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Michael Golding

Assistant Professor

Curriculum Vitae

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Phone: (979) 862-1332

Mailstop: 4466

Department: VTPP

Photo of Golding, Michael

Education

  • Postdoc Epigenetics, Childrens Health Research Institute - UWO 2009
  • Postdoc RNA Interference, Cold Spring Harbor Labs 2006
  • Ph.D. Veterinary Physiology, Texas A&M University 2003
  • BSc. Molecular Genetics, University of Western Ontario 2000

Job Functions

  • Teaching Undergraduate & Graduate Fetal Physiology. Conducting Research Examining Mammalian Pregnancy & Development

Scholarly Interests

Problems during pregnancy are responsible for several childhood disabilities including seizures and delayed abilities to speak and walk. These disabilities often show up in the children of mothers with medical conditions that cause significant hormonal problems or who drank alcohol during their pregnancy. My laboratory is interested in studying how these birth defects and mental disabilities develop and what treatments can be given in order to prevent them. I am an assistant professor within the department of veterinary physiology and pharmacology at Texas A&M University. Here, I serve as the instructor of record for two courses studying human embryology and the physiological events of pregnancy. My research program focuses on understanding the biochemical mechanisms by which chromosome structure is altered during development and how these changes serve to regulate gene expression. I am interested in understanding the mechanisms that recruit epigenetic modifiers to specific cohorts of genes, identifying the biochemical machinery directing this process, and understanding how these events are impacted by environmental toxins and teratogens. For the past four years, my laboratory has focused on epigenetic defects arising as a consequence of prenatal alcohol exposure.

