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Gladys Ko

Associate Professor

Curriculum Vitae

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Phone: (979) 845-1797

Mailstop: 4458

Department: VIBS

Photo of Ko, Gladys

Education

  • Ph.D. Neuroscience in Biomedical Sciences, Kent State U. affiliated w/ N.E. Ohio U Col. Med. 1996
  • M.S. Anatomical Sciences, National Yang-Ming Medical College, Taiwan. 1991
  • B.S. Biology, National Chang-Kung University, Taiwan. 1989

Research

  • Cell Biology
  • Toxicology
  • Neuroscience

Interdisciplinary Activities

  • Neuroscience
  • Toxicology

Scholarly Interests

The endogenous circadian clocks are important in regulating internal metabolic processes, physiological states, and behaviors, which are essential for organisms to anticipate the environmental changes that oscillate daily ( circa-dian =about one day). Misalignment of the endogenous clocks from the external time cues that happens in shift-workers and frequent across time-zone travelers, causes major health hazards with high risks in metabolic syndromes (such as diabetes), cardiovascular diseases, sleep disorders, and even cancers. In the eyes, retina is the neural tissue that receives and transmits the light information into the brain. The circadian clocks in the retina prepare the eyes to anticipate the upcoming light or darkness, since the ambient illumination changes throughout the course of a day over at least 12 orders of magnitude. We have investigated how the circadian clocks regulate the retinal physiology and function in both healthy and diabetic states. More specifically, we employ different techniques, including electroretinogram (ERG) recordings, fundus angiography, electrophysiological patch-clamp recordings, various biochemical and molecular assays, and cellular imaging to investigate the molecular mechanisms of how the circadian clocks regulate photoreceptors in both healthy and diabetic retinas. We found that the circadian clocks regulate the photoreceptor metabolism and energy expenditure, which further leads us to determine the role of retinal photoreceptors contributing to diabetic retinopathy, a leading cause of blindness in American working adults. We have recently discovered a new bioactive peptide, peptide Lv. This peptide not only regulates photoreceptor physiology, it also modulates cardiovascular functions. We now further elucidate the molecular mechanisms of peptide Lv's bioactivities, as well as its other unknown function.

