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W. Les Dees


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Phone: (979) 845-1430

Mailstop: 4458

Department: VIBS

Photo of Dees, W. Les


  • Post-Doc Neuroendocrinology, University of Texas - Southwestern Medical Center 1986
  • Ph.D. Anatomy, Texas A&M University 1982
  • M.S. Reproductive Physiology, Texas A&M University 1979
  • B.S. Biomedical Sciences, Texas A&M University 1972
  • B.S. Animal Science, Texas A&M University 1971


  • Toxicology
  • Neuroscience

Interdisciplinary Activities

  • Neuroscience
  • Toxicology
  • Reproductive Biology

Scholarly Interests

Factors controlling or altering the onset of female puberty.


Improvement in in vitro fertilization outcome following in vivo synchronization of oocyte maturation in mice.
Taiyeb AM, Muhsen-Alanssari SA, Dees W, Ridha-Albarzanchi MT, Kraemer DC
Exp Biol Med (Maywood).
Prepubertal exposure to elevated manganese results in estradiol regulated mammary gland ductal differentiation and hyperplasia in female rats.
Dearth RK, Hiney JK, Srivastava VK, Hamilton AM, Dees WL
Exp Biol Med (Maywood). 239(7):871-882.
Host neuro- immuno-endocrine responses in periodontal disease.
Rettori E, De Laurentiis A, Dees WL, Endruhn A, Rettori V
Curr Pharm Des. 20(29):4749-59.
Actions and interactions of alcohol and transforming growth factor β1 on prepubertal hypothalamic gonadotropin-releasing hormone.
Srivastava VK, Hiney JK, Dees WL
Alcohol Clin Exp Res. 38(5):1321-9.
Cilostazol administered to female mice induces ovulation of immature oocytes: a contraceptive animal model.
Taiyeb AM, Ridha MT, Sayes CM, Dees WL, Kraemer DC
Life Sci. 96(1-2):46-52.
In vitro effects of cilostazol, a phosphodiesterase 3A inhibitor, on mouse oocyte maturation and morphology.
Taiyeb AM, Dees WL, Ridha-Albarzanchi MT, Sayes CM, Kraemer DC
Clin Exp Pharmacol Physiol. 41(2):147-53.
Lipopolysaccharide-induced leptin release is neurally controlled.
Mastronardi CA, Yu WH, Srivastava VK, Dees WL, McCann SM
Proc Natl Acad Sci U S A. 98(25):14720-5.
Lamprey gonadotropin-releasing hormone-III selectively releases follicle stimulating hormone in the bovine.
Dees WL, Dearth RK, Hooper RN, Brinsko SP, Romano JE, Rahe H, Yu WH, McCann SM
Domest Anim Endocrinol. 20(4):279-88.
Neurotrophins and the neuroendocrine brain: different neurotrophins sustain anatomically and functionally segregated subsets of hypothalamic dopaminergic neurons.
Berg-von der Emde K, Dees WL, Hiney JK, Hill DF, Dissen GA, Costa ME, Moholt-Siebert M, Ojeda SR
J Neurosci. 15(6):4223-37.
An interleukin-1-alpha-like neuronal system in the preoptic-hypothalamic region and its induction by bacterial lipopolysaccharide in concentrations which alter pituitary hormone release.
Rettori V, Dees WL, Hiney JK, Lyson K, McCann SM
Neuroimmunomodulation. 1(4):251-8.
Induction by cytokines of the pattern of pituitary hormone secretion in infection.
McCann SM, Karanth S, Kamat A, Dees WL, Lyson K, Gimeno M, Rettori V
Neuroimmunomodulation. 1(1):2-13.
Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro.
Rettori V, Belova N, Dees WL, Nyberg CL, Gimeno M, McCann SM
Proc Natl Acad Sci U S A. 90(21):10130-4.
Evidence that somatostatin is localized and synthesized in lymphoid organs.
Aguila MC, Dees WL, Haensly WE, McCann SM
Proc Natl Acad Sci U S A. 88(24):11485-9.
Influences of manganese of female puberty
Dees WL, Hiney JK, Srivastava VK
Curr Trends in Neurology.
Functional recovery of the developing rat ovary after transplantation: contribution of the extrinsic innervation.
Lara HE, Dees WL, Hiney JK, Dissen GA, Rivier C, Ojeda SR
Endocrinology. 129(4):1849-60.
Insulin-like growth factor I: a possible metabolic signal involved in the regulation of female puberty.
Hiney JK, Ojeda SR, Dees WL
Neuroendocrinology. 54(4):420-3.
Expression of beta-nerve growth factor in cultured cells derived from the hypothalamus and cerebral cortex.
Gonzalez D, Dees WL, Hiney JK, Ojeda SR, Saneto RP
