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I am interested in the development of vaccines and adjuvants for the improvement of animal and human health. Many vaccine development studies conducted in in-bred mice have generated promising data. However, these outcomes have not been reproducible in humans and in livestock as well as in companion animals, the actual hosts that require protection. My current research is focused on the development of contemporary strategies for improving vaccine efficacy in outbred species. Studies are primarily directed at optimizing in vivo antigen presentation by dendritic cells following immunization. Dendritic cells are the most potent antigen presenting cells that are capable of stimulating naÃ¯ve T cells to become antigen-specific effectors. In addition, I am evaluating defined dendritic cell activation factors for their potency in enhancing vaccine immunogenicity for adjuvant development. The major on-going funded efforts are directed at generating vaccines for effective protection of neonates against Bovine Viral Diarrhea Virus and for protection of swine against African swine fever virus. Development of safe and affordable immunizations strategies will enhance animal well-being and thereby improve human life.
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