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David W Threadgill

Distinguished Professor and Director of the Texas A&M Institute of Genome Sciences and Society


Mailstop: 4467

Department: VTPB

Photo of Threadgill, David


  • Ph.D. Genetics, Texas A&M University 1989
  • BS Zoology, Texas A&M University 1983

Scholarly Interests

My laboratory uses the mouse as an experimental genetic model to investigate factors that contribute to inter-individual differences in health and disease. Our current research activities include the identification and functional characterization of alleles contributing to cancer susceptibility, the function of the Erbb gene family in development and disease, and the role of genetic variation in response to environmental stimuli. To support these investigations, we also are developing new genetic tools to support mammalian systems genetic approaches to phenotypes with complex genetic and environmental etiologies. Cancer genetics: We are focusing on colorectal and breast cancer to identify environmental factors and genetic polymorphisms contributing to differential susceptibility to the development and progression of cancer. We are also developing approaches to exploit these factors to prevent or delay cancer as well as to identify new therapies. Epidermal growth factor receptor (Egfr): We are using mouse models with genetically engineered or spontaneous mutations to elucidate the biological role of Egfr and other member of the Erbb gene family in vivo. These studies have lead to new insights into the role of these genes in neuronal survival and behavior, obesity, cancer and cardiovascular disease. We are currently performing mechanistic studies to identify how the Erbb genes contribute to normal and abnormal phenotypes. Genetics of environmental response: Just as individuals differ in their genetic constitution and disease susceptibility, they also differ in their responses to exogenous stimuli. We are using mouse models to investigate responses to environmental factors like the enteric flora of the gastrointestinal tract and diet and toxicants like dioxin and trichloroethane. The goal of these studies is to identify how individual responses to environmental factors leads to differential disease susceptibilities. Systems genetics resources: We are leading a large international effort to develop and exploit a new mouse genetic resources that will support the integration of genetics into systems biological analyses at the whole animal level. These efforts are based upon the Collaborative Cross, which is a unique recombinant inbred population of mice that have randomly assorted the genetic polymorphisms present in the eight founder inbred strains.


