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Sanjay Reddy

Professor

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Phone: (979) 458-0658

Mailstop: 4467

Department: VTPB

Photo of Reddy, Sanjay

Education

  • Ph.D. Molecular Virology, University of Maryland 1994
  • M.S. Virology, University of Maryland 1989
  • B.V.Sc. Veterinary Medicine, Andhra Pradesh Agricultural University, India 1986

Credentials

  • American College of Veterinary Microbiologists

Scholarly Interests

The long-term goal of my laboratory is to understand the molecular basis of pathogenesis of Marek’s disease virus (MDV), a potent oncogenic herpesvirus that causes T-cell tumors in chickens. MDV codes for a protein (Meq), which shares significant resemblance with the Jun/Fos family of transcriptional factors. We have shown that this gene plays a critical role in latency and transformation of T-lymphocytes. Understanding the basic mechanism of viral pathogenesis will aid in the development of improved vaccine. We are also interested in other important poultry disease like avian influenza.

Publications

Protein-coding content of the sequence of Marek's disease virus serotype 1.
Lupiani B, Lee LF, Reddy SM
Curr Top Microbiol Immunol. 255:159-90.
Expansion of a unique region in the Marek's disease virus genome occurs concomitantly with attenuation but is not sufficient to cause attenuation.
Silva RF, Reddy SM, Lupiani B
J Virol. 78(2):733-40.
Biocharacteristics shared by highly protective vaccines against Marek's disease.
Gimeno IM, Witter RL, Hunt HD, Reddy SM, Reed WM
Avian Pathol. 33(1):59-68.
Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells.
Levy AM, Izumiya Y, Brunovskis P, Xia L, Parcells MS, Reddy SM, Lee L, Chen HW, Kung HJ
J Virol. 77(23):12841-51.
Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek's disease virus.
Lee LE, Witter RL, Reddy SM, Wu P, Yanagida N, Yoshida S
Avian Dis. 47(3):549-58.
Rescue of a pathogenic Marek's disease virus with overlapping cosmid DNAs: use of a pp38 mutant to validate the technology for the study of gene function.
Reddy SM, Lupiani B, Gimeno IM, Silva RF, Lee LF, Witter RL
Proc Natl Acad Sci U S A. 99(10):7054-9.
Glycoproteins E and I of Marek's disease virus serotype 1 are essential for virus growth in cultured cells.
Schumacher D, Tischer BK, Reddy SM, Osterrieder N
J Virol. 75(23):11307-18.
Marek's disease virus infection in the brain: virus replication, cellular infiltration, and major histocompatibility complex antigen expression.
Gimeno IM, Witter RL, Hunt HD, Lee LF, Reddy SM, Neumann U
Vet Pathol. 38(5):491-503.
Differential attenuation of the induction by Marek's disease virus of transient paralysis and persistent neurological disease: a model for pathogenesis studies.
Gimeno IM, Witter RL, Hunt HD, Reddy SM, Neumann U
Avian Pathol. 30(4):397-409.
Coinfection of specific-pathogen-free chickens with Marek's disease virus (MDV) and chicken infectious anemia virus: effect of MDV pathotype.
Miles AM, Reddy SM, Morgan RW
Avian Dis. 45(1):9-18.
Development of a quantitative-competitive polymerase chain reaction assay for serotype 1 Marek's disease virus.
Reddy SM, Witter RL, Gimeno I
Avian Dis. 44(4):770-5.
Identification and structural analysis of a MDV gene encoding a protein kinase.
Reddy SM, Sui D, Wu P, Lee L
Acta Virol. 43(2-3):174-80.
RNA-seq analysis revealed novel genes and signaling pathway associated with disease resistance to avian influenza virus infection in chickens.
Wang Y, Lupiani B, Reddy SM, Lamont SJ, Zhou H
Poult Sci. 93(2):485-93.
Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers.
Wang Y, Brahmakshatriya V, Lupiani B, Reddy S, Okimoto R, Li X, Chiang H, Zhou H
Poult Sci. 91(12):3019-24.
Integrated analysis of microRNA expression and mRNA transcriptome in lungs of avian influenza virus infected broilers.
Wang Y, Brahmakshatriya V, Lupiani B, Reddy SM, Soibam B, Benham AL, Gunaratne P, Liu HC, Trakooljul N, Ing N, Okimoto R, Zhou H
BMC Genomics. 13:278.