Publications

Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling.
Shi L, Ko S, Ko ML, Kim AJ, Ko GY.
Biochim Biophys Acta. 2015 Feb; 1853(5):1154-1164.
PMID: 25698653 [PubMed - as supplied by publisher]
High-Fat Diet-Induced Retinal Dysfunction
Chang RC, Shi L, Huang CC, Kim AJ, Ko ML, Zhou B, Ko GY.
Invest Ophthalmol Vis Sci. . 2015 Apr; 56(4):2367-80.
PMID: 25788653 []
Chicken embryos as a potential new model for early onset type I diabetes.
Shi L, Ko ML, Huang CC, Park SY, Hong MP, Wu C, Ko GY.
J Diabetes Res. 2014 ; 2014:354094.
PMID: 25133191 [PubMed - in process]
Circadian phase-dependent effect of nitric oxide on L-type voltage-gated calcium channels in avian cone photoreceptors
Ko ML, Shi L, Huang CC, Grushin K, Park SY, Ko GY..
J Neurochem. 2013 Jul; doi: 10.1111/jnc.12384.
PMID: 23895452 []
Calcineurin serves in the circadian output pathway to regulate the daily rhythm of L-type voltage-gated calcium channels in the retina.
Huang CC, Ko ML, Vernikovskaya DI, Ko GY.
J Cell Biochem. 2012 Mar; 113(3):911-22.
PMID: 22371971 [PubMed - indexed for MEDLINE]
Identification of Peptide lv, a novel putative neuropeptide that regulates the expression of L-type voltage-gated calcium channels in photoreceptors.
Shi L, Ko ML, Abbott LC, Ko GY.
PLoS One. 2012 ; 7(8):e43091.
PMID: 22912796 [PubMed - in process]
Cardiac-specific mutation of Clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythms.
Ko ML, Shi L, Tsai JY, Young ME, Neuendorff N, Earnest DJ, Ko GY.
J Biol Rhythms. 2011 Oct; 26(5):412-22.
PMID: 21921295 [PubMed - indexed for MEDLINE]
Cardiac-Specific Mutation of Clock Alters the Quantitative Measurements of Physical Activities without Changing Behavioral Circadian Rhythms.
Ko ML, Shi L, Tsai JY, Young ME, Neuendorff N, Earnest DJ, Ko GY.
J Biol Rhythms. 2011 Oct; 26(5):412-22.
PMID: 21921295 [PubMed - in process]
Neuron adhesion and strengthening.
Rocha A, Jian K, Ko GK, Liang H.
J Applied Physics. 2010 ; 108:024702-1-5.
Circadian profiles in the embryonic chick heart: L-type voltage-gated calcium channels and signaling pathways.
Ko ML, Shi L, Grushin K, Nigussie F, Ko GY.
Chronobiol Int. 2010 Oct; 27(9-10):1673-96.
PMID: 20969517 [PubMed - indexed for MEDLINE]
Rhythmic expression of microRNA-26a regulates the L-type voltage-gated calcium channel alpha1C subunit in chicken cone photoreceptors.
Shi L, Ko ML, Ko GY.
J Biol Chem. 2009 Sep; 284(38):25791-803.
PMID: 19608742 [PubMed - indexed for MEDLINE]
Inhibitory effect of somatostatin-14 on L-type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calcium.
Jian K, Barhoumi R, Ko ML, Ko GY.
J Neurophysiol. 2009 Sep; 102(3):1801-10.
PMID: 19605612 [PubMed - indexed for MEDLINE]
Circadian regulation of ion channels and their functions.
Ko GY, Shi L, Ko ML.
J Neurochem. 2009 Aug; 110(4):1150-69.
PMID: 19549279 [PubMed - indexed for MEDLINE]
Circadian controls outweigh acute illumination effects on the activity of extracellular signal-regulated kinase (ERK) in the retina.
Ko ML, Shi L, Ko GY.
Neurosci Lett. 2009 Feb; 451(1):74-8.
PMID: 19111596 [PubMed - indexed for MEDLINE]
Retinoschisin, a new binding partner for L-type voltage-gated calcium channels in the retina.
Shi L, Jian K, Ko ML, Trump D, Ko GY.
J Biol Chem. 2009 Feb; 284(6):3966-75.
PMID: 19074145 [PubMed - indexed for MEDLINE]
Phosphatidylinositol 3 kinase-Akt signaling serves as a circadian output in the retina.
Ko ML, Jian K, Shi L, Ko GY.
J Neurochem. 2009 Mar; 108(6):1607-20.
PMID: 19166512 [PubMed - indexed for MEDLINE]
Circadian regulation of retinoschisin in the chick retina.
Ko ML, Liu Y, Shi L, Trump D, Ko GY.
Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1615-21.
PMID: 18385082 [PubMed - indexed for MEDLINE]
The expression of L-type voltage-gated calcium channels in retinal photoreceptors is under circadian control.
Ko ML, Liu Y, Dryer SE, Ko GY.
J Neurochem. 2007 Oct; 103(2):784-92.
PMID: 17683482 [PubMed - indexed for MEDLINE]
Tyrosine phosphorylation of cGMP-gated ion channels is under circadian control in chick retina photoreceptors.
Chae KS, Ko GY, Dryer SE.
Invest Ophthalmol Vis Sci. 2007 Feb; 48(2):901-6.
PMID: 17251493 [PubMed - indexed for MEDLINE]
Circadian and cAMP-dependent modulation of retinal cone cGMP-gated channels does not require protein synthesis or calcium influx through L-type channels.
Ko GY, Ko M, Dryer SE.
Brain Res. 2004 Sep; 1021(2):277-80.
PMID: 15342277 [PubMed - indexed for MEDLINE]
Circadian regulation of cGMP-gated channels of vertebrate cone photoreceptors: role of cAMP and Ras.
Ko GY, Ko ML, Dryer SE.
J Neurosci. 2004 Feb; 24(6):1296-304.
PMID: 14960600 [PubMed - indexed for MEDLINE]
Circadian phase-dependent modulation of cGMP-gated channels of cone photoreceptors by dopamine and D2 agonist.
Ko GY, Ko ML, Dryer SE.
J Neurosci. 2003 Apr; 23(8):3145-53.
PMID: 12716922 [PubMed - indexed for MEDLINE]


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