Publications

Identification of cell-specific patterns of reference gene stability in quantitative reverse-transcriptase polymerase chain reaction studies of embryonic, placental and neural stem models of prenatal ethanol exposure.
Carnahan MN, Veazey KJ, Muller D, Tingling JD, Miranda RC, Golding MC.
Alcohol. 2013 Mar; 47(2):109-20.
PMID: 23317542 [PubMed - indexed for MEDLINE]
Alcohol-induced epigenetic alterations to developmentally crucial genes regulating neural stemness and differentiation.
Veazey KJ, Carnahan MN, Muller D, Miranda RC, Golding MC.
Alcohol Clin Exp Res. 2013 Jul; 37(7):1111-22.
PMID: 23488822 [PubMed - in process]
Generation of trophoblast stem cells.
Golding MC.
Methods Mol Biol. 2012 ; .
PMID: 22907489 []
Production of transgenic calves expressing an shRNA targeting myostatin.
Tessanne K, Golding MC, Long CR, Peoples MD, Hannon G, Westhusin ME.
Mol Reprod Dev. 2012 Mar; 79(3):176-85.
PMID: 22139943 [PubMed - indexed for MEDLINE]
Selection of stable reference genes for quantitative rt-PCR comparisons of mouse embryonic and extra-embryonic stem cells.
Veazey KJ, Golding MC.
PLoS One. 2011 ; 6(11):e27592.
PMID: 22102912 [PubMed - indexed for MEDLINE]
Examination of DNA methyltransferase expression in cloned embryos reveals an essential role for Dnmt1 in bovine development.
Golding MC, Williamson GL, Stroud TK, Westhusin ME, Long CR.
Mol Reprod Dev. 2011 May; 78(5):306-17.
PMID: 21480430 [PubMed - in process]
Examination of DNA methyltransferase expression in cloned embryos reveals an essential role for Dnmt1 in bovine development.
Golding MC, Williamson GL, Stroud TK, Westhusin ME, Long CR.
Mol Reprod Dev. 2011 May; 78(5):306-17.
PMID: 21480430 [PubMed - indexed for MEDLINE]
Production of transgenic calves expressing an shRNA targeting myostatin.
Tessanne K, Golding MC, Long CR, Peoples MD, Hannon G, Westhusin ME.
Mol Reprod Dev. 2011 Nov; .
PMID: 22139943 [PubMed - as supplied by publisher]
Selection of stable reference genes for quantitative rt-PCR comparisons of mouse embryonic and extra-embryonic stem cells.
Veazey KJ, Golding MC.
PLoS One. 2011 ; 6(11):e27592.
PMID: 22102912 [PubMed - in process]
Depletion of Kcnq1ot1 non-coding RNA does not affect imprinting maintenance in stem cells.
Golding MC, Magri LS, Zhang L, Lalone SA, Higgins MJ, Mann MR.
Development. 2011 Sep; 138(17):3667-78.
PMID: 21775415 [PubMed - indexed for MEDLINE]
A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells.
Golding MC, Mann MR.
Gene Ther. 2011 Aug; 18(8):817-26.
PMID: 21390068 [PubMed - indexed for MEDLINE]
Multiple epigenetic modifiers induce aggressive viral extinction in extraembryonic endoderm stem cells.
Golding MC, Zhang L, Mann MR.
Cell Stem Cell. 2010 May; 6(5):457-67.
PMID: 20452320 [PubMed - indexed for MEDLINE]
Applications of RNA interference-based gene silencing in animal agriculture.
Long CR, Tessanne KJ, Golding MC.
Reprod Fertil Dev. 2010 ; 22(1):47-58.
PMID: 20003845 [PubMed - indexed for MEDLINE]
Profiling essential genes in human mammary cells by multiplex RNAi screening.
Silva JM, Marran K, Parker JS, Silva J, Golding M, Schlabach MR, Elledge SJ, Hannon GJ, Chang K.
Science. 2008 Feb; 319(5863):617-20.
PMID: 18239125 [PubMed - indexed for MEDLINE]
The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues.
Kuzmin A, Han Z, Golding MC, Mann MR, Latham KE, Varmuza S.
Gene Expr Patterns. 2008 Jan; 8(2):107-16.
PMID: 18024232 [PubMed - indexed for MEDLINE]
Cloning of GJA1 (connexin43) and its expression in canine ovarian follicles throughout the estrous cycle.
Willingham-Rocky LA, Golding MC, Wright JM, Kraemer DC, Westhusin ME, Burghardt RC.
Gene Expr Patterns. 2007 Jan; 7(1-2):66-71.
PMID: 16829210 [PubMed - indexed for MEDLINE]
Suppression of prion protein in livestock by RNA interference.
Golding MC, Long CR, Carmell MA, Hannon GJ, Westhusin ME.
Proc Natl Acad Sci U S A. 2006 Apr; 103(14):5285-90.
PMID: 16567624 [PubMed - indexed for MEDLINE]
Second-generation shRNA libraries covering the mouse and human genomes.
Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, Sachidanandam R, McCombie WR, Cleary MA, Elledge SJ, Hannon GJ.
Nat Genet. 2005 Nov; 37(11):1281-8.
PMID: 16200065 [PubMed - indexed for MEDLINE]
Evaluation of a real-time quantitative polymerase chain reaction assay for detection and quantitation of virulent Rhodococcus equi.
Harrington JR, Golding MC, Martens RJ, Halbert ND, Cohen ND.
Am J Vet Res. 2005 May; 66(5):755-61.
PMID: 15940818 [PubMed - indexed for MEDLINE]
Analysis of DNA (cytosine 5) methyltransferase mRNA sequence and expression in bovine preimplantation embryos, fetal and adult tissues.
Golding MC, Westhusin ME.
Gene Expr Patterns. 2003 Oct; 3(5):551-8.
PMID: 12971987 [PubMed - indexed for MEDLINE]
The mouse Na+-K+-ATPase gamma-subunit gene (Fxyd2) encodes three developmentally regulated transcripts.
Jones DH, Golding MC, Barr KJ, Fong GH, Kidder GM.
Physiol Genomics. 2001 Aug; 6(3):129-35.
PMID: 11526196 [PubMed - indexed for MEDLINE]