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Jonathan M Levine

Department Head, Professor, & Helen McWhorter Chair in Small Animal Clinical Sciences

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Phone: (979) 845-2351

Mailstop: 4474

Department: VSCS

Photo of Levine, Jonathan


  • N/A Residency, Neurology and Neurosurgery, Texas A&M/University of Missouri 2005
  • N/A Internship, Small Animal Medicine and Surgery, Colorado State University 2002
  • D.V.M. Veterinary Medicine, Cornell University 2001
  • B.S. Biology, Cornell University 1995


  • ACVIM (Neurology)
  • Texas Veterinary Medical License: 9993
  • Texas Veterinary Medical Specialty License: 0233-S

Clinical Areas of Interest

  • Neurology

Scholarly Interests

Spinal cord injury, in particular MR imaging and neuroprotectionNeuro-oncology


Canine astrocytic tumors: a comparative review.
Stoica G, Levine J, Wolff J, Murphy K
Vet Pathol. 2011 Jan; 48(1):266-75.
Imaging diagnosis-synovial myxoma of lumbar vertebrae articular process joint.
Blair WH, Levine JM, Kerwin SC, Spaulding KA, Young BD, Pool RR
Vet Radiol Ultrasound. 2011 May; 52(3):309-12.
Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research.
Levine JM, Levine GJ, Porter BF, Topp K, Noble-Haeusslein LJ
J Neurotrauma. 2011 Apr; 28(4):675-88.
Intracranial magnetic resonance imaging artifacts and pseudolesions in dogs and cats.
Cooper JJ, Young BD, Hoffman A, Bratton G, Hicks DG, Tidwell A, Levine JM
Vet Radiol Ultrasound. 2010 Nov; 51(6):587-95.
Evaluation of brain tissue or cerebrospinal fluid with broadly reactive polymerase chain reaction for Ehrlichia, Anaplasma, spotted fever group Rickettsia, Bartonella, and Borrelia species in canine neurological diseases (109 cases).
Barber RM, Li Q, Diniz PP, Porter BF, Breitschwerdt EB, Claiborne MK, Birkenheuer AJ, Levine JM, Levine GJ, Chandler K, Kenny P, Nghiem P, Wei S, Greene CE, Kent M, Platt SR, Greer K, Schatzberg SJ
J Vet Intern Med.. 2010 Mar; 24(2):372-8.
Multicenter case-control study of signalment, diagnostic features, and outcome associated with cervical vertebral malformation-malarticulation in horses.
Levine JM, Scrivani PV, Divers TJ, Furr M, Mayhew IJ, Reed S, Levine GJ, Foreman JH, Boudreau C, Credille BC, Tennent-Brown B, Cohen ND
J Am Vet Med Assoc. 2010 Oct; 237(7):812-22.
Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation.
Levine GJ, Levine JM, Witsberger TH, Kerwin SC, Russell KE, Suchodolski J, Steiner J, Fosgate GT
J Vet Intern Med. 2010 Jul; 24(4):890-6.
Imaging diagnosis--magnetic resonance imaging pseudolesion associated with the petrous temporal bone.
Cooper JJ, Levine JM, Young BD, Hicks DG, Hoffman A, Bratton G
Vet Radiol Ultrasound. 2010 Jan; 51(1):39-41.
Arrhythmias and elevated troponin I in a dog with steroid-responsive meningitis-arteritis.
Snyder K, Saunders AB, Levine JM, Clubb FJ
J Am Anim Hosp Assoc. 2010 Jan; 46(1):61-5.
Magnetic resonance imaging in dogs with neurologic impairment due to acute thoracic and lumbar intervertebral disk herniation.
Levine JM, Fosgate GT, Chen AV, Rushing R, Nghiem PP, Platt SR, Bagley RS, Kent M, Hicks DG, Young BD, Schatzberg SJ
J Vet Intern Med. 2009 Nov; 23(6):1220-6.
The relative sensitivity of computed tomography and myelography for identification of thoracolumbar intervertebral disk herniations in dogs.
Israel SK, Levine JM, Kerwin SC, Levine GJ, Fosgate GT
Vet Radiol Ultrasound. 2009 May; 50(3):247-52.
Imaging diagnosis--chronic canine distemper meningoencephalitis.
Griffin JF 4th, Young BD, Levine JM
