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Research Publications

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Publications in referred journals: Reports of original research


These publications can be viewed online in their full capacity for reference by looking up their title on www.pubmed.gov .


Johnson AK, Clark-Price SC, Choi YH, Hartman DL, and Hinrichs K. Physical and clinicopathologic findings in foals produced by somatic cell nuclear transfer - 14 cases (2005-2008). J. Am. Vet. Med. Assoc. (in press).


Mortensen CJ, Choi YH, Ing NH, Kraemer DC, Vogelsang MM and Hinrichs K. Heat shock protein 70 gene expression in equine blastocysts after exposure of oocytes to high temperatures in vitro or after exercise of donor mares in vivo. Theriogenology (in press).


Jacobson CC, Choi YH, Hayden SS and Hinrichs K. Recovery of mare oocytes on a fixed biweekly schedule, and resulting blastocyst formation after intracytoplasmic sperm injection. Theriogenology 73:1116-1126 (2010).


Choi YH, Harding HD, Obermiller AD, Hartman DL, Kurosaka S, McLaughlin KJ, and Hinrichs K. The uterine environment modulates trophectodermal POU5F1 levels in equine blastocysts. Reproduction 38: 589-599 (2009).


Choi YH, Hartman DL, Fissore RA, Bedford-Guaus SJ and Hinrichs K. Effect of sperm extract injection volume, injection of PLCζ cRNA, and tissue cell line on efficiency of equine nuclear transfer. Cloning Stem Cells 11: 301-308 (2009).


McPartlin LA, Suarez SS, Czaya CA, Hinrichs K and Bedford-Guaus SJ. Hyperactivation of stallion sperm is required for successful in vitro fertilization of equine oocytes. Biol. Reprod. 81:199-206 (2009).


Mortensen CJ, Choi YH, Hinrichs K, Ing NH, Kraemer DC, Vogelsang SG and Vogelsang MM. Embryo recovery from exercised mares. Anim. Reprod. Sci.110:237-244 (2009).


Bedford-Guaus SJ, Yoon S-Y, Fissore RA, Choi Y-H and Hinrichs K. Microinjection of mouse PLCz complementary RNA into mare oocytes induces long-lasting intracellular calcium ([Ca2]i) oscillations and embryonic development. Reprod. Fertil. Dev. 20:875-883 (2008).


Alm H, Choi YH, Love L, Heleil B, Torner H and Hinrichs K. Holding bovine oocytes in the absence of maturation inhibitors: kinetics of in vitro maturation and effect on blastocyst development after in vitro fertilization. Theriogenology 70:1024-1029 (2008).


Ribeiro BI, Love LB, Choi YH and Hinrichs K. Transport of equine ovaries for assisted reproduction. Anim. Reprod. Sci.108:171-179 (2008).


Hanna C, Long C, Hinrichs K, Westhusin M and Kraemer D. Assessment of canine oocyte viability after transportation and storage under different conditions. Anim. Reprod. Sci. 105:451-456 (2008).


Hinrichs K, Choi YH, Varner DD and Hartman DL. Production of cloned horse foals using roscovitine-treated donor cells and activation with sperm extract and/or ionomycin. Reproduction 134:319-325 (2007).


Hinrichs K, Choi YH, Walckenaer BE, Varner DD, and Hartman DL. In vitro-produced equine embryos: production of foals after transfer to recipient mares, assessment by differential staining, and effect of medium calcium concentrations. Theriogenology 68:521-529 (2007).


Roasa LM, Choi YH, Love CC, Romo S, Varner DD and Hinrichs K. Ejaculate and type of freezing extender affect rates of fertilization of horse oocytes in vitro. Theriogenology 68:560-566 (2007).


Choi YH, Love LB, Varner DD and Hinrichs K. Effect of holding technique and culture drop size in individual or group culture on blastocyst development after ICSI of equine oocytes with low meiotic competence. Animal Reprod. Sci., 102:38-47 (2007).


Choi YH, Love LB, Varner DD and Hinrichs K. Holding immature equine oocytes in the absence of meiotic inhibitors: Effect on germinal vesicle chromatin and blastocyst development after intracytoplasmic sperm injection. Theriogenology 66:955-63 (2006).


Hinrichs K, Choi YH, Love CC, Chung YG, Varner DD. Production of horse foals via direct injection of roscovitine-treated donor cells and activation by injection of sperm extract. Reproduction 131:1063-1072 (2006).


Choi YH, Love CC, Varner DD and Hinrichs K Equine blastocyst development after intracytoplasmic injection of sperm

subjected to two freeze-thaw cycles. Theriogenology 65:808-819 (2006).


Choi YH, Love LB Varner DD and Hinrichs K. Blastocyst development in equine oocytes with low meiotic competence after suppression of meiosis with roscovitine prior to in vitro maturation. Zygote 14:1-8 (2006).


Hinrichs K, Choi YH, Love LB, Varner DD, Love CC, and Walckenaer BE. Chromatin configuration within the germinal vesicle of horse oocytes: Changes post-mortem and relationship to meiotic and developmental competence. Biol. Reprod. 72:1142-50 (2005).


Choi YH, Roasa LM, Love CC, Varner DD, Brinsko SP and Hinrichs K. Blastocyst formation rates in vivo and in vitro of in vitro-matured equine oocytes fertilized by intracytoplasmic sperm injection. Biol. Reprod. 70: 1231-1238 (2004).


Bedford SJ, Kurokawa M, Hinrichs K, and Fissore RA. Patterns of intracellular calcium oscillations in horse oocytes fertilized by intracytoplasmic sperm injection: Possible explanations for the low success of this assisted reproduction technique in the horse. Biol. Reprod. 70:936-44 (2004).


Choi YH, Love LB, Varner DD and Hinrichs K. Factors affecting developmental competence of equine oocytes

after intracytoplasmic sperm injection. Reproduction 127:187-94 (2004).


