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Ivan Rusyn


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Department: VIBS

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  • Ph.D. Toxicology, University of North Carolina at Chapel Hill 2000
  • M.D. Medicine, Bogomolets National Medical University 1996


Prediction of human population responses to toxic compounds by a collaborative competition.
Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration
Nat Biotechnol. 2015
The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.
Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I
Toxicol Sci. 2015
IARC monographs: 40 years of evaluating carcinogenic hazards to humans.
Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, 't Mannetje A, McMichael AJ, McLaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby KC, Olshan AF, Parent ME, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini AS, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH
Environ Health Perspect. 2015 123(6):507-14.
Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making.
Berggren E, Amcoff P, Benigni R, Blackburn K, Carney E, Cronin M, Deluyker H, Gautier F, Judson RS, Kass GE, Keller D, Knight D, Lilienblum W, Mahony C, Rusyn I, Schultz T, Schwarz M, Schüürmann G, White A, Burton J, Lostia AM, Munn S, Worth A
Environ Health Perspect. 2015
Human genomics. Effect of predicted protein-truncating genetic variants on the human transcriptome.
Rivas MA, Pirinen M, Conrad DF, Lek M, Tsang EK, Karczewski KJ, Maller JB, Kukurba KR, DeLuca DS, Fromer M, Ferreira PG, Smith KS, Zhang R, Zhao F, Banks E, Poplin R, Ruderfer DM, Purcell SM, Tukiainen T, Minikel EV, Stenson PD, Cooper DN, Huang KH, Sullivan TJ, Nedzel J, GTEx Consortium, Geuvadis Consortium, Bustamante CD, Li JB, Daly MJ, Guigo R, Donnelly P, Ardlie K, Sammeth M, Dermitzakis ET, McCarthy MI, Montgomery SB, Lappalainen T, MacArthur DG
Science. 2015 348(6235):666-9.
Sharing and Specificity of Co-expression Networks across 35 Human Tissues.
Pierson E, GTEx Consortium, Koller D, Battle A, Mostafavi S, Ardlie KG, Getz G, Wright FA, Kellis M, Volpi S, Dermitzakis ET
PLoS Comput Biol. 2015 11(5):.
Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.
Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA
Environ Health Perspect. 2015 123(5):458-66.
Differentially expressed microRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.
Marrone AK, Shpyleva S, Chappell G, Tryndyak V, Uehara T, Tsuchiya M, Beland FA, Rusyn I, Pogribny IP
Mol Carcinog. 2015
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.
Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I
J Toxicol Environ Health A. 2015 78(1):32-49.
Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.
Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I
J Toxicol Environ Health A. 2015 78(1):15-31.
Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice.
Chappell G, Kobets T, O'Brien B, Tretyakova N, Sangaraju D, Kosyk O, Sexton KG, Bodnar W, Pogribny IP, Rusyn I
Toxicol Sci. 2014 142(2):375-84.
High-content high-throughput assays for characterizing the viability and morphology of human iPSC-derived neuronal cultures.
Sirenko O, Hesley J, Rusyn I, Cromwell EF
Assay Drug Dev Technol. 2014 12(9-10):536-47.
Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity.
Lash LH, Chiu WA, Guyton KZ, Rusyn I
Mutat Res Rev Mutat Res. 2014 762(762):22-36.
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Uehara T, Pogribny IP, Rusyn I
Curr Protoc Pharmacol. 2014 66(66):14.
Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone.
Benbrahim-Tallaa L, Lauby-Secretan B, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Guha N, Mattock H, Straif K, International Agency for Research on Cancer Monograph Working Group
Lancet Oncol. 2014 15(9):924-5.
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Chappell G, Kutanzi K, Uehara T, Tryndyak V, Hong HH, Hoenerhoff M, Beland FA, Rusyn I, Pogribny IP
Int J Cancer. 2014 134(12):2778-88.
Standardizing benchmark dose calculations to improve science-based decisions in human health assessments.
Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I
Environ Health Perspect. 2014 122(5):499-505.
Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.
Chiu WA, Campbell JL Jr, Clewell HJ 3rd, Zhou YH, Wright FA, Guyton KZ, Rusyn I
Environ Health Perspect. 2014 122(5):456-63.
Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix.
Buck LD, Inman SW, Rusyn I, Griffith LG
Biotechnol Bioeng. 2014 111(5):1018-27.
Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard.
Rusyn I, Chiu WA, Lash LH, Kromhout H, Hansen J, Guyton KZ
Pharmacol Ther. 2014 141(1):55-68.
High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells.
Sirenko O, Hesley J, Rusyn I, Cromwell EF
Assay Drug Dev Technol. 2014 12(1):43-54.
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity.
Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, Rusyn I
Toxicol Appl Pharmacol. 2013 273(3):500-7.
A systematic approach for identifying and presenting mechanistic evidence in human health assessments.
Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I
Regul Toxicol Pharmacol. 2013 67(2):266-77.
Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches.
Zhang L, Sedykh A, Tripathi A, Zhu H, Afantitis A, Mouchlis VD, Melagraki G, Rusyn I, Tropsha A
Toxicol Appl Pharmacol. 2013 272(1):67-76.
Integrative chemical-biological read-across approach for chemical hazard classification.
Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A
Chem Res Toxicol. 2013 26(8):1199-208.
Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer.
Hakenewerth AM, Millikan RC, Rusyn I, Herring AH, Weissler MC, Funkhouser WK, North KE, Barnholtz-Sloan JS, Olshan AF
Cancer Epidemiol. 2013 37(4):479-91.
Reply to: "The autophagic response to alcohol toxicity: the missing layer".
Rusyn I, Bataller R
J Hepatol. 2013 59(2):399-400.
Alcohol and toxicity.
Rusyn I, Bataller R
J Hepatol. 2013 59(2):387-8.
Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury.
Pogribny IP, Kutanzi K, Melnyk S, de Conti A, Tryndyak V, Montgomery B, Pogribna M, Muskhelishvili L, Latendresse JR, James SJ, Beland FA, Rusyn I
FASEB J. 2013 27(6):2233-43.
The Genotype-Tissue Expression (GTEx) project.
GTEx Consortium
Nat Genet. 2013 45(6):580-5.
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymonyak S, Bradford BU, Boorman GA, Bataller R, Rusyn I
Toxicol Sci. 2013 132(1):53-63.
ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence.
Reif DM, Sypa M, Lock EF, Wright FA, Wilson A, Cathey T, Judson RR, Rusyn I
Bioinformatics. 2013 29(3):402-3.
Acetaminophen-induced acute liver injury in HCV transgenic mice.
Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I
Toxicol Appl Pharmacol. 2013 266(2):224-32.
Addressing human variability in next-generation human health risk assessments of environmental chemicals.
Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ
Environ Health Perspect. 2013 121(1):23-31.
Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells.
Sirenko O, Crittenden C, Callamaras N, Hesley J, Chen YW, Funes C, Rusyn I, Anson B, Cromwell EF
J Biomol Screen. 2013 18(1):39-53.
Environmental toxicants, epigenetics, and cancer.
Pogribny IP, Rusyn I
Adv Exp Med Biol. 2013 754(754):215-32.
In vitro models for liver toxicity testing.
Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I
Toxicol Res (Camb). 2013 2(1):23-39.
Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites.
Guha N, Loomis D, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Baan R, Mattock H, Straif K, International Agency for Research on Cancer Monograph Working Group
Lancet Oncol. 2012 13(12):1192-3.
Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
Tryndyak V, de Conti A, Kobets T, Kutanzi K, Koturbash I, Han T, Fuscoe JC, Latendresse JR, Melnyk S, Shymonyak S, Collins L, Ross SA, Rusyn I, Beland FA, Pogribny IP
FASEB J. 2012 26(11):4592-602.
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet.
Tryndyak VP, Latendresse JR, Montgomery B, Ross SA, Beland FA, Rusyn I, Pogribny IP
Toxicol Appl Pharmacol. 2012 262(1):52-9.
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice.
Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I
Hepatology. 2012 56(1):130-9.
Indoor air pollutants and health in the United Arab Emirates.
Yeatts KB, El-Sadig M, Leith D, Kalsbeek W, Al-Maskari F, Couper D, Funk WE, Zoubeidi T, Chan RL, Trent CB, Davidson CA, Boundy MG, Kassab MM, Hasan MY, Rusyn I, Gibson JM, Olshan AF
Environ Health Perspect. 2012 120(5):687-94.
