MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation

Ying W*, Tseng A*, Chang CA, Morin A, Brehm T, Triff K, Nair V, Zhuang G, Song H, Kanameni S, Wang H, Golding MC, Bazer FW, Chapkin RS, Safe S, Zhou B (2015) Journal of Clinic Investigation (accepted)

The many faces of interferon tau

Bazer FW, Ying W, Wang X, Dunlap KA, Zhou B, Johnson GA, Wu G. (2015)  Amino Acides .  Epub. PMID: 25557050

NR4A Orphan receptors as drug target

Safe S, Lee S, Meng C, Zhou B. (2015) NR4A Orphan receptors as drug target. Editor, Michael Andreeff. Springer New York. ISBN 978-4939-1392-3

High-fat-diet induced retinal dysfunction

Chang RC, Shi L, Huang CCm Kim AJ, Ko ML, Zhou B, Ko GY (2015) High-fat-diet induced retinal dysfunction. Invest Ophthalmol Vis Sci. (in press) Epub March 18, 2015



Pregnancy-secreted acid phosphatase, uteroferrin, enhances fetal erythropoiesis

Ying W, Wang H, Bazer FW, Zhou B. (2014) Endocrinology

MicroRNAs Control Macrophage Formation and Activation: The Inflammatory Link between Obesity and Cardiovascular Diseases

Chang RCA, Ying W, Bazer FW, Zhou B (2014) Cells 3 (3). 702-712

Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.

Ying W , Kanameni S, Chang CA, Nair V, Safe S, Bazer WF, Zhou B. (2014) PLOS One e98835

microRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R.

Zhang Y, Chen X, Lian H, Liu J, Zhou B, Han S, Peng B, Yin J, Liu W, He X (2014)Oncology Reports. 31(3):1445-52  Epub 12/2013


Genome wide analysis of the rat colon reveals proximal-distal differences in histone modifications and proto-oncogene expression.

Triff K, Konganti K, Gaddis S, Zhou B, Ivanov I, Capkin RC (2013) Physiol Genomics. 45(24):1229-43 Epub 10/2013

microRNA Regulated Macrophage Activation in Obesity

Kamanemi S, Ying W, Bazer FW, Zhou B*. (2013)   J of Nutr Food Sci 3:217 July 5.

Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation

Li F, Yu X, Szynkarski CK, Meng C, Zhou B, Barhoumi R, White RE, Heaps CL, Stallone JN, Han G. (2013) Plos One, Epub June 24

MiR-150 Blocks MLL-AF9 Associated Leukemia By Repressing Multiple Oncogenes

Bousquet M, Zhuang G, Meng C, Ying W, Cheruku PS, Shie AT, Wang S, Ge G, Wong P, Wang G, Safe S, Zhou B (2013)   Mol. Cancer Res.11; 912; Epub April 19. 2013

1. Leading Highlight Article by Editors in Mol Cancer Res 2013 (11) (with highlight figure)

2. Featured Article in news on  MD Linx (the Internal Medicine) on April 23, 2013

3. Featured Article in LeadDiscovery DailyUpdate (Oncology) on June 26, 2013

Investigation of macrophage polarization using bone marrow derived macrophages

Ying W, Cheruku PS, Bazer FW, Safe S, Zhou B. Journal of Visulized Experiments (2013) J. Vis. Exp. (76), e50323, doi:10.3791/50323.

Targeted Therapy of Acute Myeloid Leukemias: NR4A Orphan Receptors as Drug Targets(29)

Safe S, Lee SO, Meng C, Zhou B. (2013); Springer. (in press)


A Novel Regulator of Macrophage Activation: miR-223 in Obesity-Associated Adipose Tissue Inflammation.

Zhuang G, Meng C (equal contribution), Guo X, Cheruku PS, Shi L, Xu H, Li H, Wang G, Evans AR, Safe S, Wu C, Zhou B.

Circulation. 2012 Jun 12;125(23):2892-903. Epub 2012 May 11. PMID: 22580331

1. Editorial: A MicroRNA Circuitry Links Macrophage Polarization to Metabolic Homeostasis Meng ZX, Wang GX, Lin JD. Circulation. 2012 Jun 12;125(23):2815-7. Epub 2012 May 11.  PMID:  22580332

2. Circulation Editors’ Pick: Most Read Articles on the Topic of Molecular Cardiology The editors, Circulation. 2013;128:e88-e99; doi: 10.1161/CIRCULATIONAHA.113.004990



Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: effect of a chemo-protective diet.

Shah MS, Schwartz SL, Zhao C, Davidson LA, Zhou B, Lupton JR, Ivanov I, Chapkin RS.

Physiological genomics. 2011 May 1;43(10):640-54. Epub 2011 Mar 15.


MicroRNA miR-125b causes leukemia.

Bousquet M, Harris MH, Zhou B, Lodish HF.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21558-63. Epub 2010 Nov 30.

Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells.

Ouyang N, Ke S, Eagleton N, Xie Y, Chen G, Laffins B, Yao H, Zhou B, Tian Y.

Br J Cancer. 2010 Jun 8;102(12):1753-61.



MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets.

Le MT, Xie H, Zhou B, Chia PH, Rizk P, Um M, Udolph G, Yang H, Lim B, Lodish HF.

Mol Cell Biol. 2009 Oct;29(19):5290-305. Epub 2009 Jul 27.PMID: 19635812

MicroRNA-125b is a novel negative regulator of p53.

Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, Lodish HF, Lim B.

Genes Dev. 2009 Apr 1;23(7):862-76. Epub 2009 Mar 17.

Micromanagement of the immune system by microRNAs.

Lodish HF, Zhou B, Liu G, Chen CZ.

Nat Rev Immunol. 2008 Feb;8(2):120-30. Review. Erratum in: Nat Rev Immunol. 2008 Mar;8(3):238. PMID: 18204468

Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity.

Liao MJ, Zhang CC, Zhou B (equal contribution), Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA.

Cancer Res. 2007 Sep 1;67(17):8131-8.PMID: 17804725

miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.

Zhou B, Wang S, Mayr C, Bartel DP, Lodish HF.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7080-5. Epub 2007 Apr 16. Erratum in: Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):18070. PMID: 17438277

Analysis of placental regulation of hematopoiesis.

Zhou B, Linzer DI.

Methods Mol Med. 2006;122:355-65.PMID: 16511993

Enhanced recovery from thrombocytopenia and neutropenia in mice constitutively expressing a placental hematopoietic cytokine.

Zhou B, Kong X, Linzer DI.

Endocrinology. 2005 Jan;146(1):64-70. Epub 2004 Sep 16.PMID: 15375031

Two placental hormones are agonists in stimulating megakaryocyte growth and differentiation.

Zhou B, Lum HE, Lin J, Linzer DI.

Endocrinology. 2002 Nov;143(11):4281-6.PMID: 12399423