Canine Chronic Enteropathy Study

We are currently enrolling dogs with chronic gastrointestinal inflammation into a study, the purpose of which is to develop a variety of non-invasive markers for dogs with gastrointestinal disease.

IBD


Patient eligibility

  • Dogs with chronic enteropathies that undergo a complete diagnostic workup that MUST include gastrointestinal biopsy
  • Dogs can have antibiotic responsive enteropathies, food responsive enteropathies, or idiopathic IBD
  • Dogs of any age, breed, or sex are eligible to be enrolled
  • Dogs under immunomodulatory drug treatments cannot be enrolled

Required samples- Please note that testing is performed free of charge only if all required samples and paperwork (including questionnaires) are received for testing.

  • 1 pre-prandial fasted serum sample (at least 4 mL)
  • 1 post-prandial serum sample (at least 2 mL)
  • 1 pre-prandial EDTA blood sample (3 mL; as well as copies of recent CBCs, if available)
  • 3 fecal samples from consecutive bowel movements
  • 1 urine sample preferably collected by cystocentesis (at least 4 mL)
  • Gastrointestinal biopsies in buffered formalin

Client incentives

For eligible patients the study will pay for the following items on receipt of a full sample set and completed forms. We are unable to offer these tests free of charge for patients with incomplete paperwork (including questionnaires) or sample sets.

  • Serum concentrations of cobalamin, folate, TLI, PLI, gastrin, pre- and post-prandial bile acids, and C-reactive protein
  • Fecal Dysbiosis Index
  • Fecal alpha1-proteinase inhibitor concentrations
  • Histopathology through the GI Lab (performed by pathologists with special expertise in evaluation of gastrointestinal specimens)
  • All shipping costs related to sending samples to our lab

For patients with complete follow-up information we offer the above tests up to 3 times for each patient (initial presentation and up to 2 rechecks).

Turnaround times

  • Same as regular sample submissions to the GI Lab
  • Usually next day for serum cobalamin, folate, TLI, PLI, gastrin, and bile acids concentrations and fecal Dysbiosis Index
  • Up to 7-10 days for serum CRP and fecal alpha1-PI, depending on day of sample submission
  • 5-7 days for histopathology

If you are interested in enrolling one of your patients, please complete this form (enrollment form) and the study team will contact you. Please email tamu.gilab@gmail.com for further details.

Please note: If you are the owner of the dog and not a veterinarian, please have your veterinarian contact the IBD Study team directly.