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Gladys Ko

Associate Professor

Curriculum Vitae

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Phone: (979) 845-1797

Mailstop: 4458

Department: VIBS

Photo of Ko, Gladys

Web Presence

Education

  • Ph.D. Neuroscience in Biomedical Sciences, Kent State U. affiliated w/ N.E. Ohio U Col. Med. 1996
  • M.S. Anatomical Sciences, National Yang-Ming Medical College, Taiwan, 1991
  • B.S. Biology, National Chang-Kung University, Taiwan, 1989

Research

  • Cell Biology
  • Toxicology
  • Neuroscience

Interdisciplinary Activities

  • Neuroscience
  • Toxicology

Scholarly Interests

Integrating major research fields in neuroscience, pharmacology, neurotoxicology, chronobiology, cell and molecular biology, and signal transduction; research projects focusing on circadian regulation of ion channels and their functions in retina photoreceptors and cardiomyocytes, circadian regulation of metabolism and synaptic plasticity, and the roles of microRNAs in circadian rhythms; techniques used in the lab including electrophysiological recordings, biochemical and pharmacological assays, and various techniques in molecular biology and morphology.

Publications

Calcineurin serves in the circadian output pathway to regulate the daily rhythm of L-type voltage-gated calcium channels in the retina.
Huang CC, Ko ML, Vernikovskaya DI, Ko GY.
J Cell Biochem. 2012 Mar; 113(3):911-22.
PMID: 22371971 [PubMed - indexed for MEDLINE]
Identification of Peptide lv, a novel putative neuropeptide that regulates the expression of L-type voltage-gated calcium channels in photoreceptors.
Shi L, Ko ML, Abbott LC, Ko GY.
PLoS One. 2012 ; 7(8):e43091.
PMID: 22912796 [PubMed - in process]
Cardiac-specific mutation of Clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythms.
Ko ML, Shi L, Tsai JY, Young ME, Neuendorff N, Earnest DJ, Ko GY.
J Biol Rhythms. 2011 Oct; 26(5):412-22.
PMID: 21921295 [PubMed - indexed for MEDLINE]
Cardiac-Specific Mutation of Clock Alters the Quantitative Measurements of Physical Activities without Changing Behavioral Circadian Rhythms.
Ko ML, Shi L, Tsai JY, Young ME, Neuendorff N, Earnest DJ, Ko GY.
J Biol Rhythms. 2011 Oct; 26(5):412-22.
PMID: 21921295 [PubMed - in process]
Neuron adhesion and strengthening.
Rocha A, Jian K, Ko GK, Liang H.
J Applied Physics. 2010 ; 108:024702-1-5.
Circadian profiles in the embryonic chick heart: L-type voltage-gated calcium channels and signaling pathways.
Ko ML, Shi L, Grushin K, Nigussie F, Ko GY.
Chronobiol Int. 2010 Oct; 27(9-10):1673-96.
PMID: 20969517 [PubMed - indexed for MEDLINE]
Rhythmic expression of microRNA-26a regulates the L-type voltage-gated calcium channel alpha1C subunit in chicken cone photoreceptors.
Shi L, Ko ML, Ko GY.
J Biol Chem. 2009 Sep; 284(38):25791-803.
PMID: 19608742 [PubMed - indexed for MEDLINE]
Inhibitory effect of somatostatin-14 on L-type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calcium.
Jian K, Barhoumi R, Ko ML, Ko GY.
J Neurophysiol. 2009 Sep; 102(3):1801-10.
PMID: 19605612 [PubMed - indexed for MEDLINE]
Circadian regulation of ion channels and their functions.
Ko GY, Shi L, Ko ML.
J Neurochem. 2009 Aug; 110(4):1150-69.
PMID: 19549279 [PubMed - indexed for MEDLINE]
Circadian controls outweigh acute illumination effects on the activity of extracellular signal-regulated kinase (ERK) in the retina.
Ko ML, Shi L, Ko GY.
Neurosci Lett. 2009 Feb; 451(1):74-8.
PMID: 19111596 [PubMed - indexed for MEDLINE]
Retinoschisin, a new binding partner for L-type voltage-gated calcium channels in the retina.
Shi L, Jian K, Ko ML, Trump D, Ko GY.
J Biol Chem. 2009 Feb; 284(6):3966-75.
PMID: 19074145 [PubMed - indexed for MEDLINE]
Phosphatidylinositol 3 kinase-Akt signaling serves as a circadian output in the retina.
Ko ML, Jian K, Shi L, Ko GY.
J Neurochem. 2009 Mar; 108(6):1607-20.
PMID: 19166512 [PubMed - indexed for MEDLINE]
Circadian regulation of retinoschisin in the chick retina.
Ko ML, Liu Y, Shi L, Trump D, Ko GY.
Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1615-21.
PMID: 18385082 [PubMed - indexed for MEDLINE]
The expression of L-type voltage-gated calcium channels in retinal photoreceptors is under circadian control.
Ko ML, Liu Y, Dryer SE, Ko GY.
J Neurochem. 2007 Oct; 103(2):784-92.
PMID: 17683482 [PubMed - indexed for MEDLINE]
Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination.
Chen SK, Ko GY, Dryer SE.
J Neurosci. 2007 Nov; 27(45):12168-75.
PMID: 17989283 [PubMed - indexed for MEDLINE]
Tyrosine phosphorylation of cGMP-gated ion channels is under circadian control in chick retina photoreceptors.
Chae KS, Ko GY, Dryer SE.
Invest Ophthalmol Vis Sci. 2007 Feb; 48(2):901-6.
PMID: 17251493 [PubMed - indexed for MEDLINE]
Circadian and cAMP-dependent modulation of retinal cone cGMP-gated channels does not require protein synthesis or calcium influx through L-type channels.
Ko GY, Ko M, Dryer SE.
Brain Res. 2004 Sep; 1021(2):277-80.
PMID: 15342277 [PubMed - indexed for MEDLINE]
Circadian regulation of cGMP-gated channels of vertebrate cone photoreceptors: role of cAMP and Ras.
Ko GY, Ko ML, Dryer SE.
J Neurosci. 2004 Feb; 24(6):1296-304.
PMID: 14960600 [PubMed - indexed for MEDLINE]
Circadian phase-dependent modulation of cGMP-gated channels of cone photoreceptors by dopamine and D2 agonist.
Ko GY, Ko ML, Dryer SE.
J Neurosci. 2003 Apr; 23(8):3145-53.
PMID: 12716922 [PubMed - indexed for MEDLINE]