Research Publications
Publications in referred journals: Reports of original
research
These publications can be viewed online in their full
capacity for reference by looking up their title on www.pubmed.gov .
Johnson AK, Clark-Price SC, Choi YH, Hartman DL, and
Hinrichs K. Physical and clinicopathologic
findings in foals produced by somatic cell nuclear transfer - 14
cases (2005-2008). J. Am. Vet. Med. Assoc. (in press).
Mortensen CJ, Choi YH, Ing NH, Kraemer DC, Vogelsang MM and
Hinrichs K. Heat shock protein 70 gene expression
in equine blastocysts after exposure of oocytes to high
temperatures in vitro or after exercise of donor mares in vivo.
Theriogenology (in press).
Jacobson CC, Choi YH, Hayden SS and Hinrichs K.
Recovery of mare oocytes on a fixed biweekly schedule, and
resulting blastocyst formation after intracytoplasmic sperm
injection. Theriogenology 73:1116-1126 (2010).
Choi YH, Harding HD, Obermiller AD, Hartman DL, Kurosaka S,
McLaughlin KJ, and Hinrichs K. The uterine
environment modulates trophectodermal POU5F1 levels in equine
blastocysts. Reproduction 38: 589-599
(2009).
Choi YH, Hartman DL, Fissore RA, Bedford-Guaus SJ and
Hinrichs K. Effect of sperm extract injection
volume, injection of PLCζ cRNA, and tissue cell line on efficiency
of equine nuclear transfer. Cloning Stem Cells 11: 301-308
(2009).
McPartlin LA, Suarez SS, Czaya CA, Hinrichs K
and Bedford-Guaus SJ. Hyperactivation of stallion sperm is required
for successful in vitro fertilization of equine oocytes.
Biol. Reprod. 81:199-206 (2009).
Mortensen CJ, Choi YH, Hinrichs K, Ing NH,
Kraemer DC, Vogelsang SG and Vogelsang MM. Embryo recovery from
exercised mares. Anim. Reprod. Sci.110:237-244 (2009).
Bedford-Guaus SJ, Yoon S-Y, Fissore RA, Choi Y-H and
Hinrichs K. Microinjection of mouse PLCz
complementary RNA into mare oocytes induces long-lasting
intracellular calcium ([Ca2]i) oscillations and embryonic
development. Reprod. Fertil. Dev. 20:875-883 (2008).
Alm H, Choi YH, Love L, Heleil B, Torner H and Hinrichs
K. Holding bovine oocytes in the absence of maturation
inhibitors: kinetics of in vitro maturation and effect on
blastocyst development after in vitro fertilization.
Theriogenology 70:1024-1029 (2008).
Ribeiro BI, Love LB, Choi YH and Hinrichs K.
Transport of equine ovaries for assisted reproduction. Anim.
Reprod. Sci.108:171-179 (2008).
Hanna C, Long C, Hinrichs K, Westhusin M and
Kraemer D. Assessment of canine oocyte viability after
transportation and storage under different conditions. Anim.
Reprod. Sci. 105:451-456 (2008).
Hinrichs K, Choi YH, Varner DD and Hartman DL.
Production of cloned horse foals using roscovitine-treated donor
cells and activation with sperm extract and/or ionomycin.
Reproduction 134:319-325 (2007).
Hinrichs K, Choi YH, Walckenaer BE, Varner DD,
and Hartman DL. In vitro-produced equine embryos: production of
foals after transfer to recipient mares, assessment by differential
staining, and effect of medium calcium concentrations.
Theriogenology 68:521-529 (2007).
Roasa LM, Choi YH, Love CC, Romo S, Varner DD and
Hinrichs K. Ejaculate and type of freezing
extender affect rates of fertilization of horse oocytes in vitro.
Theriogenology 68:560-566 (2007).
Choi YH, Love LB, Varner DD and Hinrichs K.
Effect of holding technique and culture drop size in individual or
group culture on blastocyst development after ICSI of equine
oocytes with low meiotic competence. Animal Reprod. Sci.,
102:38-47 (2007).
Choi YH, Love LB, Varner DD and Hinrichs K.
Holding immature equine oocytes in the absence of meiotic
inhibitors: Effect on germinal vesicle chromatin and blastocyst
development after intracytoplasmic sperm injection.
Theriogenology 66:955-63 (2006).
Hinrichs K, Choi YH, Love CC, Chung YG, Varner
DD. Production of horse foals via direct injection of
roscovitine-treated donor cells and activation by injection of
sperm extract. Reproduction 131:1063-1072 (2006).
Choi YH, Love CC, Varner DD and Hinrichs K
Equine blastocyst development after intracytoplasmic injection of
sperm
subjected to two freeze-thaw cycles. Theriogenology
65:808-819 (2006).
Choi YH, Love LB Varner DD and Hinrichs K.
Blastocyst development in equine oocytes with low meiotic
competence after suppression of meiosis with roscovitine prior to
in vitro maturation. Zygote 14:1-8 (2006).
Hinrichs K, Choi YH, Love LB, Varner DD, Love
CC, and Walckenaer BE. Chromatin configuration within the germinal
vesicle of horse oocytes: Changes post-mortem and relationship to
meiotic and developmental competence. Biol. Reprod.
72:1142-50 (2005).
Choi YH, Roasa LM, Love CC, Varner DD, Brinsko SP and
Hinrichs K. Blastocyst formation rates in vivo and
in vitro of in vitro-matured equine oocytes fertilized by
intracytoplasmic sperm injection. Biol. Reprod. 70:
1231-1238 (2004).
Bedford SJ, Kurokawa M, Hinrichs K, and Fissore
RA. Patterns of intracellular calcium oscillations in horse oocytes
fertilized by intracytoplasmic sperm injection: Possible
explanations for the low success of this assisted reproduction
technique in the horse. Biol. Reprod. 70:936-44
(2004).
Choi YH, Love LB, Varner DD and Hinrichs K.
Factors affecting developmental competence of equine oocytes
after intracytoplasmic sperm injection. Reproduction
127:187-94 (2004).
