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Joe Kornegay

Professor-Joint Appointment

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Department: VIBS

Photo of Kornegay, Joe


  • Ph.D. Veterinary Pathology, University of Georgia 1982
  • M.S. Veterinary Anatomy, University of Georgia 1980
  • D.V.M. Veterinary Medicine, Texas A&M University 1973
  • B.S. Veterinary Science, Texas A&M University 1972


  • Veterinary Board License - Texas
  • ACVIM (Neurology)
  • Texas Veterinary Medical License: 3430


Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials.
Kornegay JN, Spurney CF, Nghiem PP, Brinkmeyer-Langford CL, Hoffman EP, Nagaraju K.
ILAR J. 2014 55(1):119-49.
Diaphragm remodeling and compensatory respiratory mechanics in a canine model of Duchenne muscular dystrophy.
Mead AF, Petrov M, Malik AS, Mitchell MA, Childers MK, Bogan JR, Seidner G, Kornegay JN, Stedman HH
J Appl Physiol. 2014 116(7):807-15.
A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle.
Martin PT, Golden B, Okerblom J, Camboni M, Chandrasekharan K, Xu R, Varki A, Flanigan KM, Kornegay JN
PLoS One. 2014 9(2).
Characteristics of magnetic resonance imaging biomarkers in a natural history study of golden retriever muscular dystrophy.
Fan Z, Wang J, Ahn M, Shiloh-Malawsky Y, Chahin N, Elmore S, Bagnell CR Jr, Wilber K, An H, Lin W, Zhu H, Styner M, Kornegay JN
Neuromuscul Disord. 2014 24(2):178-91.
Respiratory dysfunction in unsedated dogs with golden retriever muscular dystrophy.
DeVanna JC, Kornegay JN, Bogan DJ, Bogan JR, Dow JL, Hawkins EC
Neuromuscul Disord. 2014 24(1):63-73.
Genetic myostatin decrease in the golden retriever muscular dystrophy model does not significantly affect the ubiquitin proteasome system despite enhancing the severity of disease.
Cotten SW, Kornegay JN, Bogan DJ, Wadosky KM, Patterson C, Willis MS
Am J Transl Res. 2013 6(1):43-53.
Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs
Nghiem PP, Hoffman EP, Mittal P, Brown KJ, Schatzberg SJ, Ghimbovschi S, Wang Z, Kornegay JN
Am J Pathol. 2013 183(5):1411-24.
Levels of α7 integrin and laminin-α2 are increased following prednisone treatment in the mdx mouse and GRMD dog models of Duchenne muscular dystrophy.
Wuebbles RD, Sarathy A, Kornegay JN, Burkin DJ
Dis Model Mech. 2013 6(5):1175-84.
A computerized MRI biomarker quantification scheme for a canine model of Duchenne muscular dystrophy.
Wang J, Fan Z, Vandenborne K, Walter G, Shiloh-Malawsky Y, An H, Kornegay JN, Styner MA
Int J Comput Assist Radiol Surg. 2013 8(5):763-74.
Comparative Genomics of X-linked Muscular Dystrophies: The Golden Retriever Model.
Brinkmeyer-Langford C, Kornegay JN
Curr Genomics. 2013 14(5):330-42.
Cardiac structure and function in female carriers of a canine model of Duchenne muscular dystrophy.
Kane AM, DeFrancesco TC, Boyle MC, Malarkey DE, Ritchey JW, Atkins CE, Cullen JM, Kornegay JN, Keene BW
Res Vet Sci. 2013 94(3):610-7.
MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy.
Barbash IM, Cecchini S, Faranesh AZ, Virag T, Li L, Yang Y, Hoyt RF, Kornegay JN, Bogan JR, Garcia L, Lederman RJ, Kotin RM
Gene Ther. 2013 20(3):274-82.
Two anatomic resources of canine pelvic limb muscles based on CT and MRI.
Sunico SK, Hamel C, Styner M, Robertson ID, Kornegay JN, Bettini C, Parks J, Wilber K, Smallwood JE, Thrall DE
Vet Radiol Ultrasound. 2012 53(3):266-72.
Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping.
Bish LT, Sleeper MM, Forbes SC, Wang B, Reynolds C, Singletary GE, Trafny D, Morine KJ, Sanmiguel J, Cecchini S, Virag T, Vulin A, Beley C, Bogan J, Wilson JM, Vandenborne K, Kornegay JN, Walter GA, Kotin RM, Garcia L, Sweeney HL
Mol Ther. 2012 20(3):580-9.
Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies.
Kornegay JN, Bogan JR, Bogan DJ, Childers MK, Li J, Nghiem P, Detwiler DA, Larsen CA, Grange RW, Bhavaraju-Sanka RK, Tou S, Keene BP, Howard JF Jr, Wang J, Fan Z, Schatzberg SJ, Styner MA, Flanigan KM, Xiao X, Hoffman EP
