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Randolph Stewart

Clinical Professor

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Phone: (979) 862-7764

Mailstop: 4466

Department: VTPP

Photo of Stewart, Randolph

Education

  • PhD Veterinary Physiology, Texas A&M University 1997
  • MS Veterinary Clinical Sciences, The Ohio State University 1989
  • DVM Veterinary Medicine, Texas A&M University 1983
  • BS Veterinary Science, Texas A&M University 1981

Credentials

  • Diplomate, American College of Veterinary Internal Medicine
  • Texas Veterinary Medical License: 5354

Scholarly Interests

cardiovascular physiology; lymphatic function; microvascular physiology; interstitial and cavity fluid balance

Publications

Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps.
Dongaonkar RM, Nguyen TL, Quick CM, Heaps CL, Hardy J, Laine GA, Wilson E, Stewart RH.
Am J Physiol Heart Circ Physiol. ; .
Basic determinants of epicardial transudation.
Stewart RH, Rohn DA, Allen SJ, Laine GA.
Am J Physiol. ; 273(3 Pt 2):H1408-14.
Acute renal response to rapid onset respiratory acidosis.
Ramadoss J, Stewart RH, Cudd TA.
Can J Physiol Pharmacol. ; 89: 227-31.
Intrinsic pump-conduit behavior of lymphangions.
Quick CM, Venugopal AM, Gashev AA, Zawieja DC, Stewart RH.
Am J Physiol Regul Integr Comp Physiol. ; 292: R1510-R1518.
Protein washdown as a defense mechanism against myocardial edema.
Stewart RH, Geissler HJ, Allen SJ, Laine GA.
Am J Physiol Heart Circ Physiol. ; 279(4):H1864-8.
Regulation of microvascular filtration in the myocardium by interstitial fluid pressure.
Stewart RH, Rohn DA, Mehlhorn U, Davis KL, Allen SJ, Laine GA.
Am J Physiol. ; 271(6 Pt 2):R1465-9.
Evaluation of gravimetric techniques to estimate the microvascular filtration coefficient.
Dongaonkar RM, Laine GA, Stewart RH, Quick CM.
Am J Physiol Regul Integr Comp Physiol. ; 300: R1426-R1436.
Effect of venous air embolization on pulmonary microvascular protein permeability.
Stewart RH, Allen SJ, Quick CM, Rohn DA, Cox CS, Laine GA.
Microcirculation. ; 11(5):409-14.
Merging clinical cases, client communication and physiology to enhance student engagement, learning and skills
Washburn SE, Posey D, Stewart RH, Rogers KS.
J Vet Med Educ. ; 43: 170-175.
Evaluating the effects of immediate application of negative pressure therapy after decompression from abdominal compartment syndrome in an experimental porcine model
Shah SK, Jimenez F, Walker PA, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS Jr.
European Journal of Trauma and Emergency Surgery. ; 38: 65-73.
Sodium hydrogen exchanger as a mediator of hydrostatic edema-induced intestinal contractile dysfunction.
Uray KS, Shah SK, Radhakrishnan RS, Jimenez F, Walker PA, Stewart RH, Laine GA, Cox CS Jr.
Surgery. ; 149: 114-25.
Resuscitation-induced intestinal edema and related dysfunction: state of the science.
Shah SK, Uray KS, Stewart RH, Laine GA, Cox CS Jr.
J Surg Res. ; 166: 120-30.
Nonlinear lymphangion pressure-volume relationship minimizes edema.
Venugopal AM, Stewart RH, Laine GA, Quick CM.
Am J Physiol Heart Circ Physiol. ; 299: H876-H882.
A murine model for the study of edema induced intestinal contractile dysfunction.
Shah SK, Moore-Olufemi SD, Uray KS, Jimenez F, Walker PA, Xue H, Stewart RH, Laine GA, Cox CS Jr.
Neurogastroenterol Motil. ; 22: 1132-e290.
Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function.
Dongaonkar RM, Stewart RH, Geissler HJ, Laine GA.
Cardiovasc Res. ; 87: 331-9.
A novel mechanism for neutrophil priming in trauma: potential role of peritoneal fluid.
Shah SK, Jimenez F, Walker PA, Aroom KR, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS Jr.
Surgery. ; 148: 263-70.
Evaluating the potential role of nitric oxide as a mediator of hydrostatic edema mediated intestinal contractile dysfunction.
Shah SK, Xue H, Jimenez F, Kots AY, Choi BK, Uray KS, Walker PA, Moore-Olufemi SD, Velez N, Stewart RH, Laine GA, Cox CS Jr.
J Surg Res. ; 163: 102-109.
