T, Romkes M, Safe S.
Cancer Res. 1989 Aug; 49(16):4531-5.
PMID: 2545344 [PubMed - indexed for MEDLINE]
Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Davis D, Safe S.
Toxicol Lett. 1989 Jul; 48(1):35-43.
PMID: 2501913 [PubMed - indexed for MEDLINE]
Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.
Harris M, Zacharewski T, Astroff B, Safe S.
Mol Pharmacol. 1989 May; 35(5):729-35.
PMID: 2542761 [PubMed - indexed for MEDLINE]
2,2',4,4',5,5'-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice.
Biegel L, Harris M, Davis D, Rosengren R, Safe L, Safe S.
Toxicol Appl Pharmacol. 1989 Mar; 97(3):561-71.
PMID: 2558429 [PubMed - indexed for MEDLINE]
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice.
Bannister R, Biegel L, Davis D, Astroff B, Safe S.
Toxicology. 1989 Feb; 54(2):139-50.
PMID: 2922766 [PubMed - indexed for MEDLINE]
Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride.
Makary M, Kim HL, Safe S, Womack J, Ivie GW.
Comp Biochem Physiol C. 1989 ; 92(2):171-4.
PMID: 2565179 [PubMed - indexed for MEDLINE]
Effects of sesquiterpene lactones on mitochondrial oxidative phosphorylation.
Narasimham TR, Kim HL, Safe SH.
Gen Pharmacol. 1989 ; 20(5):681-7.
PMID: 2532610 [PubMed - indexed for MEDLINE]
Radioligand-dependent differences in the molecular properties of the mouse and rat hepatic aryl hydrocarbon receptor complexes.
Piskorska-Pliszczynska J, Safe S.
Arch Biochem Biophys. 1988 Nov; 267(1):372-83.
PMID: 2848453 [PubMed - indexed for MEDLINE]
Aflatoxin B1 hydroxylation by the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450.
Halvorson MR, Safe SH, Parkinson A, Phillips TD.
Carcinogenesis. 1988 Nov; 9(11):2103-8.
PMID: 3141079 [PubMed - indexed for MEDLINE]
Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants.
Zacharewski T, Harris M, Safe S, Thoma H, Hutzinger O.
Toxicology. 1988 Oct; 51(2-3):177-89.
PMID: 2845603 [PubMed - indexed for MEDLINE]
Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat.
Astroff B, Safe S.
Toxicol Appl Pharmacol. 1988 Sep; 95(3):435-43.
PMID: 2847362 [PubMed - indexed for MEDLINE]
Role of the 4-5S binding protein in the induction of aryl hydrocarbon hydroxylase in the rat.
Harris M, Kamps C, Safe S.
Carcinogenesis. 1988 Aug; 9(8):1475-9.
PMID: 3402044 [PubMed - indexed for MEDLINE]
Immunosuppressive activities of polychlorinated dibenzofuran congeners: quantitative structure-activity relationships and interactive effects.
Davis D, Safe S.
Toxicol Appl Pharmacol. 1988 Jun; 94(1):141-9.
PMID: 2836965 [PubMed - indexed for MEDLINE]
Biologic and toxic effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in the guinea pig. Quantitative structure-activity relationships.
Holcomb M, Yao C, Safe S.
Biochem Pharmacol. 1988 Apr; 37(8):1535-9.
PMID: 3358783 [PubMed - indexed for MEDLINE]
Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus.
Romkes M, Safe S.
Toxicol Appl Pharmacol. 1988 Mar; 92(3):368-80.
PMID: 2832970 [PubMed - indexed for MEDLINE]
6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.
Astroff B, Zacharewski T, Safe S, Arlotto MP, Parkinson A, Thomas P, Levin W.
Mol Pharmacol. 1988 Feb; 33(2):231-6.
PMID: 2828916 [PubMed - indexed for MEDLINE]
Neonatal phenobarbital imprinting of rat hepatic microsomal testosterone hydroxylations.
Haake JM, Safe SH.
J Biochem Toxicol. 1988 Win; 3:309-19.
PMID: 3236337 [PubMed - indexed for MEDLINE]
Constitutive and Aroclor 1254-induced hepatic glutathione S-transferase, peroxidase and reductase activities in genetically inbred mice.
Makary M, Kim HL, Safe S, Womack J, Ivie GW.
Comp Biochem Physiol C. 1988 ; 91(2):425-9.
PMID: 2905958 [PubMed - indexed for MEDLINE]
Synthesis and aryl hydrocarbon receptor binding properties of radiolabeled polychlorinated dibenzofuran congeners.
Farrell K, Safe L, Safe S.
Arch Biochem Biophys. 1987 Nov; 259(1):185-95.
PMID: 2825595 [PubMed - indexed for MEDLINE]
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity.
Bannister R, Davis D, Zacharewski T, Tizard I, Safe S.
Toxicology. 1987 Oct; 46(1):29-42.
PMID: 3116725 [PubMed - indexed for MEDLINE]
Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Haake JM, Safe S, Mayura K, Phillips TD.
Toxicol Lett. 1987 Oct; 38(3):299-306.
PMID: 2821658 [PubMed - indexed for MEDLINE]
Absence of positive co-operativity in the binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to its cytosolic receptor protein.
Farrell K, Safe S.
Biochem J. 1987 Jun; 244(3):539-46.
PMID: 2833218 [PubMed - indexed for MEDLINE]