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Randolph Stewart

Clinical Professor

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Phone: (979) 862-7764

Mailstop: 4466

Department: VTPP

Photo of Stewart, Randolph

Education

  • PhD Veterinary Physiology, Texas A&M University 1997
  • MS Veterinary Clinical Sciences, The Ohio State University 1989
  • DVM Veterinary Medicine, Texas A&M University 1983
  • BS Veterinary Science, Texas A&M University 1981

Credentials

  • Diplomate, American College of Veterinary Internal Medicine
  • Texas Veterinary Medical License: 5354

Scholarly Interests

cardiovascular physiology; lymphatic function; microvascular physiology; interstitial and cavity fluid balance

Publications

Merging clinical cases, client communication and physiology to enhance student engagement, learning and skills
Washburn SE, Posey D, Stewart RH, Rogers KS
J Vet Med Educ. 2016 43:170-175.
Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps.
Dongaonkar RM, Nguyen TL, Quick CM, Heaps CL, Hardy J, Laine GA, Wilson E, Stewart RH
Am J Physiol Heart Circ Physiol. 2015
Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension.
Quick CM, Criscione JC, Kotiya A, Dongaonkar RM, Hardy J, Wilson E, Gashev AA, Laine GA, Stewart RH
Am J Physiol Regul Integr Comp Physiol. 2014 306(12):R901-R907.
Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure.
Dongaonkar RM, Nguyen TL, Quick CM, Hardy J, Laine GA, Wilson E, Stewart RH
Am J Physiol Heart Circ Physiol. 2013 305(2):H203-H210.
Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility.
Chu J, Pham NT, Olate N, Kislitsyna K, Day MC, LeTourneau PA, Kots A, Stewart RH, Laine GA, Cox CS Jr, Uray K
J Biol Chem. 2013 288(2):1200-13.
Award article: Microcirculatory Society Award for Excellence in Lymphatic Research: time course of myocardial interstitial edema resolution and associated left ventricular dysfunction.
Dongaonkar RM, Stewart RH, Quick CM, Uray KL, Cox CS Jr, Laine GA
Microcirculation. 2012 19(8):714-22.
Blood flow augmentation by intrinsic venular contraction in vivo.
Dongaonkar RM, Quick CM, Vo JC, Meisner JK, Laine GA, Davis MJ, Stewart RH
Am J Physiol Regul Integr Comp Physiol. 2012 302(12):R1436-R1442.
Strategies for modulating the inflammatory response after decompression from abdominal compartment syndrome.
Shah SK, Jimenez F, Letourneau PA, Walker PA, Moore-Olufemi SD, Stewart RH, Laine GA, Cox CS Jr
Scand J Trauma Resusc Emerg Med. 2012 20(20):25.
Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle.
Chu J, Miller CT, Kislitsyna K, Laine GA, Stewart RH, Cox CS, Uray KS
Neurogastroenterol Motil. 2012 24(3):257-66.
Peritoneal fluid: a potential mechanism of systemic neutrophil priming in experimental intra-abdominal sepsis.
Shah SK, Jimenez F, Walker PA, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS Jr
Am J Surg. 2012 203(2):211-6.
Evaluating the effects of immediate application of negative pressure therapy after decompression from abdominal compartment syndrome in an experimental porcine model
Shah SK, Jimenez F, Walker PA, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS Jr
European Journal of Trauma and Emergency Surgery. 2011 38:65-73.
Evaluation of gravimetric techniques to estimate the microvascular filtration coefficient.
Dongaonkar RM, Laine GA, Stewart RH, Quick CM
Am J Physiol Regul Integr Comp Physiol. 2011 300(6):R1426-R1436.
Acute renal response to rapid onset respiratory acidosis.
Ramadoss J, Stewart RH, Cudd TA
Can J Physiol Pharmacol. 2011 89(3):227-31.
Resuscitation-induced intestinal edema and related dysfunction: state of the science.
Shah SK, Uray KS, Stewart RH, Laine GA, Cox CS Jr
J Surg Res. 2011 166(1):120-30.
Sodium hydrogen exchanger as a mediator of hydrostatic edema-induced intestinal contractile dysfunction.
Uray KS, Shah SK, Radhakrishnan RS, Jimenez F, Walker PA, Stewart RH, Laine GA, Cox CS Jr
Surgery. 2011 149(1):114-25.
A murine model for the study of edema induced intestinal contractile dysfunction.
