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Paul Samollow

Professor

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Phone: (979) 845-7095

Mailstop: 4458

Department: VIBS

Photo of Samollow, Paul

Education

  • Ph.D. Zoology/Statistics, Oregon State University 1978

Research

  • Biomedical Genomics

Interdisciplinary Activities

  • Genetics

Scholarly Interests

omparative functional genomics and genome evolution in vertebrates; structural organization of genetic material and its relationship to patterns of gene regulation and expression within and among species. Epigenetics of meiotic recombination; patterns and epigenetic determinants of sexual dimorphism in meiotic recombination rates and chromosomal distributions. Population genomics: genetic and ecological processes that influence the distribution of genetic diversity within and among populations in nature; population structure, isolation, and speciation. QTL mapping: linkage mapping to detect genes that influence physiologic and health-related traits. Research in my laboratory focuses primarily on the genome of the gray, short-tailed opossum, Monodelphis domestica, the world's primary laboratory marsupial model for genomic, biomedical, and evolutionary research. We also study isolated desert populations of pupfishes of the genus Cyprinodon in west Texas.nature, and their roles in promoting population structuring, isolation, and speciation. QTL mapping: linkage mapping to detect genes that influence physiologic and health-related traits. Research in my laboratory focuses primarily on the genome of the gray, short-tailed opossum, Monodelphis domestica, the world's primary laboratory marsupial model for genomic, biomedical, and evolutionary research. We also study isolated desert populations of pupfishes of the genus Cyprinodon in west Texas.

Publications

Genome-wide histone state profiling of fibroblasts from the opossum, Monodelphis domestica, identifies the first marsupial-specific imprinted gene.
Douglas KC, Wang X, Jasti M, Wolff A, VandeBerg JL, Clark AG, Samollow PB
BMC Genomics. 15:89.
A microsatellite-based, physically anchored linkage map for the gray, short-tailed opossum (Monodelphis domestica).
Samollow PB, Gouin N, Miethke P, Mahaney SM, Kenney M, VandeBerg JL, Graves JA, Kammerer CM
Chromosome Res. 15(3):269-81.
Increased waist circumference is independently associated with hypothyroidism in Mexican Americans: replicative evidence from two large, population-based studies.
Mamtani M, Kulkarni H, Dyer TD, Almasy L, Mahaney MC, Duggirala R, Comuzzie AG, Samollow PB, Blangero J, Curran JE
BMC Endocr Disord. 14:46.
Chromosome-wide profiling of X-chromosome inactivation and epigenetic states in fetal brain and placenta of the opossum, Monodelphis domestica.
Wang X, Douglas KC, Vandeberg JL, Clark AG, Samollow PB
Genome Res. 24(1):70-83.
The sex-specific impact of meiotic recombination on nucleotide composition.
Popa A, Samollow P, Gautier C, Mouchiroud D
Genome Biol Evol. 4(3):412-22.
An X chromosome microRNA cluster in the marsupial species Monodelphis domestica.
Devor EJ, Huang L, Wise A, Peek AS, Samollow PB
J Hered. 102(5):577-83.
Permanent genetic resources added to Molecular Ecology Resources Database 1 February 2011-31 March 2011.
Molecular Ecology Resources Primer Development Consortium, Austin JD, Bertin A, Bórquez JP, Cárdenas L, Cardoza TB, Chapman F, De Sousa AC, De Souza AP, Douglas KC, Ellwood SR, Ferriol M, Garmendia A, Gouin N, Hargrove J, Jasti M, Keränen I, Knott KE, Konec M, Kuitunen K, Lima MP, Linde CC, Merle H, Oliva ME, Pérez M, Saarinen E, Samollow PB, Scarpassa VM, Segura I, Smith L, Trontelj P, Valdivia IM, Wallwork H, Wellenreuther M
Mol Ecol Resour. 11(4):757-8.
Localization of genes for V+LDL plasma cholesterol levels on two diets in the opossum Monodelphis domestica.
Kammerer CM, Rainwater DL, Gouin N, Jasti M, Douglas KC, Dressen AS, Ganta P, Vandeberg JL, Samollow PB
J Lipid Res. 51(10):2929-39.
High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution.
Reimer JM, Samollow PB, Hellman L
Immunogenetics. 62(6):369-82.
Marsupial-specific microRNAs evolved from marsupial-specific transposable elements.
Devor EJ, Peek AS, Lanier W, Samollow PB
Gene. 448(2):187-91.
PiRNA-like RNAs in the marsupial Monodelphis domestica identify transcription clusters and likely marsupial transposon targets.
Devor EJ, Huang L, Samollow PB
Mamm Genome. 19(7-8):581-6.
Extended substrate specificity of opossum chymase--implications for the origin of mast cell chymases.
Reimer JM, Enoksson M, Samollow PB, Hellman L
Mol Immunol. 45(7):2116-25.
In vitro and in silico annotation of conserved and nonconserved microRNAs in the genome of the marsupial Monodelphis domestica.
Devor EJ, Samollow PB
J Hered. 99(1):66-72.
SINEs, evolution and genome structure in the opossum.
Gu W, Ray DA, Walker JA, Barnes EW, Gentles AJ, Samollow PB, Jurka J, Batzer MA, Pollock DD
Gene. 396(1):46-58.
Integrated cytogenetic BAC map of the genome of the gray, short-tailed opossum, Monodelphis domestica.
Duke SE, Samollow PB, Mauceli E, Lindblad-Toh K, Breen M
Chromosome Res. 15(3):361-70.
The search for a marsupial XIC reveals a break with vertebrate synteny.
Davidow LS, Breen M, Duke SE, Samollow PB, McCarrey JR, Lee JT
Chromosome Res. 15(2):137-46.
Modo-UG, a marsupial nonclassical MHC class I locus.
Gouin N, Wright AM, Miska KB, Parra ZE, Samollow PB, Baker ML, Miller RD
Immunogenetics. 58(5-6):396-406.
Evolution of the "OR37" subfamily of olfactory receptors: a cross-species comparison.
Hoppe R, Lambert TD, Samollow PB, Breer H, Strotmann J
J Mol Evol. 62(4):460-72.
Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.
Belov K, Deakin JE, Papenfuss AT, Baker ML, Melman SD, Siddle HV, Gouin N, Goode DL, Sargeant TJ, Robinson MD, Wakefield MJ, Mahony S, Cross JG, Benos PV, Samollow PB, Speed TP, Graves JA, Miller RD
PLoS Biol. 4(3):e46.
Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral.
Tavtigian SV, Deffenbaugh AM, Yin L, Judkins T, Scholl T, Samollow PB, de Silva D, Zharkikh A, Thomas A
J Med Genet. 43(4):295-305.
Bone mineral density, carotid artery intimal medial thickness, and the vitamin D receptor BsmI polymorphism in Mexican American women.
Kammerer CM, Dualan AA, Samollow PB, Périssé AR, Bauer RL, MacCluer JW, O'Leary DH, Mitchell BD
Calcif Tissue Int. 75(4):292-8.
Two quantitative trait loci affect ACE activities in Mexican-Americans.
Kammerer CM, Gouin N, Samollow PB, VandeBerg JF, Hixson JE, Cole SA, MacCluer JW, Atwood LD
Hypertension. 43(2):466-70.


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