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Jonathan M Levine

Associate Professor & Helen McWhorter Chair in Small Animal Clinical Sciences

Curriculum Vitae

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Phone: (979) 845-2351

Mailstop: 4474

Department: VSCS

Photo of Levine, Jonathan

Education

  • Resident Neurology/Neurosurgery, Texas A&M University 2005
  • Internship Small Animal Surgery, Colorado State University 2002
  • D.V.M. Veterinary Medicine, Cornell University 2001
  • B.S. , Cornell University 1995

Credentials

  • DVM, Diplomate ACVIM (Neurology)

Clinical Areas of Interest

  • Neurology

Scholarly Interests

Spinal cord injury, in particular MR imaging and neuroprotectionNeuro-oncology

Publications

A COLQ Missense Mutation in Labrador Retrievers Having Congenital Myasthenic Syndrome.
Rinz CJ, Levine J, Minor KM, Humphries HD, Lara R, Starr-Moss AN, Guo LT, Williams DC, Shelton GD, Clark LA.
PLoS One. 2014 ; 9(8):e106425.
PMID: 25166616 [PubMed - in process]
Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma.
Xu S, Wei J, Wang F, Kong LY, Ling XY, Nduom E, Gabrusiewicz K, Doucette T, Yang Y, Yaghi NK, Fajt V, Levine JM, Qiao W, Li XG, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB.
J Natl Cancer Inst. 2014 Aug; 106(8).
PMID: 24974128 [PubMed - indexed for MEDLINE]
Relationships between cerebrospinal fluid characteristics, injury severity, and functional outcome in dogs with and without intervertebral disk herniation.
Levine GJ, Cook JR, Kerwin SC, Mankin J, Griffin JF, Fosgate GT, Levine JM.
Vet Clin Pathol. 2014 Sep; 43(3):437-46.
PMID: 24976308 [PubMed - in process]
A comparison of clinical, magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes.
Bentley RT, Burcham GN, Heng HG, Levine JM, Longshore R, Carrera-Justiz S, Cameron S, Kopf K, Miller MA.
Vet Comp Oncol. 2014 Jun; .
PMID: 24945683 [PubMed - as supplied by publisher]
Lymphocytic ganglioneuritis secondary to intervertebral disc extrusion in a dog.
5. Mouradian-Darby AE, Young BD, Griffin JF, Mansell J, Levine JM.
J Small Anim Pract. 2014 Sept; .
PMID: 24779364 []
Intermittent pain and scratching in a Cavalier King Charles Spaniel.
Stout-Steele M, Levine JM.
Clinicians Brief. 2014 ; .
Cerebrospinal fluid inflammatory cytokines and chemokines in naturally occurring canine spinal cord injury.
Taylor AR, Welsh CJ, Young C, Spoor E, Kerwin SC, Griffin JF, Levine GJ, Cohen ND, Levine JM.
J Neurotrauma. 2014 Sep; 31(18):1561-9.
PMID: 24786364 [PubMed - in process]
Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs.
Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ.
PLoS One. 2014 ; 9(5):e96408.
PMID: 24788791 [PubMed - in process]
Evaluation of standard magnetic resonance characteristics used to differentiate neoplastic, inflammatory, and vascular brain lesions in dogs.
Young BD, Fosgate GT, Holmes SP, Wolff CA, Chen-Allen AV, Kent M, Platt SR, Savage MY, Schatzberg SJ, Levine JM.
Vet Radiol Ultrasound. 2014 Jul; 55(4):399-406.
PMID: 24467341 [PubMed - in process]
Necrotizing meningoencephalitis in atypical dog breeds: a case series and literature review.
