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Stephen Safe

Distinguished Professor

Curriculum Vitae

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Phone: (979) 845-5988

Mailstop: 4466

Department: VTPP

Photo of Safe, Stephen

Education

  • D.Phil. Bioorganic Chemistry, Oxford University, Great Britain 1965
  • M.S. Chemistry, Queen's University, Canada 1963
  • B.S. Chemistry, Queen's University, Canada 1962

Scholarly Interests

Toxicology and molecular biology of estrogenic and antiestrogenic compounds; molecular mechanisms of estrogen receptor and Ah receptor action and their crosstalk in breast cancer cells; PPARg agonists and inhibition of cancer cell growth.

Publications

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.
Chintharlapalli S, Papineni S, Lei P, Pathi S, Safe S.
BMC Cancer. 2011 Aug; 11:371.
PMID: 21864401 [PubMed - in process]
Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line.
Barhoumi R, Mouneimne Y, Ramos E, Morisseau C, Hammock BD, Safe S, Parrish AR, Burghardt RC.
Toxicol Appl Pharmacol. 2011 May; 253(1):45-56.
PMID: 21420996 [PubMed - indexed for MEDLINE]
MDM2 regulates estrogen receptor a and estrogen responsiveness in breast cancer cells.
Kim K, Burghardt R, Barhoumi R, Lee SO, Liu X, Safe S.
J Mol Endocrinol. 2011 ; 46(2):67-79.
PMID: 21169420 [PubMed - indexed for MEDLINE]
GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.
Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S.
Mol Cancer Res. 2011 Feb; 9(2):195-202.
PMID: 21156786 [PubMed - indexed for MEDLINE]
Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.
Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S.
Nutr Cancer. 2011 Oct; 63(7):1133-42.
PMID: 21919647 [PubMed - in process]
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.
Vanderlaag K, Su Y, Frankel AE, Burghardt RC, Barhoumi R, Chadalapaka G, Jutooru I, Safe S.
BMC Cancer. 2010 Dec; 10:669.
PMID: 21129193 [PubMed - indexed for MEDLINE]
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.
Jutooru I, Chadalapaka G, Lei P, Safe S.
J Biol Chem. 2010 Aug; 285(33):25332-44.
PMID: 20538607 [PubMed - indexed for MEDLINE]
Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.
Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S.
Mol Pharmacol. 2010 Aug; 78(2):226-36.
PMID: 20488920 [PubMed - indexed for MEDLINE]
Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth.
Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S.
Exp Cell Res. 2010 Aug; 316(13):2174-88.
PMID: 20435036 [PubMed - indexed for MEDLINE]
Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.
Chadalapaka G, Jutooru I, Burghardt R, Safe S.
Mol Cancer Res. 2010 May; 8(5):739-50.
PMID: 20407012 [PubMed - indexed for MEDLINE]
MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.
Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J, Safe S.
Endocrinology. 2010 Jun; 151(6):2462-73.
PMID: 20382698 [PubMed - indexed for MEDLINE]
1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells.
Sreevalsan S, Jutooru I, Chadalapaka G, Walker M, Safe S.
Int J Oncol. 2009 Nov; 35(5):1191-9.
PMID: 19787275 [PubMed - indexed for MEDLINE]
Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.
Papineni S, Chintharlapalli S, Abdelrahim M, Lee SO, Burghardt R, Abudayyeh A, Baker C, Herrera L, Safe S.
Carcinogenesis. 2009 Jul; 30(7):1193-201.
PMID: 19406933 [PubMed - indexed for MEDLINE]
Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative.
Jutooru I, Chadalapaka G, Chintharlapalli S, Papineni S, Safe S.
Mol Carcinog. 2009 Aug; 48(8):692-702.
PMID: 19125423 [PubMed - indexed for MEDLINE]
Curcumin decreases specificity protein expression in bladder cancer cells.
Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R 3rd, Li X, Safe S.
Cancer Res. 2008 Jul; 68(13):5345-54.
PMID: 18593936 [PubMed - indexed for MEDLINE]
Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins.
Higgins KJ, Liu S, Abdelrahim M, Vanderlaag K, Liu X, Porter W, Metz R, Safe S.
Mol Endocrinol. 2008 Feb; 22(2):388-402.
PMID: 18006642 [PubMed - indexed for MEDLINE]
Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells.
Papineni S, Chintharlapalli S, Safe S.
Mol Pharmacol. 2008 Feb; 73(2):553-65.
PMID: 17989348 [PubMed - indexed for MEDLINE]
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.
Mertens-Talcott SU, Chintharlapalli S, Li X, Safe S.
Cancer Res. 2007 Nov; 67(22):11001-11.
PMID: 18006846 [PubMed - indexed for MEDLINE]