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Yongchang Qian

Research Assistant Professor

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Phone: (979) 862-4973

Mailstop: 4458

Department: VIBS

Photo of Qian, Yongchang

Education

  • Ph.D. Botany-Plant Biochemistry, Chinese Academy of Sciences, China 1990
  • B.S. Biology, Shanghai FuDan University, China 1985

Research

  • Cell Biology
  • Toxicology
  • Neuroscience

Interdisciplinary Activities

  • Neuroscience
  • Toxicology

Scholarly Interests

The research interests include astroglial cell biology and heavy metal neurotoxicity. The studies have identified that Pb deposit in astrocytes competitively with copper (Cu) binds to heavy metal binding (HMB) domain of ATP7A, a Cu-transporting ATPase that contributes to Cu release, leading to Cu accumulation intracellularly and the promotion of reactive oxygen species (ROS) production that both have been involved in neurodegenerative diseases including Alzheimer’s disease and amyotrophic lateral sclerosis. The studies have also identified a 78 kD glucose-regulated protein (GRP78), also named as HSPA5 or BiP, as one of Pb targets. GRP78 is an endoplasmic reticulum-resident molecular chaperone functioning in protein folding, assembly and trafficking in posttranslational quality control and also plays a role in protection against cytotoxicity and apoptosis induced by environmental insults. Emerging evidence indicates that the protein is involved in cancers including breast cancers, lung cancers, and others and neurodegenerative disorders including Alzheimer's disease. The studies demonstrate that Pb directly binds to GRP78 and the binding plays a “double-edged sword” role because it protects the cells from the toxicity of free Pb ions but also reduces protein secretion (e.g. IL-6) and Cu release from astrocytes. Current interests are focused on functions of GRP78 in Cu homeostasis and glucose utilization of the central nervous system that both are involved in neurodegenerative disorders and cancers.

Publications

HSPA5 forms specific complexes with copper.
Qian Y, Meng B, Zhang X, Zheng Y, Taylor R, Tiffany-Castiglioni E.
Neurochem Res. ; 38(2):321-9.
ER chaperone-metal interactions: links to protein folding disorders.
Tiffany-Castiglioni E, Qian Y.
Neurotoxicology. ; 33(3):545-57.
Copper handling by astrocytes: insights into neurodegenerative diseases.
Tiffany-Castiglioni E, Hong S, Qian Y.
Int J Dev Neurosci. ; 29(8):811-8.
Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells.
Barhoumi R, Burghardt RC, Qian Y, Tiffany-Castiglioni E.
Brain Res. ; 1145:11-8.
The involvement of copper transporter in lead-induced oxidative stress in astroglia.
Qian Y, Zheng Y, Ramos KS, Tiffany-Castiglioni E.
Neurochem Res. ; 30(4):429-38.
Image analysis of Ca2+ signals as a basis for neurotoxicity assays: promises and challenges.
Barhoumi R, Qian Y, Burghardt RC, Tiffany-Castiglioni E.
Neurotoxicol Teratol. ; 32(1):16-24.
A 78-kDa glucose-regulated protein is involved in the decrease of interleukin-6 secretion by lead treatment from astrocytes.
Qian Y, Zheng Y, Weber D, Tiffany-Castiglioni E.
Am J Physiol Cell Physiol. ; 293(3):C897-905.
Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells.
Qian Y, Zheng Y, Abraham L, Ramos KS, Tiffany-Castiglioni E.
Brain Res Mol Brain Res. ; 134(2):323-32.
GRP78 compartmentalized redistribution in Pb-treated glia: role of GRP78 in lead-induced oxidative stress.
Qian Y, Zheng Y, Ramos KS, Tiffany-Castiglioni E.
Neurotoxicology. ; 26(2):267-75.
Toxicity assessment of complex mixtures remains a goal.
Donnelly KC, Lingenfelter R, Cizmas L, Falahatpisheh MH, Qian Y, Tang Y, Garcia S, Ramos K, Tiffany-Castiglioni E, Mumtaz MM.
Environ Toxicol Pharmacol. ; 18(2):135-41.
Induction of 78 kD glucose-regulated protein (GRP78) expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells.
Qian Y, Falahatpisheh MH, Zheng Y, Ramos KS, Tiffany-Castiglioni E.
Neurotox Res. ; 3(6):581-9.
Lead-induced endoplasmic reticulum (ER) stress responses in the nervous system.
Qian Y, Tiffany-Castiglioni E.
Neurochem Res. ; 28(1):153-62.
Astroglia as metal depots: molecular mechanisms for metal accumulation, storage and release.
Tiffany-Castiglion E, Qian Y.
Neurotoxicology. ; 22(5):577-92.
Lead targets GRP78, a molecular chaperone, in C6 rat glioma cells.
Qian Y, Harris ED, Zheng Y, Tiffany-Castiglioni E.
Toxicol Appl Pharmacol. ; 163(3):260-6.
Expression of recombinant human acetylcholinesterase and its application in screening its inhibitors.
Wang XJ, Wu HX, Ye SS, Pan LY, Qian YC.
Yao Xue Xue Bao. ; 49(1):50-4.


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