Choi YH, Love LB, Westhusin ME and Hinrichs K.
Activation of equine nuclear transfer oocytes: methods and timing
of treatment in relation to nuclear remodeling. Biol.
Reprod. 70: 46-53 (2004).
Choi YH, Love CC, Varner DD, Love LB and Hinrichs
K. Effects of gas conditions, time of medium change, and
ratio of medium to embryo on in vitro development of horse oocytes
fertilized by intracytoplasmic sperm injection.
Theriogenology 59:1219-1229 (2003).
Franz LC, Choi YH, Squires EL, Seidel GE and Hinrichs
K. Effects of roscovitine on maintenance of the germinal
vesicle in horse oocytes, subsequent nuclear maturation, and
cleavage rates after intracytoplasmic sperm injection.
Reproduction 125:693-700 (2003).
Willingham-Rocky LA, Hinrichs K, Westhusin ME,
Kraemer DC. Effects of stage of oestrus cycle and progesterone
supplementation during culture on maturation of canine oocytes in
vitro. Reproduction 126:501-508 (2003).
Dell'Aquila ME, Albrizio M, Maritato F, Minoia P and
Hinrichs K. Meiotic competence of equine oocytes
and rate of pronucleus formation after intracytoplasmic sperm
injection (ICSI) as related to follicular wall apoptosis. Biol.
Reprod. 68:2065-2072 (2003).
Bedford SJ, Kurokawa M, Hinrichs K and Fissore
RA. Initiation of calcium oscillations and activation in horse
oocytes injected with equine sperm extracts. Reproduction
126:489-99 (2003).
Choi YH, Chung YG, Walker SC, Westhusin ME and Hinrichs
K. In vitro development of equine nuclear transfer
embryos: Effects of oocyte maturation media and amino acid
composition during embryo culture. Zygote 11:77-86
(2003).
Love LB, Choi YH, Love CC, Varner DD and Hinrichs
K. Effect of ovary storage and oocyte transport method on
maturation rate of horse oocytes. Theriogenology
59:765-774 (2003).
Choi YH, Love CC, Chung YG, Varner DD, Westhusin ME, Burghardt
RC and Hinrichs K. Production of nuclear transfer
horse embryos by Piezo-driven injection of somatic cell nuclei and
activation with stallion sperm cytosolic extract. Biol.
Reprod. 67:561-567 (2002).
Love CC, Love LB, Varner DD and Hinrichs K.
Effect of holding at room temperature after recovery on initial
chromatin configuration and in vitro maturation rate of equine
oocytes. Theriogenology 57:1973-1979 (2002).
Hinrichs K, Love CC, Brinsko SP, Choi YH and
Varner DD. In vitro fertilization of in vitro-matured equine
oocytes: Effect of maturation medium, duration of maturation and
sperm calcium ionophore treatment, and comparison with rates of
fertilization in vivo after oviductal transfer. Biol.
Reprod. 67: 256-262 (2002).
Choi YH, Love CC, Love LB, Varner DD, Brinsko SP and
Hinrichs K. Developmental
competence in vivo and in vitro of in vitro-matured equine oocytes
fertilized by intracytoplasmic sperm injection with fresh or
frozen-thawed sperm. Reproduction 123: 455-465 (2002).
Choi YH, Shin T, Love CC, Johnson C, Varner DD, Westhusin ME and
Hinrichs K. Effect of co-culture with theca
interna on nuclear maturation of horse oocytes with low meiotic
competence, and subsequent fusion and activation rates after
nuclear transfer. Theriogenology 57:1005-1011 (2002).
Hinrichs K, Love CC, Choi YH, Varner DD,
Wiggins CN and Reinoehl C. Suppression of meiosis by inhibitors of
m-phase proteins in horse oocytes with low meiotic competence.
Zygote 10:37-45 (2002).
Dell'Aquila ME, Masterson M, Maritato F and Hinrichs
K. Influence of oocyte collection technique on initial
chromatin configuration, meiotic competence and male pronucleus
formation after intracytoplasmic sperm injection (ICSI) of equine
oocytes. Mol. Reprod. Devel. 60:79-88 (2001).
Choi YH, Love CC, Thompson JA, Varner DD and Hinrichs
K. Activation of cumulus-free horse oocytes: effect of
maturation medium, calcium ionophore concentration and duration of
cycloheximide exposure. Reproduction 122:177-183
(2001).
Hinrichs K and Schmidt AL. Meiotic competence
in horse oocytes: Interactions among chromatin configuration,
follicle size, cumulus morphology and season. Biol.
Reprod. 62:1402-1408 (2000).
Hinrichs K, Provost PJ and Torello EM.
Treatments resulting in pregnancy in nonovulating, hormone-treated
oocyte recipient mares. Theriogenology 54:1285-1293
(2000).
Bedford SJ, Gowdy LG and Hinrichs K. Comparison
of longevity of motility of stallion spermatozoa incubated at
38oC in different capacitating media and containers.
Theriogenology 51:637-646 (1999).
Hinrichs K, Matthews GL, Freeman DA and Torello
EM. Oocyte transfer in mares. J. Am. Vet. Med. Assoc.
212:982-986 (1998).
Hinrichs K and Williams KA. Relationships among
oocyte-cumulus morphology, follicular atresia and oocyte meiotic
competence in the horse. Biol. Reprod. 57:377-384
(1997).
Alm H and Hinrichs K. Effect of cycloheximide
on nuclear maturation of horse oocytes and its relation to initial
cumulus morphology. J. Reprod. Fertil. 107:215-220
(1996).
Hawley LR, Enders AC and Hinrichs K. Comparison
of equine and bovine oocyte-cumulus morphology within the ovarian
follicle. Biol. Reprod. Mono. 1: 243-252 (1995).
Hinrichs K, Schmidt AL and Selgrath JP.
Activation of horse oocytes. Biol. Reprod. Mono. 1:
319-324 (1995).