Choi YH, Love LB, Westhusin ME and Hinrichs K. Activation of equine nuclear transfer oocytes: methods and timing of treatment in relation to nuclear remodeling. Biol. Reprod. 70: 46-53 (2004).


Choi YH, Love CC, Varner DD, Love LB and Hinrichs K. Effects of gas conditions, time of medium change, and ratio of medium to embryo on in vitro development of horse oocytes fertilized by intracytoplasmic sperm injection. Theriogenology 59:1219-1229 (2003).


Franz LC, Choi YH, Squires EL, Seidel GE and Hinrichs K. Effects of roscovitine on maintenance of the germinal vesicle in horse oocytes, subsequent nuclear maturation, and cleavage rates after intracytoplasmic sperm injection. Reproduction 125:693-700 (2003).


Willingham-Rocky LA, Hinrichs K, Westhusin ME, Kraemer DC. Effects of stage of oestrus cycle and progesterone supplementation during culture on maturation of canine oocytes in vitro. Reproduction 126:501-508 (2003).


Dell'Aquila ME, Albrizio M, Maritato F, Minoia P and Hinrichs K. Meiotic competence of equine oocytes and rate of pronucleus formation after intracytoplasmic sperm injection (ICSI) as related to follicular wall apoptosis. Biol. Reprod. 68:2065-2072 (2003).


Bedford SJ, Kurokawa M, Hinrichs K and Fissore RA. Initiation of calcium oscillations and activation in horse oocytes injected with equine sperm extracts. Reproduction 126:489-99 (2003).


Choi YH, Chung YG, Walker SC, Westhusin ME and Hinrichs K. In vitro development of equine nuclear transfer embryos: Effects of oocyte maturation media and amino acid composition during embryo culture. Zygote 11:77-86 (2003).


Love LB, Choi YH, Love CC, Varner DD and Hinrichs K. Effect of ovary storage and oocyte transport method on maturation rate of horse oocytes. Theriogenology 59:765-774 (2003).


Choi YH, Love CC, Chung YG, Varner DD, Westhusin ME, Burghardt RC and Hinrichs K. Production of nuclear transfer horse embryos by Piezo-driven injection of somatic cell nuclei and activation with stallion sperm cytosolic extract. Biol. Reprod. 67:561-567 (2002).


Love CC, Love LB, Varner DD and Hinrichs K. Effect of holding at room temperature after recovery on initial chromatin configuration and in vitro maturation rate of equine oocytes. Theriogenology 57:1973-1979 (2002).


Hinrichs K, Love CC, Brinsko SP, Choi YH and Varner DD. In vitro fertilization of in vitro-matured equine oocytes: Effect of maturation medium, duration of maturation and sperm calcium ionophore treatment, and comparison with rates of fertilization in vivo after oviductal transfer. Biol. Reprod. 67: 256-262 (2002).


Choi YH, Love CC, Love LB, Varner DD, Brinsko SP and Hinrichs K. Developmental competence in vivo and in vitro of in vitro-matured equine oocytes fertilized by intracytoplasmic sperm injection with fresh or frozen-thawed sperm. Reproduction 123: 455-465 (2002).


Choi YH, Shin T, Love CC, Johnson C, Varner DD, Westhusin ME and Hinrichs K. Effect of co-culture with theca interna on nuclear maturation of horse oocytes with low meiotic competence, and subsequent fusion and activation rates after nuclear transfer. Theriogenology 57:1005-1011 (2002).


Hinrichs K, Love CC, Choi YH, Varner DD, Wiggins CN and Reinoehl C. Suppression of meiosis by inhibitors of m-phase proteins in horse oocytes with low meiotic competence. Zygote 10:37-45 (2002).


Dell'Aquila ME, Masterson M, Maritato F and Hinrichs K. Influence of oocyte collection technique on initial chromatin configuration, meiotic competence and male pronucleus formation after intracytoplasmic sperm injection (ICSI) of equine oocytes. Mol. Reprod. Devel. 60:79-88 (2001).


Choi YH, Love CC, Thompson JA, Varner DD and Hinrichs K. Activation of cumulus-free horse oocytes: effect of maturation medium, calcium ionophore concentration and duration of cycloheximide exposure. Reproduction 122:177-183 (2001).


Hinrichs K and Schmidt AL. Meiotic competence in horse oocytes: Interactions among chromatin configuration, follicle size, cumulus morphology and season. Biol. Reprod. 62:1402-1408 (2000).

Hinrichs K, Provost PJ and Torello EM. Treatments resulting in pregnancy in nonovulating, hormone-treated oocyte recipient mares. Theriogenology 54:1285-1293 (2000).


Bedford SJ, Gowdy LG and Hinrichs K. Comparison of longevity of motility of stallion spermatozoa incubated at 38oC in different capacitating media and containers. Theriogenology 51:637-646 (1999).


Hinrichs K, Matthews GL, Freeman DA and Torello EM. Oocyte transfer in mares. J. Am. Vet. Med. Assoc. 212:982-986 (1998).


Hinrichs K and Williams KA. Relationships among oocyte-cumulus morphology, follicular atresia and oocyte meiotic competence in the horse. Biol. Reprod. 57:377-384 (1997).


Alm H and Hinrichs K. Effect of cycloheximide on nuclear maturation of horse oocytes and its relation to initial cumulus morphology. J. Reprod. Fertil. 107:215-220 (1996).


Hawley LR, Enders AC and Hinrichs K. Comparison of equine and bovine oocyte-cumulus morphology within the ovarian follicle. Biol. Reprod. Mono. 1: 243-252 (1995).


Hinrichs K, Schmidt AL and Selgrath JP. Activation of horse oocytes. Biol. Reprod. Mono. 1: 319-324 (1995).