Hydrostatic intestinal edema induced signaling pathways: potential role of mechanical forces.
Shah SK, Fogle LN, Aroom KR, Gill BS, Moore-Olufemi SD, Jimenez F, Uray KS, Walker PA, Stewart RH, Laine GA, Cox CS Jr.
Surgery. ; 147: 772-9.
A novel physiologic model for the study of abdominal compartment syndrome (ACS).
Shah SK, Jimenez F, Walker PA, Xue H, Uray KS, Aroom KR, Fischer UM, Laine GA, Stewart RH, Norbury KC, Cox CS Jr.
J Trauma. ; 68: 682-9.
The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest.
Fischer UM, Cox CS Jr, Allen SJ, Stewart RH, Mehlhorn U, Laine GA.
J Thorac Cardiovasc Surg. ; 126(5):1483-8.
Flow in lymphatic networks: interaction between hepatic and intestinal lymph vessels.
Stewart RH, Laine GA.
Microcirculation. ; 8(4):221-7.
The case for measuring plasma colloid osmotic pressure.
Stewart RH.
J Vet Intern Med. ; 14(5):473-4.
Renal lymphatic function following venous pressure elevation.
Rohn DA, Stewart RH, Elk JR, Laine GA, Drake RE.
Lymphology. ; 29(2):67-75.
Possible normokalemic variant of hyperkalemic periodic paralysis in two horses.
Stewart RH, Bertone JJ, Yvorchuk-St Jean K, Reed SM, Neil WH Jr.
J Am Vet Med Assoc. ; 203(3):421-4.
Complications of nasogastric intubation in horses: nine cases (1987-1989).
Hardy J, Stewart RH, Beard WL, Yvorchuk-St-Jean K.
J Am Vet Med Assoc. ; 201(3):483-6.
Frequency and severity of osteochondrosis in horses with cervical stenotic myelopathy.
Stewart RH, Reed SM, Weisbrode SE.
Am J Vet Res. ; 52(6):873-9.
Surgical stapling for repair of a rectal tear in a horse.
Stewart RH, Robertson JT.
J Am Vet Med Assoc. ; 197(6):746-8.
Hypertonic saline alters hydraulic conductivity and up-regulates mucosal/submucosal aquaporin 4 in resuscitation-induced intestinal edema.
Radhakrishnan RS, Shah SK, Lance SH, Radhakrishnan HR, Xue H, Radhakrishnan GL, Ramaswamy US, Walker PA, Uray KS, Laine GA, Stewart RH, Cox CS Jr.
Crit Care Med. ; 37: 2946-52.
Characteristics of the active lymph pump in bovine prenodal mesenteric lymphatics.
Gashev AA, Wang W, Laine GA, Stewart RH, Zawieja DC.
Lymphat Res Biol. ; 5: 71-9.
Intestinal edema: effect of enteral feeding on motility and gene expression.
Moore-Olufemi SD, Padalecki J, Olufemi SE, Xue H, Oliver DH, Radhakrishnan RS, Allen SJ, Moore FA, Stewart R, Laine GA, Cox CS Jr.
J Surg Res. ; 155: 283-92.
Balance point characterization of interstitial fluid volume regulation.
Dongaonkar RM, Laine GA, Stewart RH, Quick CM.
Am J Physiol Regul Integr Comp Physiol. ; 297: R6-R16.
Venomotion modulates lymphatic pumping in the bat wing.
Dongaonkar RM, Stewart RH, Laine GA, Davis MJ, Zawieja DC, Quick CM.
Am J Physiol Heart Circ Physiol. ; 296: H2015-H2021.
Lymphatic pump-conduit duality: contraction of postnodal lymphatic vessels inhibits passive flow.
Quick CM, Ngo BL, Venugopal AM, Stewart RH.
Am J Physiol Heart Circ Physiol. ; 296: H662-H668.
Optimal postnodal lymphatic network structure that maximizes active propulsion of lymph.
Venugopal AM, Quick CM, Laine GA, Stewart RH.
Am J Physiol Heart Circ Physiol. ; 296: H303-H309.
Integrating research and education at research-extensive universities with research-intensive communities.
Desai KV, Gatson SN, Stiles TW, Stewart RH, Laine GA, Quick CM.
Adv Physiol Educ. ; 32: 136-41.
Mechanics of the left ventricular myocardial interstitium: effects of acute and chronic myocardial edema.
Desai KV, Laine GA, Stewart RH, Cox CS Jr, Quick CM, Allen SJ, Fischer UM.
Am J Physiol Heart Circ Physiol. ; 294: H2428-H2434.
First-order approximation for the pressure-flow relationship of spontaneously contracting lymphangions.
Quick CM, Venugopal AM, Dongaonkar RM, Laine GA, Stewart RH.
Am J Physiol Heart Circ Physiol. ; 294: H2144-H2149.
Hypertonic saline modulation of intestinal tissue stress and fluid balance.
Cox CS Jr, Radhakrishnan R, Villarrubia L, Xue H, Uray K, Gill BS, Stewart RH, Laine GA.
Shock. ; 29: 598-602.
Myocardial fluid balance in dogs with naturally acquired heartworm infection.
