Canine C-reactive Protein
Reference Interval (dogs only)
Canine 0 - 7.6 mg/L
0.5 ml fasting (12 hours) serum; DOGS ONLY
C-reactive protein is an integrated marker of systemic
inflammation. C-reactive protein is a member of the acute phase
reactant family of proteins in the dog. Synthesis of this group of
proteins is dramatically increased during inflammatory disease.
These proteins are typically involved in regulation of the early
response of the patient to the agent causing the inflammation, and
in the regulation of immune system activity. During inflammatory
disease, hepatic synthesis of C-reactive protein is dramatically
up-regulated (up to a 1000-fold increase).
The ability to determine the severity of the disease is helpful
in planning the clinical approach to the case and in discussions
with owners/clients involving prognosis. In diseases that are
predominantly inflammatory in nature, integrated measurement of the
severity of inflammation may be superior to measurement of organ
specific marker enzymes when trying to answer the second question.
Canine C-reactive protein is a marker of systemic inflammation that
is receiving increasing attention and has been shown to reflect the
severity of canine small intestinal disease.
The greatest clinical utility of this assay is likely to be in
the monitoring of response to treatment for inflammatory bowel
disease in dogs. It is reasonable to expect that the institution of
effective dietary or medical therapy will be associated with a
decrease in serum C-reactive protein in the patient.
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