Charles R. Long
Department of Veterinary Physiology & Pharmacology
College of Veterinary Medicine & Biomedical Sciences
Texas A&M University
College Station Texas 77843
Gamete and embryo physiology, epigenetics, assisted reproductive
technologies, genetic engineering of livestock and companion
animals, biomedical models of human disease, disease resistant
VTPP 659: Gamete and Embryo Physiology
VTPP 653: Endocrinology
VTPP 452/652 Fetal & Embryo Physiology
I have conducted research on the physiology of gametes and early
embryos for over 25 years in both private industry and government
laboratories. These studied have varied from nuclear reprogramming
in cloned embryos, in vitro fertilization systems using sex sorted
sperm, embryo cryobiology, cytoskeletal and nuclear abnormalities
of in vitro produced livestock embryos as well as microtubule
nucleating components of sperm during zygotic development.
My more recent research interests have focused on the role of
histone and DNA methyltransferase genes in the control of
epigenetic reprogramming during early bovine embryonic development.
We are specifically interested in the exogenous stress that in
vitro culture of embryos places on the epigenome and how these
stresses manifest in altered or failed fetal development.
My laboratory also investigates novel transgenic approaches to
enhance production and disease resistance traits in livestock and
companion animals. For example, Dr. Mark Westhusin and I have
ongoing collaborations to produce biologically active proteins in
the milk of transgenic animals. Currently we maintain goats
that produce antigens in their milk that can be purified and
delivered as vaccines. We have ongoing projects utilizing RNA
interference and gene editing technologies to enhance production or
fight a number of economically important livestock and human
diseases. Furthermore, we utilize these same genetic engineering
strategies to produce biomedical models of human disease.
Current projects are focused on development of inducible, tissue
specific expression of transgenes to produce a model of human
obesity and metabolic syndrome in swine.
Many of the projects are accomplished in collaboration with Drs.
Golding, Westhusin and Kraemer of the Reproductive Sciences
Laboratory. This is dynamic group that offers a unique and
stimulating environment for conducting research. In addition we
maintain active collaborations with a number of other laboratories
in academia, government and private industry.
View Dr. Long's full profile and CV
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