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Ian Tizard

Distinguished Professor


Phone: (979) 845-4276

Mailstop: 4467

Department: VTPB

Photo of Tizard, Ian

Personal Statement

As a career immunologist, I have focused on applied immunology, especially on innovative methods of vaccination. Thus I am working on methods of intranasal and oral vaccination against many different diseases. My second major area of interest has been the field of emerging viruses and diseases of wild and exotic birds. Most recently we have focused on the unusual epidemiology and biology of avian bornavirus. Currently however I have come to recognize the critical importance of genomic sequencing and bioinformatics. My major current efforts are studies on the pathogenesis of, and immunity to avian bornaviruses. I have also had many productive collaborations on other vaccines, including influenza vaccines under development by KJ Biosciences. I am uniquely situated in the environment of a major College of Veterinary Medicine to assist this SBIR phase I-II project which involves the critical immunogenicity and protection studies in dogs. My role in this project is to provide assistance and oversight for these studies.


Peru: The college has two formal agreements (Convenios) with the main Peruvian Veterinary Schools. Heredia Cayetana and San Marcos. Both commit us to collaborate in the area of avian research and conservation. There are multiple collaborative projects underway in Tambopata, in investigating the wild bird trade and in studying the epidemiology of selected avian diseases.

Argentina: The Schubot Center is supporting a project to determine causes of nestling mortality in the Patagonian subspecies of the peregrine falcon.

Canada: The Schubot Center is collaborating with scientists at the University of Guelph on the detection of avian bornavirus in arctic waterfowl.


  • Ph.D. Immunology, University of Cambridge, England 1969
  • B.Sc. Pathology, University of Edinburgh, Scotland, UK 1966
  • B.V.M.& S. Veterinary Medicine, University of Edinburgh, Scotland, UK 1965


  • ACVM (Honorary)
  • DSc (Honorary). University of Guelph

Scholarly Interests

Immunology with an emphasis on innovative vaccine technology and on the immunology of domestic mammals.Avian diseases with an emphasis on diseases of psittacinesPaleovirology,Genomics with an emphasis on whole avian genomes.The intestinal microbiome and its role in immunity.


