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Replication and gene expression of coronaviruses, particularly mouse hepatitis virus (MHV) and the SARS coronavirus; the structure and function of the MHV and SARS coronavirus untranslated regions (UTRs); the interaction of MHV and SARS coronavirus UTRs with host cell proteins; virus-host interactions; molecular pathogenesis of MHV induced hepatitis, demyelination (a model of multiple sclerosis), and pneumonia (a model for SARS); platforms for the development of anti-virals for SARS coronavirus; intracellular signaling and patterns of gene expression during coronavirus infection.
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