High-Sensitivity Cardiac Troponin I

This assay is offered by the Texas A&M University VMTH Cardiology service (https://vethospital.tamu.edu/small-animal/cardiology/)

Reference intervals-Canine

< 50 pg/mL:   Active myocardial injury is unlikely.

50 – 135 pg/mL:  Some healthy dogs have serum cardiac troponin I concentrations in this range, but active myocardial injury is also possible.  Interpret results in conjunction with other clinical data.

135 pg/mL:     Active myocardial injury is likely. Interpret results in conjunction with other clinical data.

Siemens Healthineers recently discontinued their Ultra-sensitive cardiac troponin I assay and replaced it with the High-sensitivity cardiac troponin I assay. The old assay is no longer available. The new assay has a lower limit of quantification than the old assay (2.5 vs. 6 pg/mL) and is less susceptible to interference from biotin (vitamin B7).

Our investigations so far support Siemens Healthineers’ claim that there is correlation between the two assays, but unfortunately, they also suggest that in dogs the diagnostic sensitivity of the new assay for myocardial injury is slightly lower than for the old assay. Therefore, results should be interpreted with caution and in conjunction with other clinical data (possibly including, echocardiography and electrocardiography).

From now on all results will be reported in pg/mL rather ng/mL (multiply results in ng/mL by 1,000 to convert to pg/mL).

We have not developed a reference interval on feline patients for Cardiac Troponin I. This assay is not considered to be species specific. However, feline or non-canine species reports will not include reference intervals or interpretations

Sample Requirements and Shipping Information

Minimum sample 500 µL fasting, non-hemolyzed serum.

Samples should be frozen prior to shipment and shipped with dry ice or sufficient ice packs to remain frozen during shipment.

Turnaround time: 2-3 business days after receipt of sample