Vet Radiol Ultrasound. 2009 Mar; 50(2):182-4.
Description and repeatability of a newly developed spinal cord injury scale for dogs.
Levine GJ, Levine JM, Budke CM, Kerwin SC, Au J, Vinayak A, Hettlich BF, Slater MR
Prev Vet Med. 2009 May; 89(1-2):121-7.
Identification of cancer stem cells in dog glioblastoma.
Stoica G, Lungu G, Martini-Stoica H, Waghela S, Levine J, Smith R 3rd
Vet Pathol. 2009 May; 46(3):391-406.
Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy.
Dewey CW, Cerda-Gonzalez S, Levine JM, Badgley BL, Ducoté JM, Silver GM, Cooper JJ, Packer RA, Lavely JA
J Am Vet Med Assoc.. 2009 Dec; 15;235(12):1442-9.
Broadly reactive pan-paramyxovirus reverse transcription polymerase chain reaction and sequence analysis for the detection of Canine distemper virus in a case of canine meningoencephalitis of unknown etiology.
Schatzberg SJ, Li Q, Porter BF, Barber RM, Claiborne MK, Levine JM, Levine GJ, Israel SK, Young BD, Kiupel M, Greene C, Ruone S, Anderson L, Tong S
J Vet Diagn Invest.. 2009 Nov; 21(6):844-9.
Cervical vertebral malformation-malarticulation syndrome in the Bernese mountain dog: clinical and magnetic resonance imaging features.
Eagleson JS, Diaz J, Platt SR, Kent M, Levine JM, Sharp NJ, Schatzberg SJ
J Small Anim Pract.. 2009 Apr; 50(4):186-93.
Cervical spinal locking plate in combination with cortical ring allograft for a one level fusion in dogs with cervical spondylotic myelopathy.
Bergman RL, Levine JM, Coates JR, Bahr A, Hettlich BF, Kerwin SC
Vet Surg.. 2008 Aug; 37(6):530-6.
Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease.
Baltzer WI, McMichael MA, Hosgood GL, Kerwin SC, Levine JM, Steiner JM, Ruaux CG
Spine (Phila Pa 1976). 2008 Jun; 1;33(13):1397-402.
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma.
Aloisio F, Levine JM, Edwards JF
J Vet Diagn Invest. 2008 Nov; 20(6):836-8.
Associations of sex, breed, and age with cervical vertebral compressive myelopathy in horses: 811 cases (1974-2007).
Levine JM, Ngheim PP, Levine GJ, Cohen ND
J Am Vet Med Assoc. 2008 Nov; 233(9):1453-8.
Owner-perceived, weighted quality-of-life assessments in dogs with spinal cord injuries.
Levine JM, Budke CM, Levine GJ, Kerwin SC, Hettlich BF, Slater MR
J Am Vet Med Assoc. 2008 Sep; 233(6):931-5.
Evaluation of a questionnaire for obtaining owner-perceived, weighted quality-of-life assessments for dogs with spinal cord injuries.
Budke CM, Levine JM, Kerwin SC, Levine GJ, Hettlich BF, Slater MR
J Am Vet Med Assoc. 2008 Sep; 233(6):925-30.
Epidemiology of necrotizing meningoencephalitis in Pug dogs.
Levine JM, Fosgate GT, Porter B, Schatzberg SJ, Greer K
J Vet Intern Med. 2008 Jul; 22(4):961-8.
Meningomyelitis in dogs: a retrospective review of 28 cases (1999 to 2007).
Griffin JF, Levine JM, Levine GJ, Fosgate GT
J Small Anim Pract. 2008 Oct; 49(10):509-17.
Adverse effects and outcome associated with dexamethasone administration in dogs with acute thoracolumbar intervertebral disk herniation: 161 cases (2000-2006).
Levine JM, Levine GJ, Boozer L, Schatzberg SJ, Platt SR, Kent M, Kerwin SC, Fosgate GT
J Am Vet Med Assoc. 2008 Feb; 232(3):411-7.
Confirmed and presumptive cervical vertebral compressive myelopathy in older horses: a retrospective study (1992-2004).
Levine JM, Adam E, MacKay RJ, Walker MA, Frederick JD, Cohen ND
J Vet Intern Med. 2007 Jul; 21(4):812-9.
Evaluation of the success of medical management for presumptive cervical intervertebral disk herniation in dogs.
Levine JM, Levine GJ, Johnson SI, Kerwin SC, Hettlich BF, Fosgate GT
Vet Surg. 2007 Jul; 36(5):492-9.