Hinrichs K, Martin MG, Schmidt AL and Friedman
PP. Effect of follicular components on meiotic arrest and
resumption in horse oocytes. J. Reprod. Fertil.
104:149-156 (1995).
Bedford S and Hinrichs K. The effect of
insemination volume on pregnancy rates in pony mares.
Theriogenology 42:571-578 (1994).
Hinrichs K, Schmidt AL, Friedman PP, Selgrath
JP and Martin MG. In vitro maturation of horse oocytes:
Characterization of chromatin configuration using fluorescence
microscopy. Biol. Reprod. 48:363-370 (1993).
Hinrichs K, Spensley MS and McDonough PL.
Evaluation of progesterone treatment to create a model for equine
endometritis. Equine Vet. J. 23:457-461 (1992).
Hinrichs K and DiGiorgio LM. Embryonic
development after intrafollicular transfer of immature horse
oocytes. J. Reprod. Fertil. Suppl. 44:369-374 (1991).
Hinrichs K. The relationship of follicle
atresia to follicle size, oocyte recovery rate on aspiration, and
oocyte morphology in the mare. Theriogenology 36:157-168
(1991).
Hinrichs K, Rand WM and Palmer E. Effect of
aspiration of the preovulatory follicle on luteinization, corpus
luteum function, and peripheral plasma gonadotropin concentrations
in the mare. Biol. Reprod. 44:292-298 (1991).
Hinrichs K and Watson ED. Effect of
administration of phenylbutazone or progesterone on recovery of
embryos from the uterus 5 days after ovulation in mares. Am. J.
Vet. Res. 52:678-681 (1991).
Hinrichs K, Schmidt AL, Memon MA, Selgrath JP
and Ebert KM. Culture of 5-day horse embryos in microdroplets for
10 to 20 days. Theriogenology 34:643-654 (1990).
Hinrichs K, Kenney DF and Kenney RM. Aspiration
of oocytes from mature and immature pre-ovulatory follicles in the
mare. Theriogenology 34:107-112 (1990).
Hinrichs K and Riera FL. Effect of
administration of prostaglandin F2 alpha on embryo recovery from
the uterus on day 5 after ovulation in mares. Am. J. Vet.
Res. 51:451-453 (1990).
Hinrichs K and Hunt PR. Ultrasound as an aid to
diagnosis of granulosa cell tumor in the mare. Equine Vet.
J. 22:99-103 (1990).
Hinrichs K, Riera FL and Klunder LR.
Establishment of pregnancy after embryo transfer in mares with
gonadal dysgenesis. J. In Vitro Fertilization Embryo
Transfer 6:305-309 (1989).
Watson ED and Hinrichs K. Adrenal production of
sex steroids in the mare. Theriogenology 32:913-919
(1989).
Sertich PL, Hinrichs K and Kenney RM.
Histological aspects of uterine involution of the postparturient,
ovariectomised, embryo-recipient mare: a model for the study of
involution. Equine Vet. J. Suppl. 8:56-58
(1989).
Hinrichs K, Sharp DC and Kenney RM. Differences
in protein content of uterine fluid related to duration of
progesterone treatment in ovariectomised mares used as embryo
transfer recipients. Equine Vet. J. Suppl. 8:49-55
(1989).
Watson ED and Hinrichs K. Effect of
prostaglandin F2 alpha on adrenal-produced steroid hormones in the
cow. Am. J. Vet. Res. 50:1078-1079 (1989).
Watson ED and Hinrichs K. Changes in
concentrations of steroids and prostaglandin F in preovulatory
follicles of the mare after administration of hCG. J. Reprod.
Fertil. 84:557-561 (1988).
Hinrichs K, Cummings MR, Sertich PL and Kenney
RM. Clinical significance of aerobic bacterial flora from the
uterus, vagina, vestibule and clitoral fossa of clinically normal
mares. J. Am. Vet. Med. Assn. 193:72-75 (1988).
Sertich PL, Hinrichs K, Schiereck DE and Kenney
RM. Periparturient events in ovariectomized embryo transfer
recipient mares. Theriogenology 30:401-409 (1988).
Hinrichs K, Sertich PL, Solorzano NM and
Caldwell LA. Use of an immediate, qualitative progesterone assay
for determination of day of ovulation in an equine embryo transfer
program. Theriogenology 29:1123-1130 (1988).
McDonnell SM, Hinrichs K, Cooper WL and Kenney
RM. Use of an androgenized mare as an aid in detection of estrus in
mares. Theriogenology 30:547-553 (1988).
Hinrichs K and Kenney RM. Effect of timing of
progesterone administration on pregnancy rate after embryo transfer
in ovariectomized mares. J. Reprod. Fertil. Suppl.
35:439-443 (1987).
Hinrichs K, Sertich PL, Palmer E, and Kenney
RM. Establishment and maintenance of pregnancy after embryo
transfer in ovariectomized mares treated with progesterone. J.
Reprod. Fertil. 80:395-401 (1987).
Hinrichs K, Sertich PL, and Kenney RM. Use of
altrenogest to prepare ovariectomized mares as embryo transfer
recipients. Theriogenology. 26:455-460 (1986).
Van Huffel XM, Varner DD, Hinrichs K, Garcia
MC, Strzemienski PJ, and Kenney RM. Photomicrographic evaluation of
stallion spermatozoal motility characteristics. Am. J. Vet.
Res. 46:1272-1275 (1985).
Varner DD, Hinrichs K, Garcia MC, Osborne HG,
Blanchard TL, and Kenney RM. A comparison between the cervical
dimensions of pregnant and non-pregnant Santa Gertrudis and Bos
taurus cows. Theriogenology. 24:109-118 (1985).
Publications in refereed journals:
Clinical reports
Mancill SS, Blodgett G, Arnott RJ, Alvarenga M, Love CC and
Hinrichs K. Monozygotic equine twins resulting
from transfer of a single embryo, verified by DNA typing (3 cases).
