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Sangeeta Khare

Adjunct Assistant Professor

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Phone: (979) 845-9814

Mailstop: 4467

Department: VTPB

Photo of Khare, Sangeeta

Education

  • Ph.D. Immunology & Microbiology, All India Institute of Medical Science, India 1996
  • M.S. Life Sciences, Kanpur University, India 1988
  • B.S. Biology and Chemistry, Kanpur University, India 1985

Scholarly Interests

Intracellular pathogens and its cellular and molecular interaction with host (using in vivo and in vitro models) by genomics and transcriptomics approaches. Modulation of host immune responses by natural immunomodulator/vaccination strategy. Genetic diversity within Mycobacterium avium subsp. paratuberculosis and new approaches for molecular diagnosis of Mycobacterium avium subsp. paratuberculosis. Involvement of Mycobacterium avium subsp. paratuberculosis in Crohn’s disease.

Publications

Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: linking systems biology with vaccine development.
Adams LG, Khare S, Lawhon SD, Rossetti CA, Lewin HA, Lipton MS, Turse JE, Wylie DC, Bai Y, Drake KL
Vaccine. 2011 29(41):7197-206.
Multi-comparative systems biology analysis reveals time-course biosignatures of in vivo bovine pathway responses to B.melitensis, S.enterica Typhimurium and M.avium paratuberculosis.
Adams LG, Khare S, Lawhon SD, Rossetti CA, Lewin HA, Lipton MS, Turse JE, Wylie DC, Bai Y, Drake KL
BMC Proc. 2011 5(Suppl 4):S6.
Amplified fragment length polymorphism reveals specific epigenetic distinctions between Mycobacterium avium subspecies paratuberculosis isolates of various isolation types.
O'Shea B, Khare S, Klein P, Roussel A, Adams LG, Ficht TA, Rice-Ficht AC
J Clin Microbiol. 2011 49(6):2222-9.
Vaccination with attenuated Salmonella enterica Dublin expressing E coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E coli O157:H7 in cattle.
Khare S, Alali W, Zhang S, Hunter D, Pugh R, Fang FC, Libby SJ, Adams LG
BMC Vet Res. 2010 6(6):35.
The Salmonella enterica serotype Typhi Vi capsular antigen is expressed after the bacterium enters the ileal mucosa.
Tran QT, Gomez G, Khare S, Lawhon SD, Raffatellu M, Bäumler AJ, Ajithdoss D, Dhavala S, Adams LG
Infect Immun. 2010 78(1):527-35.
Early phase morphological lesions and transcriptional responses of bovine ileum infected with Mycobacterium avium subsp. paratuberculosis.
Khare S, Nunes JS, Figueiredo JF, Lawhon SD, Rossetti CA, Gull T, Rice-Ficht AC, Adams LG
Vet Pathol. 2009 46(4):717-28.
Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways.
Figueiredo JF, Lawhon SD, Gokulan K, Khare S, Raffatellu M, Tsolis RM, Bäumler AJ, McCormick BA, Adams LG
Microbes Infect. 2009 11(2):302-10.
Mycobacterium bovis DeltaleuD auxotroph-induced protective immunity against tissue colonization, burden and distribution in cattle intranasally challenged with Mycobacterium bovis Ravenel S.
Khare S, Hondalus MK, Nunes J, Bloom BR, Garry Adams L
Vaccine. 2007 25(10):1743-55.
Amplified fragment length polymorphism reveals genomic variability among Mycobacterium avium subsp. paratuberculosis isolates.
O'Shea B, Khare S, Bliss K, Klein P, Ficht TA, Adams LG, Rice-Ficht AC
J Clin Microbiol. 2004 42(8):3600-6.
Rapid and sensitive detection of Mycobacterium avium subsp. paratuberculosis in bovine milk and feces by a combination of immunomagnetic bead separation-conventional PCR and real-time PCR.
Khare S, Ficht TA, Santos RL, Romano J, Ficht AR, Zhang S, Grant IR, Libal M, Hunter D, Adams LG
J Clin Microbiol. 2004 42(3):1075-81.
Secreted effector proteins of Salmonella enterica serotype typhimurium elicit host-specific chemokine profiles in animal models of typhoid fever and enterocolitis.
Zhang S, Adams LG, Nunes J, Khare S, Tsolis RM, Bäumler AJ
Infect Immun. 2003 71(8):4795-803.


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