Hinrichs K, Martin MG, Schmidt AL and Friedman PP. Effect of follicular components on meiotic arrest and resumption in horse oocytes. J. Reprod. Fertil. 104:149-156 (1995).


Bedford S and Hinrichs K. The effect of insemination volume on pregnancy rates in pony mares. Theriogenology 42:571-578 (1994).

Hinrichs K, Schmidt AL, Friedman PP, Selgrath JP and Martin MG. In vitro maturation of horse oocytes: Characterization of chromatin configuration using fluorescence microscopy. Biol. Reprod. 48:363-370 (1993).


Hinrichs K, Spensley MS and McDonough PL. Evaluation of progesterone treatment to create a model for equine endometritis. Equine Vet. J. 23:457-461 (1992).


Hinrichs K and DiGiorgio LM. Embryonic development after intrafollicular transfer of immature horse oocytes. J. Reprod. Fertil. Suppl. 44:369-374 (1991).


Hinrichs K. The relationship of follicle atresia to follicle size, oocyte recovery rate on aspiration, and oocyte morphology in the mare. Theriogenology 36:157-168 (1991).


Hinrichs K, Rand WM and Palmer E. Effect of aspiration of the preovulatory follicle on luteinization, corpus luteum function, and peripheral plasma gonadotropin concentrations in the mare. Biol. Reprod. 44:292-298 (1991).


Hinrichs K and Watson ED. Effect of administration of phenylbutazone or progesterone on recovery of embryos from the uterus 5 days after ovulation in mares. Am. J. Vet. Res. 52:678-681 (1991).


Hinrichs K, Schmidt AL, Memon MA, Selgrath JP and Ebert KM. Culture of 5-day horse embryos in microdroplets for 10 to 20 days. Theriogenology 34:643-654 (1990).


Hinrichs K, Kenney DF and Kenney RM. Aspiration of oocytes from mature and immature pre-ovulatory follicles in the mare. Theriogenology 34:107-112 (1990).


Hinrichs K and Riera FL. Effect of administration of prostaglandin F2 alpha on embryo recovery from the uterus on day 5 after ovulation in mares. Am. J. Vet. Res. 51:451-453 (1990).


Hinrichs K and Hunt PR. Ultrasound as an aid to diagnosis of granulosa cell tumor in the mare. Equine Vet. J. 22:99-103 (1990).


Hinrichs K, Riera FL and Klunder LR. Establishment of pregnancy after embryo transfer in mares with gonadal dysgenesis. J. In Vitro Fertilization Embryo Transfer 6:305-309 (1989).


Watson ED and Hinrichs K. Adrenal production of sex steroids in the mare. Theriogenology 32:913-919 (1989).


Sertich PL, Hinrichs K and Kenney RM. Histological aspects of uterine involution of the postparturient, ovariectomised, embryo-recipient mare: a model for the study of involution. Equine Vet. J. Suppl. 8:56-58 (1989).


Hinrichs K, Sharp DC and Kenney RM. Differences in protein content of uterine fluid related to duration of progesterone treatment in ovariectomised mares used as embryo transfer recipients. Equine Vet. J. Suppl. 8:49-55 (1989).


Watson ED and Hinrichs K. Effect of prostaglandin F2 alpha on adrenal-produced steroid hormones in the cow. Am. J. Vet. Res. 50:1078-1079 (1989).


Watson ED and Hinrichs K. Changes in concentrations of steroids and prostaglandin F in preovulatory follicles of the mare after administration of hCG. J. Reprod. Fertil. 84:557-561 (1988).


Hinrichs K, Cummings MR, Sertich PL and Kenney RM. Clinical significance of aerobic bacterial flora from the uterus, vagina, vestibule and clitoral fossa of clinically normal mares. J. Am. Vet. Med. Assn. 193:72-75 (1988).


Sertich PL, Hinrichs K, Schiereck DE and Kenney RM. Periparturient events in ovariectomized embryo transfer recipient mares. Theriogenology 30:401-409 (1988).


Hinrichs K, Sertich PL, Solorzano NM and Caldwell LA. Use of an immediate, qualitative progesterone assay for determination of day of ovulation in an equine embryo transfer program. Theriogenology 29:1123-1130 (1988).


McDonnell SM, Hinrichs K, Cooper WL and Kenney RM. Use of an androgenized mare as an aid in detection of estrus in mares. Theriogenology 30:547-553 (1988).


Hinrichs K and Kenney RM. Effect of timing of progesterone administration on pregnancy rate after embryo transfer in ovariectomized mares. J. Reprod. Fertil. Suppl. 35:439-443 (1987).


Hinrichs K, Sertich PL, Palmer E, and Kenney RM. Establishment and maintenance of pregnancy after embryo transfer in ovariectomized mares treated with progesterone. J. Reprod. Fertil. 80:395-401 (1987).


Hinrichs K, Sertich PL, and Kenney RM. Use of altrenogest to prepare ovariectomized mares as embryo transfer recipients. Theriogenology. 26:455-460 (1986).


Van Huffel XM, Varner DD, Hinrichs K, Garcia MC, Strzemienski PJ, and Kenney RM. Photomicrographic evaluation of stallion spermatozoal motility characteristics. Am. J. Vet. Res. 46:1272-1275 (1985).


Varner DD, Hinrichs K, Garcia MC, Osborne HG, Blanchard TL, and Kenney RM. A comparison be­tween the cervical dimensions of pregnant and non-pregnant Santa Gertrudis and Bos taurus cows. Theriogenology. 24:109-118 (1985).


Publications in refereed journals: Clinical reports


Mancill SS, Blodgett G, Arnott RJ, Alvarenga M, Love CC and Hinrichs K. Monozygotic equine twins resulting from transfer of a single embryo, verified by DNA typing (3 cases). J. Am. Vet. Med. Assoc. (in press).