J. Am. Vet. Med. Assoc. (in press).
Hinrichs K, Buoen LC and Ruth GR. XX/XY
chimerism and freemartinism in a female llama co-twin to a male.
J. Am. Vet. Med. Assoc. 215:1140-1141 (1999).
Hinrichs K, Provost PJ and Torello EM. Birth of
a foal after oocyte transfer to a nonovulating, hormone-treated
mare. Theriogenology 51:1251-1258 (1999).
Hinrichs K, Horin SE, Buoen LC, Zhang TQ and
Ruth GR. X-chromosome monosomy in an infertile female llama. J.
Am. Vet. Med. Assoc. 210:1503-1504 (1997).
Bedford SJ, Hawes M, Paradis MR, Mort JD and Hinrichs
K. Peritonitis associated with passage of the placenta
into the abdominal cavity in a llama. J. Am. Vet. Med.
Assoc. 209:1914-1916 (1996).
Hinrichs K, Cochran SL, Schelling SH, and
Steckel RR. Granulosa-theca cell tumor associated with an ovulation
fossa and normal ovarian stroma in a mare. J. Am. Vet. Med.
Assoc. 200:696-698 (1992).
Hinrichs K, Watson ED and Kenney RM. Granulosa
cell tumor in a mare with a functional contralateral ovary. J.
Am. Vet. Med. Assoc. 197:1037-1038 (1990).
Riera FL, Hinrichs K, Hunt PR and Kenney RM.
Cervical hyperplasia with prolapse in a mare. J. Am. Vet. Med.
Assoc. 195:1393-1394 (1989).
Hinrichs K, Frazer GS, deGannes RVG, Richardson
DW and Kenney RM. Serous cystadenoma with elevated plasma
testosterone levels in a normally cyclic mare. J. Am. Vet. Med.
Assoc. 194:381-382 (1989).
Hinrichs K and Watson ED. Recovery of a
degenerating 14-day embryo on uterine flush 7 days after ovulation
in a mare. Theriogenology 30:349-353 (1988).
Hinrichs K, Gentile DG, Hurtgen JP, and
Richardson DW. Complications from a testicular prosthesis in a
stallion. J. Am. Vet. Med. Assoc. 186:390-391 (1985).
Hinrichs K, Hurtgen JP, and Kenney RM.
Unilateral hydrosalpinx and absence of the infundibulum in a mare.
Theriogenology 22:571-577 (1984).
Hinrichs K and Kenney RM. Infertility due to
foreign objects in the cervix of a cow. J. Am. Vet. Med.
Assoc. 185:788-789 (1984).
Brown JS, Varner DD, Hinrichs K, and Kenney RM.
Surgical repair of the lacerated cervix in the mare.
Theriogenology 22:351-359 (1984).
Reviews and Book Chapters
Hinrichs K. Application of assisted
reproductive technologies (ART) to clinical practice (Review).
Proceedings, Am. Assoc. Equine Pract. (submitted).
Hinrichs K. In vitro production of equine
embryos: state of the ART (Review). Reprod. Domestic Anim.
(in press).
Hinrichs K. The equine oocyte: factors
affecting meiotic and developmental competence (Review). Molec.
Reprod. Devel. (in press).
Hinrichs K. Cloning in domestic animals. In:
The Merck Veterinary Manual, 10th Edition. Merck and Co., Inc.,
Rahway, NJ (in press).
Hinrichs K. Advances in assisted reproductive
technologies. In: Manual of Equine Reproduction (3rd
Edition), Blanchard TL, Varner DD, Schumacher J, et al., eds.
Mosby-Year Book, Inc., St. Louis, MO (in press).
Hinrichs K. Immature oocyte collection and
maturation; Nuclear transfer. In: Equine Reproduction
(2nd Edition), McKinnon AO, Squires EL, Vaala W and
Varner DD, eds. Blackwell Publishing, Malden, MA (in press).
Choi YH and Hinrichs K. Intracytoplasmic sperm
injection. In: Equine Reproduction (2nd Edition),
McKinnon AO, Squires EL, Vaala W and Varner DD, eds. Blackwell
Publishing, Malden, MA (in press).
Hinrichs K. Irregularities of the Estrus Cycle
and Ovulation in Mares (including Seasonal Transition). In: Current
Therapy in Large Animal Theriogenology 2, Youngquist RS and
Threlfall WR, eds., Saunders Elsevier, St. Louis, MO, pp.144-152
(2007).
Hinrichs K. Equine Cloning. In: Veterinary
Clinics of North America: Equine Practice, Carnevale EM, ed., W.B.
Saunders Co., Philadelphia, PA, pp. 857-866 (2006).
Hinrichs K. In vitro fertilization; In vitro
oocyte maturation. In: Current Therapy in Equine Reproduction,
Samper J, Pycock J and McKinnon AO, eds. Saunders Elsevier, St.
Louis, MO, pp. 308-309; 310-314 (2006).
Hinrichs K. A review of cloning in the horse.
(Review) Proceedings, Am. Assoc. Equine Pract, pp. 398-401
(2006).
Hinrichs K and Choi YH. Assisted Reproductive
Techniques in the Horse. In: Clinical Techniques in Equine Practice
4 (3): Equine Reproduction. Elsevier, Philadelphia, PA pp 210-218
(2005).
Hinrichs K. An update on equine ICSI and
cloning. (Review) Theriogenology. 64:535-41 (2005)
Hinrichs K. Breeding soundness examination in
the male; Embryo transfer in farm animals; Hormonal control of
estrus. In: The Merck Veterinary Manual, 9th Edition. Merck and
Co., Inc., Rahway, NJ pp 1797-1811 (2005).
Westhusin ME, Hinrichs K, Choi YH, Shin T, Liu
L and Kraemer D. Cloning Companion Animals (Horses, Cats, and
Dogs). (Review) Cloning Stem Cells 5: 301-317 (2003).
Hinrichs K. Current status and clinical
potential of IVF, ICSI and cloning in horses. (Review)
Proceedings, Soc. Theriogenology, pp. 133-141 (2002).