Evaluation of the success of medical management for presumptive thoracolumbar intervertebral disk herniation in dogs.
Levine JM, Levine GJ, Johnson SI, Kerwin SC, Hettlich BF, Fosgate GT
Vet Surg. 2007 Jul; 36(5):482-91.
Dystrophin-deficient muscular dystrophy in a Weimaraner.
Baltzer WI, Calise DV, Levine JM, Shelton GD, Edwards JF, Steiner JM
J Am Anim Hosp Assoc.. 2007 Jul; 43(4):227-32.
Imaging diagnosis--bacterial diskospondylitis in a goat.
Levine GJ, Bissett WT, Cole RC, Janke JJ, Nunes J, Porter B, Levine JM
Vet Radiol Ultrasound. 2006 Oct; 47(6):585-8.
Association between various physical factors and acute thoracolumbar intervertebral disk extrusion or protrusion in Dachshunds.
Levine JM, Levine GJ, Kerwin SC, Hettlich BF, Fosgate GT
J Am Vet Med Assoc. 2006 Aug; 229(3):370-5.
Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease.
Levine JM, Ruaux CG, Bergman RL, Coates JR, Steiner JM, Williams DA
Am J Vet Res. 2006 Feb; 67(2):283-7.
Evaluation of the association between spondylosis deformans and clinical signs of intervertebral disk disease in dogs: 172 cases (1999-2000).
Levine GJ, Levine JM, Walker MA, Pool RR, Fosgate GT
J Am Vet Med Assoc. 2006 Jan; 228(1):96-100.
Myasthenia gravis and hypothyroidism in a dog with meningomyelitis.
Levine JM, Bergman RL, Coates JR, Shelton GD
J Am Anim Hosp Assoc. 2005 Jul; 41(4):247-51.
Cerebrospinal fluid from a dog with neurologic collapse.
Thompson CA, Russell KE, Levine JM, Weeks BR
Vet Clin Pathol. 2003 32(3):143-6.
Use of an ankle-foot orthosis in a dog with traumatic sciatic neuropathy.
Levine JM, Fitch RB
J Small Anim Pract.. 2003 May; 44(5):236-8.
The influence of age on patellar reflex response in the dog.
Levine JM, Hillman RB, Erb HN, deLahunta A
J Vet Intern Med.. 2002 May; 16(3):244-6.
Evaluator agreeement and outcome associations in dogs with spinal cord injury caused by intervertebral disk herniation
Griffin JF, Davis MC, Cohen ND, Young BY, Levine JM
Relationships between cerebrospinal fluid characteristics, injury severity, and functional outcome in dogs with and without intervertebral disk herniation
Levine GJ, Cook JR, Kerwin SC, Mankin J, Griffin JF, Fosgate GT, Levine JM
Vet Clini Pathol. Epub Ahead of Print PMID: 24976308.
A comparison of clinical, magnetic resonance imaging, and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes
Bentley RT, Burcham GN, Heng HG, Levine JM, Longshore R, Carrera-Justiz S, Cameron S, Koft K, Miller MA
Vet Comp Oncol. Epub Ahead of Print PMID: 24945683.
Inflammatory cytokines in cerberospinal fluid of dogs with acute spinal cord injury
Taylor AR, Welsh J, Young C, Cohen ND, Levine GJ, Levine JM
ACVIM Forum.
Matrix metalloproteinase inhibitor, GM6001 improves bladder and locomotor function after moderate-severe contusion spinal cord injury in mice
Trivendi A, Fandel TM, Martinez AF, Zhang H, Levine JM, Noble-Haeusslein LJ
ISNR, Asilomar, CA.
Acute treatment with the matrix maetalloproteinase inhibitor GM 6001 improves long-term locomotor and bladder function in a murine model of spinal cord injury
Fandel TM, Trivendi A, Gimlin K, Zhang H, Levine JM, Martinez AF, Noble-Haeusslein LJ
Society for Neuroscience, San Diego.
Intervertebral disc degeneration in dogs: consequences, diagnosis, treatment, and future directions
Jeffery ND, Levine JM, Olby NJ, Stein V
J Vet Intern Med. 27: 1318-1333.
Prospectively recorded versus medical record-derived spinal cord injury scores in a cohort of dogs with intervertebral disk herniation
Van Wie EY, Fosgate GT, Mankin JM, Jeffery ND, Kerwin SC, Levine GJ, Greatting HH, Chen AV, Levine JM
