Education
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Diplomate , American College of Veterinary Microbiologists 2009
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Ph.D. Comparative Biomedical Science, North Carolina State University 2003
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D.V.M. Veterinary Medicine, Texas A&M University 1997
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B.S. Veterinary Science, Texas A&M University 1993
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B.S. Biomedical Science, Texas A&M University 1991
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Credentials
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Diplomate , American College of Veterinary Microbiologists 2009
Scholarly Interests
My work seeks to understand, on a molecular level, the interactions between the intestinal pathogen, Salmonella enterica, and mammalian hosts. I am particularly interested in how Salmonella spp. regulate their genes in response to environmental signals present in the gastrointestinal tract, the pathogenic mechanisms by which Salmonella spp. induce enteritis and diarrhea in mammalian hosts, and how the host responds to Salmonella infection. I am also interested in how Salmonella spp. survive in the external environment and are transmitted within populations of cattle and other mammals. As an outgrowth of my clinical interests, my research program has also begun to focus on understanding the carriage of Staphylococcus in veterinary species and the role of methicillin resistance on survival and virulence of commensal and pathogenic Staphylococcus.
Publications
Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis.
Adams LG, Khare S, Lawhon SD, Rossetti CA, Lewin HA, Lipton MS, Turse JE, Wylie DC, Bai Y, Drake KL.
BMC Proc. 2011 Jun; 5 Suppl 4:S6.
PMID: 21645321 [PubMed]
Morphologic and cytokine profile characterization of Salmonella enterica serovar typhimurium infection in calves with bovine leukocyte adhesion deficiency.
Nunes JS, Lawhon SD, Rossetti CA, Khare S, Figueiredo JF, Gull T, Burghardt RC, Bäumler AJ, Tsolis RM, Andrews-Polymenis HL, Adams LG.
Vet Pathol. 2010 Mar; 47(2):322-33.
PMID: 20118318 [PubMed - indexed for MEDLINE]
Contribution of flagellin pattern recognition to intestinal inflammation during Salmonella enterica serotype typhimurium infection.
Winter SE, Thiennimitr P, Nuccio SP, Haneda T, Winter MG, Wilson RP, Russell JM, Henry T, Tran QT, Lawhon SD, Gomez G, Bevins CL, Rüssmann H, Monack DM, Adams LG, Bäumler AJ.
Infect Immun. 2009 May; 77(5):1904-16.
PMID: 19237529 [PubMed - indexed for MEDLINE]
SdiA, an N-acylhomoserine lactone receptor, becomes active during the transit of Salmonella enterica through the gastrointestinal tract of turtles.
Smith JN, Dyszel JL, Soares JA, Ellermeier CD, Altier C, Lawhon SD, Adams LG, Konjufca V, Curtiss R 3rd, Slauch JM, Ahmer BM.
PLoS One. 2008 Jul; 3(7):e2826.
PMID: 18665275 [PubMed - indexed for MEDLINE]
The capsule encoding the viaB locus reduces interleukin-17 expression and mucosal innate responses in the bovine intestinal mucosa during infection with Salmonella enterica serotype Typhi.
Raffatellu M, Santos RL, Chessa D, Wilson RP, Winter SE, Rossetti CA, Lawhon SD, Chu H, Lau T, Bevins CL, Adams LG, Bäumler AJ.
Infect Immun. 2007 Sep; 75(9):4342-50.
PMID: 17591794 [PubMed - indexed for MEDLINE]
Host restriction of Salmonella enterica serotype Typhi is not caused by functional alteration of SipA, SopB, or SopD.
Raffatellu M, Sun YH, Wilson RP, Tran QT, Chessa D, Andrews-Polymenis HL, Lawhon SD, Figueiredo JF, Tsolis RM, Adams LG, Bäumler AJ.
Infect Immun. 2005 Dec; 73(12):7817-26.
PMID: 16299271 [PubMed - indexed for MEDLINE]
SipA, SopA, SopB, SopD, and SopE2 contribute to Salmonella enterica serotype typhimurium invasion of epithelial cells.
Raffatellu M, Wilson RP, Chessa D, Andrews-Polymenis H, Tran QT, Lawhon S, Khare S, Adams LG, Bäumler AJ.
Infect Immun. 2005 Jan; 73(1):146-54.
PMID: 15618149 [PubMed - indexed for MEDLINE]