Hinrichs K, Buoen LC and Ruth GR. XX/XY chimerism and freemartinism in a female llama co-twin to a male. J. Am. Vet. Med. Assoc. 215:1140-1141 (1999).


Hinrichs K, Provost PJ and Torello EM. Birth of a foal after oocyte transfer to a nonovulating, hormone-treated mare. Theriogenology 51:1251-1258 (1999).


Hinrichs K, Horin SE, Buoen LC, Zhang TQ and Ruth GR. X-chromosome monosomy in an infertile female llama. J. Am. Vet. Med. Assoc. 210:1503-1504 (1997).


Bedford SJ, Hawes M, Paradis MR, Mort JD and Hinrichs K. Peritonitis associated with passage of the placenta into the abdominal cavity in a llama. J. Am. Vet. Med. Assoc. 209:1914-1916 (1996).


Hinrichs K, Cochran SL, Schelling SH, and Steckel RR. Granulosa-theca cell tumor associated with an ovulation fossa and normal ovarian stroma in a mare. J. Am. Vet. Med. Assoc. 200:696-698 (1992).


Hinrichs K, Watson ED and Kenney RM. Granulosa cell tumor in a mare with a functional contralateral ovary. J. Am. Vet. Med. Assoc. 197:1037-1038 (1990).


Riera FL, Hinrichs K, Hunt PR and Kenney RM. Cervical hyperplasia with prolapse in a mare. J. Am. Vet. Med. Assoc. 195:1393-1394 (1989).


Hinrichs K, Frazer GS, deGannes RVG, Richardson DW and Kenney RM. Serous cystadenoma with elevated plasma testosterone levels in a normally cyclic mare. J. Am. Vet. Med. Assoc. 194:381-382 (1989).


Hinrichs K and Watson ED. Recovery of a degenerating 14-day embryo on uterine flush 7 days after ovula­tion in a mare. Theriogenology 30:349-353 (1988).


Hinrichs K, Gentile DG, Hurtgen JP, and Richardson DW. Complications from a testicular prosthesis in a stallion. J. Am. Vet. Med. Assoc. 186:390-391 (1985).


Hinrichs K, Hurtgen JP, and Kenney RM. Unilateral hydrosalpinx and absence of the infundibulum in a mare. Theriogenology 22:571-577 (1984).


Hinrichs K and Kenney RM. Infertility due to foreign objects in the cervix of a cow. J. Am. Vet. Med. Assoc. 185:788-789 (1984).


Brown JS, Varner DD, Hinrichs K, and Kenney RM. Surgical repair of the lacerated cervix in the mare. Theriogenology 22:351-359 (1984).


Reviews and Book Chapters


Hinrichs K. Application of assisted reproductive technologies (ART) to clinical practice (Review). Proceedings, Am. Assoc. Equine Pract. (submitted).


Hinrichs K. In vitro production of equine embryos: state of the ART (Review). Reprod. Domestic Anim. (in press).

Hinrichs K. The equine oocyte: factors affecting meiotic and developmental competence (Review). Molec. Reprod. Devel. (in press).

Hinrichs K. Cloning in domestic animals. In: The Merck Veterinary Manual, 10th Edition. Merck and Co., Inc., Rahway, NJ (in press).


Hinrichs K. Advances in assisted reproductive technologies. In: Manual of Equine Reproduction (3rd Edition), Blanchard TL, Varner DD, Schumacher J, et al., eds. Mosby-Year Book, Inc., St. Louis, MO (in press).

Hinrichs K. Immature oocyte collection and maturation; Nuclear transfer. In: Equine Reproduction (2nd Edition), McKinnon AO, Squires EL, Vaala W and Varner DD, eds. Blackwell Publishing, Malden, MA (in press).


Choi YH and Hinrichs K. Intracytoplasmic sperm injection. In: Equine Reproduction (2nd Edition), McKinnon AO, Squires EL, Vaala W and Varner DD, eds. Blackwell Publishing, Malden, MA (in press).

Hinrichs K. Irregularities of the Estrus Cycle and Ovulation in Mares (including Seasonal Transition). In: Current Therapy in Large Animal Theriogenology 2, Youngquist RS and Threlfall WR, eds., Saunders Elsevier, St. Louis, MO, pp.144-152 (2007).

Hinrichs K. Equine Cloning. In: Veterinary Clinics of North America: Equine Practice, Carnevale EM, ed., W.B. Saunders Co., Philadelphia, PA, pp. 857-866 (2006).


Hinrichs K. In vitro fertilization; In vitro oocyte maturation. In: Current Therapy in Equine Reproduction, Samper J, Pycock J and McKinnon AO, eds. Saunders Elsevier, St. Louis, MO, pp. 308-309; 310-314 (2006).

Hinrichs K. A review of cloning in the horse. (Review) Proceedings, Am. Assoc. Equine Pract, pp. 398-401 (2006).


Hinrichs K and Choi YH. Assisted Reproductive Techniques in the Horse. In: Clinical Techniques in Equine Practice 4 (3): Equine Reproduction. Elsevier, Philadelphia, PA pp 210-218 (2005).

Hinrichs K. An update on equine ICSI and cloning. (Review) Theriogenology. 64:535-41 (2005)


Hinrichs K. Breeding soundness examination in the male; Embryo transfer in farm animals; Hormonal control of estrus. In: The Merck Veterinary Manual, 9th Edition. Merck and Co., Inc., Rahway, NJ pp 1797-1811 (2005).

Westhusin ME, Hinrichs K, Choi YH, Shin T, Liu L and Kraemer D. Cloning Companion Animals (Horses, Cats, and Dogs). (Review) Cloning Stem Cells 5: 301-317 (2003).


Hinrichs K. Current status and clinical potential of IVF, ICSI and cloning in horses. (Review) Proceedings, Soc. Theriogenology, pp. 133-141 (2002).


