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Shuping Zhang

Associate Professor

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Phone: (979) 845-9189

Department: VTPB

Photo of Zhang, Shuping

Education

  • Ph.D. Microbiology, Kansas State University, Manhattan, Kansas 1999
  • M.S. Veterinary Histology, Northwestern Agricultrual University, China 1988
  • D.V.M. Veterinary Medicine, Shanxi Agricultural University, China 1985

Credentials

  • Texas Veterinary Medical Specialty License: 0404-S

Scholarly Interests

Infectious diseases exact a heavy toll on human and animal health. According to the Centers for Disease Control and Prevention (CDC) reports, 160,000 Americans die each year with an infectious disease as the underlying cause of death. Salmonella enterica induced enterocolitis is the second most frequent cause of bacterial food-borne illness in the United States, with an estimated 1.4 million cases per year. Although Salmonella enterica can cause life-threatening infections in people, the organisms usually do not induce overt clinical signs in certain host species, such as adult birds, cats, and dogs. The silent colonization status often complicates the effort of diagnosis and prevention, thereby contributing to the transmission of salmonellosis. In addition to Salmonella organisms, many other bacterial and fungal pathogens can cause life-threatening diseases in animals. My research focuses on pathogenesis, diagnosis and treatment of infectious diseases. Listed here are on-going research projects in my laboratory. 1. Salmonella enterica serovar Enteritidis colonization of chickens: The molecular interaction between bacterial virulence genes and host cationic antimicrobial peptides. 2. Surveillance of Salmonella enterica in companion Animals. The surveillance of Salmonella in dogs, cats, and horses are investigated using both classical and molecular microbiology approaches. 3. Prevalence of Salmonella and other microbial pathogens in Bobwhite Quail. 4. Preclinical analysis of a novel antifungal agent named Occidiofungin. Murine systemic and gastrointestinal candidiasis models are utilized to evaluate the efficacy of this drug.

Publications

Vaccination with attenuated Salmonella enterica Dublin expressing E coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E coli O157:H7 in cattle.
Khare S, Alali W, Zhang S, Hunter D, Pugh R, Fang FC, Libby SJ, Adams LG
BMC Vet Res. 6:35.
MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.
Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J, Safe S
Endocrinology. 151(6):2462-73.
Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay.
Zhang S, Rowlands C, Safe S
Toxicol Appl Pharmacol. 227(2):196-206.
Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds.
Li X, Zhang S, Safe S
J Steroid Biochem Mol Biol. 98(2-3):122-32.
Salmonella-induced cell death is not required for enteritis in calves.
Santos RL, Tsolis RM, Zhang S, Ficht TA, Bäumler AJ, Adams LG
Infect Immun. 69(7):4610-7.
Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells.
Zhang S, Li X, Burghardt R, Smith R 3rd, Safe SH
J Mol Endocrinol. 35(3):433-47.
Rapid and sensitive detection of Mycobacterium avium subsp. paratuberculosis in bovine milk and feces by a combination of immunomagnetic bead separation-conventional PCR and real-time PCR.
Khare S, Ficht TA, Santos RL, Romano J, Ficht AR, Zhang S, Grant IR, Libal M, Hunter D, Adams LG
J Clin Microbiol. 42(3):1075-81.
Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
Zhang S, Qin C, Safe SH
Environ Health Perspect. 111(16):1877-82.
Secreted effector proteins of Salmonella enterica serotype typhimurium elicit host-specific chemokine profiles in animal models of typhoid fever and enterocolitis.
Zhang S, Adams LG, Nunes J, Khare S, Tsolis RM, Bäumler AJ
Infect Immun. 71(8):4795-803.
Molecular pathogenesis of Salmonella enterica serotype typhimurium-induced diarrhea.
Zhang S, Kingsley RA, Santos RL, Andrews-Polymenis H, Raffatellu M, Figueiredo J, Nunes J, Tsolis RM, Adams LG, Bäumler AJ
Infect Immun. 71(1):1-12.
Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves.
Zhang S, Santos RL, Tsolis RM, Mirold S, Hardt WD, Adams LG, Bäumler AJ
FEMS Microbiol Lett. 217(2):243-7.
The Salmonella enterica serotype typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves.
Zhang S, Santos RL, Tsolis RM, Stender S, Hardt WD, Bäumler AJ, Adams LG
Infect Immun. 70(7):3843-55.
Morphologic and molecular characterization of Salmonella typhimurium infection in neonatal calves.
Santos RL, Zhang S, Tsolis RM, Bäumler AJ, Adams LG
Vet Pathol. 39(2):200-15.
Animal models of Salmonella infections: enteritis versus typhoid fever.
Santos RL, Zhang S, Tsolis RM, Kingsley RA, Adams LG, Bäumler AJ
Microbes Infect. 3(14-15):1335-44.


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