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Patricia Holman

Research Associate Professor

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Phone: (979) 845-4202

Mailstop: 4467

Department: VTPB

Photo of Holman, Patricia

Education

  • PhD Veterinary Microbiology, Texas A&M University 1994
  • MS Microbiology, University of Nebraska 1976
  • BA Biology, Winthrop College 1974

Scholarly Interests

Molecular mechanisms driving interactions between Babesia spp. and their hosts; characterization of potential vaccine or drug targets for babesiosis; molecular phylogeny of the hemoparasites; genetic basis of bovine resistance/susceptibility to ectoparasitism; development of molecular diagnostic tests for piroplasms.

Publications

Molecular detection of Babesia bovis and Babesia bigemina in white-tailed deer (Odocoileus virginianus) from Tom Green County in central Texas.
Holman PJ, Carroll JE, Pugh R, Davis DS
Vet Parasitol. 2011 May; 177(3-4):298-304.
Molecular and serologic evidence for Babesia bovis-like parasites in white-tailed deer (Odocoileus virginianus) in south Texas.
Ramos CM, Cooper SM, Holman PJ
Vet Parasitol. 2010 Sep; 172(3-4):214-20.
Canine hepatozoonosis and babesiosis, and feline cytauxzoonosis.
Holman PJ, Snowden KF
Vet Clin North Am Small Anim Pract. 2009 Nov; 39(6):1035-53, v.
Detection of a large unnamed Babesia piroplasm originally identified in dogs in North Carolina in a dog with no history of travel to that state.
Holman PJ, Backlund BB, Wilcox AL, Stone R, Stricklin AL, Bardin KE
J Am Vet Med Assoc. 2009 Oct; 235(7):851-4.
Anthelmintic resistant Haemonchus contortus in a giraffe (Giraffa camelopardalis) in Florida.
Garretson PD, Hammond EE, Craig TM, Holman PJ
J Zoo Wildl Med. 2009 Mar; 40(1):131-9.
In vitro cultivation of a newly recognized Babesia sp. in dogs in North Carolina.
Lehtinen LE, Birkenheuer AJ, Droleskey RE, Holman PJ
Vet Parasitol. 2008 Feb; 151(2-4):150-7.
Phylogenetic and biologic evidence that Babesia divergens is not endemic in the United States.
Holman PJ
Ann N Y Acad Sci. 2006 Oct; 1081:518-25.
In vitro host erythrocyte specificity and differential morphology of Babesia divergens and a zoonotic Babesia sp. from eastern cottontail rabbits (Sylvilagus floridanus).
Spencer AM, Goethert HK, Telford SR 3rd, Holman PJ
J Parasitol. 2006 Apr; 92(2):333-40.
New ruminant hosts and wider geographic range identified for Babesia odocoilei (Emerson and Wright 1970).
Schoelkopf L, Hutchinson CE, Bendele KG, Goff WL, Willette M, Rasmussen JM, Holman PJ
J Wildl Dis. 2005 Oct; 41(4):683-90.
In vitro cultivation of a zoonotic Babesia sp. isolated from eastern cottontail rabbits (Sylvilagus floridanus) on Nantucket Island, Massachusetts.
Holman PJ, Spencer AM, Droleskey RE, Goethert HK, Telford SR 3rd
J Clin Microbiol. 2005 Aug; 43(8):3995-4001.
A comparison of homologous genes encoding aminopeptidases among bird and human Encephalitozoon hellem isolates and a rabbit E. cuniculi isolate.
Waters PF, Snowden KF, Holman PJ
Parasitol Res. 2004 Aug; 93(5):410-8.
Ribosomal RNA analysis of Babesia odocoilei isolates from farmed reindeer (Rangifer tarandus tarandus) and elk (Cervus elaphus canadensis) in Wisconsin.
Holman PJ, Bendele KG, Schoelkopf L, Jones-Witthuhn RL, Jones SO
Parasitol Res. 2003 Nov; 91(5):378-83.
Babesiosis and heartwater: threats without boundaries.
Wagner GG, Holman P, Waghela S
Vet Clin North Am Food Anim Pract. 2002 Nov; 18(3):417-30, vi-vii.
Genotypically unique Babesia spp. isolated from reindeer (Rangifer tarandus tarandus) in the United States.
Holman PJ, Swift PK, Frey RE, Bennett J, Cruz D, Wagner GG
Parasitol Res. 2002 May; 88(5):405-11.