Brain Res. 511(2):249-58.
Ethanol alters vasoactive intestinal peptide-induced steroid release from immature rat ovaries in vitro.
Dees WL, Hiney JK, Fuentes F, Forrest DW
Life Sci. 46(3):165-72.
Effects of ethanol during the onset of female puberty.
Dees WL, Skelley CW
Neuroendocrinology. 51(1):64-9.
Influence of ethanol on growth hormone secretion in adult and prepubertal female rats.
Dees WL, Skelley CW, Rettori V, Kentroti MS, McCann SM
Neuroendocrinology. 48(5):495-9.
Evidence for a physiological role of hypothalamic gastrin-releasing peptide to suppress growth hormone and prolactin release in the rat.
Kentroti S, Dees WL, McCann SM
Proc Natl Acad Sci U S A. 85(3):953-7.
Detrimental effects of short-term ethanol exposure on reproductive function in the female rat.
Rettori V, Skelley CW, McCann SM, Dees WL
Biol Reprod. 37(5):1089-96.
Biochemical and immunocytochemical characterization of neuropeptide Y in the immature rat ovary.
McDonald JK, Dees WL, Ahmed CE, Noe BD, Ojeda SR
Endocrinology. 120(5):1703-10.
Substance P- and vasoactive intestinal peptide-containing fibers reach the ovary by independent routes.
Dees WL, Ahmed CE, Ojeda SR
Endocrinology. 119(2):638-41.
The immature rat ovary is innervated by vasoactive intestinal peptide (VIP)-containing fibers and responds to VIP with steroid secretion.
Ahmed CE, Dees WL, Ojeda SR
Endocrinology. 118(4):1682-9.
Central effects of an antagonist and an antiserum to substance P on serum gonadotropin and prolactin secretion.
Dees WL, Skelley CW, Kozlowski GP
Life Sci. 37(17):1627-31.
Ethanol and the pulsatile release of luteinizing hormone, follicle stimulating hormone and prolactin in ovariectomized rats.
Dees WL, Rettori V, Kozlowski GP, McCann SM
Alcohol. 2(5):641-6.
Evidence for the existence of substance P in the prepubertal rat ovary. II. Immunocytochemical localization.
Dees WL, Kozlowski GP, Dey R, Ojeda SR
Biol Reprod. 33(2):471-6.
Differential effects of ethanol on luteinizing hormone, follicle stimulating hormone and prolactin secretion in the female rat.
Dees WL, Kozlowski GP
Alcohol. 1(6):429-33.
Effects of castration and ethanol on amygdaloid substance P immunoreactivity.
Dees WL, Kozlowski GP
Neuroendocrinology. 39(3):231-5.
Intragastric cannulation as a method of ethanol administration for neuroendocrine studies.
Dees WL, Skelley CW, Kozlowski GP
Alcohol. 1(3):177-80.
Immunocytochemistry for LHRH neurons in the arcuate nucleus area of the rat: fact or artifact?
Kozlowski GP, Dees WL
J Histochem Cytochem. 32(1):83-91.
Quantitative and qualitative effects of ethanol on the LHRH-LH axis of the rat.
Dees WL, Kozlowski GP
Peptides. 5 Suppl 1:209-13.
Effects of ethanol on hypothalamic luteinizing hormone-releasing hormone (LHRH) in the male rat. An immunocytochemical study.
Dees WL, McArthur NH, Harms PG
Exp Brain Res. 54(2):197-202.
Effects of ethanol on rat hypothalamic luteinizing hormone releasing hormone. A study utilizing radioimmunoassay.
Dees WL, Mc Arthur NH, Farr KL, Culler MD, Harms PG
Biol Reprod. 28(5):1066-70.
Inhibition of the postovariectomy depletion of hypothalamic luteinizing hormone releasing hormone (LHRH) by suckling.
Culler MD, McArthur NH, Dees WL, Owens RE, Harms PG
Biol Reprod. 26(4):633-9.
Immunocytochemical evidence that suckling inhibits the postovariectomy depletion of median eminence luteinizing hormone releasing hormone.
Culler MD, McArthur NH, Dees WL, Owens RE, Harms PG
Neuroendocrinology. 34(4):258-64.
Immunohistochemical localization of gonadotropin releasing hormone (GnRH) in the bovine hypothalamus and infundibulum.
Dees WL, McArthur NH
Anat Rec. 200(3):281-5.
GnRH localization in the equine brain and infundibulum: an immunohistochemical study.
Dees WL, Sorensen AM Jr, Kemp WM, McArthur NH
Brain Res. 208(1):123-34.
Immunohistochemical localization of gonadotropin-releasing hormone (GnRH) in the brain and infundibulum of the sheep.
Dees WL, Sorensen AM Jr, Kemp WM, McArthur NH
