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Beiyan Zhou

Assistant Professor

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Phone: (979) 845-7175

Mailstop: 4466

Department: VTPP

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  • Postdoc non-coding RNA, hematopoiesis, Whitehead Institute/MIT 2009
  • Ph.D Molecular and Cell Biology/Reproductive Biology, Northwestern University 2004
  • M.S Molecular and Cell Biology, Peking University 1999

Scholarly Interests

The long-term goal of our lab is to understand the systemic network governed by epigenetic factors in stem cells and their progenies. We want to dissect the mechanisms that makes a stem cell a stem cell (cell identity), maintains as a stem cell (stemness) or goes to a specific lineage (cell fate determination). We adopted well established systems to dissect the interactive network controlling adult stem cells and cancer stem cells, and differentiated blood cells functions in the context of diabetes from the angle of non-coding RNAs. Two major direction that we are currently interested in are: a.Mechanism of microRNAs in immune cell function, including macrophage activation and obesity induced cardiac vascular diseases and metabolic syndroms. b.The regulation of microRNAs in hematopoietic stem cell function and leukemic transformation


MiR-150 Blocks MLL-AF9 Associated Leukemia By Repressing Multiple Oncogenes.
Bousquet M, Zhuang G, Meng C, Ying W, Cheruku PS, Shie AT, Wang S, Ge G, Wong P, Wang G, Safe S, Zhou B.
Mol Cancer Res. 2013 Apr; .
PMID: 23604034 [PubMed - as supplied by publisher]
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.
Zhuang G, Meng C, Guo X, Cheruku PS, Shi L, Xu H, Li H, Wang G, Evans AR, Safe S, Wu C, Zhou B.
Circulation. 2012 Jun; 125(23):2892-903.
PMID: 22580331 [PubMed - indexed for MEDLINE]
Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet.
Shah MS, Schwartz SL, Zhao C, Davidson LA, Zhou B, Lupton JR, Ivanov I, Chapkin RS.
Physiol Genomics. 2011 May; 43(10):640-54.
PMID: 21406606 [PubMed - indexed for MEDLINE]
Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells.
Ouyang N, Ke S, Eagleton N, Xie Y, Chen G, Laffins B, Yao H, Zhou B, Tian Y.
Br J Cancer. 2010 Jun; 102(12):1753-61.
PMID: 20531417 [PubMed - indexed for MEDLINE]
MicroRNA miR-125b causes leukemia.
Bousquet M, Harris MH, Zhou B, Lodish HF.
Proc Natl Acad Sci U S A. 2010 Dec; 107(50):21558-63.
PMID: 21118985 [PubMed - indexed for MEDLINE]
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets.
Le MT, Xie H, Zhou B, Chia PH, Rizk P, Um M, Udolph G, Yang H, Lim B, Lodish HF.
Mol Cell Biol. 2009 Oct; 29(19):5290-305.
PMID: 19635812 [PubMed - indexed for MEDLINE]
MicroRNA-125b is a novel negative regulator of p53.
Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, Lodish HF, Lim B.
Genes Dev. 2009 Apr; 23(7):862-76.
PMID: 19293287 [PubMed - indexed for MEDLINE]
Micromanagement of the immune system by microRNAs.
Lodish HF, Zhou B, Liu G, Chen CZ.
Nat Rev Immunol. 2008 Feb; 8(2):120-30.
PMID: 18204468 [PubMed - indexed for MEDLINE]
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity.
Liao MJ, Zhang CC, Zhou B, Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA.
Cancer Res. 2007 Sep; 67(17):8131-8.
PMID: 17804725 [PubMed - indexed for MEDLINE]
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.
Zhou B, Wang S, Mayr C, Bartel DP, Lodish HF.
Proc Natl Acad Sci U S A. 2007 Apr; 104(17):7080-5.
PMID: 17438277 [PubMed - indexed for MEDLINE]
Analysis of placental regulation of hematopoiesis.
Zhou B, Linzer DI.
Methods Mol Med. 2006 ; 122:355-65.
PMID: 16511993 [PubMed - indexed for MEDLINE]
Enhanced recovery from thrombocytopenia and neutropenia in mice constitutively expressing a placental hematopoietic cytokine.
Zhou B, Kong X, Linzer DI.
Endocrinology. 2005 Jan; 146(1):64-70.
PMID: 15375031 [PubMed - indexed for MEDLINE]
Two placental hormones are agonists in stimulating megakaryocyte growth and differentiation.
Zhou B, Lum HE, Lin J, Linzer DI.
Endocrinology. 2002 Nov; 143(11):4281-6.
PMID: 12399423 [PubMed - indexed for MEDLINE]

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