A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner.
Donohoe DR, Holley D, Collins LB, Montgomery SA, Whitmore AC, Hillhouse A, Curry KP, Renner SW, Greenwalt A, Ryan EP, Godfrey V, Heise MT, Threadgill DS, Han A, Swenberg JA, Threadgill DW, Bultman SJ
Cancer Discov. 2014 4(12):1387-97.
Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice.
Church RJ, Gatti DM, Urban TJ, Long N, Yang X, Shi Q, Eaddy JS, Mosedale M, Ballard S, Churchill GA, Navarro V, Watkins PB, Threadgill DW, Harrill AH
Food Chem Toxicol. 2014 76C:19-26.
Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice.
Scheving LA, Zhang X, Stevenson MC, Threadgill DW, Russell WE
Am J Physiol Gastrointest Liver Physiol. 2014
SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.
Didion JP, Buus RJ, Naghashfar Z, Threadgill DW, Morse HC 3rd, de Villena FP
BMC Genomics. 2014 15(15):847.
The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.
Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJ
PLoS Genet. 2014 10(6):.
Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice.
Scheving LA, Zhang X, Garcia OA, Wang RF, Stevenson MC, Threadgill DW, Russell WE
Am J Physiol Gastrointest Liver Physiol. 2014 306(5):.
Using the emerging Collaborative Cross to probe the immune system.
Phillippi J, Xie Y, Miller DR, Bell TA, Zhang Z, Lenarcic AB, Aylor DL, Krovi SH, Threadgill DW, de Villena FP, Wang W, Valdar W, Frelinger JA
Genes Immun. 2014 15(1):38-46.
Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK.
Neufert C, Becker C, Türeci Ö, Waldner MJ, Backert I, Floh K, Atreya I, Leppkes M, Jefremow A, Vieth M, Schneider-Stock R, Klinger P, Greten FR, Threadgill DW, Sahin U, Neurath MF
J Clin Invest. 2013 123(4):1428-43.
Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.
Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Villena F, Baric RS, Heise MT
PLoS Pathog. 2013 9(2):.
Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones.
Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill D, Okada Y, Toyama Y, Sato K
PLoS One. 2013 8(1):.
Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross.
Eversley CD, Yuying X, Pearsall RS, Threadgill DW
G3 (Bethesda). 2012 2(12):1577-84.
Status and access to the Collaborative Cross population.
Welsh CE, Miller DR, Manly KF, Wang J, McMillan L, Morahan G, Mott R, Iraqi FA, Threadgill DW, de Villena FP
Mamm Genome. 2012 23(9-10):706-12.
Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts.
Mustafi R, Dougherty U, Shah H, Dehghan H, Gliksberg A, Wu J, Zhu H, Joseph L, Hart J, Dive C, Fichera A, Threadgill D, Bissonnette M
Carcinogenesis. 2012 33(10):1930-9.
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.
Franzke CW, Cobzaru C, Triantafyllopoulou A, Löffek S, Horiuchi K, Threadgill DW, Kurz T, van Rooijen N, Bruckner-Tuderman L, Blobel CP
J Exp Med. 2012 209(6):1105-19.
Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice.
Crowley JJ, Kim Y, Szatkiewicz JP, Pratt AL, Quackenbush CR, Adkins DE, van den Oord E, Bogue MA, Yang H, Wang W, Threadgill DW, de Villena FP, McLeod HL, Sullivan PF
Mamm Genome. 2012 23(5-6):322-35.
EGFR signaling promotes TGFβ-dependent renal fibrosis.
Chen J, Chen JK, Nagai K, Plieth D, Tan M, Lee TC, Threadgill DW, Neilson EG, Harris RC
J Am Soc Nephrol. 2012 23(2):215-24.
Genetic analysis of hematological parameters in incipient lines of the collaborative cross.
Kelada SN, Aylor DL, Peck BC, Ryan JF, Tavarez U, Buus RJ, Miller DR, Chesler EJ, Threadgill DW, Churchill GA, Pardo-Manuel de Villena F, Collins FS
G3 (Bethesda). 2012 2(2):157-65.
Ten years of the collaborative cross.
Threadgill DW, Churchill GA
G3 (Bethesda). 2012 2(2):153-6.
Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer.
Rinella ES, Bankaitis ED, Threadgill DW
Cancer Biol Ther. 2012 13(3):130-7.
Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice.
Bottomly D, Ferris MT, Aicher LD, Rosenzweig E, Whitmore A, Aylor DL, Haagmans BL, Gralinski LE, Bradel-Tretheway BG, Bryan JT, Threadgill DW, de Villena FP, Baric RS, Katze MG, Heise M, McWeeney SK
G3 (Bethesda). 2012 2(2):213-21.
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.
Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL
Nat Med. 2011 17(10):1242-50.
MicroRNA expression in the livers of inbred mice.
Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I
Mutat Res. 2011 714(1-2):126-33.
Genetic analysis of complex traits in the emerging Collaborative Cross.
Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SN, Collins FS, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, de Villena FP, Churchill GA