Conducting environmental health research in the Arabian Middle East: lessons learned and opportunities.
Yeatts KB, El-Sadig M, Ali HI, Al-Maskari F, Campbell A, Ng SW, Reeves L, Chan RL, Davidson CA, Funk WE, Boundy MG, Leith D, Popkin B, Gibson JM, Rusyn I, Olshan AF
Environ Health Perspect. 2012 120(5):632-6.
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model.
Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I
Toxicol Sci. 2012 126(2):578-88.
Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice.
Jeannot E, Boorman GA, Kosyk O, Bradford BU, Shymoniak S, Tumurbaatar B, Weinman SA, Melnyk SB, Tryndyak V, Pogribny IP, Rusyn I
Int J Cancer. 2012 130(6):1347-56.
Computational tools for discovery and interpretation of expression quantitative trait loci.
Wright FA, Shabalin AA, Rusyn I
Pharmacogenomics. 2012 13(3):343-52.
Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer.
Hakenewerth AM, Millikan RC, Rusyn I, Herring AH, North KE, Barnholtz-Sloan JS, Funkhouser WF, Weissler MC, Olshan AF
Cancer Epidemiol Biomarkers Prev. 2011 20(11):2438-49.
MicroRNA expression in the livers of inbred mice.
Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I
Mutat Res. 2011 714(1-2):126-33.
Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches.
Low Y, Uehara T, Minowa Y, Yamada H, Ohno Y, Urushidani T, Sedykh A, Muratov E, Kuz'min V, Fourches D, Zhu H, Rusyn I, Tropsha A
Chem Res Toxicol. 2011 24(8):1251-62.
Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene.
Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Swenberg JA, Beland FA, Pardo-Manuel Devillena F, Rusyn I, Pogribny IP
Toxicol Sci. 2011 122(2):448-56.
Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene.
Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Tryndyak V, Latendresse JR, Swenberg JA, Beland FA, Pogribny IP, Rusyn I
Environ Health Perspect. 2011 119(5):635-40.
Carcinogenicity of chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination byproducts.
Grosse Y, Baan R, Secretan-Lauby B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Islami F, Galichet L, Straif K, WHO International Agency for Research on Cancer Monograph Working Group
Lancet Oncol. 2011 12(4):328-9.
Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.
Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I
Toxicol Sci. 2011 120(1):206-17.
Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity.
Sedykh A, Zhu H, Tang H, Zhang L, Richard A, Rusyn I, Tropsha A
Environ Health Perspect. 2011 119(3):364-70.
In vitro screening for population variability in chemical toxicity.
O'Shea SH, Schwarz J, Kosyk O, Ross PK, Ha MJ, Wright FA, Rusyn I
Toxicol Sci. 2011 119(2):398-407.
Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.
Martinez SM, Bradford BU, Soldatow VY, Kosyk O, Sandot A, Witek R, Kaiser R, Stewart T, Amaral K, Freeman K, Black C, LeCluyse EL, Ferguson SS, Rusyn I
Toxicol Appl Pharmacol. 2010 249(3):208-16.
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.
Starlard-Davenport A, Tryndyak V, Kosyk O, Ross SR, Rusyn I, Beland FA, Pogribny IP
J Nutrigenet Nutrigenomics. 2010 3(4-6):259-66.
Heading down the wrong pathway: on the influence of correlation within gene sets.
Gatti DM, Barry WT, Nobel AB, Rusyn I, Wright FA
BMC Genomics. 2010 11(11):574.
Adiponectin lowers glucose production by increasing SOGA.
Cowherd RB, Asmar MM, Alderman JM, Alderman EA, Garland AL, Busby WH, Bodnar WM, Rusyn I, Medoff BD, Tisch R, Mayer-Davis E, Swenberg JA, Zeisel SH, Combs TP
Am J Pathol. 2010 177(4):1936-45.
Computational toxicology: realizing the promise of the toxicity testing in the 21st century.
Rusyn I, Daston GP
Environ Health Perspect. 2010 118(8):1047-50.
Toxicogenetics: population-based testing of drug and chemical safety in mouse models.