Characterization of a new genotype of avian bornavirus from wild ducks.
Guo J, Shivaprasad HL, Rech RR, Heatley JJ, Tizard I, Payne S
Virol J. 2014 11(1):197.
Avian bornaviruses: diagnosis, isolation, and genotyping.
Guo J, Payne S, Zhang S, Turner D, Tizard I, Suchodolski P
Curr Protoc Microbiol. 2014 34(34):15.
A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene.
Halley YA, Dowd SE, Decker JE, Seabury PM, Bhattarai E, Johnson CD, Rollins D, Tizard IR, Brightsmith DJ, Peterson MJ, Taylor JF, Seabury CM
PLoS One. 2014 9(3):.
Supercritical fluid extraction provides an enhancement to the immune response for orally-delivered hepatitis B surface antigen.
Hayden CA, Smith EM, Turner DD, Keener TK, Wong JC, Walker JH, Tizard IR, Jimenez-Flores R, Howard JA
Vaccine. 2014 32(11):1240-6.
A multi-platform draft de novo genome assembly and comparative analysis for the Scarlet Macaw (Ara macao).
Seabury CM, Dowd SE, Seabury PM, Raudsepp T, Brightsmith DJ, Liboriussen P, Halley Y, Fisher CA, Owens E, Viswanathan G, Tizard IR
PLoS One. 2013 8(5):.
Avian bornavirus and proventricular dilatation disease: diagnostics, pathology, prevalence, and control.
Hoppes SM, Tizard I, Shivaprasad HL
Vet Clin North Am Exot Anim Pract. 2013 16(2):339-55.
Ancient T-independence of mucosal IgX/A: gut microbiota unaffected by larval thymectomy in Xenopus laevis.
Mashoof S, Goodroe A, Du CC, Eubanks JO, Jacobs N, Steiner JM, Tizard I, Suchodolski JS, Criscitiello MF
Mucosal Immunol. 2013 6(2):358-68.
Positive reinforcement training facilitates the voluntary participation of laboratory macaws with veterinary procedures.
Daugette KF, Hoppes S, Tizard I, Brightsmith D
J Avian Med Surg. 2012 26(4):248-54.
Birds and bornaviruses.
Payne SL, Delnatte P, Guo J, Heatley JJ, Tizard I, Smith DA
Anim Health Res Rev. 2012 13(2):145-56.
Bioencapsulation of the hepatitis B surface antigen and its use as an effective oral immunogen.
Hayden CA, Streatfield SJ, Lamphear BJ, Fake GM, Keener TK, Walker JH, Clements JD, Turner DD, Tizard IR, Howard JA
Vaccine. 2012 30(19):2937-42.
Detection and characterization of a distinct bornavirus lineage from healthy Canada geese (Branta canadensis).
Payne S, Covaleda L, Jianhua G, Swafford S, Baroch J, Ferro PJ, Lupiani B, Heatley J, Tizard I
J Virol. 2011 85(22):12053-6.
Proventricular dilatation disease in cockatiels (Nymphicus hollandicus) after infection with a genotype 2 avian bornavirus.
Mirhosseini N, Gray PL, Hoppes S, Tizard I, Shivaprasad HL, Payne S
J Avian Med Surg. 2011 25(3):199-204.
Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine.
Velasquez LS, Shira S, Berta AN, Kilbourne J, Medi BM, Tizard I, Ni Y, Arntzen CJ, Herbst-Kralovetz MM
Vaccine. 2011 29(32):5221-31.
Molecular characterization of the cloacal microbiota of wild and captive parrots.
Xenoulis PG, Gray PL, Brightsmith D, Palculict B, Hoppes S, Steiner JM, Tizard I, Suchodolski JS
Vet Microbiol. 2010 146(3-4):320-5.
The diagnosis of proventricular dilatation disease: use of a Western blot assay to detect antibodies against avian Borna virus.
Villanueva I, Gray P, Mirhosseini N, Payne S, Hoppes S, Honkavuori KS, Briese T, Turner D, Tizard I
Vet Microbiol. 2010 143(2-4):196-201.
Histopathology and the detection of avian bornavirus in the nervous system of birds diagnosed with proventricular dilatation disease.
Ouyang N, Storts R, Tian Y, Wigle W, Villanueva I, Mirhosseini N, Payne S, Gray P, Tizard I
Avian Pathol. 2009 38(5):393-401.
Humoral response to Mycobacterium avium subsp. avium in naturally infected ring-neck doves (Streptopelia risoria).
Gray PL, Saggese MD, Phalen DN, Tizard I
Vet Immunol Immunopathol. 2008 125(3-4):216-24.
Development of a contagious ecthyma vaccine for goats.
Musser JM, Taylor CA, Guo J, Tizard IR, Walker JW
Am J Vet Res. 2008 69(10):1366-70.
Sickness behavior, its mechanisms and significance.
Tizard I
Anim Health Res Rev. 2008 9(1):87-99.
Stabilization of growth factors relevant to wound healing by a plant cell wall biomaterial.
Ni Y, Turner D, Yates K, Tizard I
Planta Med. 2007 73(12):1260-6.
Isolation and characterization of structural components of Aloe vera L. leaf pulp.
Ni Y, Turner D, Yates KM, Tizard I
Int Immunopharmacol. 2004 4(14):1745-55.
In situ detection and quantification of bursa of fabricius cellular proliferation or apoptosis in normal or steroid-treated neonatal chicks.
Higgins SE, Berghman LR, Moore RW, Caldwell DJ, Caldwell DY, Tizard I, Hargis BM
Poult Sci. 2002 81(8):1136-41.
Specificity and prevalence of natural bovine antimannan antibodies.
Srinivasan A, Ni Y, Tizard I
Clin Diagn Lab Immunol. 1999 6(6):946-52.
Use of serologic testing to assess immune status of companion animals.
Tizard I, Ni Y
J Am Vet Med Assoc. 1998 213(1):54-60.
Antigen dependent adjuvant activity of a polydispersed beta-(1,4)-linked acetylated mannan (acemannan).
Chinnah AD, Baig MA, Tizard IR, Kemp MC
Vaccine. 1992 10(8):551-7.
Evaluation of a killed, whole virion feline leukemia virus vaccine.
Tizard I, Bass EP
J Am Vet Med Assoc. 1991 199(10):1410-3.
Risks associated with use of live vaccines.
Tizard I
J Am Vet Med Assoc. 1990 196(11):1851-8.
The biological activities of mannans and related complex carbohydrates.
Tizard IR, Carpenter RH, McAnalley BH, Kemp MC
Mol Biother. 1989 1(6):290-6.
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity.
Bannister R, Davis D, Zacharewski T, Tizard I, Safe S
Toxicology. 1987 46(1):29-42.

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