Genome Res. 2011 21(8):1213-22.
Architecture of energy balance traits in emerging lines of the Collaborative Cross.
Mathes WF, Aylor DL, Miller DR, Churchill GA, Chesler EJ, de Villena FP, Threadgill DW, Pomp D
Am J Physiol Endocrinol Metab. 2011 300(6):.
Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice.
Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I
Toxicol Sci. 2011 120(1):206-17.
Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross.
Eversley CD, Clark T, Xie Y, Steigerwalt J, Bell TA, de Villena FP, Threadgill DW
BMC Genet. 2010 11(11):98.
SYSGENET: a meeting report from a new European network for systems genetics.
Schughart K, SYSGENET consortium
Mamm Genome. 2010 21(7-8):331-6.
Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis.
Gordon RR, La Merrill M, Hunter KW, Sørensen P, Threadgill DW, Pomp D
Clin Exp Metastasis. 2010 27(5):279-93.
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors.
Powell CL, Bradford BU, Craig CP, Tsuchiya M, Uehara T, O'Connell TM, Pogribny IP, Melnyk S, Koop DR, Bleyle L, Threadgill DW, Rusyn I
Toxicol Sci. 2010 115(1):131-9.
Targeted inactivation of EGF receptor inhibits renal collecting duct development and function.
Zhang Z, Pascuet E, Hueber PA, Chu L, Bichet DG, Lee TC, Threadgill DW, Goodyer P
J Am Soc Nephrol. 2010 21(4):573-8.
EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo.
Mascia F, Cataisson C, Lee TC, Threadgill D, Mariani V, Amerio P, Chandrasekhara C, Souto Adeva G, Girolomoni G, Yuspa SH, Pastore S
J Invest Dermatol. 2010 130(3):682-93.
Dietary fat alters pulmonary metastasis of mammary cancers through cancer autonomous and non-autonomous changes in gene expression.
La Merrill M, Gordon RR, Hunter KW, Threadgill DW, Pomp D
Clin Exp Metastasis. 2010 27(2):107-16.
Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia.
Moy SS, Ghashghaei HT, Nonneman RJ, Weimer JM, Yokota Y, Lee D, Lai C, Threadgill DW, Anton ES
J Neurodev Disord. 2009 1(4):302-12.
Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2.
Dougherty U, Cerasi D, Taylor I, Kocherginsky M, Tekin U, Badal S, Aluri L, Sehdev A, Cerda S, Mustafi R, Delgado J, Joseph L, Zhu H, Hart J, Threadgill D, Fichera A, Bissonnette M
Clin Cancer Res. 2009 15(22):6780-9.
Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW
Genome Res. 2009 19(9):1507-15.
Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium.
Lee D, Yu M, Lee E, Kim H, Yang Y, Kim K, Pannicia C, Kurie JM, Threadgill DW
J Clin Invest. 2009 119(9):2702-13.
Animal models of autism spectrum disorders: information for neurotoxicologists.
Halladay AK, Amaral D, Aschner M, Bolivar VJ, Bowman A, DiCicco-Bloom E, Hyman SL, Keller F, Lein P, Pessah I, Restifo L, Threadgill DW
Neurotoxicology. 2009 30(5):811-21.
Parent-of-origin effects on cardiac response to pressure overload in mice.
Barrick CJ, Dong A, Waikel R, Corn D, Yang F, Threadgill DW, Smyth SS
Am J Physiol Heart Circ Physiol. 2009 297(3):.
The gastrointestinal microbiome: a malleable, third genome of mammals.
Carroll IM, Threadgill DW, Threadgill DS
Mamm Genome. 2009 20(7):395-403.
Replication and narrowing of gene expression quantitative trait loci using inbred mice.
Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I
Mamm Genome. 2009 20(7):437-46.
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice.
Barrick CJ, Roberts RB, Rojas M, Rajamannan NM, Suitt CB, O'Brien KD, Smyth SS, Threadgill DW
Am J Physiol Heart Circ Physiol. 2009 297(1):.
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.
Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I
Toxicol Sci. 2009 110(1):235-43.
Murine models of colorectal cancer.
Uronis JM, Threadgill DW
Mamm Genome. 2009 20(5):261-8.
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW, Janssen KP, Robine S, Velcich A, Augenlicht LH, Black AR, Black JD
Exp Cell Res. 2009 315(8):1415-28.
The EGFR is required for proper innervation to the skin.
Maklad A, Nicolai JR, Bichsel KJ, Evenson JE, Lee TC, Threadgill DW, Hansen LA
J Invest Dermatol. 2009 129(3):690-8.
ERBBs in the gastrointestinal tract: recent progress and new perspectives.
Fiske WH, Threadgill D, Coffey RJ
Exp Cell Res. 2009 315(4):583-601.
Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat.
La Merrill M, Baston DS, Denison MS, Birnbaum LS, Pomp D, Threadgill DW
Am J Physiol Endocrinol Metab. 2009 296(1):.
The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics.