Mamm Genome. 2012 23(1-2):85-108.
Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of duchenne muscular dystrophy.
Childers MK, Bogan JR, Bogan DJ, Greiner H, Holder M, Grange RW, Kornegay JN
Front Pharmacol. 2012 2(2):89.
Polystyrene-coated micropallets for culture and separation of primary muscle cells.
Detwiler DA, Dobes NC, Sims CE, Kornegay JN, Allbritton NL
Anal Bioanal Chem. 2012 402(3):1083-91.
Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy.
Bish LT, Sleeper MM, Forbes SC, Morine KJ, Reynolds C, Singletary GE, Trafny D, Pham J, Bogan J, Kornegay JN, Vandenborne K, Walter GA, Sweeney HL
Hum Gene Ther. 2011 22(12):1499-509.
Regulation of the calpain and ubiquitin-proteasome systems in a canine model of muscular dystrophy.
Wadosky KM, Li L, Rodríguez JE, Min JN, Bogan D, Gonzalez J, Patterson C, Kornegay JN, Willis M
Muscle Nerve. 2011 44(4):553-62.
Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.
Peterson JM, Kline W, Canan BD, Ricca DJ, Kaspar B, Delfín DA, DiRienzo K, Clemens PR, Robbins PD, Baldwin AS, Flood P, Kaumaya P, Freitas M, Kornegay JN, Mendell JR, Rafael-Fortney JA, Guttridge DC, Janssen PM
Mol Med. 2011 17(5-6):508-15.
Muscular dystrophy in dogs: does the crossing of breeds influence disease phenotype?
Miyazato LG, Moraes JR, Beretta DC, Kornegay JN
Vet Pathol. 2011 48(3):655-62.
In vivo canine muscle function assay.
Childers MK, Grange RW, Kornegay JN
J Vis Exp. 2011 (50).
An intronic LINE-1 element insertion in the dystrophin gene aborts dystrophin expression and results in Duchenne-like muscular dystrophy in the corgi breed.
Smith BF, Yue Y, Woods PR, Kornegay JN, Shin JH, Williams RR, Duan D
Lab Invest. 2011 91(2):216-31.
Widespread muscle expression of an AAV9 human mini-dystrophin vector after intravenous injection in neonatal dystrophin-deficient dogs.
Kornegay JN, Li J, Bogan JR, Bogan DJ, Chen C, Zheng H, Wang B, Qiao C, Howard JF Jr, Xiao X
Mol Ther. 2010 18(8):1501-8.
Expression of dog microdystrophin in mouse and dog muscles by gene therapy.
Pichavant C, Chapdelaine P, Cerri DG, Dominique JC, Quenneville SP, Skuk D, Kornegay JN, Bizario JC, Xiao X, Tremblay JP
Mol Ther. 2010 18(5):1002-9.
Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs.
Townsend D, Turner I, Yasuda S, Martindale J, Davis J, Shillingford M, Kornegay JN, Metzger JM
J Clin Invest. 2010 120(4):1140-50.
Kinematics of gait in golden retriever muscular dystrophy.
Marsh AP, Eggebeen JD, Kornegay JN, Markert CD, Childers MK
Neuromuscul Disord. 2010 20(1):16-20.
Evaluation of a prototype real-time PCR assay for carcinogenic human papillomavirus (HPV) detection and simultaneous HPV genotype 16 (HPV16) and HPV18 genotyping.
Castle PE, Sadorra M, Lau T, Aldrich C, Garcia FA, Kornegay J
J Clin Microbiol. 2009 47(10):3344-7.
A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs.
Yue Y, Ghosh A, Long C, Bostick B, Smith BF, Kornegay JN, Duan D
Mol Ther. 2008 16(12):1944-52.
A canine minidystrophin is functional and therapeutic in mdx mice.
Wang B, Li J, Qiao C, Chen C, Hu P, Zhu X, Zhou L, Bogan J, Kornegay J, Xiao X
Gene Ther. 2008 15(15):1099-106.
Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy.
Hanft LM, Bogan DJ, Mayer U, Kaufman SJ, Kornegay JN, Ervasti JM
Neuromuscul Disord. 2007 17(7):569-74.
Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs.
Dell'Agnola C, Wang Z, Storb R, Tapscott SJ, Kuhr CS, Hauschka SD, Lee RS, Sale GE, Zellmer E, Gisburne S, Bogan J, Kornegay JN, Cooper BJ, Gooley TA, Little MT
Blood. 2004 104(13):4311-8.
Respiratory dysfunction in unsedated dogs with golden retriever muscular dystrophy.
DeVanna JC, Kornegay JN, Bogan DJ, Bogan JR, Dow JL, Hawkins EC
Neuromuscul Disord. 24(24):63-73.

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