Hinrichs K. Embryo production by assisted
reproduction in the horse. (Review). Theriogenology
49:13-21 (1998).
Hinrichs K. Breeding soundness examination in
the male; Embryo transfer in farm animals; Hormonal control of
estrus. In: The Merck Veterinary Manual, 8th Edition. Merck and
Co., Inc., Rahway, NJ. pp. 1508-1520 (1998).
Hinrichs K. Theriogenology. In: Review
Questions and Answers for Veterinary Boards, Small Animal Medicine
and Surgery, 2nd Edition, Pratt PW, ed. Mosby-Year Book, Inc.,
Santa Barbara, CA pp277-281 (1998).
Hinrichs K. Cumulus expansion, chromatin
configuration and meiotic competence in horse oocytes. (Review).
Equine Vet. J. Suppl. 25:43-46 (1997).
Hinrichs K. Irregularities of the estrus cycle
and ovulation in the mare. In: Current Therapy in Theriogenology
III: Large Animal, Youngquist RS, ed., W.B. Saunders Co.,
Philadelphia, PA pp. 166-171 (1997).
Hinrichs K. Assisted reproductive techniques in
the mare. In: Current Therapy in Equine Medicine 4, Robinson NE,
ed., W.B. Saunders Co., Philadelphia. pp. 565-571 (1997).
Hinrichs K, Matthews GL, Freeman DA and Torello
EM. Oocyte transfer as a clinical procedure in the mare. (Review).
Proceedings, Am. Assoc. Equine Pract., pp. 187-188
(1997).
Hinrichs K. Oocyte collection and maturation.
(Review). Proceedings, Soc. Theriogenology, pp. 147-151
(1997).
Hinrichs K. Manipulation of oocyte maturation
in vitro. (Review). Archiv fur Tierzucht., Dummerstorf
(Special Issue) 39:43-50 (1996).
Hinrichs K. Assisted reproductive technology in
the horse. (Review). Proceedings, Soc. Theriogenology,
pp.162-173 (1994).
Hinrichs K. Use of ovariectomized mares as
embryo transfer recipients and Future technology: oocyte
transfer, maturation and in vitro fertilization. (Review). Ars
Veterinaria 10 (Suppl.): 89-98 (1994).
Hinrichs K, Schmidt AL and Selgrath JP. Atlas
of chromatin configurations of germinal vesicle stage and maturing
horse oocytes. (Review). Equine Vet. J. Suppl. 15:60-63
(1993).
Hinrichs K. Embryo transfer in the mare: a
status report. In: Current Advances in the Manipulation of
Reproductive Functions in Domesticated Species of Animals,
Anim. Reprod. Sci., 33:227-240 (1993).
Hinrichs K. Potential for gamete manipulation
in the horse: GIFT, IVF and embryo transfer. (Review).
Proceedings, Soc. Theriogenology, pp. 14-17 (1992).
Hinrichs K. Ultrasonographic techniques in mare
reproduction. (Review). Proceedings, Am. College of
Theriogenologists Equine Theriogenology Short Course, pp. 92-94
(1992).
Hinrichs K. Effect of cumulus morphology on
maturation of horse oocytes in vitro / Wspolzaleznosc pomiedzy
wygladem morfologicznym komorek wzgorka, a dojrzewaniem in vitro
oocytow klaczy. (Review). Proceedings, Int. Scientific
Conference on Biotechnics in Horse Reproduction, Agricultural
University of Crakow, pp. 18-19 / 21-22 (1992).
Hinrichs K. Prospects for oocyte aspiration,
fertilization and transfer in the horse. (Review).
Proceedings, Am. Assoc. Equine Pract. pp. 189-196
(1992).
Hinrichs K. Embryo transfer in the mare. In:
Current Therapy in Equine Medicine 3, Robinson NE, ed., W.B.
Saunders Co., Philadelphia; pp. 637-642. (1991).
Hinrichs K. Ultrasonographic assessment of
ovarian abnormalities. (Review) Proceedings, Am. Assoc.
Equine Pract., pp. 31-40 (1991).
Freeman DE and Hinrichs K. Granulosa cell
tumor. In: Current Practice of Equine Surgery, White NA and Moore
JN, eds. JB Lippincott Co., Philadelphia; pp. 711-716 (1990).
Hinrichs K. Use of ovariectomized, progestogen
treated mares as embryo transfer recipients. (Review)
Proceedings, Soc. Theriogenology, pp. 107-110 (1986).
Non-refereed publications, proceedings, and
abstracts
Choi YH, Norris JD, Velez IC, Jacobson CC, Hartman DL and
Hinrichs K. Use of metaphase I oocytes or a
histone deacetylase inhibitor in equine nuclear transfer.
(Abstract) Anim. Reprod. Sci., in press.
Hinrichs K, Choi YH, Norris JD, Love LB,
Bedford-Guaus SJ, Hartman DL and Velez IC. Use of intracytoplasmic
sperm injection and in vitro culture to the blastocyst stage for
clinical production of foals post mortem. (Abstract) Anim.
Reprod. Sci., in press.
Loux SC, Crawford KR, Norris JD, Ing NH, Reynolds EA, Love CC,
Varner DD, Velez IC, Dangott LJ, Thornton ER, Choi YH and
Hinrichs K. The CatSper ion channel and
hyperactivated motility of equine spermatozoa. (Abstract) Anim.
Reprod. Sci., in press.
Velez IC, Norris JD, Ballard K, Lassell K, Choi YH and
Hinrichs K. Effect of method of overnight shipment
of oocytes or ovaries on blastocyst formation after
intracytoplasmic sperm injection. (Abstract) Anim. Reprod.
Sci., in press.
Choi YH, Hartman DL, Bliss SB, Hayden SS, Blanchard TL and
Hinrichs K. High pregnancy rates after transfer of
large equine blastocysts collapsed via micromanipulation before
vitrification (Abstract) Reprod. Fertil. Dev. 22:203
(2010).
Hinrichs K. Equine ICSI: History and current
status. (Abstract) Reprod. Domestic Anim. 44: 62
(2009).
