Education
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Postdoc non-coding RNA, hematopoiesis, Whitehead Institue/MIT 2009
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Ph.D Molecular and Cell Biology/Reproductive Biology, Northwestern University 2004
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M.S Molecular and Cell Biology, Peking University 1999
Scholarly Interests
Limited self-renewal and differentiation of hematopoietic stem cells (HSCs) and their progenies rely on a well-orchestrated regulatory network, mainly comprising transcription factors, cytokines and their receptors mediated signaling pathways, and a group of newly discovered microRNAs (miRNAs). Even though there are experimental evidences suggesting the important roles played by miRNAs in this network, the detailed picture is largely unknown.
Our research goal is to reveal the mechanism of leukemogenesis by identifying oncogenes, tumor suppressors and their downstream molecular events that are directly or indirectly targeted by abnormally expressed miRNAs.
Publications
MiR-150 Blocks MLL-AF9 Associated Leukemia By Repressing Multiple Oncogenes.
Bousquet M, Zhuang G, Meng C, Ying W, Cheruku PS, Shie AT, Wang S, Ge G, Wong P, Wang G, Safe S, Zhou B.
Mol Cancer Res. 2013 Apr; .
PMID: 23604034 [PubMed - as supplied by publisher]
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.
Zhuang G, Meng C, Guo X, Cheruku PS, Shi L, Xu H, Li H, Wang G, Evans AR, Safe S, Wu C, Zhou B.
Circulation. 2012 Jun; 125(23):2892-903.
PMID: 22580331 [PubMed - indexed for MEDLINE]
MicroRNA miR-125b causes leukemia.
Bousquet M, Harris MH, Zhou B, Lodish HF.
Proc Natl Acad Sci U S A. 2010 Dec; 107(50):21558-63.
PMID: 21118985 [PubMed - indexed for MEDLINE]
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity.
Liao MJ, Zhang CC, Zhou B, Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA.
Cancer Res. 2007 Sep; 67(17):8131-8.
PMID: 17804725 [PubMed - indexed for MEDLINE]