Hinrichs K. Embryo production by assisted reproduction in the horse. (Review). Theriogenology 49:13-21 (1998).


Hinrichs K. Breeding soundness examination in the male; Embryo transfer in farm animals; Hormonal control of estrus. In: The Merck Veterinary Manual, 8th Edition. Merck and Co., Inc., Rahway, NJ. pp. 1508-1520 (1998).


Hinrichs K. Theriogenology. In: Review Questions and Answers for Veterinary Boards, Small Animal Medicine and Surgery, 2nd Edition, Pratt PW, ed. Mosby-Year Book, Inc., Santa Barbara, CA pp277-281 (1998).


Hinrichs K. Cumulus expansion, chromatin configuration and meiotic competence in horse oocytes. (Review). Equine Vet. J. Suppl. 25:43-46 (1997).


Hinrichs K. Irregularities of the estrus cycle and ovulation in the mare. In: Current Therapy in Theriogenology III: Large Animal, Youngquist RS, ed., W.B. Saunders Co., Philadelphia, PA pp. 166-171 (1997).


Hinrichs K. Assisted reproductive techniques in the mare. In: Current Therapy in Equine Medicine 4, Robinson NE, ed., W.B. Saunders Co., Philadelphia. pp. 565-571 (1997).


Hinrichs K, Matthews GL, Freeman DA and Torello EM. Oocyte transfer as a clinical procedure in the mare. (Review). Proceedings, Am. Assoc. Equine Pract., pp. 187-188 (1997).


Hinrichs K. Oocyte collection and maturation. (Review). Proceedings, Soc. Theriogenology, pp. 147-151 (1997).


Hinrichs K. Manipulation of oocyte maturation in vitro. (Review). Archiv fur Tierzucht., Dummerstorf (Special Issue) 39:43-50 (1996).


Hinrichs K. Assisted reproductive technology in the horse. (Review). Proceedings, Soc. Theriogenology, pp.162-173 (1994).

Hinrichs K. Use of ovariectomized mares as embryo transfer recipients and Future technology: oocyte transfer, maturation and in vitro fertilization. (Review). Ars Veterinaria 10 (Suppl.): 89-98 (1994).


Hinrichs K, Schmidt AL and Selgrath JP. Atlas of chromatin configurations of germinal vesicle stage and maturing horse oocytes. (Review). Equine Vet. J. Suppl. 15:60-63 (1993).


Hinrichs K. Embryo transfer in the mare: a status report. In: Current Advances in the Manipulation of Reproductive Functions in Domesticated Species of Animals, Anim. Reprod. Sci., 33:227-240 (1993).

Hinrichs K. Potential for gamete manipulation in the horse: GIFT, IVF and embryo transfer. (Review). Proceedings, Soc. Theriogenology, pp. 14-17 (1992).


Hinrichs K. Ultrasonographic techniques in mare reproduction. (Review). Proceedings, Am. College of Theriogenologists Equine Theriogenology Short Course, pp. 92-94 (1992).


Hinrichs K. Effect of cumulus morphology on maturation of horse oocytes in vitro / Wspolzaleznosc pomiedzy wygladem morfologicznym komorek wzgorka, a dojrzewaniem in vitro oocytow klaczy. (Review). Proceedings, Int. Scientific Conference on Biotechnics in Horse Reproduction, Agricultural University of Crakow, pp. 18-19 / 21-22 (1992).


Hinrichs K. Prospects for oocyte aspiration, fertilization and transfer in the horse. (Review). Proceedings, Am. Assoc. Equine Pract. pp. 189-196 (1992).


Hinrichs K. Embryo transfer in the mare. In: Current Therapy in Equine Medicine 3, Robinson NE, ed., W.B. Saunders Co., Philadelphia; pp. 637-642. (1991).

Hinrichs K. Ultrasonographic assessment of ovarian abnormalities. (Review) Proceedings, Am. Assoc. Equine Pract., pp. 31-40 (1991).


Freeman DE and Hinrichs K. Granulosa cell tumor. In: Current Practice of Equine Surgery, White NA and Moore JN, eds. JB Lippincott Co., Philadelphia; pp. 711-716 (1990).


Hinrichs K. Use of ovariectomized, progestogen treated mares as embryo transfer recipients. (Review) Proceedings, Soc. Theriogenology, pp. 107-110 (1986).


Non-refereed publications, proceedings, and abstracts

Choi YH, Norris JD, Velez IC, Jacobson CC, Hartman DL and Hinrichs K. Use of metaphase I oocytes or a histone deacetylase inhibitor in equine nuclear transfer. (Abstract) Anim. Reprod. Sci., in press.


Hinrichs K, Choi YH, Norris JD, Love LB, Bedford-Guaus SJ, Hartman DL and Velez IC. Use of intracytoplasmic sperm injection and in vitro culture to the blastocyst stage for clinical production of foals post mortem. (Abstract) Anim. Reprod. Sci., in press.


Loux SC, Crawford KR, Norris JD, Ing NH, Reynolds EA, Love CC, Varner DD, Velez IC, Dangott LJ, Thornton ER, Choi YH and Hinrichs K. The CatSper ion channel and hyperactivated motility of equine spermatozoa. (Abstract) Anim. Reprod. Sci., in press.


Velez IC, Norris JD, Ballard K, Lassell K, Choi YH and Hinrichs K. Effect of method of overnight shipment of oocytes or ovaries on blastocyst formation after intracytoplasmic sperm injection. (Abstract) Anim. Reprod. Sci., in press.


Choi YH, Hartman DL, Bliss SB, Hayden SS, Blanchard TL and Hinrichs K. High pregnancy rates after transfer of large equine blastocysts collapsed via micromanipulation before vitrification (Abstract) Reprod. Fertil. Dev. 22:203 (2010).

Hinrichs K. Equine ICSI: History and current status. (Abstract) Reprod. Domestic Anim. 44: 62 (2009).


