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Christopher M Seabury

Associate Professor

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Phone: (979) 845-2720

Mailstop: 4467

Department: VTPB

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Web Presence

Education

  • Ph.D. Genetics, Texas A&M University 2004
  • M.S. Biology, Sul Ross State University 2000
  • B.S. Zoology, Sul Ross State University 1997

Scholarly Interests

Mammalian molecular genetics, genomics, and population genetics; animal disease genomics; utilization of population and quantitative genetics to elucidate host loci and relevant variation influencing differential susceptibility to disease, adaptability, and feed efficiency; next generation sequencing and de novo genome assembly as a mechanism to enable novel research programs in non-model mammalian and avian species of interest.

Publications

Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle.
Brian W Brunelle, Allison M O'Grady, Eric M Nicholson, Christopher M Seabury
PloS one. 2016 11(5).
Production of hornless dairy cattle from genome-edited cell lines.
Daniel F Carlson, Cheryl A Lancto, Bin Zang, Eui-Soo Kim, Mark Walton, David Oldeschulte, Christopher Seabury, Tad S Sonstegard, Scott C Fahrenkrug
Nature biotechnology. 2016 34(5):479-81.
Northern Bobwhite (Colinus virginianus) Mitochondrial Population Genomics Reveals Structure, Divergence, and Evidence for Heteroplasmy.
Yvette A Halley, David L Oldeschulte, Eric K Bhattarai, Joshua Hill, Richard P Metz, Charles D Johnson, Steven M Presley, Rebekah E Ruzicka, Dale Rollins, Markus J Peterson, William J Murphy, Christopher M Seabury
PloS one. 2015 10(12).
Mechanisms Underlying Mammalian Hybrid Sterility in Two Feline Interspecies Models.
Brian W Davis, Christopher M Seabury, Wesley A Brashear, Gang Li, Melody Roelke-Parker, William J Murphy
Molecular biology and evolution. 2015 32(10):2534-46.
Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome.
Polyana C Tizioto, JaeWoo Kim, Christopher M Seabury, Robert D Schnabel, Laurel J Gershwin, Alison L Van Eenennaam, Rachel Toaff-Rosenstein, Holly L Neibergs, , Jeremy F Taylor
PloS one. 2015 10(6).
Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility.
Alison Van Eenennaam, Holly Neibergs, Christopher Seabury, Jeremy Taylor, Zeping Wang, Erik Scraggs, Robert D Schnabel, Jared Decker, Andrzej Wojtowicz, Sharif Aly, Jessica Davis, Patricia Blanchard, Beate Crossley, Paul Rossitto, Terry Lehenbauer, Robert Hagevoort, Erik Chavez, J Shannon Neibergs, James E Womack
Animal health research reviews. 2014 15(2):157-60.
Susceptibility Loci Revealed for Bovine Respiratory Disease Complex in Pre-Weaned Holstein Calves
*Holly L. Neibergs, *Christopher M. Seabury, Andrzej J. Wojtowicz, Zeping Wang,Erik Scraggs, Jennifer Kiser, Mahesh Neupane, James E. Womack, Alison Van Eenennaam, G. Robert Hagevoort, Terry W. Lehenbauer, Sharif Aly, Jessica Davis, Jeremy F. Taylor
BMC Genomics . 2014
QTLs associated with dry matter intake, metabolic mid-test weight, growth or feed efficiency have little overlap across 4 beef cattle studies
Mahdi Saatchi, Jonathan E Beever, Jared E. Decker, Dan B. Faulkner, Harvey C Freetly, Stephanie L Hansen, Helen Yampara-Iquise, Kristen A Johnson, Stephen D Kachman, Monty S Kerley, JaeWoo Kim, Daniel D Loy, Elisa Marques, Holly L Neibergs, E John Pollak, Robert D Schnabel, Christopher M Seabury, Daniel W Shike, Warren M Snelling, Matthew L Spangler, Robert L Weaber, Dorian J Garrick, and Jeremy F Taylor
BMC genomics. 2014
A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene.
Halley YA, Dowd SE, Decker JE, Seabury PM, Bhattarai E, Johnson CD, Rollins D, Tizard IR, Brightsmith DJ, Peterson MJ, Taylor JF, Seabury CM
PLoS One. 2014 9(3).
Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle.
Decker JE, McKay SD, Rolf MM, Kim J, Molina Alcalá A, Sonstegard TS, Hanotte O, Götherström A, Seabury CM, Praharani L, Babar ME, Correia de Almeida Regitano L, Yildiz MA, Heaton MP, Liu WS, Lei CZ, Reecy JM, Saif-Ur-Rehman M, Schnabel RD, Taylor JF
PLoS Genet. 2014 10(3).
A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao).
Christopher M Seabury, Scot E Dowd, Paul M Seabury, Terje Raudsepp, Donald J Brightsmith, Poul Liboriussen, Yvette Halley, Colleen A Fisher, Elaine Owens, Ganesh Viswanathan, Ian R Tizard
PloS one. 2013 8(5).
Evolution of the bovine TLR gene family and member associations with Mycobacterium avium subspecies paratuberculosis infection.
