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Cristine Heaps

Associate Professor

Curriculum Vitae

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Phone: (979) 458-0753

Mailstop: 4466

Department: VTPP

Photo of Heaps, Cristine

Education

  • Ph.D. Physiology, University of Missouri 1999
  • M.A. Exercise Physiology, University of Texas 1990
  • B.S. Kinesiology, University of Michigan 1988
  • ,

Scholarly Interests

Dr. Heaps' lab examines the effects of exercise training on cellular and functional adaptations in the coronary circulation in response to coronary artery disease. We are currently exploring adaptive responses in intact vessels and isolated smooth muscle and endothelial cells using isometric tension studies, cannulated microvessel preparations, electrophysiology, fluorescence imaging, and biochemical and molecular techniques.

Publications

Effect of exercise training on nitric oxide and superoxide/H2O2 signaling pathways in collateral-dependent porcine coronary arterioles.
Xie W, Parker JL, Heaps CL.
J Appl Physiol. 2012 May; 112(9):1546-55.
PMID: 22323648 [PubMed - in process]
Exercise training-enhanced, endothelium-dependent dilation mediated by altered regulation of BK(Ca) channels in collateral-dependent porcine coronary arterioles.
Xie W, Parker JL, Heaps CL.
Microcirculation. 2012 Sep; .
PMID: 23002811 [PubMed - as supplied by publisher]
Ca2+ sensitization of cardiac myofilament proteins contributes to exercise training-enhanced myocardial function in a porcine model of chronic occlusion.
Sarin V, Muthuchamy M, Heaps CL.
Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1579-87.
PMID: 21856915 [PubMed - in process]
Effects of exercise training on coronary collateralization and control of collateral resistance.
Heaps CL, Parker JL.
J Appl Physiol. 2011 Aug; 111(2):587-98.
PMID: 21565987 [PubMed - in process]
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
Robles JC, Sturek M, Parker JL, Heaps CL.
Am J Physiol Heart Circ Physiol. 2011 Apr; 300(4):H1201-9.
PMID: 21297028 [PubMed - indexed for MEDLINE]
Fibronectin increases the force production of mouse papillary muscles via a5ß1 integrin.
Wu X, Chakraborty S, Heaps CL, Davis MJ, Meininger GA, Muthuchamy M.
J Mol Cell Cardiol. 2011 Jan; 50(1):203-13.
PMID: 20937283 [PubMed - indexed for MEDLINE]
Effects of exercise training on cellular mechanisms of endothelial nitric oxide synthase regulation in coronary arteries after chronic occlusion.
Zhou M, Widmer RJ, Xie W, Jimmy Widmer A, Miller MW, Schroeder F, Parker JL, Heaps CL.
Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1857-69.
PMID: 20363881 [PubMed - indexed for MEDLINE]
Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs.
Fogarty JA, Delp MD, Muller-Delp JM, Laine GA, Parker JL, Heaps CL.
J Vasc Res. 2009 ; 46(2):152-61.
PMID: 18769069 [PubMed - indexed for MEDLINE]
Effects of exercise training and hypercholesterolemia on adenosine activation of voltage-dependent K+ channels in coronary arterioles.
Heaps CL, Jeffery EC, Laine GA, Price EM, Bowles DK.
J Appl Physiol. 2008 Dec; 105(6):1761-71.
PMID: 18832757 [PubMed - indexed for MEDLINE]
Exercise training increases basal tone in arterioles distal to chronic coronary occlusion.
Heaps CL, Mattox ML, Kelly KA, Meininger CJ, Parker JL.
Am J Physiol Heart Circ Physiol. 2006 Mar; 290(3):H1128-35.
PMID: 16243909 [PubMed - indexed for MEDLINE]
Hypercholesterolemia abolishes voltage-dependent K+ channel contribution to adenosine-mediated relaxation in porcine coronary arterioles.
Heaps CL, Tharp DL, Bowles DK.
Am J Physiol Heart Circ Physiol. 2005 Feb; 288(2):H568-76.
PMID: 15458946 [PubMed - indexed for MEDLINE]
Altered calcium sensitivity contributes to enhanced contractility of collateral-dependent coronary arteries.
Heaps CL, Parker JL, Sturek M, Bowles DK.
J Appl Physiol. 2004 Jul; 97(1):310-6.
PMID: 14978011 [PubMed - indexed for MEDLINE]