Commaille LF, Vogelsang MM, Sigler DH and Hinrichs
K. Intrauterine temperature of mares under different
management conditions (Abstract) J. Equine Vet. Sci. Vol
29: 344-345(2009).
Choi YH, Hartman DL and Hinrichs K. Viability
of equine blastocysts subjected to biopsy for pre-implantation
genetic diagnosis. (Abstract) Reprod. Fertil. Dev. 21:166-167
(2009).
Mancill SS, Arnott RJ, Love CC and Hinrichs K.
Monozygotic twins after embryo transfer, verified by DNA typing.
(Abstract) Proceedings, Am. Assoc. Equine Pract., p. 278
(2008).
McPartlin LA, Suarez SS, Czaya CA, Hinrichs K
and Bedford-Guaus SJ. Hyperactivation of stallion sperm is required
for successful in vitro fertilization of equine oocytes.
(Abstract) Proceedings, Soc. Study Reprod., p. 206
(2008).
Hinrichs K, Choi YH, Harding HD, Obermiller AD
and Hartman DL. Oct-4 expression in in vivo and in vitro-produced
equine blastocysts. (Abstract) Proceedings, 7th
International Symposium on Equine Embryo Transfer, Havemeyer
Foundation, p. 46 (2008).
Choi YH, Hartman DL, Fissore RA, Bedford SJ and Hinrichs
K. Activation methods associated with cloning efficiency
in the horse. (Abstract) Proceedings, 7th
International Symposium on Equine Embryo Transfer, Havemeyer
Foundation, pp. 26-27 (2008).
Riera FL, Roldan JE and Hinrichs K. Pregnancy rate after embryo
transfer in ovulating versus progesterone treated-anestrous
recipient mares in a commercial embryo transfer programme.
(Abstract) Proceedings, 7th International
Symposium on Equine Embryo Transfer, Havemeyer Foundation, pp.
79-80 (2008).
Alm H, Choi YH, Love L, Heleil B, Torner H, Hinrichs
K. Effect of holding technique of bovine oocytes before in
vitro maturation on their further blastocyst development in vitro.
(Abstract) Reprod. Domestic Anim. 43: Suppl. 1, p 3
(2008).
Choi YH, Hartman DL, Fissore RA, Bedford SJ and Hinrichs
K. Effect of activation methods and biopsy sample on
nuclear transfer blastocyst production and cloning efficiency in a
horse. (Abstract) Reprod. Fertil. Devel. 20:94 (2008).
Choi YH, Harding HD, Obermiller AD, and Hinrichs
K. Oct-4 expression pattern in the equine embryo.
(Abstract) Reprod. Fertil. Devel. 19:189-190 (2007).
Choi YH, Varner DD, Hartman DL and Hinrichs K.
Blastocyst production from equine oocytes fertilized by
intracytoplasmic injection of lyophilized sperm. (Abstract)
Anim. Reprod. Sci. 94:307-308 (2006).
Petersen MM, Choi YH, Brück Bøgh I, and Hinrichs
K. Incubation of equine oocytes in roscovitine before in
vitro maturation: Influence of maturation time before
fertilization. (Abstract) Anim. Reprod. Sci 94:362-363
(2006).
Hinrichs K, Choi YH, Varner DD, and Hartman DL.
Efficient production of cloned horse pregnancies using
roscovitine-treated donor cells. (Abstract) Anim. Reprod.
Sci 94:309-310 (2006).
Varner DD, Love CC, Choi YH, Teague S, Thompson JA and
Hinrichs K. Effect of multiple lyophilization or
freeze-thaw cycles on chromatin quality of stallion sperm.
(Abstract) Anim. Reprod. Sci 94:19-20 (2006).
Riera FL, Roldán JE and Hinrichs K. Patterns of
embryo recovery in mares with unilateral and bilateral double
ovulations. (Abstract). Anim. Reprod. Sci 94:398-399
(2006).
Mortensen C, Choi YH, Hinrichs K, Ing N,
Kraemer D, Vogelsang S and Vogelsang M. Effects of exercise on
embryo recovery rates and embryo quality score in the horse.
(Abstract) Anim. Reprod. Sci 94:395-397 (2006).
Hinrichs K, Choi YH, Hartman DL and Varner DD.
Blastocysts, pregnancies and foals from ICSI and nuclear transfer.
(Abstract) Proceedings, 4th Meeting of the
International Equine Gamete Group, Havemeyer Foundation Monograph
18: 45-46 (2006).
Varner DD, Love CC, Choi YH and Hinrichs K.
Exposure of stallion semen to two freeze-thaw cycles: Effects on
spermatozoal viability. (Abstract) Proceedings,
4th Meeting of the International Equine Gamete Group
Havemeyer Foundation Monograph 18: 15-16 (2006).
Choi YH, Love CC, Varner DD and Hinrichs K.
Equine embryo development after intracytoplasmic fertilization
with twice frozen-thawed sperm. (Abstract) Proceedings,
4th Meeting of the International Equine Gamete Group
Havemeyer Foundation Monograph 18: 19-20 (2006).
Choi YH, Chung YG, Varner DD and Hinrichs K.
Birth of a cloned foal by adult somatic cell nuclear transfer with
roscovitine-treated donor cells. (Abstract) Reprod. Fertil.
Dev. 18:123 (2006).
Hinrichs K, Choi YH, Love LB, and Varner DD.
Transfer of in vitro-produced equine embryos. (Abstract)
Proceedings, 6th International Symposium on
Equine Embryo Transfer, Havemeyer Foundation, p. 38-39 (2005).
Riera FL, Roldán JE and Hinrichs K. Ipsilateral
double ovulation is associated with reduced embryo recovery in
mares. (Abstract) Proceedings, 6th International Equine
Embryo Transfer Symposium, Havemeyer Foundation, p. 108-109
(2005).
Choi YH, Love LB, Varner DD and Hinrichs K.