Shah SK, Moore-Olufemi SD, Uray KS, Jimenez F, Walker PA, Xue H, Stewart RH, Laine GA, Cox CS Jr
Neurogastroenterol Motil. 2010 22(10):1132-e290.
Nonlinear lymphangion pressure-volume relationship minimizes edema.
Venugopal AM, Stewart RH, Laine GA, Quick CM
Am J Physiol Heart Circ Physiol. 2010 299(3):H876-H882.
Evaluating the potential role of nitric oxide as a mediator of hydrostatic edema mediated intestinal contractile dysfunction.
Shah SK, Xue H, Jimenez F, Kots AY, Choi BK, Uray KS, Walker PA, Moore-Olufemi SD, Velez N, Stewart RH, Laine GA, Cox CS Jr
J Surg Res. 2010 163(1):102-109.
A novel mechanism for neutrophil priming in trauma: potential role of peritoneal fluid.
Shah SK, Jimenez F, Walker PA, Aroom KR, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS Jr
Surgery. 2010 148(2):263-70.
Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function.
Dongaonkar RM, Stewart RH, Geissler HJ, Laine GA
Cardiovasc Res. 2010 87(2):331-9.
Hydrostatic intestinal edema induced signaling pathways: potential role of mechanical forces.
Shah SK, Fogle LN, Aroom KR, Gill BS, Moore-Olufemi SD, Jimenez F, Uray KS, Walker PA, Stewart RH, Laine GA, Cox CS Jr
Surgery. 2010 147(6):772-9.
A novel physiologic model for the study of abdominal compartment syndrome (ACS).
Shah SK, Jimenez F, Walker PA, Xue H, Uray KS, Aroom KR, Fischer UM, Laine GA, Stewart RH, Norbury KC, Cox CS Jr
J Trauma. 2010 68(3):682-9.
Hypertonic saline alters hydraulic conductivity and up-regulates mucosal/submucosal aquaporin 4 in resuscitation-induced intestinal edema.
Radhakrishnan RS, Shah SK, Lance SH, Radhakrishnan HR, Xue H, Radhakrishnan GL, Ramaswamy US, Walker PA, Uray KS, Laine GA, Stewart RH, Cox CS Jr
Crit Care Med. 2009 37(11):2946-52.
Intestinal edema: effect of enteral feeding on motility and gene expression.
Moore-Olufemi SD, Padalecki J, Olufemi SE, Xue H, Oliver DH, Radhakrishnan RS, Allen SJ, Moore FA, Stewart R, Laine GA, Cox CS Jr
J Surg Res. 2009 155(2):283-92.
Balance point characterization of interstitial fluid volume regulation.
Dongaonkar RM, Laine GA, Stewart RH, Quick CM
Am J Physiol Regul Integr Comp Physiol. 2009 297(1):R6-R16.
Venomotion modulates lymphatic pumping in the bat wing.
Dongaonkar RM, Stewart RH, Laine GA, Davis MJ, Zawieja DC, Quick CM
Am J Physiol Heart Circ Physiol. 2009 296(6):H2015-H2021.
Lymphatic pump-conduit duality: contraction of postnodal lymphatic vessels inhibits passive flow.
Quick CM, Ngo BL, Venugopal AM, Stewart RH
Am J Physiol Heart Circ Physiol. 2009 296(3):H662-H668.
Optimal postnodal lymphatic network structure that maximizes active propulsion of lymph.
Venugopal AM, Quick CM, Laine GA, Stewart RH
Am J Physiol Heart Circ Physiol. 2009 296(2):H303-H309.
Integrating research and education at research-extensive universities with research-intensive communities.
Desai KV, Gatson SN, Stiles TW, Stewart RH, Laine GA, Quick CM
Adv Physiol Educ. 2008 32(2):136-41.
Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema.
Desai KV, Laine GA, Stewart RH, Cox CS Jr, Quick CM, Allen SJ, Fischer UM
Am J Physiol Heart Circ Physiol. 2008 294(6):H2428-H2434.
First-order approximation for the pressure-flow relationship of spontaneously contracting lymphangions.
Quick CM, Venugopal AM, Dongaonkar RM, Laine GA, Stewart RH
Am J Physiol Heart Circ Physiol. 2008 294(5):H2144-H2149.
Hypertonic saline modulation of intestinal tissue stress and fluid balance.
Cox CS Jr, Radhakrishnan R, Villarrubia L, Xue H, Uray K, Gill BS, Stewart RH, Laine GA
Shock. 2008 29(5):598-602.
Myocardial fluid balance in dogs with naturally acquired heartworm infection.
Stewart RH, Uray K, Cox CS, Laine GA
Am J Vet Res. 2008 69(3):356-61.
Edemagenic gain and interstitial fluid volume regulation.
Dongaonkar RM, Quick CM, Stewart RH, Drake RE, Cox CS Jr, Laine GA
Am J Physiol Regul Integr Comp Physiol. 2008 294(2):R651-R659.
Characteristics of the active lymph pump in bovine prenodal mesenteric lymphatics.