Commaille LF, Vogelsang MM, Sigler DH and Hinrichs K. Intrauterine temperature of mares under different management conditions (Abstract) J. Equine Vet. Sci. Vol 29: 344-345(2009).


Choi YH, Hartman DL and Hinrichs K. Viability of equine blastocysts subjected to biopsy for pre-implantation genetic diagnosis. (Abstract) Reprod. Fertil. Dev. 21:166-167 (2009).


Mancill SS, Arnott RJ, Love CC and Hinrichs K. Monozygotic twins after embryo transfer, verified by DNA typing. (Abstract) Proceedings, Am. Assoc. Equine Pract., p. 278 (2008).


McPartlin LA, Suarez SS, Czaya CA, Hinrichs K and Bedford-Guaus SJ. Hyperactivation of stallion sperm is required for successful in vitro fertilization of equine oocytes. (Abstract) Proceedings, Soc. Study Reprod., p. 206 (2008).


Hinrichs K, Choi YH, Harding HD, Obermiller AD and Hartman DL. Oct-4 expression in in vivo and in vitro-produced equine blastocysts. (Abstract) Proceedings, 7th International Symposium on Equine Embryo Transfer, Havemeyer Foundation, p. 46 (2008).


Choi YH, Hartman DL, Fissore RA, Bedford SJ and Hinrichs K. Activation methods associated with cloning efficiency in the horse. (Abstract) Proceedings, 7th International Symposium on Equine Embryo Transfer, Havemeyer Foundation, pp. 26-27 (2008).


Riera FL, Roldan JE and Hinrichs K. Pregnancy rate after embryo transfer in ovulating versus progesterone treated-anestrous recipient mares in a commercial embryo transfer programme. (Abstract) Proceedings, 7th International Symposium on Equine Embryo Transfer, Havemeyer Foundation, pp. 79-80 (2008).


Alm H, Choi YH, Love L, Heleil B, Torner H, Hinrichs K. Effect of holding technique of bovine oocytes before in vitro maturation on their further blastocyst development in vitro. (Abstract) Reprod. Domestic Anim. 43: Suppl. 1, p 3 (2008).


Choi YH, Hartman DL, Fissore RA, Bedford SJ and Hinrichs K. Effect of activation methods and biopsy sample on nuclear transfer blastocyst production and cloning efficiency in a horse. (Abstract) Reprod. Fertil. Devel. 20:94 (2008).


Choi YH, Harding HD, Obermiller AD, and Hinrichs K. Oct-4 expression pattern in the equine embryo. (Abstract) Reprod. Fertil. Devel. 19:189-190 (2007).

Choi YH, Varner DD, Hartman DL and Hinrichs K. Blastocyst production from equine oocytes fertilized by intracytoplasmic injection of lyophilized sperm. (Abstract) Anim. Reprod. Sci. 94:307-308 (2006).


Petersen MM, Choi YH, Brück Bøgh I, and Hinrichs K. Incubation of equine oocytes in roscovitine before in vitro maturation: Influence of maturation time before fertilization. (Abstract) Anim. Reprod. Sci 94:362-363 (2006).


Hinrichs K, Choi YH, Varner DD, and Hartman DL. Efficient production of cloned horse pregnancies using roscovitine-treated donor cells. (Abstract) Anim. Reprod. Sci 94:309-310 (2006).


Varner DD, Love CC, Choi YH, Teague S, Thompson JA and Hinrichs K. Effect of multiple lyophilization or freeze-thaw cycles on chromatin quality of stallion sperm. (Abstract) Anim. Reprod. Sci 94:19-20 (2006).


Riera FL, Roldán JE and Hinrichs K. Patterns of embryo recovery in mares with unilateral and bilateral double ovulations. (Abstract). Anim. Reprod. Sci 94:398-399 (2006).


Mortensen C, Choi YH, Hinrichs K, Ing N, Kraemer D, Vogelsang S and Vogelsang M. Effects of exercise on embryo recovery rates and embryo quality score in the horse. (Abstract) Anim. Reprod. Sci 94:395-397 (2006).


Hinrichs K, Choi YH, Hartman DL and Varner DD. Blastocysts, pregnancies and foals from ICSI and nuclear transfer. (Abstract) Proceedings, 4th Meeting of the International Equine Gamete Group, Havemeyer Foundation Monograph 18: 45-46 (2006).


Varner DD, Love CC, Choi YH and Hinrichs K. Exposure of stallion semen to two freeze-thaw cycles: Effects on spermatozoal viability. (Abstract) Proceedings, 4th Meeting of the International Equine Gamete Group Havemeyer Foundation Monograph 18: 15-16 (2006).


Choi YH, Love CC, Varner DD and Hinrichs K. Equine embryo development after intracytoplasmic fertilization

with twice frozen-thawed sperm. (Abstract) Proceedings, 4th Meeting of the International Equine Gamete Group Havemeyer Foundation Monograph 18: 19-20 (2006).


Choi YH, Chung YG, Varner DD and Hinrichs K. Birth of a cloned foal by adult somatic cell nuclear transfer with roscovitine-treated donor cells. (Abstract) Reprod. Fertil. Dev. 18:123 (2006).


Hinrichs K, Choi YH, Love LB, and Varner DD. Transfer of in vitro-produced equine embryos. (Abstract) Proceedings, 6th International Symposium on Equine Embryo Transfer, Havemeyer Foundation, p. 38-39 (2005).


Riera FL, Roldán JE and Hinrichs K. Ipsilateral double ovulation is associated with reduced embryo recovery in mares. (Abstract) Proceedings, 6th International Equine Embryo Transfer Symposium, Havemeyer Foundation, p. 108-109 (2005).