In vitro generation of organophosphate resistant boophilus microplus (Acari: Ixodidae) cell lines.
Cossio-Bayugar R, Wagner GG, Holman PJ
J Med Entomol. 2002 Mar; 39(2):278-84.
Theileria buffeli infection of a Michigan cow confirmed by small subunit ribosomal RNA gene analysis.
Cossio-Bayugar R, Pillars R, Schlater J, Holman PJ
Vet Parasitol. 2002 Apr; 105(2):105-10.
A cathepsin L-like cysteine protease is conserved among Babesia equi isolates.
Holman PJ, Hsieh MM, Nix JL, Bendele KG, Wagner GG, Ball JM
Mol Biochem Parasitol. 2002 Feb; 119(2):295-300.
Antigenic, phenotypic and molecular characterization confirms Babesia odocoilei isolated from three cervids.
Holman PJ, Madeley J, Craig TM, Allsopp BA, Allsopp MT, Petrini KR, Waghela SD, Wagner GG
J Wildl Dis. 2000 Jul; 36(3):518-30.
A common high molecular weight antigen of Babesia bovis isolates from Mexico.
Sahagun Ruiz A, Waghela SD, Romany MM, Holman PJ, Melendy D, Cruz D, Wagner GG
Int J Parasitol. 2000 Jan; 30(1):59-64.
Restriction-fragment-length polymorphism analysis of small-subunit rRNA genes of Blastocystis isolates from animal hosts.
Snowden K, Logan K, Blozinski C, Hoevers J, Holman P
Parasitol Res. 2000 Jan; 86(1):62-6.
Restriction-fragment-length polymorphism analysis of small-subunit rRNA genes of Blastocystis hominis isolates from geographically diverse human hosts.
Hoevers J, Holman P, Logan K, Hommel M, Ashford R, Snowden K
Parasitol Res. 2000 Jan; 86(1):57-61.
Two Theileria cervi SSU RRNA gene sequence types found in isolates from white-tailed deer and elk in North America.
Chae JS, Waghela SD, Craig TM, Kocan AA, Wagner GG, Holman PJ
J Wildl Dis. 1999 Jul; 35(3):458-65.
Theileria sp. Infections associated with bovine fatalities in the United States confirmed by small-subunit rRNA gene analyses of blood and tick samples.
Chae J, Levy M, Hunt J Jr, Schlater J, Snider G, Waghela SD, Holman PJ, Wagner GG
J Clin Microbiol. 1999 Sep; 37(9):3037-40.
Babesia equi field isolates cultured from horse blood using a microcentrifuge method.
Holman PJ, Becu T, Bakos E, Polledo G, Cruz D, Wagner GG
J Parasitol. 1998 Aug; 84(4):696-9.
Nucleotide sequence heterogeneity in the small subunit ribosomal RNA gene variable (V4) region among and within geographic isolates of Theileria from cattle, elk and white-tailed deer.
Chae J, Lee J, Kwon O, Holman PJ, Waghela SD, Wagner GG
Vet Parasitol. 1998 Feb; 75(1):41-52.
Identical small subunit ribosomal RNA gene nucleotide sequence of bovine Theileria isolates (Korea and Japan) and Theileria buffeli (Marula, Kenya).
Chae JS, Kwon OD, Holman PJ, Waghela SD, Wagner GG, Lee JM
Korean J Parasitol. 1998 Mar; 36(1):47-53.
Biotin-labeled DNA probe in a PCR-based assay increases detection sensitivity for the equine hemoparasite Babesia caballi.
Sahagun-Ruiz A, Waghela SD, Holman PJ, Chieves LP, Wagner GG
Vet Parasitol. 1997 Dec; 73(1-2):53-63.
Culture isolation and partial characterization of a Babesia sp. from a North American elk (Cervus elaphus).
Holman PJ, Craig TM, Crider DL, Petrini KR, Rhyan J, Wagner GG
J Wildl Dis. 1994 Jul; 30(3):460-5.
Babesia equi erythrocytic stage continuously cultured in an enriched medium.
Holman PJ, Chieves L, Frerichs WM, Olson D, Wagner GG
J Parasitol. 1994 Apr; 80(2):232-6.
In vitro isolation and cultivation of a Babesia from an American woodland caribou (Rangifer tarandus caribou).
Holman PJ, Petrini K, Rhyan J, Wagner GG
J Wildl Dis. 1994 Apr; 30(2):195-200.
In vitro growth of Babesia bovis in white-tailed deer (Odocoileus virginianus) erythrocytes.
Holman PJ, Waldrup KA, Droleskey RE, Corrier DE, Wagner GG
J Parasitol. 1993 Apr; 79(2):233-7.
Culture confirmation of the carrier status of Babesia caballi-infected horses.
Holman PJ, Frerichs WM, Chieves L, Wagner GG