Gashev AA, Wang W, Laine GA, Stewart RH, Zawieja DC
Lymphat Res Biol. 2007 5(2):71-9.
Lymphangion coordination minimally affects mean flow in lymphatic vessels.
Venugopal AM, Stewart RH, Laine GA, Dongaonkar RM, Quick CM
Am J Physiol Heart Circ Physiol. 2007 293(2):H1183-H1189.
Lymphatic vessels transition to state of summation above a critical contraction frequency.
Meisner JK, Stewart RH, Laine GA, Quick CM
Am J Physiol Regul Integr Comp Physiol. 2007 293(1):R200-R208.
Application of local heat induces capillary recruitment in the Pallid bat wing.
Widmer RJ, Stewart RH, Young MF, Laurinec JE, Laine GA, Quick CM
Am J Physiol Regul Integr Comp Physiol. 2007 292(6):R2312-R2317.
Intrinsic pump-conduit behavior of lymphangions.
Quick CM, Venugopal AM, Gashev AA, Zawieja DC, Stewart RH
Am J Physiol Regul Integr Comp Physiol. 2007 292(4):R1510-R1518.
Pulmonary air embolization inhibits lung lymph flow by increasing lymphatic outflow pressure.
Stewart RH, Quick CM, Zawieja DC, Cox CS, Allen SJ, Laine GA
Lymphat Res Biol. 2006 4(1):18-22.
Resolving the hemodynamic inverse problem.
Quick CM, Berger DS, Stewart RH, Laine GA, Hartley CJ, Noordergraaf A
IEEE Trans Biomed Eng. 2006 53(3):361-8.
Impact of acute myocardial edema on left ventricular function.
Fischer UM, Cox CS Jr, Stewart RH, Laine GA, Allen SJ
J Invest Surg. 2006 19(1):31-8.
Inhibition of intestinal transit by resuscitation-induced gut edema is reversed by L-NIL.
Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS Jr
J Surg Res. 2005 129(1):1-5.
Effects of primary and secondary intra-abdominal hypertension on mesenteric lymph flow: implications for the abdominal compartment syndrome.
Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS Jr
Shock. 2005 23(6):571-5.
Resuscitation-induced gut edema and intestinal dysfunction.
Moore-Olufemi SD, Xue H, Attuwaybi BO, Fischer U, Harari Y, Oliver DH, Weisbrodt N, Allen SJ, Moore FA, Stewart R, Laine GA, Cox CS Jr
J Trauma. 2005 58(2):264-70.
Optimal lymphatic vessel structure.
Venugopal AM, Stewart RH, Rajagopalan S, Laine GA, Quick CM
Conf Proc IEEE Eng Med Biol Soc. 2004 5(5):3700-3.
Effect of venous air embolization on pulmonary microvascular protein permeability.
Stewart RH, Allen SJ, Quick CM, Rohn DA, Cox CS, Laine GA
Microcirculation. 2004 11(5):409-14.
The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest.
Fischer UM, Cox CS Jr, Allen SJ, Stewart RH, Mehlhorn U, Laine GA
J Thorac Cardiovasc Surg. 2003 126(5):1483-8.
Flow in lymphatic networks: interaction between hepatic and intestinal lymph vessels.
Stewart RH, Laine GA
Microcirculation. 2001 8(4):221-7.
Protein washdown as a defense mechanism against myocardial edema.
Stewart RH, Geissler HJ, Allen SJ, Laine GA
Am J Physiol Heart Circ Physiol. 2000 279(4):H1864-8.
The case for measuring plasma colloid osmotic pressure.
Stewart RH
J Vet Intern Med. 2000 14(5):473-4.
Basic determinants of epicardial transudation.
Stewart RH, Rohn DA, Allen SJ, Laine GA
Am J Physiol. 1997 273(3 Pt 2):H1408-14.
Regulation of microvascular filtration in the myocardium by interstitial fluid pressure.
Stewart RH, Rohn DA, Mehlhorn U, Davis KL, Allen SJ, Laine GA
Am J Physiol. 1996 271(6 Pt 2):R1465-9.
Renal lymphatic function following venous pressure elevation.
Rohn DA, Stewart RH, Elk JR, Laine GA, Drake RE
Lymphology. 1996 29(2):67-75.
Possible normokalemic variant of hyperkalemic periodic paralysis in two horses.
Stewart RH, Bertone JJ, Yvorchuk-St Jean K, Reed SM, Neil WH Jr
J Am Vet Med Assoc. 1993 203(3):421-4.
Complications of nasogastric intubation in horses: nine cases (1987-1989).
Hardy J, Stewart RH, Beard WL, Yvorchuk-St-Jean K
J Am Vet Med Assoc. 1992 201(3):483-6.
Frequency and severity of osteochondrosis in horses with cervical stenotic myelopathy.
Stewart RH, Reed SM, Weisbrode SE
Am J Vet Res. 1991 52(6):873-9.
Surgical stapling for repair of a rectal tear in a horse.
Stewart RH, Robertson JT
J Am Vet Med Assoc. 1990 197(6):746-8.


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