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Dr. Gladys Ko
Curriculum Vitae
Research Interests
Curriculum Vitae
Education
1996 Ph.D., Neuroscience program in Biomedical Sciences (Aug. 1992-Aug. 1996)
Northeastern Ohio Universities College of Medicine affiliated with Kent State University (NEOUCOM / KSU)
Kent, Ohio, U.S.A.
1991 M.S., Anatomical Sciences (Sept. 1989-June 1991)
National Yang-Ming Medical College
Taipei,
Taiwan
, R.O.C.
1989 B.S., Biology (Sept. 1985-June 1989)
National Cheng-Kung University
Tainan,
Taiwan
, R.O.C.
Professional Affiliations
Society for Neuroscience (1990-current)
The Association of Anatomists of R.O.C. (1989-1992)
Publications
Research papers
Ko, G.Y.-P.,
Ko, M.L. and Dryer, S.E. Circadian and cAMP-dependent modulation of retinal cone cGMP-gated channels does not require protein synthesis or calcium influx through L-type channels. Brain Research, 1021:277-280; 2004.
Ko, G.Y.-P.
,Ko, M.L. and Dryer, S.E. Circadian regulation of cGMP-gated channels of verbebrate cone photoreceptors: Role of cAMP and Ras. J. Neuroscience, 24:1296-1304; 2004.
Ko, G.Y.-P.
, Ko, M.L. and Dryer, S.E. Circadian phase-dependent modulation of cyclic GMP-gated channels of cone photoreceptors by dopamine and D2 agonists. J. Neuroscience, 23: 3145-3153; 2003.
Ko, G.Y.-P.
, Ko, M.L. and Dryer, S.E. Circadian regulation of cGMP-gated cationic channels of chick retinal cones: Erk MAP kinase and Ca
2+
/calmodulin-dependent protein kinase II. Neuron, 29: 255-266; 2001.
Ko, G.Y.-P.
, Ko, M.L. and Dryer, S.E. Developmental expression of retinal cone cGMP-gated channels: Evidence for rapid turnover and trophic regulation. J. Neuroscience, 21: 221-229; 2001.
Ko, G.Y.
and Kelly, P.T. Nitric oxide acts as a postsynaptic signaling molecule in calcium/calmodulin-induced synaptic potentiation in hippocampal CA1 pyramidal neurons. J. Neuroscience, 19: 6784-6794; 1999.
Ko, G.Y.-P.
, Brown, L.M., and Teyler, T.J. The effects of anticonvulsant drugs-phenobarbital, phenytoin, and valproic acid on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus. Brain Res. Bull. 42: 297-302; 1997.
Lee, G.Y.-P.
; Brown, L.M. and Teyler, T.J. The effects of anticonvulsant drugs on long-term potentiation (LTP) in the rat hippocampus. Brain Res. Bull. 39: 39-42; 1996.
Brown, L.M.;
Lee, G.Y.-P.
and Teyler, T.J. Anti-epileptics inhibit cortical NMDA evoked [
3
H]-norepinephrine efflux. Eur. J. Pharm. 254: 307-309; 1994.
Lee, G.Y.-P.
; Chen, S.-T. and Shen, C.-L. Autoradiographic study of the retinal projections on the Chinese Pangolin,
Manis pentadactyla
. Brain, Behavior and Evolution 37: 104-110; 1991.
Review papers (including book chapters)
Wang, J.-H.,
Ko, G.Y.P.
, and Kelly, P.T. Cellular and molecular bases of memory: synaptic and neuronal plasticity. J. Clin. Neurophysiol. 14: 264-293; 1997.
Teyler, T.J.; Cavus, I.; Coussens, C.; DiScenna, P.; Grover, L.;
Lee, Y.-P.
and Little, Z. The multideterminant role of calcium in synaptic plasticity. Hippocampus 4: 623-634; 1994.
Teyler, T.J.; Cavus, I.; Coussens, C.; DiScenna, P.; Grover, L.;
Lee, Y.-P.
and Little, Z. Advances in understanding the mechanisms underlying synaptic plasticity. J. Neurosci. Meth. A8; 1994.
Teyler, T.J.; Cavus, I.; Coussens, C.; DiScenna, P.; Grover, L.;
Lee, Y.-P.
and Little, Z. Advances in understanding the mechanisms underlying synaptic plasticity.
Brain Slices in Basic and Clinical Research
, A. Schurr and B. Rigor eds., pp1-25, CRC press, Boca Raton, FL; 1994.
Abstracts and Presentations (* - presented)
Chen, S.,
Ko, G. Y.-P.
, Dryer, S.E. Somatostatin modulates gating properties of chicken cone CNGCs: role of circadian oscillators and light history. Society for Neuroscience 750.3; 2004.
Ko, G.Y.-P.*,
Ko, M.L. and Dryer, S.E. Circadian regulation of dark current channels of chicken cone photoreceptors. Society for Neuroscience 513.4; 2003.