Cooper JJ, Schatzberg SJ, Vernau KM, Summers BA, Porter BF, Siso S, Young BD, Levine JM.
J Vet Intern Med. 2014 Jan; 28(1):198-203.
PMID: 24428322 [PubMed - indexed for MEDLINE]
Comparison between noncontrast computed tomography and magnetic resonance imaging for detection and characterization of thoracolumbar myelopathy caused by intervertebral disk herniation in dogs.
Cooper JJ, Young BD, Griffin JF 4th, Fosgate GT, Levine JM.
Vet Radiol Ultrasound. 2014 Mar; 55(2):182-9.
PMID: 24118546 [PubMed - in process]
Intervertebral disk degeneration in dogs: consequences, diagnosis, treatment, and future directions.
Jeffery ND, Levine JM, Olby NJ, Stein VM.
J Vet Intern Med. 2013 Nov; 27(6):1318-33.
PMID: 24010573 [PubMed - in process]
ZIP4 is a novel molecular marker for glioma.
Lin Y, Chen Y, Wang Y, Yang J, Zhu VF, Liu Y, Cui X, Chen L, Yan W, Jiang T, Hergenroeder GW, Fletcher SA, Levine JM, Kim DH, Tandon N, Zhu JJ, Li M.
Neuro Oncol. 2013 Aug; 15(8):1008-16.
PMID: 23595627 [PubMed - indexed for MEDLINE]
Application and machine accuracy of a new frameless computed tomography-guided stereotactic brain biopsy system in dogs.
Taylor AR, Cohen ND, Fletcher S, Griffin JF, Levine JM.
Vet Radiol Ultrasound. 2013 Jul; 54(4):332-42.
PMID: 23551960 [PubMed - indexed for MEDLINE]
Thoracic and lumbar spinal cord diffusion tensor imaging in dogs.
Griffin JF 4th, Cohen ND, Young BD, Eichelberger BM, Padua A Jr, Purdy D, Levine JM.
J Magn Reson Imaging. 2013 Mar; 37(3):632-41.
PMID: 23348907 [PubMed - indexed for MEDLINE]
Prospectively recorded versus medical record-derived spinal cord injury scores in dogs with intervertebral disk herniation.
Van Wie EY, Fosgate GT, Mankin JM, Jeffery ND, Kerwin SC, Levine GJ, Greatting HH, Chen AV, Barker AK, Levine JM.
J Vet Intern Med. 2013 Sep; 27(5):1273-7.
PMID: 23888873 [PubMed - in process]
MRI characteristics of cerebral microbleeds in four dogs.
Fulkerson CV, Young BD, Jackson ND, Porter B, Levine JM.
Vet Radiol Ultrasound. 2012 Jul; 53(4):389-93.
PMID: 22235951 [PubMed - indexed for MEDLINE]
Broadly reactive polymerase chain reaction for pathogen detection in canine granulomatous meningoencephalomyelitis and necrotizing meningoencephalitis.
Barber RM, Porter BF, Li Q, May M, Claiborne MK, Allison AB, Howerth EW, Butler A, Wei S, Levine JM, Levine GJ, Brown DR, Schatzberg SJ.
J Vet Intern Med. 2012 Jul; 26(4):962-8.
PMID: 22686439 [PubMed - indexed for MEDLINE]
Magnetic resonance imaging for the differentiation of neoplastic, inflammatory, and cerebrovascular brain disease in dogs.
Wolff CA, Holmes SP, Young BD, Chen AV, Kent M, Platt SR, Savage MY, Schatzberg SJ, Fosgate GT, Levine JM.
J Vet Intern Med. 2012 May; 26(3):589-97.
PMID: 22404482 [PubMed - indexed for MEDLINE]
Early reherniation of disk material in eleven dogs with surgically treated thoracolumbar intervertebral disk extrusion.
Hettlich BF, Kerwin SC, Levine JM.
Vet Surg. 2012 Feb; 41(2):215-20.
PMID: 22103469 [PubMed - indexed for MEDLINE]
Magnetic resonance imaging for the differentiation of neoplastic, inflammatory, and cerebrovascular brain disease in dogs.