J Vet Intern Med. 27: 1273-1277.
Comparison between noncontrast computed tomography and magnetic resonance imaging for detection and characterization of thoracolumbar myelopathy caused by intervertebral disk herniation in dogs
Cooper JJ, Young BD, Griffin JF, Fosgate GT, Levine JM
Vet Radiol Ultrasound. 55: 182-189.
Lymphocytic ganglioneuritis secondary to intervertebral disc extrusion in a dog
Mouradian-Darby AE, Young BD, Griffin JF, Mansell J, Levine JM
J Small Anim Pract. Epub Ahead of Print PMID: 24779364.
Cerebrospinal fluid inflammatory cytokines and chemokines in naturally-occurring canine spinal cord injury
Taylor AR, Welsh J, Young C, Spoor E, Kerwin SC, Griffin JF, Levine GJ, Cohen ND, Levine JM
J Neurotrauma. Epub Ahead of Print PMID: 24786364.
Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma.
Xu S, Wei J, Wang F, Kong LY, Ling XY, Nduom E, Gabrusiewicz K, Doucette T, Yang Y, Yaghi NK, Fajt V, Levine JM, Qiao W, Li XG, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB
J Natl Cancer Inst. 106(8).
Comparison of two fat-suppressed magnetic resonance imaging pulse sequences to standard t2-weighted images for brain parenchymal contrast and lesion detection in dogs with inflammatory intracranial disease.
Young BD, Mankin JM, Griffin JF, Fosgate GT, Fowler JL, Levine JM
Vet Radiol Ultrasound. 56(2):204-11.
Quantitative magnetic resonance imaging in a naturally occurring canine model of spinal cord injury.
Griffin JF, Davis MC, Ji JX, Cohen ND, Young BD, Levine JM
Spinal Cord. 53(4):278-84.
Cerebral oligodendroglioma mimicking intraventricular neoplasia in 3 dogs
Rissi DR, Levine JM, Eden KB, Watson VE, Griffin JF, Edwards JF, Porter BF
J Vet Diagn Invest.
Lynphocytic ganglioneuritis secondary to intervertebral disc extrusion in a dog
Mouradian-Darby AE, Young BD, Griffin JF, Mansell J, Levine JM
J Small Anim Pract.
Acute Phase Proteins in Cerebrospinal Fluid from Dogs with Naturally-Occurring Spinal Cord Injury.
Anderson KM, Welsh CJ, Young C, Levine GJ, Kerwin SC, Boudreau CE, Reyes I, Mondragon A, Griffin JF 4th, Cohen ND, Levine JM
J Neurotrauma.
High-resolution MRI of spinal cords by compressive sensing parallel imaging
Li P, Yu X, Griffin J, Levine JM, Ji J
IEEE Eng Med Biol Soc.
Prospective cohort study to analyze physical and temporal prognostic factors associated with recovery from paraplegia in dogs that have lost deep pain perception
Jeffery ND, Baker A, Alcott, Hu HZ, Kraus K, Scanlin E, Granger N, Levine JM
J Am Vet Med Assoc.
Magnetic resonance imaging and clinical features of dogs with central nervous system aspergillosis
aylor AR, Young BD, Levine GJ, Eden K, Corapi W, Rossmeisl JH, Levine JM
J Vet Intern Med. 29: 1556-1563.
Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients
LeBlanc AK, Mazcko C, Brown DB, Koehler JW, Miller AD, Miller CR, Bentley RT, Packer RA, Breen M, Boudreau CE, Levine JM, Simpson MR, Halsey C, Kisseberth W, Rossmeisl JH, Dickinson PJ, Fan T, Corps K, Aldape K, Puduvalli V, Pluhar GE, Gilbert MR
Neuro Oncol. ePub PMID 27179361.
Application of a frameless computed tomography-guided stereotactic biopsy system for the collection of nasal biopsies in dogs: 5 cases (2012-2014)
Kuhlman GM, Taylor AR, Griffin JF, Thieman KT, Cook AK, Levine JM
J Am Vet Med Assoc. 248: 929-934.
Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury
Russell RL, Levine JM, Jeffery ND, Mondragon A, Lee B, Boudreau CE, Welsh CJ, Levine GJ
BMC Neurosci. 17: 31.

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