Blastocyst development of equine oocytes with low meiotic
competence held in roscovitine before in vitro maturation.
(Abstract) Reprod. Fertil. Dev. p. 216-217 (2005).
Pryor J, Romo S, Varner DD, Hinrichs K and
Looney CR. Comparison of two sperm separation products for use in
bovine IVF. (Abstract) Reprod. Fertil. Dev. p. 277
(2005).
Romo S, Pryor J, Varner DD, Hinrichs K and
Looney CR. Comparison of three different IVF protocols for bovine
oocytes. (Abstract) Reprod. Fertil. Dev. p. 276
(2005).
Hinrichs K, Choi YH, Walckenaer BE and Varner
DD. Interactions between time of oocyte recovery (immediate vs
delayed) and duration of in vitro maturation on developmental
competence of horse oocytes. (Abstract) Proceedings,
Havemeyer Foundation Workshop: Transporting Gametes and Embryos p.
5-6 (2004).
Bedford SJ, Hinrichs K and Fissore RA. Oocyte
maturation and effect on sperm or sperm extract induced
intracellular calcium oscillations. (Abstract)
Proceedings, Havemeyer Foundation Workshop: Transporting
Gametes and Embryos p. 9-10 (2004).
Choi YH, Roasa LM, Varner DD, Hinrichs K.
Blastocyst development of in vitro- and in vivo-matured equine
oocytes fertilised by ICSI. (Abstract) Proceedings,
Havemeyer Foundation Workshop: Transporting Gametes and Embryos p.
29-30 (2004).
Choi YH, Varner DD and Hinrichs K. Comparison
of embryo culture media for blastocyst development after
intracytoplasmic sperm injection of in vitro-matured equine
oocytes. (Abstract) Reprod. Fertil. Dev. 16:195
(2004).
Hinrichs K, Choi YH, Love CC, Varner DD,
Brinsko SP and Love LB. Relationships between equine oocyte
characteristics and developmental potential. (Abstract)
Proceedings, Havemeyer Foundation Workshop: From
Epididymis to Embryo p. 48-49 (2003).
Choi YH, Love CC, Love LB, Varner DD and Hinrichs
K. Techniques for achieving fertilization in vitro in the
horse. (Abstract) Proceedings, Havemeyer Foundation
Workshop: From Epididymis to Embryo p. 64-65 (2003).
Choi YH, Love CC, Chung YG, Varner DD, Westhusin ME, Burghardt
RC and Hinrichs K. Use of Piezo-driven direct
nuclear injection and activation with stallion sperm extract to
produce horse nuclear transfer embryos. (Abstract)
Theriogenology 58:771-774 (2002).
Bedford SJ, Kurokawa M, Hinrichs K and Fissore
RA. Patterns of [Ca2+]i oscillations after
intracytoplasmic sperm injection of in vitro and in vivo matured
horse oocytes. (Abstract) Theriogenology 58:701-704
(2002).
Hinrichs K, Choi YH, Love LB, Love CC, Varner
DD and Ingram LA. Effect of holding time and media on meiotic
and developmental competence of horse oocytes. (Abstract)
Theriogenology 58:675-678 (2002).
Franz LC, Choi YH, Squires EL, Seidel GE and Hinrichs
K. Effect of transient suppression of meiosis with
roscovitine on subsequent developmental competence of equine
oocytes. (Abstract) Biol. Reprod. 66; Suppl.1:175-176 (2002).
Riera FL, Roldán JE, Love CC and Hinrichs K.
Effect of stallion on embryo recovery, quality, and stage, and on
pregnancy rate after transfer, in a commercial embryo transfer
program. (Abstract) Proceedings, Havemeyer Foundation Workshop on
Advanced Clinical Topics in Stallion Reproduction.
Bedford SJ, Kurokawa M, Hinrichs K and Fissore
R. Activation and intracellular calcium
([Ca2+]I) transients induced by
microinjection of equine sperm factor on murine and equine oocytes.
(Abstract) Theriogenology 57:699 (2002).
Alm H, Hinrichs K, Torner H and Kanitz W.
Evaluation of germinal vesicle status in horse oocytes using
different staining methods. (Abstract) Proceedings,
5th Annual Conference European Society for Domestic
Animal Reproduction, p.48 (2001).
Choi YH, Love CC, Love LB, Varner DD, Brinsko SP and
Hinrichs K. In vitro and in vivo development of in
vitro-matured horse oocytes fertilized by intracytoplasmic sperm
injection. (Abstract) Proceedings, Soc. Theriogenology,
p.8 (2001).
Dell'Aquila ME, Masterson M, Maritato F and Hinrichs
K. Chromatin configuration, meiotic competence and success
of intra-cytoplasmic sperm injection in horse oocytes collected by
follicular aspiration or scraping. (Abstract) Proceedings,
5th International Symposium on Equine Embryo Transfer,
Havemeyer Foundation, T. Katila and J. Wade, eds. pp. 37-38
(2001).
Hinrichs K, Shin TS, Love CC, Varner DD and
Westhusin M. Comparison of bovine and equine oocytes as host
cytoplasts for equine nuclear transfer. (Abstract)
Proceedings, 5th International Symposium on
Equine Embryo Transfer, Havemeyer Foundation, T. Katila and J.
Wade, eds. pp. 43-44 (2001).
Love CC, Brinsko SP, Varner DD and Hinrichs K.
Fertilisation rates of in vitro-matured oocytes transferred into
the oviduct of inseminated mares. (Abstract) Proceedings,
5th International Symposium on Equine Embryo Transfer,
Havemeyer Foundation, T. Katila and J. Wade, eds. pp. 41-42
(2001).
Riera FL, Roldán JE, and Hinrichs K. Effect of
insemination timing on embryo recovery rate, pregnancy rate after
transfer, and pregnancy loss rate in a commercial embryo transfer
programme. (Abstract) Proceedings, 5th
International Symposium on Equine Embryo Transfer, Havemeyer
Foundation, T. Katila and J. Wade, eds. pp. 89-90 (2001).