Wolff CA, Holmes SP, Young BD, Chen AV, Kent M, Platt SR, Savage MY, Schatzberg SJ, Fosgate GT, Levine JM.
J Vet Intern Med. 2012 May; 26(3):589-97.
PMID: 22404482 [PubMed - in process]
Associations between cerebrospinal fluid biomarkers and long-term neurologic outcome in dogs with acute intervertebral disk herniation.
Witsberger TH, Levine JM, Fosgate GT, Slater MR, Kerwin SC, Russell KE, Levine GJ.
J Am Vet Med Assoc. 2012 Mar; 240(5):555-62.
PMID: 22332624 [PubMed - indexed for MEDLINE]
Incidence of postoperative seizures with and without levetiracetam pretreatment in dogs undergoing portosystemic shunt attenuation.
Fryer KJ, Levine JM, Peycke LE, Thompson JA, Cohen ND.
J Vet Intern Med. 2011 Nov; 25(6):1379-84.
PMID: 22092631 [PubMed - indexed for MEDLINE]
Imaging diagnosis-synovial myxoma of lumbar vertebrae articular process joint.
Blair WH, Levine JM, Kerwin SC, Spaulding KA, Young BD, Pool RR.
Vet Radiol Ultrasound. 2011 May; 52(3):309-12.
PMID: 21554479 [PubMed - indexed for MEDLINE]
Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research.
Levine JM, Levine GJ, Porter BF, Topp K, Noble-Haeusslein LJ.
J Neurotrauma. 2011 Apr; 28(4):675-88.
PMID: 21438715 [PubMed - indexed for MEDLINE]
Observer agreement study of cervical-vertebral ratios in horses.
Scrivani PV, Levine JM, Holmes NL, Furr M, Divers TJ, Cohen ND.
Equine Vet J. 2011 Jul; 43(4):399-403.
PMID: 21496073 [PubMed - indexed for MEDLINE]
Observer agreement study of cervical vertebral ratios in horses
Scrivani PV, Levine JM, Holmes NL, Furr M, Divers TJ, Cohen ND.
Equine Vet. 2011 May; 43:399-403.
Diffuse idiopathic skeletal hyperostosis (DISH).
Greatting HH, Young BD, Pool RR, Levine JM.
Vet Radiol Ultrasound. 2011 Jul; 52(4):472-3.
PMID: 21771167 []
Magnetic resonance imaging features of intracranial astrocytomas and oligodendrogliomas in dogs.
Young BD, Levine JM, Porter BF, Chen-Allen AV, Rossmeisl JH, Platt SR, Kent M, Fosgate GT, Schatzberg SJ.
Vet Radiol Ultrasound. 2011 Mar; 52(2):132-41.
PMID: 21388463 []
Canine astrocytic tumors: a comparative review.
Stoica G, Levine J, Wolff J, Murphy K.
Vet Pathol. 2011 Jan; 48(1):266-75.
PMID: 21059873 [PubMed - indexed for MEDLINE]
Multicenter case-control study of signalment, diagnostic features, and outcome associated with cervical vertebral malformation-malarticulation in horses.
Levine JM, Scrivani PV, Divers TJ, Furr M, Mayhew IJ, Reed S, Levine GJ, Foreman JH, Boudreau C, Credille BC, Tennent-Brown B, Cohen ND.
J Am Vet Med Assoc. 2010 Oct; 237(7):812-22.
PMID: 20919847 [PubMed - indexed for MEDLINE]
Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation.
Levine GJ, Levine JM, Witsberger TH, Kerwin SC, Russell KE, Suchodolski J, Steiner J, Fosgate GT.
J Vet Intern Med. 2010 Jul; 24(4):890-6.
PMID: 20492479 [PubMed - indexed for MEDLINE]
Imaging diagnosis--magnetic resonance imaging pseudolesion associated with the petrous temporal bone.
Cooper JJ, Levine JM, Young BD, Hicks DG, Hoffman A, Bratton G.
Vet Radiol Ultrasound. 2010 Jan; 51(1):39-41.
PMID: 20166391 [PubMed - indexed for MEDLINE]
Arrhythmias and elevated troponin I in a dog with steroid-responsive meningitis-arteritis.