Rusyn I, Gatti DM, Wiltshire T, Kleeberger SR, Threadgill DW
Pharmacogenomics. 2010 11(8):1127-36.
Sex-specific gene expression in the BXD mouse liver.
Gatti DM, Zhao N, Chesler EJ, Bradford BU, Shabalin AA, Yordanova R, Lu L, Rusyn I
Physiol Genomics. 2010 42(3):456-68.
Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage.
Jeannot E, Mellottee L, Bioulac-Sage P, Balabaud C, Scoazec JY, Tran Van Nhieu J, Bacq Y, Michalak S, Buob D, Groupe d'étude Génétique des Tumeurs Hépatiques (INSERM Network), Laurent-Puig P, Rusyn I, Zucman-Rossi J
Diabetes. 2010 59(7):1836-44.
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors.
Powell CL, Bradford BU, Craig CP, Tsuchiya M, Uehara T, O'Connell TM, Pogribny IP, Melnyk S, Koop DR, Bleyle L, Threadgill DW, Rusyn I
Toxicol Sci. 2010 115(1):131-9.
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.
Starlard-Davenport A, Tryndyak V, Kosyk O, Ross SR, Rusyn I, Beland FA, Pogribny IP
World Rev Nutr Diet. 2010 101(101):123-30.
Modeling liver-related adverse effects of drugs using knearest neighbor quantitative structure-activity relationship method.
Rodgers AD, Zhu H, Fourches D, Rusyn I, Tropsha A
Chem Res Toxicol. 2010 23(4):724-32.
Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma.
Tsuchiya M, Parker JS, Kono H, Matsuda M, Fujii H, Rusyn I
Mol Cancer. 2010 9(9):74.
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW
Genome Res. 2009 19(9):1507-15.
A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents.
Zhu H, Ye L, Richard A, Golbraikh A, Wright FA, Rusyn I, Tropsha A
Environ Health Perspect. 2009 117(8):1257-64.
Replication and narrowing of gene expression quantitative trait loci using inbred mice.
Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I
Mamm Genome. 2009 20(7):437-46.
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.
Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I
Toxicol Sci. 2009 110(1):235-43.
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.
Pogribny IP, Tryndyak VP, Bagnyukova TV, Melnyk S, Montgomery B, Ross SA, Latendresse JR, Rusyn I, Beland FA
J Hepatol. 2009 51(1):176-86.
Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver.
Ross PK, Woods CG, Bradford BU, Kosyk O, Gatti DM, Cunningham ML, Rusyn I
Toxicol Appl Pharmacol. 2009 235(2):199-207.
FastMap: fast eQTL mapping in homozygous populations.
Gatti DM, Shabalin AA, Lam TC, Wright FA, Rusyn I, Nobel AB
Bioinformatics. 2009 25(4):482-9.
SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy.
Gatti DM, Sypa M, Rusyn I, Wright FA, Barry WT
Bioinformatics. 2009 25(4):541-2.
Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease.
Bradford BU, O'Connell TM, Han J, Kosyk O, Shymonyak S, Ross PK, Winnike J, Kono H, Rusyn I
Toxicol Appl Pharmacol. 2008 232(2):236-43.
Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.
Pogribny IP, Tryndyak VP, Boureiko A, Melnyk S, Bagnyukova TV, Montgomery B, Rusyn I
Mutat Res. 2008 644(1-2):17-23.
Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry.
Han J, Danell RM, Patel JR, Gumerov DR, Scarlett CO, Speir JP, Parker CE, Rusyn I, Zeisel S, Borchers CH
Metabolomics. 2008 4(2):128-140.
Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents.
Pogribny IP, Rusyn I, Beland FA
Environ Mol Mutagen. 2008 49(1):9-15.
Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression.
Woods CG, Kosyk O, Bradford BU, Ross PK, Burns AM, Cunningham ML, Qu P, Ibrahim JG, Rusyn I
Toxicol Appl Pharmacol. 2007 225(3):267-77.
Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates.
Rusyn I, Fry RC, Begley TJ, Klapacz J, Svensson JP, Ambrose M, Samson LD
PLoS One. 2007 2(11):.
Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.
Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, Kayton RJ, Kerr KF, Kosyk O, Lobenhofer EK, Sieber SO, Vliet PA, Weis BK, Wolfinger R, Woods CG, Freedman JH, Linney E, Kaufmann WK, Kavanagh TJ, Paules RS, Rusyn I, Samson LD, Spencer PS, Suk W, Tennant RJ, Zarbl H, Members of the Toxicogenomics Research Consortium
Toxicol Sci. 2007 99(1):326-37.
Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.
Peffer RC, Moggs JG, Pastoor T, Currie RA, Wright J, Milburn G, Waechter F, Rusyn I
Toxicol Sci. 2007 99(1):315-25.
Genome-level analysis of genetic regulation of liver gene expression networks.
Gatti D, Maki A, Chesler EJ, Kirova R, Kosyk O, Lu L, Manly KF, Williams RW, Perkins A, Langston MA, Threadgill DW, Rusyn I
Hepatology. 2007 46(2):548-57.
WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.
Woods CG, Burns AM, Bradford BU, Ross PK, Kosyk O, Swenberg JA, Cunningham ML, Rusyn I
Toxicol Sci. 2007 98(2):366-74.
Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows.
Roberts A, McMillan L, Wang W, Parker J, Rusyn I, Threadgill D
Bioinformatics. 2007 23(13):.
Glycine as a potent anti-angiogenic nutrient for tumor growth.
Yamashina S, Ikejima K, Rusyn I, Sato N
J Gastroenterol Hepatol. 2007 22(Suppl 1):S62-4.
Genomic profiling in nuclear receptor-mediated toxicity.
Woods CG, Heuvel JP, Rusyn I
Toxicol Pathol. 2007 35(4):474-94.
Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice.
Hammond LE, Albright CD, He L, Rusyn I, Watkins SM, Doughman SD, Lemasters JJ, Coleman RA
Exp Mol Pathol. 2007 82(2):210-9.
Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma.
Maki A, Kono H, Gupta M, Asakawa M, Suzuki T, Matsuda M, Fujii H, Rusyn I
Ann Surg Oncol. 2007 14(3):1182-90.
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis.
Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, Klaunig JE
Toxicol Sci. 2007 96(1):2-15.
Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase.
Woods CG, Burns AM, Maki A, Bradford BU, Cunningham ML, Connor HD, Kadiiska MB, Mason RP, Peters JM, Rusyn I
Free Radic Biol Med. 2007 42(3):335-42.
Methyl deficiency, alterations in global histone modifications, and carcinogenesis.
Pogribny IP, Tryndyak VP, Muskhelishvili L, Rusyn I, Ross SA
J Nutr. 2007 137(1 Suppl):216S-222S.
[Ethanol into acetaldehyde bioconversion by mutant strains of Hansenula polymorpha Felcao de Morais & Dália Maia].
Moroz OM, Kulachkovs'kyĭ OR, Rusyn IB, Hnatush SO, Pavlova IuO, Lytvyn ZhV
Mikrobiol Z. 2007 69(1):20-34.
Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver.
Powell CL, Kosyk O, Ross PK, Schoonhoven R, Boysen G, Swenberg JA, Heinloth AN, Boorman GA, Cunningham ML, Paules RS, Rusyn I
Toxicol Sci. 2006 93(1):213-22.
Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.
Rusyn I, Peters JM, Cunningham ML
Crit Rev Toxicol. 2006 36(5):459-79.
Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage.
Powell CL, Swenberg JA, Rusyn I
Cancer Lett. 2005 229(1):1-11.
Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury.
Powell CL, Kosyk O, Bradford BU, Parker JS, Lobenhofer EK, Denda A, Uematsu F, Nakae D, Rusyn I
Hepatology. 2005 42(5):1137-47.
Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver.
Rusyn I, Asakura S, Li Y, Kosyk O, Koc H, Nakamura J, Upton PB, Swenberg JA
DNA Repair (Amst). 2005 4(10):1099-110.
Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined diet.
Uematsu F, Takahashi M, Yoshida M, Igarashi M, Watanabe N, Suzuki N, Abe M, Rusyn I, Floyd RA, Nakae D
Cancer Sci. 2005 96(7):414-24.
Standardizing global gene expression analysis between laboratories and across platforms.