Cell Tissue Res. 215(1):181-91.
Comparison of four kits for enzymatic determination of ethanol in blood.
Redetzki HM, Dees WL
Clin Chem. 22(1):83-6.
Influence of potassium chloride on alcohol absorption.
Redetzki HM, Dees WL, Maddox JH
Life Sci. 15(12):2145-56.
Early life manganese exposure upregulates tumor-associated genes in the hypothalamus of female rats: relationship to manganese-induced precocious puberty.
Srivastava VK, Hiney JK, Dees WL
Toxicol Sci. 136(2):373-81.
Cilostazol blocks pregnancy in naturally cycling mice.
Albarzanchi AM, Sayes CM, Ridha Albarzanchi MT, Fajt VR, Dees WL, Kraemer DC
Contraception. 87(4):443-8.
Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancer.
Dearth RK, Delgado DA, Hiney JK, Pathiraja T, Oesterreich S, Medina D, Dees WL, Lee AV
Cancer Prev Res (Phila). 3(3):312-21.
Actions and interactions of alcohol and insulin-like growth factor-1 on female pubertal development.
Dees WL, Srivastava V, Hiney JK
Alcohol Clin Exp Res. 33(11):1847-56.
Acute effect of manganese on hypothalamic luteinizing hormone releasing hormone secretion in adult male rats: involvement of specific neurotransmitter systems.
Prestifilippo JP, Fernández-Solari J, De Laurentiis A, Mohn CE, de la Cal C, Reynoso R, Dees WL, Rettori V
Toxicol Sci. 105(2):295-302.
Effect of manganese on luteinizing hormone-releasing hormone secretion in adult male rats.
Prestifilippo JP, Fernández-Solari J, Mohn C, De Laurentiis A, McCann SM, Dees W, Rettori V
Toxicol Sci. 97(1):75-80.
Origin and ontogeny of mammalian ovarian neurons.
Dees WL, Hiney JK, McArthur NH, Johnson GA, Dissen GA, Ojeda SR
Endocrinology. 147(8):3789-96.
Lipopolysaccharide-induced leptin synthesis and release are differentially controlled by alpha-melanocyte-stimulating hormone.
Mastronardi CA, Srivastava V, Yu WH, Dees WL, McCann SM
Neuroimmunomodulation. 12(3):182-8.
Alcohol alters luteinizing hormone secretion in immature female rhesus monkeys by a hypothalamic action.
Dissen GA, Dearth RK, Scott HM, Ojeda SR, Dees WL
Endocrinology. 145(10):4558-64.
Influence of estradiol on insulin-like growth factor-1-induced luteinizing hormone secretion.
Hiney JK, Srivastava V, Dearth RK, Dees WL
Brain Res. 1013(1):91-7.
Hypothalamic control of gonadotropin secretion.
McCann SM, Karanth S, Mastronardi CA, Dees WL, Childs G, Miller B, Sower S, Yu WH
Prog Brain Res. 141:151-64.
Intrinsic neurons in the mammalian ovary.
D'Albora H, Anesetti G, Lombide P, Dees WL, Ojeda SR
Microsc Res Tech. 59(6):484-9.
Lamprey GnRH-III acts on its putative receptor via nitric oxide to release follicle-stimulating hormone specifically.
Yu WH, Karanth S, Mastronardi CA, Sealfon S, Dean C, Dees WL, McCann SM
Exp Biol Med (Maywood). 227(9):786-93.
Alcohol and female puberty: the role of intraovarian systems.
Dees WL, Srivastava VK, Hiney JK
Alcohol Res Health. 25(4):271-5.
Control of gonadotropin secretion by follicle-stimulating hormone-releasing factor, luteinizing hormone-releasing hormone, and leptin.
McCann SM, Karanth S, Mastronardi CA, Dees WL, Childs G, Miller B, Sower S, Yu WH
Arch Med Res. 32(6):476-85.
Manganesse protects against the effects of alcohol on hypothalamic puberty-related hormones.
Hiney JK, VK Srivastava, WL Dees
Life Sciences.
Manganese stimulated kisspeptin is mediated by the IGF-1/Akt/mTOR pathway.
Srivastava VK, JK Hiney, WL Dees
Alcohol alters IGF-1 and transforming growth factor beta1 synthesis in the medial basal hypothalamus of the prepubertal female rat.
Hiney JK, Srivastava VK, Dees WL
Alc: Clin. Exp. Res.
Alcohol alters hypothalamic glial-neuronal communications involved in the neuroendocrine control of puberty: In vivo and in vitro assessments.
Dees WL, Hiney JK, Srivastava VK
Differential effects of alcohol on excitatory and inhibitory puberty-related peptides in the basal hypothalamus of the female rat.
Srivastava VK, JK Hiney, K Stevener, WL Dees
Alc: Clin Exp Res.

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