Development of DIVA (differentiation of infected from vaccinated animals) vaccines utilizing heterologous NA and NS1 protein strategies for the control of triple reassortant H3N2 influenza in turkeys.
Wang L, Qin Z, Pantin-Jackwood M, Faulkner O, Suarez DL, Garcia M, Lupiani B, Reddy SM, Saif YM, Lee CW
Vaccine. 29(45):7966-74.
Characterization and evaluation of avian influenza NS1 mutant virus as a potential live and killed DIVA (differentiating between infected and vaccinated animals) vaccine for chickens.
Brahmakshatriya VR, Lupiani B, Reddy SM
Vaccine. 28(12):2388-96.
Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach.
Wang Y, Brahmakshatriya V, Zhu H, Lupiani B, Reddy SM, Yoon BJ, Gunaratne PH, Kim JH, Chen R, Wang J, Zhou H
BMC Genomics. 10:512.
The history of avian influenza.
Lupiani B, Reddy SM
Comp Immunol Microbiol Infect Dis. 32(4):311-23.
Cloning of a very virulent plus, 686 strain of Marek's disease virus as a bacterial artificial chromosome.
Reddy SM, Sun A, Khan OA, Lee LF, Lupiani B
Avian Dis. 57(2 Suppl):469-73.
Deletion of Marek's disease virus large subunit of ribonucleotide reductase impairs virus growth in vitro and in vivo.
Sun A, Lee LF, Khan OA, Heidari M, Zhang H, Lupiani B, Reddy SM
Avian Dis. 57(2 Suppl):464-8.
Insertion of reticuloendotheliosis virus long terminal repeat into the genome of CVI988 strain of Marek's disease virus results in enhanced growth and protection.
Lupiani B, Lee LF, Kreager KS, Witter RL, Reddy SM
Avian Dis. 57(2 Suppl):427-31.
Avian influenza virus surveillance in hunter-harvested waterfowl, Texas coast, September 2009-January 2010.
Ferro PJ, Khan O, Peterson MJ, Batchuluun D, Reddy SM, Lupiani B
Avian Dis. 56(4 Suppl):1006-9.
Avian influenza virus investigation in wild bobwhite quail from Texas.
Ferro PJ, Khan O, Vuong C, Reddy SM, LaCoste L, Rollins D, Lupiani B
Avian Dis. 56(4 Suppl):858-60.
Simultaneous detection of avian influenza virus NP and H5 antibodies in chicken sera using a fluorescence microsphere immunoassay.
Lupiani B, Mozisek B, Mason PW, Lamichhane C, Reddy SM
Avian Dis. 54(1 Suppl):668-72.
Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens.
Suchodolski PF, Izumiya Y, Lupiani B, Ajithdoss DK, Lee LF, Kung HJ, Reddy SM
Virology. 399(2):312-21.
Preliminary study for evaluation of avian influenza virus inactivation in contaminated poultry products using electron beam irradiation.
Brahmakshatriya V, Lupiani B, Brinlee JL, Cepeda M, Pillai SD, Reddy SM
Avian Pathol. 38(3):245-50.
A multiplexed immunoassay for detection of antibodies against avian influenza virus.
Watson DS, Reddy SM, Brahmakshatriya V, Lupiani B
J Immunol Methods. 340(2):123-31.
Homodimerization of Marek's disease virus-encoded Meq protein is not sufficient for transformation of lymphocytes in chickens.
Suchodolski PF, Izumiya Y, Lupiani B, Ajithdoss DK, Gilad O, Lee LF, Kung HJ, Reddy SM
J Virol. 83(2):859-69.
Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication.
Lupiani B, Lee LF, Cui X, Gimeno I, Anderson A, Morgan RW, Silva RF, Witter RL, Kung HJ, Reddy SM
Proc Natl Acad Sci U S A. 101(32):11815-20.
Mapping the domains on the phosphoprotein of bovine respiratory syncytial virus required for N-P interaction using a two-hybrid system.
Mallipeddi SK, Lupiani B, Samal SK
J Gen Virol. 77 ( Pt 5):1019-23.
Analysis of the ovine respiratory syncytial virus (RSV) G glycoprotein gene defines a subgroup of ungulate RSV.
Mallipeddi SK, Samal SK
J Gen Virol. 74 ( Pt 12):2787-91.
Sequence variability of the glycoprotein gene of bovine respiratory syncytial virus.
Mallipeddi SK, Samal SK
J Gen Virol. 74 ( Pt 9):2001-4.
Structural difference in the fusion protein among strains of bovine respiratory syncytial virus.
Mallipeddi SK, Samal SK
Vet Microbiol. 36(3-4):359-67.
Sequence comparison between the phosphoprotein mRNAs of human and bovine respiratory syncytial viruses identifies a divergent domain in the predicted protein.
Mallipeddi SK, Samal SK
J Gen Virol. 73 ( Pt 9):2441-4.
Analysis of polypeptides synthesized in bovine respiratory syncytial virus-infected cells.
Mallipeddi SK, Samal SK, Mohanty SB
Arch Virol. 115(1-2):23-36.