Snyder K, Saunders AB, Levine JM, Clubb FJ.
J Am Anim Hosp Assoc. 2010 Jan; 46(1):61-5.
PMID: 20045839 [PubMed - indexed for MEDLINE]
Mycophenolate mofetil treatment in dogs with serologically diagnosed acquired myasthenia gravis: 27 cases (1999-2008).
Dewey CW, Cerda-Gonzalez S, Fletcher DJ, Harb-Hauser MF, Levine JM, Badgley BL, Olby NJ, Shelton GD.
J Am Vet Med Assoc.. 2010 Mar; 15;236(6):664-8.
PMID: 20225980 []
Accuracy of conventional radiography and computed tomography in predicting implant position in relation to the vertebral canal in dogs.
Hettlich BF, Fosgate GT, Levine JM, Young BD, Kerwin SC, Walker M, Griffin J, Maierl J.
Vet Surg. 2010 Aug; 39(6):680-7.
PMID: 20459486 [PubMed - indexed for MEDLINE]
Evaluation of brain tissue or cerebrospinal fluid with broadly reactive polymerase chain reaction for Ehrlichia, Anaplasma, spotted fever group Rickettsia, Bartonella, and Borrelia species in canine neurological diseases (109 cases).
Barber RM, Li Q, Diniz PP, Porter BF, Breitschwerdt EB, Claiborne MK, Birkenheuer AJ, Levine JM, Levine GJ, Chandler K, Kenny P, Nghiem P, Wei S, Greene CE, Kent M, Platt SR, Greer K, Schatzberg SJ.
J Vet Intern Med. 2010 Mar; 24(2):372-8.
PMID: 20102497 [PubMed - indexed for MEDLINE]
Intracranial magnetic resonance imaging artifacts and pseudolesions in dogs and cats.
Cooper JJ, Young BD, Hoffman A, Bratton G, Hicks DG, Tidwell A, Levine JM.
Vet Radiol Ultrasound. 2010 Nov; 51(6):587-95.
PMID: 21158228 [PubMed - indexed for MEDLINE]
Medical record-derived functional assessments of spinal cord injury.
Levine JM, Fosgate GT.
J Small Anim Pract. 2009 Oct; 50(10):507-8.
PMID: 19796308 [PubMed - indexed for MEDLINE]
Cervical vertebral malformation-malarticulation syndrome in the Bernese mountain dog: clinical and magnetic resonance imaging features.
Eagleson JS, Diaz J, Platt SR, Kent M, Levine JM, Sharp NJ, Schatzberg SJ.
J Small Anim Pract. 2009 Apr; 50(4):186-93.
PMID: 19320813 [PubMed - indexed for MEDLINE]
Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy.
Dewey CW, Cerda-Gonzalez S, Levine JM, Badgley BL, Ducoté JM, Silver GM, Cooper JJ, Packer RA, Lavely JA.
J Am Vet Med Assoc.. 2009 Dec; 15;235(12):1442-9.
PMID: 20001779 []
Broadly reactive pan-paramyxovirus reverse transcription polymerase chain reaction and sequence analysis for the detection of Canine distemper virus in a case of canine meningoencephalitis of unknown etiology.
Schatzberg SJ, Li Q, Porter BF, Barber RM, Claiborne MK, Levine JM, Levine GJ, Israel SK, Young BD, Kiupel M, Greene C, Ruone S, Anderson L, Tong S.
J Vet Diagn Invest.. 2009 Nov; 21(6):844-9.
PMID: 19901287 []
Cervical vertebral malformation-malarticulation syndrome in the Bernese mountain dog: clinical and magnetic resonance imaging features.
Eagleson JS, Diaz J, Platt SR, Kent M, Levine JM, Sharp NJ, Schatzberg SJ.
J Small Anim Pract.. 2009 Apr; 50(4):186-93.
PMID: 19320813 []
Magnetic resonance imaging in dogs with neurologic impairment due to acute thoracic and lumbar intervertebral disk herniation.
Levine JM, Fosgate GT, Chen AV, Rushing R, Nghiem PP, Platt SR, Bagley RS, Kent M, Hicks DG, Young BD, Schatzberg SJ.
