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Sanjay Reddy

Professor

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Phone: (979) 458-0658

Mailstop: 4467

Department: VTPB

Photo of Reddy, Sanjay

Education

  • Ph.D. Molecular Virology, University of Maryland 1994
  • M.S. Virology, University of Maryland 1989
  • B.V.Sc. Veterinary Medicine, Andhra Pradesh Agricultural University, India 1986

Credentials

  • American College of Veterinary Microbiologists

Scholarly Interests

The long-term goal of my laboratory is to understand the molecular basis of pathogenesis of Marek’s disease virus (MDV), a potent oncogenic herpesvirus that causes T-cell tumors in chickens. MDV codes for a protein (Meq), which shares significant resemblance with the Jun/Fos family of transcriptional factors. We have shown that this gene plays a critical role in latency and transformation of T-lymphocytes. Understanding the basic mechanism of viral pathogenesis will aid in the development of improved vaccine. We are also interested in other important poultry disease like avian influenza.

Publications

Marek's disease vaccines: current challenges and future strategies
Reddy, S.M. and Lupiani, B.
Veterinary Microbiology. 2016
Neoplastic diseases of poultry: avian leucosis, reticuloendotheliosis and Marek’s disease
Reddy, S.M. and Lupiani, B
XIX World Veterinary Poultry Association Congress Proceeding. 2015
Cloning of a very virulent plus, 686 strain of Marek's disease virus as a bacterial artificial chromosome.
Reddy SM, Sun A, Khan OA, Lee LF, Lupiani B
Avian Dis. 2013 2 Suppl(57):469-73.
Deletion of Marek's disease virus large subunit of ribonucleotide reductase impairs virus growth in vitro and in vivo.
Sun A, Lee LF, Khan OA, Heidari M, Zhang H, Lupiani B, Reddy SM
Avian Dis. 2013 2 Suppl(57):464-8.
Identification and in vitro characterization of a Marek's disease virus-encoded Ribonucleotide reductase.
Lee LF, Heidari M, Sun A, Zhang H, Lupiani B, Reddy S
Avian Dis. 2013 57(2):178-87.
Avian influenza virus surveillance in hunter-harvested waterfowl, Texas coast, September 2009-January 2010.
Ferro PJ, Khan O, Peterson MJ, Batchuluun D, Reddy SM, Lupiani B
Avian Dis. 2012 4 Suppl(56):1006-9.
Avian influenza virus investigation in wild bobwhite quail from Texas.
Ferro PJ, Khan O, Vuong C, Reddy SM, LaCoste L, Rollins D, Lupiani B
Avian Dis. 2012 4 Suppl(56):858-60.
Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers.
Wang Y, Brahmakshatriya V, Lupiani B, Reddy S, Okimoto R, Li X, Chiang H, Zhou H
Poult Sci. 2012 91(12):3019-24.
Integrated analysis of microRNA expression and mRNA transcriptome in lungs of avian influenza virus infected broilers.
Wang Y, Brahmakshatriya V, Lupiani B, Reddy SM, Soibam B, Benham AL, Gunaratne P, Liu HC, Trakooljul N, Ing N, Okimoto R, Zhou H
BMC Genomics. 2012 13(13):278.
Selection of a recombinant Marek's disease virus in vivo through expression of the Marek's EcoRI-Q (Meq)-encoded oncoprotein: characterization of an rMd5-based mutant expressing the Meq of strain RB-1B.
Kumar P, Dong H, Lenihan D, Gaddamanugu S, Katneni U, Shaikh S, Tavlarides-Hontz P, Reddy SM, Peters W, Parcells MS
Avian Dis. 2012 56(2):328-40.
Standardization of a model to study revaccination against Marek's disease under laboratory conditions.
Gimeno IM, Witter RL, Cortes AL, Reddy SM, Pandiri AR
Avian Pathol. 2012 41(1):59-68.
Development of DIVA (differentiation of infected from vaccinated animals) vaccines utilizing heterologous NA and NS1 protein strategies for the control of triple reassortant H3N2 influenza in turkeys.
Wang L, Qin Z, Pantin-Jackwood M, Faulkner O, Suarez DL, Garcia M, Lupiani B, Reddy SM, Saif YM, Lee CW
Vaccine. 2011 29(45):7966-74.
Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens.
Suchodolski PF, Izumiya Y, Lupiani B, Ajithdoss DK, Lee LF, Kung HJ, Reddy SM
Virology. 2010 399(2):312-21.
Simultaneous detection of avian influenza virus NP and H5 antibodies in chicken sera using a fluorescence microsphere immunoassay.