Choi YH, Love LB, Varner DD and Hinrichs K. Blastocyst development of equine oocytes with low meiotic competence held in roscovitine before in vitro maturation. (Abstract) Reprod. Fertil. Dev. p. 216-217 (2005).


Pryor J, Romo S, Varner DD, Hinrichs K and Looney CR. Comparison of two sperm separation products for use in bovine IVF. (Abstract) Reprod. Fertil. Dev. p. 277 (2005).


Romo S, Pryor J, Varner DD, Hinrichs K and Looney CR. Comparison of three different IVF protocols for bovine oocytes. (Abstract) Reprod. Fertil. Dev. p. 276 (2005).

Hinrichs K, Choi YH, Walckenaer BE and Varner DD. Interactions between time of oocyte recovery (immediate vs delayed) and duration of in vitro maturation on developmental competence of horse oocytes. (Abstract) Proceedings, Havemeyer Foundation Workshop: Transporting Gametes and Embryos p. 5-6 (2004).


Bedford SJ, Hinrichs K and Fissore RA. Oocyte maturation and effect on sperm or sperm extract induced intracellular calcium oscillations. (Abstract) Proceedings, Havemeyer Foundation Workshop: Transporting Gametes and Embryos p. 9-10 (2004).


Choi YH, Roasa LM, Varner DD, Hinrichs K. Blastocyst development of in vitro- and in vivo-matured equine oocytes fertilised by ICSI. (Abstract) Proceedings, Havemeyer Foundation Workshop: Transporting Gametes and Embryos p. 29-30 (2004).


Choi YH, Varner DD and Hinrichs K. Comparison of embryo culture media for blastocyst development after intracytoplasmic sperm injection of in vitro-matured equine oocytes. (Abstract) Reprod. Fertil. Dev. 16:195 (2004).


Hinrichs K, Choi YH, Love CC, Varner DD, Brinsko SP and Love LB. Relationships between equine oocyte characteristics and developmental potential. (Abstract) Proceedings, Havemeyer Foundation Workshop: From Epididymis to Embryo p. 48-49 (2003).


Choi YH, Love CC, Love LB, Varner DD and Hinrichs K. Techniques for achieving fertilization in vitro in the horse. (Abstract) Proceedings, Havemeyer Foundation Workshop: From Epididymis to Embryo p. 64-65 (2003).


Choi YH, Love CC, Chung YG, Varner DD, Westhusin ME, Burghardt RC and Hinrichs K. Use of Piezo-driven direct nuclear injection and activation with stallion sperm extract to produce horse nuclear transfer embryos. (Abstract) Theriogenology 58:771-774 (2002).


Bedford SJ, Kurokawa M, Hinrichs K and Fissore RA. Patterns of [Ca2+]i oscillations after intracytoplasmic sperm injection of in vitro and in vivo matured horse oocytes. (Abstract) Theriogenology 58:701-704 (2002).


Hinrichs K, Choi YH, Love LB, Love CC, Varner DD and Ingram LA. Effect of holding time and media on meiotic

and developmental competence of horse oocytes. (Abstract) Theriogenology 58:675-678 (2002).


Franz LC, Choi YH, Squires EL, Seidel GE and Hinrichs K. Effect of transient suppression of meiosis with roscovitine on subsequent developmental competence of equine oocytes. (Abstract) Biol. Reprod. 66; Suppl.1:175-176 (2002).


Riera FL, Roldán JE, Love CC and Hinrichs K. Effect of stallion on embryo recovery, quality, and stage, and on pregnancy rate after transfer, in a commercial embryo transfer program. (Abstract) Proceedings, Havemeyer Foundation Workshop on Advanced Clinical Topics in Stallion Reproduction.


Bedford SJ, Kurokawa M, Hinrichs K and Fissore R. Activation and intracellular calcium ([Ca2+]I) transients induced by microinjection of equine sperm factor on murine and equine oocytes. (Abstract) Theriogenology 57:699 (2002).


Alm H, Hinrichs K, Torner H and Kanitz W. Evaluation of germinal vesicle status in horse oocytes using different staining methods. (Abstract) Proceedings, 5th Annual Conference European Society for Domestic Animal Reproduction, p.48 (2001).


Choi YH, Love CC, Love LB, Varner DD, Brinsko SP and Hinrichs K. In vitro and in vivo development of in vitro-matured horse oocytes fertilized by intracytoplasmic sperm injection. (Abstract) Proceedings, Soc. Theriogenology, p.8 (2001).


Dell'Aquila ME, Masterson M, Maritato F and Hinrichs K. Chromatin configuration, meiotic competence and success of intra-cytoplasmic sperm injection in horse oocytes collected by follicular aspiration or scraping. (Abstract) Proceedings, 5th International Symposium on Equine Embryo Transfer, Havemeyer Foundation, T. Katila and J. Wade, eds. pp. 37-38 (2001).


Hinrichs K, Shin TS, Love CC, Varner DD and Westhusin M. Comparison of bovine and equine oocytes as host cytoplasts for equine nuclear transfer. (Abstract) Proceedings, 5th International Symposium on Equine Embryo Transfer, Havemeyer Foundation, T. Katila and J. Wade, eds. pp. 43-44 (2001).


Love CC, Brinsko SP, Varner DD and Hinrichs K. Fertilisation rates of in vitro-matured oocytes transferred into the oviduct of inseminated mares. (Abstract) Proceedings, 5th International Symposium on Equine Embryo Transfer, Havemeyer Foundation, T. Katila and J. Wade, eds. pp. 41-42 (2001).


Riera FL, Roldán JE, and Hinrichs K. Effect of insemination timing on embryo recovery rate, pregnancy rate after transfer, and pregnancy loss rate in a commercial embryo transfer programme. (Abstract) Proceedings, 5th International Symposium on Equine Embryo Transfer, Havemeyer Foundation, T. Katila and J. Wade, eds. pp. 89-90 (2001).