J Vet Intern Med. 2009 Nov; 23(6):1220-6.
PMID: 19780928 [PubMed - indexed for MEDLINE]
The relative sensitivity of computed tomography and myelography for identification of thoracolumbar intervertebral disk herniations in dogs.
Israel SK, Levine JM, Kerwin SC, Levine GJ, Fosgate GT.
Vet Radiol Ultrasound. 2009 May; 50(3):247-52.
PMID: 19507385 [PubMed - indexed for MEDLINE]
Imaging diagnosis--chronic canine distemper meningoencephalitis.
Griffin JF 4th, Young BD, Levine JM.
Vet Radiol Ultrasound. 2009 Mar; 50(2):182-4.
PMID: 19400465 [PubMed - indexed for MEDLINE]
Description and repeatability of a newly developed spinal cord injury scale for dogs.
Levine GJ, Levine JM, Budke CM, Kerwin SC, Au J, Vinayak A, Hettlich BF, Slater MR.
Prev Vet Med. 2009 May; 89(1-2):121-7.
PMID: 19303151 [PubMed - indexed for MEDLINE]
Identification of cancer stem cells in dog glioblastoma.
Stoica G, Lungu G, Martini-Stoica H, Waghela S, Levine J, Smith R 3rd.
Vet Pathol. 2009 May; 46(3):391-406.
PMID: 19176492 [PubMed - indexed for MEDLINE]
Magnetic resonance imaging characteristics of necrotizing meningoencephalitis in Pug dogs.
Young BD, Levine JM, Fosgate GT, de Lahunta A, Flegel T, Matiasek K, Miller A, Silver G, Sharp N, Greer K, Schatzberg SJ.
J Vet Intern Med. 2009 May; 23(3):527-35.
PMID: 19645838 [PubMed - indexed for MEDLINE]
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma.
Aloisio F, Levine JM, Edwards JF.
J Vet Diagn Invest. 2008 Nov; 20(6):836-8.
PMID: 18987242 [PubMed - indexed for MEDLINE]
Associations of sex, breed, and age with cervical vertebral compressive myelopathy in horses: 811 cases (1974-2007).
Levine JM, Ngheim PP, Levine GJ, Cohen ND.
J Am Vet Med Assoc. 2008 Nov; 233(9):1453-8.
PMID: 18980501 [PubMed - indexed for MEDLINE]
Owner-perceived, weighted quality-of-life assessments in dogs with spinal cord injuries.
Levine JM, Budke CM, Levine GJ, Kerwin SC, Hettlich BF, Slater MR.
J Am Vet Med Assoc. 2008 Sep; 233(6):931-5.
PMID: 18795855 [PubMed - indexed for MEDLINE]
Evaluation of a questionnaire for obtaining owner-perceived, weighted quality-of-life assessments for dogs with spinal cord injuries.
Budke CM, Levine JM, Kerwin SC, Levine GJ, Hettlich BF, Slater MR.
J Am Vet Med Assoc. 2008 Sep; 233(6):925-30.
PMID: 18795853 [PubMed - indexed for MEDLINE]
Epidemiology of necrotizing meningoencephalitis in Pug dogs.
Levine JM, Fosgate GT, Porter B, Schatzberg SJ, Greer K.
J Vet Intern Med. 2008 Jul; 22(4):961-8.
PMID: 18647157 [PubMed - indexed for MEDLINE]
Meningomyelitis in dogs: a retrospective review of 28 cases (1999 to 2007).
Griffin JF, Levine JM, Levine GJ, Fosgate GT.
J Small Anim Pract. 2008 Oct; 49(10):509-17.
PMID: 18631217 [PubMed - indexed for MEDLINE]
Adverse effects and outcome associated with dexamethasone administration in dogs with acute thoracolumbar intervertebral disk herniation: 161 cases (2000-2006).
Levine JM, Levine GJ, Boozer L, Schatzberg SJ, Platt SR, Kent M, Kerwin SC, Fosgate GT.
J Am Vet Med Assoc. 2008 Feb; 232(3):411-7.
PMID: 18241109 [PubMed - indexed for MEDLINE]
