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Research

Regenerative Medicine

Regenerative Medicine (the restoration of the structure and function of injured or diseased body parts in mammals) represents a rapidly growing area of faculty expertise.  Efforts in this relatively new field currently encompass limb/digit regeneration, wound and bone healing as well as morphogenesis.  Without doubt rapid advances across the fields of developmental, stem cell and regeneration biology are transforming the future of regenerative medicine.  Our research efforts are at the center of these transformative areas.  Research efforts are supported by funding from the National Institutes of Health, Texas Heart Institute, Texas A&M AgriLife Research, and private industry. Our funded research efforts expand across all educational levels, including high school students, undergraduates, graduate professional and residency training.

Reproductive Physiology

Research in reproductive physiology is focused on understanding the requirements for normal embryonic development, in addition to the development and application of animal biotechnology. Specific research projects involve experiments designed to improve the efficiency of nuclear transplantation (cloning) which can be used to produce genetically identical animals and/or transgenic animals. Other research projects are focused on improving methods for producing mammalian embryos in vitro. The Reproductive Sciences Laboratory consists of approximately 23,000 sq ft of space composed of a fully equipped tissue culture room, embryo micromanipulation room, ovary/oocyte/embryo/sperm processing room, medium preparation room, and molecular biology room. Additional space located in adjacent rooms is available for offices and conferences, and a large assortment of laboratory equipment is available. Funding for research is provided by the National Institutes of Health, Texas Higher education Coordinating Board of Higher Education, Texas AgriLife Research, Morris Animal Foundation, and private industry.

Cardiovascular Physiology

The Cardiovascular Physiology and Applied Physics Facility is located in a 14,000 sq ft freestanding facility. This facility contains operating rooms for both acute and chronic sterile surgeries, recovery rooms, treatment rooms, as well as animal housing facilities for both acute and chronic animals ranging from small species to dogs. Surgical facilities for larger animals are also available at our Veterinary Medical Park Research Facility. Individual laboratories are supported by a common-use machine shop, tissue culture facility, and molecular biology laboratory. State of the art instrumentation for evaluating cardiac function and hemodynamic parameters as well as the tools of molecular biology are available within the facility. Imaging via nuclear magnetic resonance and echocardiography is also available. Close collaborative relationships exist with the institutions in the world's largest medical center in Houston, Texas. Funding from the National Institutes of Health, National Science Foundation, American Heart Association, American Lung Association, and numerous other sources exists for studies of cardiovascular physiology and pharmacology. The use of comparative physiology techniques allows us to address traditional problems in veterinary medicine while utilizing animal models of human pathologies to seek cures for diseases common to all species.

Pharmacology

Pharmacology represents an additional area of faculty expertise currently focusing on the clinical application of basic research. Research efforts include the establishment of safe and effective dosing regimens for drugs. This broad focus covers studies that vary from the establishment of dose-response relationships, through pharmacokinetic analysis of drugs in targeted species, to clinical trials that establish efficacy. Dose-response studies include, but are not limited to, antimicrobials and anticonvulsants. Pharmacokinetic studies have included drugs intended to treat infections, seizures, cardiac disorders, behavioral disorders and gastrointestinal disorders. A more recent focus for pharmacokinetic studies has been novel drug delivery systems with an emphasis on prolonged delivery systems. Clinical trials include antimicrobial and anticonvulsant therapy. More basic research includes antimicrobial uptake by peripheral leukocytes and the impact of uptake on tissue distribution and leukocyte function. Our research efforts expand across all educational levels, including high school students, undergraduates, graduate professional and residency training.

Texas A&M Institute for Genomic Medicine

The Texas A&M Institute for Genomic Medicine (TIGM) is an essential resource for researchers looking to obtain transgenic services. Since 2006, TIGM has delivered more than 800 mouse and cells orders to more than 270 academic and commercial institutions in over 26 countries. These are featured in more than 180 peer-reviewed publications. TIGM provides transgenic core services to researchers within and outside the Texas A&M system including blastocyst or pronuclear injections (including CRISPR/Cas9), rederivation, embryo transfer, design and production of vectors for custom knockout (stable and Cre-ready conditional) and knock in projects, various aspects of ES cell manipulations and embryo and sperm cryopreservation.