Bammler T, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li YJ, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin LX, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin JL, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl H, Members of the Toxicogenomics Research Consortium
Nat Methods. 2005 2(5):351-6.
Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver.
Bradford BU, Kono H, Isayama F, Kosyk O, Wheeler MD, Akiyama TE, Bleye L, Krausz KW, Gonzalez FJ, Koop DR, Rusyn I
Hepatology. 2005 41(2):336-44.
Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis.
Hays T, Rusyn I, Burns AM, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM
Carcinogenesis. 2005 26(1):219-27.
[Biodegradation of oil hydrocarbons by Candida yeast].
Rusyn IB, Moroz OM, Karabyn VV, Kulachkovs'kiĭ OR, Hudz' SP
Mikrobiol Z. 2003 65(6):36-42.
Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy.
Wheeler MD, Smutney OM, Check JF, Rusyn I, Schulte-Hermann R, Thurman RG
Am J Physiol Gastrointest Liver Physiol. 2003 284(2):.
Functional heterogeneity of the kupffer cell population is involved in the mechanism of gadolinium chloride in rats administered endotoxin.
Kono H, Fujii H, Asakawa M, Yamamoto M, Maki A, Matsuda M, Rusyn I, Matsumoto Y
J Surg Res. 2002 106(1):179-87.
Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo.
Yin M, Zhong Z, Connor HD, Bunzendahl H, Finn WF, Rusyn I, Li X, Raleigh JA, Mason RP, Thurman RG
Am J Physiol Renal Physiol. 2002 282(3):.
The role of Kupffer cell oxidant production in early ethanol-induced liver disease.
Wheeler MD, Kono H, Yin M, Nakagami M, Uesugi T, Arteel GE, Gäbele E, Rusyn I, Yamashina S, Froh M, Adachi Y, Iimuro Y, Bradford BU, Smutney OM, Connor HD, Mason RP, Goyert SM, Peters JM, Gonzalez FJ, Samulski RJ, Thurman RG
Free Radic Biol Med. 2001 31(12):1544-9.
In memoriam: Ronald G. Thurman (1941-2001).
Rusyn I
Carcinogenesis. 2001 22(12):1899-901.
Alcohol-induced free radicals in mice: direct toxicants or signaling molecules?
Yin M, Gäbele E, Wheeler MD, Connor H, Bradford BU, Dikalova A, Rusyn I, Mason R, Thurman RG
Hepatology. 2001 34(5):935-42.
PPARalpha-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator.
Xu S, Zhu BT, Turan V, Rusyn I, Thurman R, Peters JM, Gonzalez FJ, Conney AH
Endocrinology. 2001 142(8):3554-7.
ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice.
Kono H, Uesugi T, Froh M, Rusyn I, Bradford BU, Thurman RG
Am J Physiol Gastrointest Liver Physiol. 2001 280(6):.
Development of an animal model of chronic alcohol-induced pancreatitis in the rat.
Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B, Brenner DA, Mason RP, Arteel GE, Thurman RG
Am J Physiol Gastrointest Liver Physiol. 2001 280(6):.
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.
Kono H, Rusyn I, Uesugi T, Yamashina S, Connor HD, Dikalova A, Mason RP, Thurman RG
Am J Physiol Gastrointest Liver Physiol. 2001 280(5):.
Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats.
Wheeler MD, Kono H, Yin M, Rusyn I, Froh M, Connor HD, Mason RP, Samulski RJ, Thurman RG
Gastroenterology. 2001 120(5):1241-50.
Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells.
Rusyn I, Kadiiska MB, Dikalova A, Kono H, Yin M, Tsuchiya K, Mason RP, Peters JM, Gonzalez FJ, Segal BH, Holland SM, Thurman RG
Mol Pharmacol. 2001 59(4):744-50.
Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production.
Wheeler MD, Yamashina S, Froh M, Rusyn I, Thurman RG
J Leukoc Biol. 2001 69(4):622-30.
Ebselen prevents early alcohol-induced liver injury in rats.
Kono H, Arteel GE, Rusyn I, Sies H, Thurman RG
Free Radic Biol Med. 2001 30(4):403-11.
Endothelial cells contain a glycine-gated chloride channel.