Choi YH, Shin T, Love CC, Burghardt RC, Varner DD and Hinrichs K. Effects of initial cumulus morphology and addition of cytochalasin B on fusion, activation and cleavage of horse oocytes undergoing nuclear transfer. (Abstract) Theriogenology 55:261 (2001).

Hinrichs K, Shin TS, Love CC, Varner DD and Westhusin M. Production of equine embryos by nuclear transfer: comparison of efficiency of equine and bovine cytoplasts. (Abstract) Proceedings, Soc. Theriogenology, p.133 (2000).


Dell'Aquila ME, Albrizio M, Lacalandra GM, Maritato F, Hinrichs K and Minoia P. Follicular wall apoptosis and pronuclear formation in equine oocytes submitted to intracytoplasmic sperm injection (ICSI) [Apoptosi follicolare e formazione dei pronuclei in ovociti equini sottoposti ad iniezione intracitoplasmatica dello spermatozoo (ICSI)]. (Abstract) Proceedings, LIV Congresso Società Italiana Scienze Veterinarie; vol LIV: pp.127-128 (2000).


Kanitz W, Alm H, Becker F, Nurnberg G, Kurth J and Hinrichs K. Repeated follicular aspiration in mares: consequences for follicular growth and oocyte quality. (Original research report) J. Reprod. Fertil. Suppl. 56:463-472 (2000).

Hinrichs K, Betschart RW, McCue PM and Squires EL. Effect of time of follicle aspiration on pregnancy rate after oocyte transfer in the mare. (Original research report) J. Reprod. Fertil. Suppl. 56:493-498 (2000).


Hinrichs K, Provost PJ and Torello EM. Use of non-ovulating, hormone-treated mares as oocyte transfer recipients. (Abstract) Proceedings, Soc. Theriogenology, p. 43 (1999).


Alm H, Torner H, Kanitz W, Becker F and Hinrichs K. Comparison of different methods for recovery of horse oocytes. (Original Report). Equine Vet. J. Suppl. 25:47-50 (1997).


Hinrichs K, Matthews GL and Freeman DA. Effect of oocyte maturation time on embryo development after oocyte transfer in the mare. (Abstract). Theriogenology 47:392 (1997).


Alm H and Hinrichs K. Effect of cycloheximide on nuclear maturation of horse oocytes. (Abstract). Archiv fur Tierzucht., Dummerstorf (Special Issue) 39:77 (1996).


Williams KA and Hinrichs K. Morphology and meiotic competence of oocytes in relation to follicle atresia in the mare. (Abstract). Proceedings, 12th Int. Cong. Anim. Reprod. 3:17-4 (1996).


Overstrom EW, Duby RT, Dobrinsky J, Hinrichs K, Roche JF, and Boland MP. Sodium transport properties of the bovine and equine blastocyst. (Abstract) in: Bavister B, ed., Preimplantation Embryonic Development, Springer-Verlag, New York, p. 323 (1993).


Hinrichs K and Schmidt AL. Reversible meiotic arrest of horse oocytes by coculture with follicular components. (Abstract) Theriogenology 39:232 (1993).


Hinrichs K, Friedman PP, Martin MG. Evaluation of in vitro maturation of horse oocytes using fluorescence microscopy. (Brief communication) Proceedings, 12th Int. Cong. Anim. Reprod. 1:330-332 (1992).


Hinrichs K, Martin MG and Friedman PP. Effect of follicular components on maintenance of meiotic arrest in horse oocytes. (Abstract) Theriogenology 37:223 (1992).


Hinrichs K. The role of endometrial swabs in the diagnosis (and pathogenesis?) of endometritis. (Editorial) Cornell Vet. 81:233-237 (1991). Reprinted in the New Zealand Veterinary Association Equine Branch Newsletter March 1992, pp. 31-34.


Hinrichs K. A simple technique that may improve the rate of embryo recovery on uterine flushing in mares. (Work-in-progress report) Theriogenology 33:937-942 (1990).


Hinrichs K, Cummings MR, Sertich PL and Kenney RM. Bacteria recovered from the reproductive tracts of normal mares. (Brief communication) Proceedings, Am. Assoc. Equine Pract., pp. 11-16 (1989).


Hinrichs K, Klunder LR and Riera FL. Embryo transfer in mares with gonadal dysgenesis. (Abstract) Theriogenology 31:204 (1989).


Sertich PL, Hinrichs K, Schiereck DE and Kenney RM. Periparturient events in ovariectomized embryo transfer recipient mares. (Brief communication) Proceedings, 11th Int. Cong. Anim. Reprod. Artificial Insemination, p. 193. (1988).


Hinrichs K. Establishment of pregnancy after embryo transfer in ovariectomized mares: Effect of length of progesterone treatment on pregnancy rate and pattern of uterine proteins. Ph.D. Dissertation, University of Pennsylvania. (1988).


Hinrichs K and Kenney RM. A colpotomy procedure to increase oocyte recovery rates on aspiration of equine preovulatory follicles. (Abstract) Theriogenology 27:237 (1987).


Hinrichs K, Sertich PL, Cummings MR, and Kenney RM. Pregnancy in ovariectomized mares achieved by embryo transfer. (Brief communication) Equine Vet. J. Suppl. 3:74-75 (1985).


Van Huffel XM, Varner DD, Hinrichs K, Garcia MC, Strzemienski PJ and Kenney RM. A comparison of visual and photomicrographic techniques for stallion spermatozoal motility analysis. (Brief communication) Proceedings, Soc. Theriogenology, pp. 162-166 (1983).


Submitted for publication

Choi YH, Gustafson-Seabury A, Velez IC, Hartman DL, Bliss S, Riera FL Roldán JE, Chowdhary B and Hinrichs K. Normal rates of pregnancy and live birth after biopsy of equine embryos for preimplantation genetic diagnosis.


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