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Robert S Chapkin

Professor - Joint Appointment

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Phone: (979) 845-0419

Mailstop: 2253

Department: VIBS

Photo of Chapkin, Robert

Education

  • Ph.D. Nutr. & Physiol. Chemistry, University of California - Davis 1986
  • M.Sc. Nutrition, University of Guelph, Ontario, Canada 1983
  • B.Sc. Nutrition & Biochemistry, University of Guelph, Ontario, Canada 1981

Scholarly Interests

Dr. Robert S. Chapkin, Distinguished Professor is an expert in dietary/microbial modulators related to prevention of cancer and chronic inflammatory diseases. He has been continuously funded by the National Institutes of Health (NIH) for the past 27 years, having published over 240 peer reviewed papers. Recently, he was awarded a National Cancer Institute R35 Outstanding Investigator Grant (2016 - 2023). This very prestigious award is given to an exceptional and long-established cancer researcher who has been continuously funded by the NIH. To date only 43 investigators across the U.S.A. have received this recognition. The award will fund Dr. Chapkin’s cancer research program for the next 7 years for a total of $6,202,207. This research will break new ground in cancer prevention. Specifically, the overall goal is to better understand how intestinal epithelial cells respond to exogenous (diet-derived natural products) and endogenous (gut microbial) derived bioactive agents to reduce colon cancer risk. The lab’s novel research objectives include: 1. Determining the role of Arylhydrocarbon Receptor (AhR) ligands as modulators of colon stem cell homeostasis and malignant transformation. 2. Utilize novel complementary model systems to screen natural products/ therapeutics, e.g., Membrane Targeted Dietary Bioactives (MTDB’s), with regard to their ability to antagonize cancer-causing protein clustering and downstream signaling.

Publications

Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function.
Chapkin RS, Hong MY, Fan YY, Davidson LA, Sanders LM, Henderson CE, Barhoumi R, Burghardt RC, Turner ND, Lupton JR
Lipids. 37(2):193-9.
Dietary fiber differentially alters cellular fatty acid-binding protein expression in exfoliated colonocytes during tumor development.
Chapkin RS, Clark AE, Davidson LA, Schroeder F, Zoran DL, Lupton JR
Nutr Cancer. 32(2):107-12.
Interference with protein kinase C-related signal transduction in vascular smooth muscle cells by benzo[a]pyrene.
Ou X, Weber TJ, Chapkin RS, Ramos KS
Arch Biochem Biophys. 318(1):122-30.
Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains.
Kim W, Barhoumi R, McMurray DN, Chapkin RS
Br J Nutr. 111(2):254-60.
Classification of diet-modulated gene signatures at the colon cancer initiation and progression stages.
Kachroo P, Ivanov I, Davidson LA, Chowdhary BP, Lupton JR, Chapkin RS
Dig Dis Sci. 56(9):2595-604.


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