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Michael Golding

Michael GoldingAssistant Professor
Department of Veterinary Physiology & Pharmacology
College of Veterinary Medicine & Biomedical Sciences
Texas A&M University
Room 332 VMA
College Station, TX 77843-4466

Research Interests

Fetal Physiology and the Developmental Origins of Birth Defects, Epigenetics and Developmental Programming, Teratogens

Teaching

My undergraduate and graduate courses explore the physiological processes of pregnancy and fetal development with a special emphasis on concepts related to developmental programming.

One of the main goals outlined in the Vison 2020 plan is to elevate the impact our teaching has upon students and therefore to advance the state, the nation and the world in meeting societal challenges and opportunities.  Faculty at Texas A&M constantly endeavor to remain on the forefront of educational techniques and enhance the student environment in order to maximize learning.   In my course, I utilize the high-impact-technique of service-learning to achieve this goal.  Learn More

Summary

I am an assistant professor within the department of veterinary physiology and pharmacology at Texas A&M University.  Here, I serve as the instructor of record for two courses studying human embryology and the physiological events of pregnancy.  My research program focuses on understanding the biochemical mechanisms by which chromatin structure is altered during development and how these changes serve to regulate gene expression.  I began my scientific career examining the role of failed epigenetic programming during the development of cloned embryos.  I have since pioneered studies examining epigenetic mechanisms regulating imprinted gene expression and developmental programming within mammalian embryonic, extraembryonic and neural precursor stem cells.  I am interested in understanding the mechanisms that recruit epigenetic modifiers to specific cohorts of genes, and identifying the biochemical machinery directing this process.  My lab seeks to understand how these events are impacted by environmental toxins / teratogens and how these interactions contribute to the development of both birth defects and failed pregnancies.

For the past four years, my laboratory has focused on epigenetic defects arising as a consequence of prenatal alcohol exposure.

View Dr. Golding's full profile and CV >>

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Education and Training

  • BSc in Honours Genetics, University of Western Ontario, London, Ontario Canada, 1996 - 2000
  • PhD in Veterinary Physiology, Texas A&M University, College Station, Texas USA, 2000 - 2003
  • Postdoctoral Fellowship, Cold Spring Harbour Laboratories, Cold Spring Harbour, New York USA, 2004 - 2006
  • Canadian Institute of Health Postdoctoral Fellow, University of Western Ontario, London, Ontario Canada, 2006 - 2009

Awards

  • Texas A&M University Center for Teaching Excellence - 2013 - 2014 Service Learning Scholar.
  • Zoetis 2013 Award for Research Excellence
  • Texas A&M University Center for Teaching Excellence - Montague Scholar 2012
  • Texas A&M University - Richard H. Davis Teaching Award, 2012
  • Perinatal Research Society - Early Career Award, 2010
  • NIH Young Investigator Award, Perinatal Research Society, 2008
  • Wyeth Award for Excellence in Research, Department of Obstetrics and Gynaecology, 2007
  • Ontario Women's Health Council/Canadian Institutes of Health Research - Institute of Gender and Health, Postdoctoral Fellowship, 2006
  • Dr. David Whaley Postdoctoral Fellowship in Maternal/Fetal/Neonatal Research, 2006

Teaching

Golding Teaching Green BackgroundVTPP 452/652 Fetal & Embryo Physiology explores the physiological processes of pregnancy and fetal development.   In this class we cover the processes of placentation and development of the major organ systems. We then use this information as a framework to better understand how birth defects arise and why.

VTPP 651 - Epigenetics & Systems Physiology examines the molecular mechanisms of developmental programming and the impact of nutrition & environmental toxins on the development of disease. The purpose of this course is to provide graduate level students with a journal club style seminar class focusing on the most current research in Epigenetics as it relates to systems physiology and disease. This course focuses on "big picture" concepts and requires students to focus their presentations on the scientific methods employed, rather than emphasizing an understanding of the specific biological systems being studied.

Research

Mammalian Development and Epigenetics

Mammalian development consists of a series of carefully orchestrated changes in gene expression that occur as stem or progenitor cells differentiate to form the tissues and organs making up the growing fetus. These dynamic changes in gene expression arise from cell-specific alterations in the way in which the DNA encoding each gene becomes packaged within the nucleus. Much like a closed book cannot be read while an open book can, genes can either be tightly wound up and silent or in a relaxed, open, active state. As development proceeds, the DNA of each cell becomes packaged in a way that is unique to that cell type and thus "programmed" to express a specific cohort of genes, which confer its individual identity and physiological function. During fetal development, the processes of developmental programming are profoundly influenced by maternal nutrition and exposure to environmental toxins.

My lab is interested in understanding how both the maternal consumption of alcohol during pregnancy and exposure to environmental toxins alter fetal developmental programming and cause disease. Using mouse embryonic, placental and neural stem cells, we conduct basic research examining the influence of these teratogens on mammalian differentiation and development.

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Parts of a blastocyst XEN

Extra-embryonic Endoderm Stem Cells
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