Yamashina S, Konno A, Wheeler MD, Rusyn I, Rusyn EV, Cox AD, Thurman RG
Nutr Cancer. 2001 40(2):197-204.
Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency.
Rusyn I, Denissenko MF, Wong VA, Butterworth BE, Cunningham ML, Upton PB, Thurman RG, Swenberg JA
Carcinogenesis. 2000 21(12):2141-5.
Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase.
Yamashina S, Wheeler MD, Rusyn I, Ikejima K, Sato N, Thurman RG
Biochem Biophys Res Commun. 2000 277(3):686-90.
Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFkappaB-dependent mechanisms.
Wheeler MD, Kono H, Rusyn I, Arteel GE, McCarty D, Samulski RJ, Thurman RG
Hepatology. 2000 32(5):1050-9.
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.
Kono H, Rusyn I, Yin M, Gäbele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, Thurman RG
J Clin Invest. 2000 106(7):867-72.
Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.
Rusyn I, Yamashina S, Segal BH, Schoonhoven R, Holland SM, Cattley RC, Swenberg JA, Thurman RG
Cancer Res. 2000 60(17):4798-803.
Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators.
Rusyn I, Rose ML, Bojes HK, Thurman RG
Antioxid Redox Signal. 2000 2(3):607-21.
Gender differences in early alcohol-induced liver injury: role of CD14, NF-kappaB, and TNF-alpha.
Kono H, Wheeler MD, Rusyn I, Lin M, Seabra V, Rivera CA, Bradford BU, Forman DT, Thurman RG
Am J Physiol Gastrointest Liver Physiol. 2000 278(4):.
Allopurinol prevents early alcohol-induced liver injury in rats.
Kono H, Rusyn I, Bradford BU, Connor HD, Mason RP, Thurman RG
J Pharmacol Exp Ther. 2000 293(1):296-303.
Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation.
Rose ML, Rusyn I, Bojes HK, Belyea J, Cattley RC, Thurman RG
Mutat Res. 2000 448(2):179-92.
Inhibition of chronic rejection of aortic allografts by dietary glycine.
Yin M, Rusyn I, Schoonhoven R, Graves LM, Rusyn EV, Li X, Li F, Cox AD, Harding TW, Bunzendahl H, Swenberg JA, Thurman RG
Transplantation. 2000 69(5):773-80.
The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat.
Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D, Brenner D, Thurman RG
Hepatology. 2000 31(2):391-8.
Development of an intragastric enteral model in the mouse: studies of alcohol-induced liver disease using knockout technology.
Kono H, Bradford BU, Rusyn I, Fujii H, Matsumoto Y, Yin M, Thurman RG
J Hepatobiliary Pancreat Surg. 2000 7(4):395-400.
Glycine: a new anti-inflammatory immunonutrient.
Wheeler MD, Ikejema K, Enomoto N, Stacklewitz RF, Seabra V, Zhong Z, Yin M, Schemmer P, Rose ML, Rusyn I, Bradford B, Thurman RG
Cell Mol Life Sci. 1999 56(9-10):843-56.
Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms.
Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA, Brenner DA, Thurman RG
Carcinogenesis. 1999 20(11):2095-100.
Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite.
Arteel GE, Kadiiska MB, Rusyn I, Bradford BU, Mason RP, Raleigh JA, Thurman RG
Mol Pharmacol. 1999 55(4):708-15.
Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells.
Stachlewitz RF, Seabra V, Bradford B, Bradham CA, Rusyn I, Germolec D, Thurman RG
Hepatology. 1999 29(3):737-45.
Role of Kupffer cells in peroxisome proliferator-induced hepatocyte proliferation.
Rose ML, Rusyn I, Bojes HK, Germolec DR, Luster M, Thurman RG
Drug Metab Rev. 1999 31(1):87-116.
Glycine accelerates recovery from alcohol-induced liver injury.
Yin M, Ikejima K, Arteel GE, Seabra V, Bradford BU, Kono H, Rusyn I, Thurman RG
J Pharmacol Exp Ther. 1998 286(2):1014-9.
WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes.
Rusyn I, Tsukamoto H, Thurman RG
Carcinogenesis. 1998 19(7):1217-22.

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