Skip Navigation

Christopher M Seabury

Associate Professor

Send Email

Phone: (979) 845-2720

Mailstop: 4467

Department: VTPB

Photo of Seabury, Christopher

Web Presence


  • Ph.D. Genetics, Texas A&M University 2004
  • M.S. Biology, Sul Ross State University 2000
  • B.S. Zoology, Sul Ross State University 1997

Scholarly Interests

Mammalian molecular genetics, genomics, and population genetics; animal disease genomics; utilization of population and quantitative genetics to elucidate host loci and relevant variation influencing differential susceptibility to disease, adaptability, and feed efficiency; next generation sequencing and de novo genome assembly as a mechanism to enable novel research programs in non-model mammalian and avian species of interest.


Production of hornless dairy cattle from genome-edited cell lines.
Carlson DF, Lancto CA, Zang B, Kim ES, Walton M, Oldeschulte D, Seabury C, Sonstegard TS, Fahrenkrug SC..
Nat Biotechnol.. 2016 May; 34(5):479-81.
PMID: 27153274 []
Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle.
Brunelle BW, O'Grady AM, Nicholson EM, Seabury CM..
PLoS One. 2016 May; 11(5):e0155924.
PMID: 27224046 []
Mechanisms underlying mammalian hybrid sterility in two feline interspecies models.
Davis BW, Seabury CM, Brashear W, Li G, Roelke-Parker M, Murphy WJ..
Molecular Biology and Evolution. 2015 May; .
PMID: 26006188 []
Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome.
Tizioto PC, Kim J, Seabury CM, Schnabel RD, Gershwin LJ, Van Eenennaam AL, Toaff-Rosenstein R, Neibergs HL, Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team, Taylor JF.
PLoS One. 2015 ; 10(6):e0131459.
PMID: 26121276 [PubMed - as supplied by publisher]
Northern Bobwhite (Colinus virginianus) Mitochondrial Population Genomics Reveals Structure, Divergence, and Evidence for Heteroplasmy
Yvette A. Halley, David L. Oldeschulte, Eric K. Bhattarai, Joshua Hill, Richard P. Metz, Charles D. Johnson, Steven M. Presley, Rebekah E. Ruzicka, Dale Rollins, Markus J. Peterson, William J. Murphy, Christopher M. Seabury .
PLoS One. 2015 Dec; .
PMID: 26713762 []
Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle.
Decker JE, McKay SD, Rolf MM, Kim J, Molina Alcalá A, Sonstegard TS, Hanotte O, Götherström A, Seabury CM, Praharani L, Babar ME, Correia de Almeida Regitano L, Yildiz MA, Heaton MP, Liu WS, Lei CZ, Reecy JM, Saif-Ur-Rehman M, Schnabel RD, Taylor JF.
PLoS Genet. 2014 Mar; 10(3):e1004254.
PMID: 24675901 [PubMed - in process]
A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene.
Halley YA, Dowd SE, Decker JE, Seabury PM, Bhattarai E, Johnson CD, Rollins D, Tizard IR, Brightsmith DJ, Peterson MJ, Taylor JF, Seabury CM.
PLoS One. 2014 ; 9(3):e90240.
PMID: 24621616 [PubMed - in process]
QTLs associated with dry matter intake, metabolic mid-test weight, growth and feed efficiency have little overlap across 4 beef cattle studies.
Saatchi M, Beever JE, Decker JE, Faulkner DB, Freetly HC, Hansen SL, Yampara-Iquise H, Johnson KA, Kachman SD, Kerley MS, Kim J, Loy DD, Marques E, Neibergs HL, Pollak EJ, Schnabel RD, Seabury CM, Shike DW, Snelling WM, Spangler ML, Weaber RL, Garrick DJ, Taylor JF.
BMC Genomics. 2014 Nov; 15:1004.
PMID: 25410110 [PubMed - in process]
Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility.
Van Eenennaam A, Neibergs H, Seabury C, Taylor J, Wang Z, Scraggs E, Schnabel RD, Decker J, Wojtowicz A, Aly S, Davis J, Blanchard P, Crossley B, Rossitto P, Lehenbauer T, Hagevoort R, Chavez E, Neibergs JS, Womack JE.
Anim Health Res Rev. 2014 Nov; :1-4.
PMID: 25384903 [PubMed - as supplied by publisher]
Susceptibility loci revealed for bovine respiratory disease complex in pre-weaned holstein calves.
Neibergs HL, Seabury CM, Wojtowicz AJ, Wang Z, Scraggs E, Kiser J, Neupane M, Womack JE, Van Eenennaam A, Hagevoort GR, Lehenbauer TW, Aly S, Davis J, Taylor JF.
BMC Genomics. 2014 Dec; 15(1):1164.
PMID: 25534905 [PubMed - as supplied by publisher]
A Multi-Platform Draft de novo Genome Assembly and Comparative Analysis for the Scarlet Macaw (Ara macao).
Seabury CM, Dowd SE, Seabury PM, Raudsepp T, Brightsmith DJ, Liboriussen P, Halley Y, Fisher CA, Owens E, Viswanathan G, Tizard IR.
PLoS One. 2013 ; 8(5):e62415.
PMID: 23667475 [PubMed - in process]
Innate immune gene variation and differential susceptibility to uterine diseases in Holstein cows.
Pinedo PJ, Galvão KN, Seabury CM.
Theriogenology. 2013 Sep; 80(4):384-90.
PMID: 23768650 [PubMed - in process]