Stewart RH, Uray K, Cox CS, Laine GA.
Am J Vet Res. ; 69: 356-61.
Edemagenic gain and interstitial fluid volume regulation.
Dongaonkar RM, Quick CM, Stewart RH, Drake RE, Cox CS Jr, Laine GA.
Am J Physiol Regul Integr Comp Physiol. ; 294: R651-R659.
Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension.
Quick CM, Criscione JC, Kotiya A, Dongaonkar RM, Hardy J, Wilson E, Gashev AA, Laine GA, Stewart RH.
Am J Physiol Regul Integr Comp Physiol. ; 306: R901-R907.
Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure.
Dongaonkar RM, Nguyen TL, Quick CM, Hardy J, Laine GA, Wilson E, Stewart RH.
Am J Physiol Heart Circ Physiol. ; 305: H203-H210.
Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility.
Chu J, Pham NT, Olate N, Kislitsyna K, Day MC, LeTourneau PA, Kots A, Stewart RH, Laine GA, Cox CS Jr, Uray K.
J Biol Chem. ; 288: 1200-13.
Award article: Microcirculatory Society Award for Excellence in Lymphatic Research: time course of myocardial interstitial edema resolution and associated left ventricular dysfunction.
Dongaonkar RM, Stewart RH, Quick CM, Uray KL, Cox CS Jr, Laine GA.
Microcirculation. ; 19: 714-22.
Blood flow augmentation by intrinsic venular contraction in vivo.
Dongaonkar RM, Quick CM, Vo JC, Meisner JK, Laine GA, Davis MJ, Stewart RH.
Am J Physiol Regul Integr Comp Physiol. ; 302: R1436-R1442.
Strategies for modulating the inflammatory response after decompression from abdominal compartment syndrome.
Shah SK, Jimenez F, Letourneau PA, Walker PA, Moore-Olufemi SD, Stewart RH, Laine GA, Cox CS Jr.
Scand J Trauma Resusc Emerg Med. ; 20: 25.
Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper-interacting kinase activities in edematous intestinal smooth muscle.
Chu J, Miller CT, Kislitsyna K, Laine GA, Stewart RH, Cox CS, Uray KS.
Neurogastroenterol Motil. ; 24: 257-66.
Peritoneal fluid: a potential mechanism of systemic neutrophil priming in experimental intra-abdominal sepsis.
Shah SK, Jimenez F, Walker PA, Xue H, Feeley TD, Uray KS, Norbury KC, Stewart RH, Laine GA, Cox CS Jr.
Am J Surg. ; 203: 211-6.
Lymphangion coordination minimally affects mean flow in lymphatic vessels.
Venugopal AM, Stewart RH, Laine GA, Dongaonkar RM, Quick CM.
Am J Physiol Heart Circ Physiol. ; 293: H1183-H1189.
Lymphatic vessels transition to state of summation above a critical contraction frequency.
Meisner JK, Stewart RH, Laine GA, Quick CM.
Am J Physiol Regul Integr Comp Physiol. ; 293: R200-R208.
Application of local heat induces capillary recruitment in the Pallid bat wing.
Widmer RJ, Stewart RH, Young MF, Laurinec JE, Laine GA, Quick CM.
Am J Physiol Regul Integr Comp Physiol. ; 292: R2312-R2317.
Pulmonary air embolization inhibits lung lymph flow by increasing lymphatic outflow pressure.
Stewart RH, Quick CM, Zawieja DC, Cox CS, Allen SJ, Laine GA.
Lymphat Res Biol. ; 4(1):18-22.
Impact of acute myocardial edema on left ventricular function.
Fischer UM, Cox CS Jr, Stewart RH, Laine GA, Allen SJ.
J Invest Surg. ; 19(1):31-8.
Resolving the hemodynamic inverse problem.
Quick CM, Berger DS, Stewart RH, Laine GA, Hartley CJ, Noordergraaf A.
IEEE Trans Biomed Eng. ; 53(3):361-8.
Inhibition of intestinal transit by resuscitation-induced gut edema is reversed by L-NIL.
Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS Jr.
J Surg Res. ; 129(1):1-5.
Effects of primary and secondary intra-abdominal hypertension on mesenteric lymph flow: implications for the abdominal compartment syndrome.
Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS Jr.
Shock. ; 23(6):571-5.
Resuscitation-induced gut edema and intestinal dysfunction.
Moore-Olufemi SD, Xue H, Attuwaybi BO, Fischer U, Harari Y, Oliver DH, Weisbrodt N, Allen SJ, Moore FA, Stewart R, Laine GA, Cox CS Jr.
J Trauma. ; 58(2):264-70.
Optimal lymphatic vessel structure.
Venugopal AM, Stewart RH, Rajagopalan S, Laine GA, Quick CM.
Conf Proc IEEE Eng Med Biol Soc. ; 5:3700-3.


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