Identification and in vitro characterization of a Marek's disease virus-encoded Ribonucleotide reductase.
Lee LF, Heidari M, Sun A, Zhang H, Lupiani B, Reddy S
Avian Dis. 57(2):178-87.
Properties of a meq-deleted rmd5 Marek's disease vaccine: protection against virulent MDV challenge and induction of lymphoid organ atrophy are simultaneously attenuated by serial passage in vitro.
Lee LF, Kreager K, Heidari M, Zhang H, Lupiani B, Reddy SM, Fadly A
Avian Dis. 57(2 Suppl):491-7.
Selection of a recombinant Marek's disease virus in vivo through expression of the Marek's EcoRI-Q (Meq)-encoded oncoprotein: characterization of an rMd5-based mutant expressing the Meq of strain RB-1B.
Kumar P, Dong H, Lenihan D, Gaddamanugu S, Katneni U, Shaikh S, Tavlarides-Hontz P, Reddy SM, Peters W, Parcells MS
Avian Dis. 56(2):328-40.
Standardization of a model to study revaccination against Marek's disease under laboratory conditions.
Gimeno IM, Witter RL, Cortes AL, Reddy SM, Pandiri AR
Avian Pathol. 41(1):59-68.
Cell culture attenuation eliminates rMd5ΔMeq-induced bursal and thymic atrophy and renders the mutant virus as an effective and safe vaccine against Marek's disease.
Lee LF, Heidari M, Zhang H, Lupiani B, Reddy SM, Fadly A
Vaccine. 30(34):5151-8.
Evaluation of factors affecting vaccine efficacy of recombinant Marek's disease virus lacking the Meq oncogene in chickens.
Lee LF, Zhang H, Heidari M, Lupiani B, Reddy SM
Avian Dis. 55(2):172-9.
Comparative evaluation of vaccine efficacy of recombinant Marek's disease virus vaccine lacking Meq oncogene in commercial chickens.
Lee LF, Kreager KS, Arango J, Paraguassu A, Beckman B, Zhang H, Fadly A, Lupiani B, Reddy SM
Vaccine. 28(5):1294-9.
Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. II: expression of the latent MDV genome.
Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS
Avian Dis. 53(2):156-65.
Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. I: uptake and structure of the latent MDV genome.
Arumugaswami V, Kumar PM, Konjufca V, Dienglewicz RL, Reddy SM, Parcells MS
Avian Dis. 53(2):149-55.
In vitro characterization of the Meq proteins of Marek's disease virus vaccine strain CVI988.
Ajithdoss DK, Reddy SM, Suchodolski PF, Lee LF, Kung HJ, Lupiani B
Virus Res. 142(1-2):57-67.
Recombinant Marek's disease virus (MDV) lacking the Meq oncogene confers protection against challenge with a very virulent plus strain of MDV.
Lee LF, Lupiani B, Silva RF, Kung HJ, Reddy SM
Vaccine. 26(15):1887-92.
Characterization of LORF11, a unique gene common to the three Marek's disease virus serotypes.
Lee LF, Silva RF, Cui X, Zhang H, Heidari M, Reddy SM
Avian Dis. 51(4):851-7.
The role of pp38 in regulation of Marek's disease virus bi-directional promoter between pp38 and 1.8-kb mRNA.
Ding J, Cui Z, Lee LF, Cui X, Reddy SM
Virus Genes. 32(2):193-201.
A Marek's disease virus vIL-8 deletion mutant has attenuated virulence and confers protection against challenge with a very virulent plus strain.
Cui X, Lee LF, Hunt HD, Reed WM, Lupiani B, Reddy SM
Avian Dis. 49(2):199-206.
Characterization of a very virulent Marek's disease virus mutant expressing the pp38 protein from the serotype 1 vaccine strain CVI988/Rispens.
Lee LF, Cui X, Cui Z, Gimeno I, Lupiani B, Reddy SM
Virus Genes. 31(1):73-80.
The pp38 gene of Marek's disease virus (MDV) is necessary for cytolytic infection of B cells and maintenance of the transformed state but not for cytolytic infection of the feather follicle epithelium and horizontal spread of MDV.
Gimeno IM, Witter RL, Hunt HD, Reddy SM, Lee LF, Silva RF
J Virol. 79(7):4545-9.
Marek's disease virus-encoded vIL-8 gene is involved in early cytolytic infection but dispensable for establishment of latency.
Cui X, Lee LF, Reed WM, Kung HJ, Reddy SM
J Virol. 78(9):4753-60.
Neoplastic diseases of poultry: avian leucosis, reticuloendotheliosis and Marek’s disease
Reddy, S.M. and Lupiani, B
XIX World Veterinary Poultry Association Congress Proceeding.
Marek's disease vaccines: current challenges and future strategies
Reddy, S.M. and Lupiani, B.
Veterinary Microbiology.


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