Choi YH, Shin T, Love CC, Burghardt RC, Varner DD and
Hinrichs K. Effects of initial cumulus morphology
and addition of cytochalasin B on fusion, activation and cleavage
of horse oocytes undergoing nuclear transfer. (Abstract)
Theriogenology 55:261 (2001).
Hinrichs K, Shin TS, Love CC, Varner DD and
Westhusin M. Production of equine embryos by nuclear transfer:
comparison of efficiency of equine and bovine cytoplasts.
(Abstract) Proceedings, Soc. Theriogenology, p.133
(2000).
Dell'Aquila ME, Albrizio M, Lacalandra GM, Maritato F,
Hinrichs K and Minoia P. Follicular wall apoptosis
and pronuclear formation in equine oocytes submitted to
intracytoplasmic sperm injection (ICSI) [Apoptosi follicolare e
formazione dei pronuclei in ovociti equini sottoposti ad iniezione
intracitoplasmatica dello spermatozoo (ICSI)]. (Abstract)
Proceedings, LIV Congresso Società Italiana Scienze
Veterinarie; vol LIV: pp.127-128 (2000).
Kanitz W, Alm H, Becker F, Nurnberg G, Kurth J and
Hinrichs K. Repeated follicular aspiration in
mares: consequences for follicular growth and oocyte quality.
(Original research report) J. Reprod. Fertil. Suppl.
56:463-472 (2000).
Hinrichs K, Betschart RW, McCue PM and Squires
EL. Effect of time of follicle aspiration on pregnancy rate after
oocyte transfer in the mare. (Original research report) J.
Reprod. Fertil. Suppl. 56:493-498 (2000).
Hinrichs K, Provost PJ and Torello EM. Use of
non-ovulating, hormone-treated mares as oocyte transfer recipients.
(Abstract) Proceedings, Soc. Theriogenology, p. 43
(1999).
Alm H, Torner H, Kanitz W, Becker F and Hinrichs
K. Comparison of different methods for recovery of horse
oocytes. (Original Report). Equine Vet. J. Suppl. 25:47-50
(1997).
Hinrichs K, Matthews GL and Freeman DA. Effect
of oocyte maturation time on embryo development after oocyte
transfer in the mare. (Abstract). Theriogenology 47:392
(1997).
Alm H and Hinrichs K. Effect of cycloheximide
on nuclear maturation of horse oocytes. (Abstract). Archiv fur
Tierzucht., Dummerstorf (Special Issue) 39:77
(1996).
Williams KA and Hinrichs K. Morphology and
meiotic competence of oocytes in relation to follicle atresia in
the mare. (Abstract). Proceedings, 12th Int. Cong. Anim.
Reprod. 3:17-4 (1996).
Overstrom EW, Duby RT, Dobrinsky J, Hinrichs K,
Roche JF, and Boland MP. Sodium transport properties of the bovine
and equine blastocyst. (Abstract) in: Bavister B, ed.,
Preimplantation Embryonic Development, Springer-Verlag,
New York, p. 323 (1993).
Hinrichs K and Schmidt AL. Reversible meiotic
arrest of horse oocytes by coculture with follicular components.
(Abstract) Theriogenology 39:232 (1993).
Hinrichs K, Friedman PP, Martin MG. Evaluation
of in vitro maturation of horse oocytes using fluorescence
microscopy. (Brief communication) Proceedings, 12th Int.
Cong. Anim. Reprod. 1:330-332 (1992).
Hinrichs K, Martin MG and Friedman PP. Effect
of follicular components on maintenance of meiotic arrest in horse
oocytes. (Abstract) Theriogenology 37:223 (1992).
Hinrichs K. The role of endometrial swabs in
the diagnosis (and pathogenesis?) of endometritis. (Editorial)
Cornell Vet. 81:233-237 (1991). Reprinted in the New
Zealand Veterinary Association Equine Branch Newsletter March 1992,
pp. 31-34.
Hinrichs K. A simple technique that may improve
the rate of embryo recovery on uterine flushing in mares.
(Work-in-progress report) Theriogenology 33:937-942
(1990).
Hinrichs K, Cummings MR, Sertich PL and Kenney
RM. Bacteria recovered from the reproductive tracts of normal
mares. (Brief communication) Proceedings, Am. Assoc.
Equine Pract., pp. 11-16 (1989).
Hinrichs K, Klunder LR and Riera FL. Embryo
transfer in mares with gonadal dysgenesis. (Abstract)
Theriogenology 31:204 (1989).
Sertich PL, Hinrichs K, Schiereck DE and Kenney
RM. Periparturient events in ovariectomized embryo transfer
recipient mares. (Brief communication) Proceedings, 11th
Int. Cong. Anim. Reprod. Artificial Insemination, p. 193.
(1988).
Hinrichs K. Establishment of pregnancy after
embryo transfer in ovariectomized mares: Effect of length of
progesterone treatment on pregnancy rate and pattern of uterine
proteins. Ph.D. Dissertation, University of Pennsylvania.
(1988).
Hinrichs K and Kenney RM. A colpotomy procedure
to increase oocyte recovery rates on aspiration of equine
preovulatory follicles. (Abstract) Theriogenology 27:237
(1987).
Hinrichs K, Sertich PL, Cummings MR, and Kenney
RM. Pregnancy in ovariectomized mares achieved by embryo transfer.
(Brief communication) Equine Vet. J. Suppl. 3:74-75
(1985).
Van Huffel XM, Varner DD, Hinrichs K, Garcia
MC, Strzemienski PJ and Kenney RM. A comparison of visual and
photomicrographic techniques for stallion spermatozoal motility
analysis. (Brief communication) Proceedings, Soc.
Theriogenology, pp. 162-166 (1983).
Submitted for publication
Choi YH, Gustafson-Seabury A, Velez IC, Hartman DL, Bliss S,
Riera FL Roldán JE, Chowdhary B and Hinrichs K.
Normal rates of pregnancy and live birth after biopsy of equine
embryos for preimplantation genetic diagnosis.
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