J Clin Microbiol. 1993 Mar; 31(3):698-701.
In vitro cultivation of a Babesia isolated from a white-tailed deer (Odocoileus virginianus).
Holman PJ, Waldrup KA, Wagner GG
J Parasitol. 1988 Feb; 74(1):111-5.
Basal cellular alterations of esterase, glutathione, glutathione-S-transferase, intracellular calcium, and membrane potentials in coumaphos-resistant Boophilus microplus (Acari: Ixodidae) cell lines
Cossío-Bayúgar, R., R. Barhoumi, R.C. Burghardt, G.G. Wagner, P.J. Holman
Pesticide Biochemistry and Physiology. 72:1-9 .
A study of the systematics of Theileria spp. based upon SSU rRNA gene sequences
Chae, J.S., B.A. Allsopp, S.D. Waghela, J.H. Park, T. Kukuda, C. Sugimoto, M. Allsopp, G.G.Wagner, P.J. Holman
Parasitology Research . 85:877-883.
Expression of bovine genes associated with local and systemic immune response to infestation with the Lone Star tick, Amblyomma americanum
58. Brannan, JL, P K Riggs, P M Olafson, I Ivanov, PJ Holman
Ticks and Tick-borne Diseases . 5(6):676-688 .
Expression of bovine genes associated with local and systemic immune response to infestation with the Lone Star tick, Amblyomma americanum
Brannan, JL, Penny K. Riggs, Pia M. Olafson, Ivan Ivanov, Patricia J. Holman
Ticks and Tick-Borne Diseases.
Babesia odocoilei in elk (Cervus elaphus canadensis) in Indiana. Journal of the
Gallatin, L., A.R. Irizarry Rovira, M.Renninger, P.J. Holman, G.G. Wagner, J. Sojka, J.A. Christian
American Veterinary Medical Association . 223:1027-1032 .
Identification and sequence analysis of SSU rRNA gene of bovine Theileria isolates from Korea and Japan.
Chae, J.S. O.D. Kwon, S.D. Waghela, P.J. Holman, G.G.Wagner, J.M. Lee
Korean Journal of Parasitology . 38:909-917.
Babesia odocoilei infection in a North American elk (Cervus elaphus canadensis)
Ameri, M, WI Anderson, PJ Holman, GW Palmer.
Comparative Clinical Pathology. 21: 3, 363-365.
A new species of coccidia (Apicomplexa: Sarcocystidae) from the slender-tailed meerkat Suricata suricatta (Scheber, 1776) from South Africa
El-Gayar, A.K., P.J. Holman, T.M. Craig, T.W. deMaar, S.C. Wilson, P. Chung, K.M. Woods, C. Norris, S.J. Upton.
Acta Protozoologica 47: 69-76 . 47: 69-76.
Sequence polymorphism in the ribosomal DNA internal transcribed spacers differs among Theileria species.
Aktas, M., K.G. Bendele, K. Altay, N. Dumanli, M. Tsuji, P.J. Holman
Veterinary Parasitology. 147:221-230.
Molecular cloning of a phospholipid-hydroperoxide glutathione peroxidase gene from the tick, Boophilus microplus (Acari: Ixodidae)
Cossío-Bayúgar, R., E. Miranda, P.J. Holman
Insect Biochemistry and Molecular Biology . 35 (12):1378-1387 .
Acute babesiosis caused by Babesia divergens in a resident of Kentucky.
Beattie, J.F, M.L. Michelson, P.J. Holman
The New England Journal of Medicine . 347:697-698 .
Detection of Theileria ovis in infected sheep by nested PCR
Altay, K., N. Dumanli, P.J. Holman, M. Aktas
Veterinary Parasitology. 127: 99-104.
Molecular characterization of Trypanosoma (Megatrypanum) spp. infecting cattle (Bos taurus), white-tailed deer (Odocoileus virginianus), and elk (Cervus elaphus canadensis) in the United States
Fisher, AC, G Schuster, WJ Cobb, AJ James, SM Cooper, AA Peréz de León, PJ Holman
Veterinary Parasitology. 197: 29-42.
Sika deer carrying Babesia parasites closely related to B. divergens, Japan
Zamoto-Niikura A, Tsuji M, Imaoka K, Kimura M, Morikawa S, Holman PJ, Hirata H, Ishihara C
Emerg Infect Dis. 20(8):1398-1400 .
Naturally-acquired babesiosis in a reindeer (Rangifer tarandus tarandus) herd in Great Britain.
Langton, C., J. Gray, P.F. Waters, P.J. Holman.
Parasitology Research. 89:194-198 .


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