Colleen A Fisher, Eric K Bhattarai, Jason B Osterstock, Scot E Dowd, Paul M Seabury, Meenu Vikram, Robert H Whitlock, Ynte H Schukken, Robert D Schnabel, Jeremy F Taylor, James E Womack, Christopher M Seabury
PloS one. 2011 6(11).
Quantum dots trigger immunomodulation of the NFκB pathway in human skin cells.
Amelia A Romoser, Patricia L Chen, J Michael Berg, Christopher Seabury, Ivan Ivanov, Michael F Criscitiello, Christie M Sayes
Molecular immunology. 2011 48(12-13):1349-59.
Genome-wide polymorphism and comparative analyses in the white-tailed deer (Odocoileus virginianus): a model for conservation genomics.
Christopher M Seabury, Eric K Bhattarai, Jeremy F Taylor, Ganesh G Viswanathan, Susan M Cooper, Donald S Davis, Scot E Dowd, Mitch L Lockwood, Paul M Seabury
PloS one. 2011 6(1).
Effect of classifying disease states in genetic association studies for paratuberculosis.
J B Osterstock, S Sinha, C M Seabury, N D Cohen
Preventive veterinary medicine. 2010 95(1-2):41-9.
Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattle.
Christopher M Seabury, Paul M Seabury, Jared E Decker, Robert D Schnabel, Jeremy F Taylor, James E Womack
Proceedings of the National Academy of Sciences of the United States of America. 2010 107(1):151-6.
Resolving the evolution of extant and extinct ruminants with high-throughput phylogenomics.
Jared E Decker, J Chris Pires, Gavin C Conant, Stephanie D McKay, Michael P Heaton, Kefei Chen, Alan Cooper, Johanna Vilkki, Christopher M Seabury, Alexandre R Caetano, Gary S Johnson, Rick A Brenneman, Olivier Hanotte, Lori S Eggert, Pamela Wiener, Jong-Joo Kim, Kwan Suk Kim, Tad S Sonstegard, Curt P Van Tassell, Holly L Neibergs, John C McEwan, Rudiger Brauning, Luiz L Coutinho, Masroor E Babar, Gregory A Wilson, Matthew C McClure, Megan M Rolf, Jaewoo Kim, Robert D Schnabel, Jeremy F Taylor
Proceedings of the National Academy of Sciences of the United States of America. 2009 106(44):18644-9.
Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.
Erin N Gillenwaters, Christopher M Seabury, Janice S Elliott, James E Womack
The Journal of heredity. 2009 100(2):241-5.
A 4,103 marker integrated physical and comparative map of the horse genome.
T Raudsepp, A Gustafson-Seabury, K Durkin, M L Wagner, G Goh, C M Seabury, C Brinkmeyer-Langford, E-J Lee, R Agarwala, E Stallknecht-Rice, A A Schäffer, L C Skow, T Tozaki, H Yasue, M C T Penedo, L A Lyons, K A Khazanehdari, M M Binns, J N MacLeod, O Distl, G Guérin, T Leeb, J R Mickelson, B P Chowdhary
Cytogenetic and genome research. 2008 122(1):28-36.
Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattle.
Brian W Brunelle, Justin J Greenlee, Christopher M Seabury, Charles E Brown, Eric M Nicholson
BMC veterinary research. 2008 4:36.
Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6.
C M Seabury, J E Womack
Genomics. 2008 92(4):235-45.
Molecular characterization of the Rocky Mountain elk (Cervus elaphus nelsoni) PRNP putative promoter.
Christopher M Seabury, Clare A Gill, Joe W Templeton, Joseph B Dyar, James N Derr, David L Adelson, Elaine Owens, Donald S Davis, Duane C Kraemer, James E Womack
The Journal of heredity. 2007 98(7):678-86.
Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10.
C M Seabury, E J Cargill, J E Womack
Genomics. 2007 90(4):502-15.
Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosis.
Melissa M Kahl-McDonagh, Philip H Elzer, Sue D Hagius, Joel V Walker, Quinesha L Perry, Christopher M Seabury, Andreas B den Hartigh, Renee M Tsolis, L Garry Adams, Donald S Davis, Thomas A Ficht
Vaccine. 2006 24(24):5169-77.
Bison PRNP genotyping and potential association with Brucella spp. seroprevalence.
C M Seabury, N D Halbert, P J P Gogan, J W Templeton, J N Derr
Animal genetics. 2005 36(2):104-10.
Comparative PRNP genotyping of U.S. cattle sires for potential association with BSE.
Christopher M Seabury, James E Womack, Jorge Piedrahita, James N Derr
Mammalian genome : official journal of the International Mammalian Genome Society. 2004 15(10):828-33.
Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3.
Christopher M Seabury, Rodney L Honeycutt, Alejandro P Rooney, Natalie D Halbert, James N Derr
Proceedings of the National Academy of Sciences of the United States of America. 2004 101(42):15142-7.
Identification of a novel ovine PrP polymorphism and scrapie-resistant genotypes for St. Croix White and a related composite breed.
C M Seabury, J N Derr
Cytogenetic and genome research. 2004 102(1-4):85-8.


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