Evolution of the Bovine TLR Gene Family and Member Associations with Mycobacterium avium Subspecies paratuberculosis Infection.
Fisher CA, Bhattarai EK, Osterstock JB, Dowd SE, Seabury PM, Vikram M, Whitlock RH, Schukken YH, Schnabel RD, Taylor JF, Womack JE, Seabury CM.
PLoS One. 2011 ; 6(11):e27744.
PMID: 22164200 [PubMed - as supplied by publisher]
Quantum dots trigger immunomodulation of the NF?B pathway in human skin cells.
Romoser AA, Chen PL, Berg JM, Seabury C, Ivanov I, Criscitiello MF, Sayes CM.
Mol Immunol. 2011 Jul; 48(12-13):1349-59.
PMID: 21481475 [PubMed - indexed for MEDLINE]
Genome-wide polymorphism and comparative analyses in the white-tailed deer (Odocoileus virginianus): a model for conservation genomics.
Seabury CM, Bhattarai EK, Taylor JF, Viswanathan GG, Cooper SM, Davis DS, Dowd SE, Lockwood ML, Seabury PM.
PLoS One. 2011 Jan; 6(1):e15811.
PMID: 21283515 [PubMed - indexed for MEDLINE]
Effect of classifying disease states in genetic association studies for paratuberculosis.
Osterstock JB, Sinha S, Seabury CM, Cohen ND.
Prev Vet Med. 2010 Jun; 95(1-2):41-9.
PMID: 20363040 [PubMed - indexed for MEDLINE]
Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattle.
Seabury CM, Seabury PM, Decker JE, Schnabel RD, Taylor JF, Womack JE.
Proc Natl Acad Sci U S A. 2010 Jan; 107(1):151-6.
PMID: 20018671 [PubMed - indexed for MEDLINE]
Resolving the evolution of extant and extinct ruminants with high-throughput phylogenomics.
Decker JE, Pires JC, Conant GC, McKay SD, Heaton MP, Chen K, Cooper A, Vilkki J, Seabury CM, Caetano AR, Johnson GS, Brenneman RA, Hanotte O, Eggert LS, Wiener P, Kim JJ, Kim KS, Sonstegard TS, Van Tassell CP, Neibergs HL, McEwan JC, Brauning R, Coutinho LL, Babar ME, Wilson GA, McClure MC, Rolf MM, Kim J, Schnabel RD, Taylor JF.
Proc Natl Acad Sci U S A. 2009 Nov; 106(44):18644-9.
PMID: 19846765 [PubMed - indexed for MEDLINE]
Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.
Gillenwaters EN, Seabury CM, Elliott JS, Womack JE.
J Hered. 2009 Mar; 100(2):241-5.
PMID: 19136450 [PubMed - indexed for MEDLINE]
A 4,103 marker integrated physical and comparative map of the horse genome.
Raudsepp T, Gustafson-Seabury A, Durkin K, Wagner ML, Goh G, Seabury CM, Brinkmeyer-Langford C, Lee EJ, Agarwala R, Stallknecht-Rice E, Schäffer AA, Skow LC, Tozaki T, Yasue H, Penedo MC, Lyons LA, Khazanehdari KA, Binns MM, MacLeod JN, Distl O, Guérin G, Leeb T, Mickelson JR, Chowdhary BP.
Cytogenet Genome Res. 2008 ; 122(1):28-36.
PMID: 18931483 [PubMed - indexed for MEDLINE]
Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattle.
Brunelle BW, Greenlee JJ, Seabury CM, Brown CE 2nd, Nicholson EM.
BMC Vet Res. 2008 Sep; 4:36.
PMID: 18808703 [PubMed - indexed for MEDLINE]
Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6.
Seabury CM, Womack JE.
Genomics. 2008 Oct; 92(4):235-45.
PMID: 18639626 [PubMed - indexed for MEDLINE]
Molecular characterization of the Rocky Mountain elk (Cervus elaphus nelsoni) PRNP putative promoter.
Seabury CM, Gill CA, Templeton JW, Dyar JB, Derr JN, Adelson DL, Owens E, Davis DS, Kraemer DC, Womack JE.
J Hered. 2007 Nov; 98(7):678-86.
PMID: 18032463 [PubMed - indexed for MEDLINE]
Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10.
Seabury CM, Cargill EJ, Womack JE.
Genomics. 2007 Oct; 90(4):502-15.
PMID: 17719743 [PubMed - indexed for MEDLINE]
Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosis.
Kahl-McDonagh MM, Elzer PH, Hagius SD, Walker JV, Perry QL, Seabury CM, den Hartigh AB, Tsolis RM, Adams LG, Davis DS, Ficht TA.
Vaccine. 2006 Jun; 24(24):5169-77.
PMID: 16697090 [PubMed - indexed for MEDLINE]
Bison PRNP genotyping and potential association with Brucella spp. seroprevalence.
Seabury CM, Halbert ND, Gogan PJ, Templeton JW, Derr JN.
Anim Genet. 2005 Apr; 36(2):104-10.
PMID: 15771718 [PubMed - indexed for MEDLINE]
Comparative PRNP genotyping of U.S. cattle sires for potential association with BSE.
Seabury CM, Womack JE, Piedrahita J, Derr JN.
Mamm Genome. 2004 Oct; 15(10):828-33.
PMID: 15520885 [PubMed - indexed for MEDLINE]
Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3.
Seabury CM, Honeycutt RL, Rooney AP, Halbert ND, Derr JN.
Proc Natl Acad Sci U S A. 2004 Oct; 101(42):15142-7.
PMID: 15477588 [PubMed - indexed for MEDLINE]
Identification of a novel ovine PrP polymorphism and scrapie-resistant genotypes for St. Croix White and a related composite breed.
Seabury CM, Derr JN.
Cytogenet Genome Res. 2003 ; 102(1-4):85-8.
PMID: 14970684 [PubMed - indexed for MEDLINE]

Request Update