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Beiyan Zhou

Assistant Professor

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Phone: (979) 845-7175

Mailstop: 4466

Department: VTPP

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Scholarly Interests

Limited self-renewal and differentiation of hematopoietic stem cells (HSCs) and their progenies rely on a well-orchestrated regulatory network, mainly comprising transcription factors, cytokines and their receptors mediated signaling pathways, and a group of newly discovered microRNAs (miRNAs). Even though there are experimental evidences suggesting the important roles played by miRNAs in this network, the detailed picture is largely unknown.

Our research goal is to reveal the mechanism of leukemogenesis by identifying oncogenes, tumor suppressors and their downstream molecular events that are directly or indirectly targeted by abnormally expressed miRNAs.

Publications

Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet.
Shah MS, Schwartz SL, Zhao C, Davidson LA, Zhou B, Lupton JR, Ivanov I, Chapkin RS.
Physiol Genomics. 2011 May; 43(10):640-54.
PMID: 21406606 [PubMed - in process]
MicroRNA miR-125b causes leukemia.
Bousquet M, Harris MH, Zhou B, Lodish HF.
Proc Natl Acad Sci U S A. 2010 Dec; 107(50):21558-63.
PMID: 21118985 [PubMed - indexed for MEDLINE]
Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells.
Ouyang N, Ke S, Eagleton N, Xie Y, Chen G, Laffins B, Yao H, Zhou B, Tian Y.
Br J Cancer. 2010 Jun; 102(12):1753-61.
PMID: 20531417 [PubMed - indexed for MEDLINE]
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets.
Le MT, Xie H, Zhou B, Chia PH, Rizk P, Um M, Udolph G, Yang H, Lim B, Lodish HF.
Mol Cell Biol. 2009 Oct; 29(19):5290-305.
PMID: 19635812 [PubMed - indexed for MEDLINE]
MicroRNA-125b is a novel negative regulator of p53.
Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, Lodish HF, Lim B.
Genes Dev. 2009 Apr; 23(7):862-76.
PMID: 19293287 [PubMed - indexed for MEDLINE]
Micromanagement of the immune system by microRNAs.
Lodish HF, Zhou B, Liu G, Chen CZ.
Nat Rev Immunol. 2008 Feb; 8(2):120-30.
PMID: 18204468 [PubMed - indexed for MEDLINE]
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity.
Liao MJ, Zhang CC, Zhou B, Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA.
Cancer Res. 2007 Sep; 67(17):8131-8.
PMID: 17804725 [PubMed - indexed for MEDLINE]
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.
Zhou B, Wang S, Mayr C, Bartel DP, Lodish HF.
Proc Natl Acad Sci U S A. 2007 Apr; 104(17):7080-5.
PMID: 17438277 [PubMed - indexed for MEDLINE]
Analysis of placental regulation of hematopoiesis.
Zhou B, Linzer DI.
Methods Mol Med. 2006 ; 122:355-65.
PMID: 16511993 [PubMed - indexed for MEDLINE]
Enhanced recovery from thrombocytopenia and neutropenia in mice constitutively expressing a placental hematopoietic cytokine.
Zhou B, Kong X, Linzer DI.
Endocrinology. 2005 Jan; 146(1):64-70.
PMID: 15375031 [PubMed - indexed for MEDLINE]
Two placental hormones are agonists in stimulating megakaryocyte growth and differentiation.
Zhou B, Lum HE, Lin J, Linzer DI.
Endocrinology. 2002 Nov; 143(11):4281-6.
PMID: 12399423 [PubMed - indexed for MEDLINE]