Lupiani B, Mozisek B, Mason PW, Lamichhane C, Reddy SM
Avian Dis. 2010 1 Suppl(54):668-72.
Comparative evaluation of vaccine efficacy of recombinant Marek's disease virus vaccine lacking Meq oncogene in commercial chickens.
Lee LF, Kreager KS, Arango J, Paraguassu A, Beckman B, Zhang H, Fadly A, Lupiani B, Reddy SM
Vaccine. 2010 28(5):1294-9.
Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach.
Wang Y, Brahmakshatriya V, Zhu H, Lupiani B, Reddy SM, Yoon BJ, Gunaratne PH, Kim JH, Chen R, Wang J, Zhou H
BMC Genomics. 2009 10(10):512.
The history of avian influenza.
Lupiani B, Reddy SM
Comp Immunol Microbiol Infect Dis. 2009 32(4):311-23.
Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. II: expression of the latent MDV genome.
Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS
Avian Dis. 2009 53(2):156-65.
Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. I: uptake and structure of the latent MDV genome.
Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS
Avian Dis. 2009 53(2):149-55.
In vitro characterization of the Meq proteins of Marek's disease virus vaccine strain CVI988.
Ajithdoss DK, Reddy SM, Suchodolski PF, Lee LF, Kung HJ, Lupiani B
Virus Res. 2009 142(1-2):57-67.
Preliminary study for evaluation of avian influenza virus inactivation in contaminated poultry products using electron beam irradiation.
Brahmakshatriya V, Lupiani B, Brinlee JL, Cepeda M, Pillai SD, Reddy SM
Avian Pathol. 2009 38(3):245-50.
A multiplexed immunoassay for detection of antibodies against avian influenza virus.
Watson DS, Reddy SM, Brahmakshatriya V, Lupiani B
J Immunol Methods. 2009 340(2):123-31.
Homodimerization of Marek's disease virus-encoded Meq protein is not sufficient for transformation of lymphocytes in chickens.
Suchodolski PF, Izumiya Y, Lupiani B, Ajithdoss DK, Gilad O, Lee LF, Kung HJ, Reddy SM
J Virol. 2009 83(2):859-69.
Characterization of LORF11, a unique gene common to the three Marek's disease virus serotypes.
Lee LF, Silva RF, Cui X, Zhang H, Heidari M, Reddy SM
Avian Dis. 2007 51(4):851-7.
The role of pp38 in regulation of Marek's disease virus bi-directional promoter between pp38 and 1.8-kb mRNA.
Ding J, Cui Z, Lee LF, Cui X, Reddy SM
Virus Genes. 2006 32(2):193-201.
Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication.
Lupiani B, Lee LF, Cui X, Gimeno I, Anderson A, Morgan RW, Silva RF, Witter RL, Kung HJ, Reddy SM
Proc Natl Acad Sci U S A. 2004 101(32):11815-20.
Biocharacteristics shared by highly protective vaccines against Marek's disease.
Gimeno IM, Witter RL, Hunt HD, Reddy SM, Reed WM
Avian Pathol. 2004 33(1):59-68.
Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells.
Levy AM, Izumiya Y, Brunovskis P, Xia L, Parcells MS, Reddy SM, Lee L, Chen HW, Kung HJ
J Virol. 2003 77(23):12841-51.
Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek's disease virus.
Lee LE, Witter RL, Reddy SM, Wu P, Yanagida N, Yoshida S
Avian Dis. 2003 47(3):549-58.
Rescue of a pathogenic Marek's disease virus with overlapping cosmid DNAs: use of a pp38 mutant to validate the technology for the study of gene function.
Reddy SM, Lupiani B, Gimeno IM, Silva RF, Lee LF, Witter RL
Proc Natl Acad Sci U S A. 2002 99(10):7054-9.
Glycoproteins E and I of Marek's disease virus serotype 1 are essential for virus growth in cultured cells.
Schumacher D, Tischer BK, Reddy SM, Osterrieder N
J Virol. 2001 75(23):11307-18.
Protein-coding content of the sequence of Marek's disease virus serotype 1.
Lupiani B, Lee LF, Reddy SM
Curr Top Microbiol Immunol. 2001 255(255):159-90.
Identification and structural analysis of a MDV gene encoding a protein kinase.
Reddy SM, Sui D, Wu P, Lee L
Acta Virol. 1999 43(2-3):174-80.
Sequence variability of the glycoprotein gene of bovine respiratory syncytial virus.
Mallipeddi SK, Samal SK
J Gen Virol. 1993 Pt 9(74):2001-4.
Analysis of polypeptides synthesized in bovine respiratory syncytial virus-infected cells.
Mallipeddi SK, Samal SK, Mohanty SB
Arch Virol. 1990 115(1-2):23-36.


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