Chesler EJ, Miller DR, Branstetter LR, Galloway LD, Jackson BL, Philip VM, Voy BH, Culiat CT, Threadgill DW, Williams RW, Churchill GA, Johnson DK, Manly KF
Mamm Genome. 2008 19(6):382-9.
Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice.
Barrick CJ, Yu M, Chao HH, Threadgill DW
Toxicol Appl Pharmacol. 2008 228(3):315-25.
Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis.
Gordon RR, Hunter KW, La Merrill M, Sørensen P, Threadgill DW, Pomp D
Mamm Genome. 2008 19(3):179-89.
Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos.
Dackor J, Strunk KE, Wehmeyer MM, Threadgill DW
Placenta. 2007 28(11-12):1211-8.
Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome.
Huang H, Eversley CD, Threadgill DW, Zou F
Genetics. 2007 176(4):2529-40.
The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics.
Roberts A, Pardo-Manuel de Villena F, Wang W, McMillan L, Threadgill DW
Mamm Genome. 2007 18(6-7):473-81.
Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy.
Barrick CJ, Rojas M, Schoonhoven R, Smyth SS, Threadgill DW
Am J Physiol Heart Circ Physiol. 2007 292(5):.
Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation.
Hsieh M, Lee D, Panigone S, Horner K, Chen R, Theologis A, Lee DC, Threadgill DW, Conti M
Mol Cell Biol. 2007 27(5):1914-24.
Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains.
Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP, Barbaro JR, Wilson LM, Threadgill DW, Lauder JM, Magnuson TR, Crawley JN
Behav Brain Res. 2007 176(1):4-20.
Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice.
Roberts RB, Thompson CL, Lee D, Mankinen RW, Sancar A, Threadgill DW
J Circadian Rhythms. 2006 4(4):15.
Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment.
Deloris Alexander A, Orcutt RP, Henry JC, Baker J Jr, Bissahoyo AC, Threadgill DW
Mamm Genome. 2006 17(11):1093-104.
Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype.
Nadler JJ, Zou F, Huang H, Moy SS, Lauder J, Crawley JN, Threadgill DW, Wright FA, Magnuson TR
Genetics. 2006 174(3):1229-36.
Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet.
Bissahoyo A, Pearsall RS, Hanlon K, Amann V, Hicks D, Godfrey VL, Threadgill DW
Toxicol Sci. 2005 88(2):340-5.
Quantitative trait locus analysis using recombinant inbred intercrosses: theoretical and empirical considerations.
Zou F, Gelfond JA, Airey DC, Lu L, Manly KF, Williams RW, Threadgill DW
Genetics. 2005 170(3):1299-311.
Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function.
Chesler EJ, Lu L, Shou S, Qu Y, Gu J, Wang J, Hsu HC, Mountz JD, Baldwin NE, Langston MA, Threadgill DW, Manly KF, Williams RW
Nat Genet. 2005 37(3):233-42.
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis.
Roberts RB, Min L, Washington MK, Olsen SJ, Settle SH, Coffey RJ, Threadgill DW
Proc Natl Acad Sci U S A. 2002 99(3):1521-6.
Microarray foray.
Coffey RJ, Threadgill D
Breast Cancer Res. 2000 2(1):8-9.
Syntenic assignment of human chromosome 1 homologous loci in the bovine.
Threadgill DS, Threadgill DW, Moll YD, Weiss JA, Zhang N, Davey HW, Wildeman AG, Womack JE
Genomics. 1994 22(3):626-30.
Physical mapping of the lysozyme gene family in cattle.
Gallagher DS Jr, Threadgill DW, Ryan AM, Womack JE, Irwin DM
Mamm Genome. 1993 4(7):368-73.
Synteny mapping in the bovine: genes from human chromosome 4.
Zhang N, Threadgill DW, Womack JE
Genomics. 1992 14(1):131-6.
Somatic cell mapping, polymorphism, and linkage analysis of bovine prolactin-related proteins and placental lactogen.
Dietz AB, Georges M, Threadgill DW, Womack JE, Schuler LA
Genomics. 1992 14(1):137-43.
Synteny mapping of human chromosome 8 loci in cattle.
Threadgill DW, Womack JE
Anim Genet. 1991 22(2):117-22.
Somatic cell mapping of bovine clathrin light chain genes: identification of a new bovine syntenic group.
Gallagher DS, Threadgill DW, Jackson AP, Parham P, Womack JE
Cytogenet Cell Genet. 1991 56(3-4):154-6.
Genomic analysis of the major bovine milk protein genes.
Threadgill DW, Womack JE
Nucleic Acids Res. 1990 18(23):6935-42.
Syntenic conservation between humans and cattle. II. Human chromosome 12.
Threadgill DW, Adkison LR, Womack JE
Genomics. 1990 8(1):29-34.
Syntenic conservation between humans and cattle. I. Human chromosome 9.
Threadgill DW, Womack JE
Genomics. 1990 8(1):22-8.
The thyroglobulin gene is syntenic with the MYC and MOS protooncogenes and carbonic anhydrase II and maps to chromosome 14 in cattle.
Threadgill DW, Fries R, Faber LK, Vassart G, Gunawardana A, Stranzinger G, Womack JE
Cytogenet Cell Genet. 1990 53(1):32-6.

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