Dryer, S.E.,
Ko, G.Y.-P.
and Ko, M.L. An essential role for Ras in a circadian output pathway in vertebrate cones. The Association for Research in Vision and Ophthalmology 2872; 2003.
Ko, G.Y.-P.*
, Ko, M.L. and Dryer, S.E. Cyclic AMP mediates circadian phase-dependent modulation of cGMP-gated cation channels in the chick retina. Society for Neuroscience 843.19; 2002.
Dryer, S.E.,
Ko, G.Y.-P.
and Ko, M.L. Potential intracellular mechanisms for circadian modulation of phototransduction cGMP-gated cation channels in the vertebrate retina. The Association for Research in Vision and Ophthalmology 1354; 2002.
Ko, G.Y.-P.*
, Ko, M.L. and Dryer, S.E. Dopamine causes circadian phase-dependent modulation of cyclic GMP-gated cationic channels of chick retinal cones. Society for Neuroscience 720.15; 2001.
Ko, G.Y.-P.
*, Ko, M.L. and Dryer, S.E. Circadian modulation of the gating of cyclic GMP-activated cationic channels in chick retina photoreceptors. Society for Neuroscience 26: 1963; 2000.
Ko, G.Y.
* and Kelly, P.T. A role of nitric oxide synthase in Ca
2+
/Calmodulin-induced synaptic potentiation in hippocampal CA1 neurons. Neuroscience Research Center's Fifth Annual Poster Session, University of Texas-Houston Medical School; 1998.
Ko, G.Y.
* and Kelly, P.T. A role of nitric oxide synthase in Ca
2+
/Calmodulin-induced synaptic potentiation in hippocampal CA1 neurons. Society for Neuroscience 24:1074; 1998.
Ko, G.Y.-P.*
and Teyler, T.J. The role of protein kinase C on different forms of long-term potentiation (LTP) in the rat hippocampus. Society for Neuroscience 22:1510; 1996.
Brown-Croyts, L.M.,
Ko, G.Y.-P.*
and Teyler, T.J. The effects of anticonvulsant drugs-phenobarbital, phenytoin and valproic acid on NMDA-EPSP, AMPA-EPSP and GABA-IPSP in the rat hippocampus. Society for Neuroscience 22:2106; 1996.
Lee, G.Y.-P.*
, Teyler, T.J. and Brown, L.M. The effects of valproic acid on PMA-induced regulation of protein kinase C activity and NMDA-EPSP in the rat hippocampus. Society for Neuroscience 21: 2116; 1995.
Brown, L.M.*, Auer, J.A. and
Lee, G.Y.-P.
The interactions of antiepileptic drugs with the N-methyl-D-aspartate receptor in rat cortical tissue. Epilepsia 36 (supplement 4): 39; 1995.
Lee, G.Y.-P.*
; Teyler, T.J. and Brown, L.M. The effects of valproic acid on PKC activity in the rat hippocampus. Society for Neuroscience 20: 1239; 1994.
Lee, G.Y.-P.*
, Teyler, T.J. and Brown, L.M. Anti-convulsant drugs inhibit NMDA stimulated [
3
H]-norepinephrine efflux in rat brain cortex and hippocampus. Society for Neuroscience 19: 1631; 1993.
Lee, Y.-P.*
, Min, M.-Y. and Hwang, H.-M. Timing of noradrenergic depletion and occurrence of dark cells in hippocampus after subcutaneous administration of DSP4 or 6-OHDA at neonate. Society for Neuroscience 18: 458; 1992.
Lee, Y.-P.*
and Hwang, H.-M. Characterization of "dark" cells induced by noradrenergic depletion in the rat hippocampus. Society for Neuroscience 17: 126; 1991.
Lee, Y.-P.*
and Hwang, H.-M. Ultrastructural study on neuronal changes in the rat hippocampus after neonatal administration of 6-OHDA. Proceeding of the Twelfth R.O.C. Symposium on Electron Microscopy, 19-20; 1991.
Lee, Y.-P.*
and Hwang, H.-M. Noradrenergic depletion produces changes in hippocampus by neonatal 6-hydroxydopamine administration. The 6th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, R.O.C., 253; 1991.
Hwang, H.-M.*, Tsai, W.-H.,
Lee, Y.-P.
and Chiu, T.-H. Noradrenergic (NA) enhancement of hippocampal synapses after neonatal administration of 6-hydroxydopamine (6-OHDA) is due to an increase of beta2-adrenergic receptor number. Society for Neuroscience 16: 428; 1990.
Lee, Y.-P.*
, Chen, S.-T. and Shen, C.-L. The autoradiographic study of the retinal projections in the Chinese Pangolin,
Manis pentadactyla
. Symposium, The Association of Anatomists of R.O.C. 2nd Annual Meeting, Taipei; 1990.
Mak, O.T. and
Lee, Y.-P.*
Study of the effect of TPA on prostaglandin metabolism in the mouse spleen. The First International Prostaglandin and Leukotriene Conference in Taipei, Taiwan, R.O.C.; 1988.