Cervical spinal locking plate in combination with cortical ring allograft for a one level fusion in dogs with cervical spondylotic myelopathy.
Bergman RL, Levine JM, Coates JR, Bahr A, Hettlich BF, Kerwin SC.
Vet Surg.. 2008 Aug; 37(6):530-6.
PMID: 19134102 []
Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease.
Baltzer WI, McMichael MA, Hosgood GL, Kerwin SC, Levine JM, Steiner JM, Ruaux CG.
Spine (Phila Pa 1976). 2008 Jun; 1;33(13):1397-402.
PMID: 18520934 []
Dystrophin-deficient muscular dystrophy in a Weimaraner.
Baltzer WI, Calise DV, Levine JM, Shelton GD, Edwards JF, Steiner JM.
J Am Anim Hosp Assoc.. 2007 Jul; 43(4):227-32.
PMID: 17615404 []
Confirmed and presumptive cervical vertebral compressive myelopathy in older horses: a retrospective study (1992-2004).
Levine JM, Adam E, MacKay RJ, Walker MA, Frederick JD, Cohen ND.
J Vet Intern Med. 2007 Jul; 21(4):812-9.
PMID: 17708404 [PubMed - indexed for MEDLINE]
Evaluation of the success of medical management for presumptive cervical intervertebral disk herniation in dogs.
Levine JM, Levine GJ, Johnson SI, Kerwin SC, Hettlich BF, Fosgate GT.
Vet Surg. 2007 Jul; 36(5):492-9.
PMID: 17614931 [PubMed - indexed for MEDLINE]
Evaluation of the success of medical management for presumptive thoracolumbar intervertebral disk herniation in dogs.
Levine JM, Levine GJ, Johnson SI, Kerwin SC, Hettlich BF, Fosgate GT.
Vet Surg. 2007 Jul; 36(5):482-91.
PMID: 17614930 [PubMed - indexed for MEDLINE]
Imaging diagnosis--bacterial diskospondylitis in a goat.
Levine GJ, Bissett WT, Cole RC, Janke JJ, Nunes J, Porter B, Levine JM.
Vet Radiol Ultrasound. 2006 Oct; 47(6):585-8.
PMID: 17153069 [PubMed - indexed for MEDLINE]
Association between various physical factors and acute thoracolumbar intervertebral disk extrusion or protrusion in Dachshunds.
Levine JM, Levine GJ, Kerwin SC, Hettlich BF, Fosgate GT.
J Am Vet Med Assoc. 2006 Aug; 229(3):370-5.
PMID: 16881827 [PubMed - indexed for MEDLINE]
Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease.
Levine JM, Ruaux CG, Bergman RL, Coates JR, Steiner JM, Williams DA.
Am J Vet Res. 2006 Feb; 67(2):283-7.
PMID: 16454634 [PubMed - indexed for MEDLINE]
Evaluation of the association between spondylosis deformans and clinical signs of intervertebral disk disease in dogs: 172 cases (1999-2000).
Levine GJ, Levine JM, Walker MA, Pool RR, Fosgate GT.
J Am Vet Med Assoc. 2006 Jan; 228(1):96-100.
PMID: 16426177 [PubMed - indexed for MEDLINE]
Myasthenia gravis and hypothyroidism in a dog with meningomyelitis.
Levine JM, Bergman RL, Coates JR, Shelton GD.
J Am Anim Hosp Assoc. 2005 Jul; 41(4):247-51.
PMID: 15995162 [PubMed - indexed for MEDLINE]
Cerebrospinal fluid from a dog with neurologic collapse.
Thompson CA, Russell KE, Levine JM, Weeks BR.
Vet Clin Pathol. 2003 ; 32(3):143-6.
PMID: 12966466 [PubMed - indexed for MEDLINE]
Use of an ankle-foot orthosis in a dog with traumatic sciatic neuropathy.
Levine JM, Fitch RB.
J Small Anim Pract.. 2003 May; 44(5):236-8.
PMID: 12779177 []
The influence of age on patellar reflex response in the dog.
Levine JM, Hillman RB, Erb HN, deLahunta A.
J Vet Intern Med. 2002 May; 16(3):244-6.
PMID: 12041652 [PubMed - indexed for MEDLINE]