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Friedhelm Schroeder

Professor

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Phone: (979) 862-1433

Mailstop: 4466

Department: VTPP

Photo of Schroeder, Friedhelm

Education

  • Postdoctoral Biological Chemistry, Washington University Medical 1976
  • PhD Biochemistry, Michigan State University 1973
  • BS Chemistry Mathematics, University of Pittsburgh 1970

Scholarly Interests

Intracellular lipid transfer proteins; lipid metabolism; multiphoton imaging of intracellular lipid transport and targeting in living cells and tissues of gene targeted animals.

Publications

Human liver fatty acid binding protein (L-FABP) T94A variant enhances cholesterol uptake
Huang H, McIntosh AL, Martin GG, Landrock KK, Landrock D, Storey SM, Gupta S, Atshaves BP, Kier AB, Schroeder F.
Biochim Biophys Acta. ; 1851:946-955.
Loss of L-FABP, SCP-2/SCPx, or both induces hepatic lipid accumulation in female mice
Martin GG, Atshaves BP, Landrock KK, Landrock D, Schroeder F, Kier AB.
Arch Biochem Biophys. ; 580:41-49.
FABP1: a novel hepatic endocannabinoid and cannabinoid binding protein
Huang H, McIntosh A L, Martin GG, Landrock D, Chung S, Landrock KK, Dangott LJ, Li S, Kier AB, Schroeder F. .
Biochemistry. ; 55: 5243-5255.
Fatty acid binding protein-1 (FABP1) and the human FABP1 T94A variant: Roles in the endocannabinoid system and dyslipidemias
Schroeder, F., McIntosh, A. L., Martin, G. G., Huang, H., Landrock D., Chung, S., Landrock, K. K., Dangott, L. J., Li, S., Kaczocha, M., Murphy, E. J., Atshaves, B. P., and Kier, A. B. .
Lipids. ; 51: 655-676.
Duplicated bovine NK-lysin family members exhibit antimicrobial activities against members of the bovine respiratory disease complex
Chen J, Yang C, Tizioto P, Huan H, Lee MOK, Payne R, Lawhon S, Schroeder F, Taylor JF, Womack JE.
Plos Pathogens. ; DOI:10.1371/journal.pone.0158882: DOI:10.1371/journal.pone.0158882.
Fabp1 gene ablation inhibits high fat diet-induced increase in brain endocannabinoids
Martin GG, Landrock D, Chung S, Dangott LJ, Seeger DR, Murphy EJ, Golovko MY, Kier AB, and Schroeder F.
J Neurochem. ; .
Interactions and functional studies of Rotavirus NSP4 with caveolin-1, immunophilins, and cholesterol
Yakshe KA, Gibbons TF, Schroeder F, Lopez S, Ball JM.
Virology. ; .
Endocthelial nitric oxide synthase protein distribution in endothelial cells along the coronary vascular tree
Heaps CL, Bray JF, McIntosh AL, Schroeder F, Israel JH.
Microcirculation. ; .
Female mice are resistant to FABP1 gene ablation-induced alterations in brain endocannabinoid levels
Martin GG, Chung S, Landrock D, Landrock KK, Dangott LJ, Peng X, Kaczocha M, Murphy EJ, Kier AB, and Schroeder F.
Lipids. ; 51: 1007-1020.
Mutational analysis of the rotavirus NSP4 enterotoxic domain that binds to caveolin-1
Ball JM, Schroeder ME, Williams CV, Schroeder F, Parr RD. .
Virology Journal . ; 10:336.
L-FABP gene ablation exacerbates weight gain in high-fat fed female mice
McIntosh AL, Atshaves BP, Landrock D, Landrock KK, Martin GG, Storey SM, Kier AB, Schroeder F.
Lipids . ; 48:435-448, 2013.
Ablating L-FABP in SCP-2/SCP-x null mice impairs bile acid metabolism and biliary HDL-cholesterol secretion
Martin, GG, Atshaves, BP, Landrock, KK, Landrock, D, Storey, SM, Howles, PN, Kier, AB, Schroeder, F.
Am J Physiol Gastrointest Liver Physiol. ; 10.11521ajpgi.00209.2014.
Structural and functional interaction of fatty acids with human liver fatty acid binding protein (L-FABP) T94A variant
Huang, H., McIntosh, A.L., Martin, G.G., Landrock, K.K., Landrock, D., Gupta, S., Atshaves, B.P., Kier, A.B., and Schroeder, F. .
FEBS J. ; 281:2266-2283, 2014..
Human FABP1 T94A variant impacts fatty acid metabolism and PPAR activation in cultured human primary hepatocytes
McIntosh, A.L., Huang, H., Storey, S.M., Landrock, K.K., Landrock, D., Petrescu, A.D., Gupta, S., Atshaves, B.P., Kier, A.B., Schroeder, F..
Am. J. Physiol. Gastrointest. Liver Physiol. . ; 307:G164-G176, 2014.
Human L-FABP T94A variant alters structure, stability, and interaction with fibrates
Martin GG, McIntosh AL, Huang H, Gupta S, Atshaves BP, Kier AB, Schroeder F. .
Biochemistry. ; 52:9347-9357, 2013. .
L-FABP interacts with HNF4alpha
McIntosh AL, Petrescu AD, Hostetler HA, Kier AB, Schroeder F.
FEBS Letters. ; 587:3787-3791, 2013.
High glucose potentiates L-FABP-mediated fibrate induction of PPAR in mouse hepatocytes
Petrescu AD, McIntosh AL, Storey SM, Huang H, Martin GG, Landrock D, Kier AB, Schroeder F.
Biochim Biophys Acta. ; 1831:1412-1425, 2013. .
Inhibitors of fatty acid synthesis induce PPAR-regulated fatty acid -oxidative enzymes: synergistic roles of L-FABP and glucose
Huang H, McIntosh AL, Martin GG, Petrescu AD, Landrock K, Landrock D, Kier AB, Schroeder F..
PPAR Research . ; Article ID 865604.
Impact of L-FABP and glucose on polyunsaturated fatty acid induction of PPAR regulated -oxidative enzymes
Petrescu AD, Huang H, Martin GG, McIntosh AL, Storey SM, Landrock D, Kier AB, Schroeder F. .
Am J Physiol Gastrointest and Liver Phys . ; 301: G241-G256, 2013. .
SCP-2/SCP-x gene ablation exacerbates high-cholesterol induced hepatic lipid accumulation
Klipsic D, Landrock D, Martin GG, McIntosh AL, Landrock KK, Mackie JT, Schroeder F, Kier AB.
Am J Physiol Gastrointest Liver Physiol. ; 309:G387-G399.
FABP1 gene ablation impacts brain endocannabinoid system in male mice
Martin, G., Chung, S., Landrock D., Landrock, K. K., Huang, H., Dangott, L. J., Peng, X., Kaczocha, M., Seeger, D. R., Murphy, E. J., Golovko, M. Y., Kier, A. B., and Schroeder, F..
J Neurochem. ; 138: 407-422.
Relative contributions of L-FABP, SCP-2/SCPx, or both to hepatic biliary phenotype of female mice
Martin GG, Landrock D, Landrock KK, Howles P, Atshaves BP, Kier AB, Schroeder F.
Arch Biochem Biophys. ; .
Duplicated bovine NK-lysin family members exhibit antimicrobial activities against members of the bovine respiratory disease complex
Chen J, Yang C, Tizioto P, Huan H, Lee MOK, Payne R, Lawhon S, Schroeder F, Taylor JF, Womack JE.
PLos Pathogens. ; .


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