Texas A&M Radiation Oncology Team Treats Baylor Mascot With Therapy Never Before Used On Bear

While there are two other bear thymoma cases noted in veterinary literature, Judge Lady is the first to be treated with TomoTherapy, a system found at only one other veterinary school in the U.S.

Story by Megan Myers, Texas A&M College of Veterinary Medicine & Biomedical Sciences

 

Lady sitting in the sun at the bears’ off-campus enrichment facility
Lady sitting in the sun at the bears’ off-campus enrichment facility. Photo credit: Matthew Minard/Baylor University

Judge Sue “Lady” Sloan is no ordinary American black bear.

In Waco, Lady holds a distinguished role as one of Baylor University’s two live animal mascots.

She also has the luxury of regular veterinary care from zoological specialists at the Texas A&M College of Veterinary Medicine & Biomedical Sciences’ (CVM) Veterinary Medical Teaching Hospital (VMTH).

When these veterinary specialists discovered a benign mass called a thymoma in Lady’s chest, they teamed up with other VMTH services to deliver a course of treatment never before used on a bear—stereotactic body radiation therapy using the TomoTherapy system.

This treatment has the potential to completely stop the tumor’s growth while also preserving the 17-year-old bear’s quality of life, which is the utmost goal of both her veterinarians and her care team from Baylor.

Lady was diagnosed with her thymoma in summer 2019, when she arrived in College Station for a routine checkup with CVM professor emerita Dr. Sharman Hoppes.

“For a checkup of a large animal like this, we do a full workup including blood work, physical exam under anesthesia, and imaging,” said associate professor Dr. J. Jill Heatley, zoological medicine specialist who joined the case later that summer. “Based on numerous radiographs, we found this mass in the chest. Gwendolyn Levine, one of the radiologists, got a really good sample and one of our clinical pathology specialists told us told us it’s an epithelial inclusive thymoma.”

Lady enters the TomoTherapy system with a veterinary technician by her side
Lady was treated for a benign thymoma with the TomoTherapy System. Photo credit: Matthew Minard/Baylor University

When plans for treatment began, Heatley recruited Dr. Lauren Smith, CVM clinical assistant professor and radiation oncologist, to figure out the best way to deliver precise, effective treatment to Lady’s tumor, which was already larger than a softball.

Only two other cases of thymomas in bears exist in veterinary literature, one of which was found after the bear had died and the other was only found after the bear began showing signs that something was wrong.

“The good news for Lady is that she’s completely asymptomatic; she has no clinical signs of the mass, which means that we caught it early,” Smith said. “Early detection is key with cancer. Being able to intervene at an early point is why we have a very positive outlook for her.”

They decided that Lady’s best treatment option was stereotactic body radiation therapy, which uses many beams of high-energy photons to deliver large doses of radiation to the tumor and spare surrounding tissues.

Although there is no record of this form of treatment ever being used on a bear, Smith said it was a good patient-based treatment option because it allowed Lady to go home between treatments and avoid complications, side effects, or risks associated with surgery.

“This treatment plan allows Lady to spend as little time in the hospital as possible and keeps her quality of life first, as well as gives her the best chance moving forward,” Smith said.

To apply this form of radiation therapy, Lady would need to be anesthetized and placed inside the TomoTherapy system, a unique technology that is only used in veterinary medicine in one other hospital in the world.

A team of VMTH staff prepares Lady to enter the TomoTherapy system.
A team of VMTH staff prepares Lady to enter the TomoTherapy system.

“What makes TomoTherapy unique is that we treat these tumors in a slice-by-slice fashion,” Smith said. “We get millions of opportunities to get a dose into the tumor while avoiding normal tissues; it allows us to have much better and more conformal plans and much tighter doses of distributions to the tumor itself. Where TomoTherapy shines in cancer treatment across the world is treating tumors with complex shapes and geometries.

“Lady’s tumor is sitting right up in front of the heart and between the lungs, so we’re trying to get really high ablative doses to kill this tumor while it’s sitting in between those fairly sensitive, important structures,” she said. “TomoTherapy allows us that opportunity to still treat aggressively with these cancers while maintaining good quality of life. This is probably the first large exotic animal treated with TomoTherapy.”

TomoTherapy offers another benefit in that it has onboard CT imaging capabilities; during Lady’s three doses of treatment, the CT scanner was used to make sure she was in the exact same position every day.

“TomoTherapy allows us to compare the original CT scan with the CT scan of the day to make sure she aligns to the sub-millimeter so that we’re delivering treatment as precisely as possible,” Smith said.

During her treatments, Lady was accompanied and supported by Baylor students in the Baylor Bear Program and Dakota Farquhar-Caddell, associate director of student activities and the Robert L. Reid Director of the Baylor Chamber of Commerce.

“We say in the animal husbandry world that all animals deserve as many good days as possible,” Farquhar-Caddell said. “My hope is that we keep giving Lady the best days we can while she’s with us and that we do so in a way that isn’t stressful or invasive but that really helps keep her healthy and happy.

Radiation oncologist Dr. Michael Deveau watches a screen of colorful scans to monitor Lady as she undergoes her TomoTherapy treatment
Radiation oncologist Dr. Michael Deveau monitors Lady as she undergoes her TomoTherapy treatment. Photo credit: Matthew Minard/Baylor University

“We are really lucky to be this close to Texas A&M,” he said. “The care has been exceptional. I have direct contact with many of the staff on a daily basis; they reach out to me after we get home, checking in on how Lady is doing. We’ve had great communication and conversation with them and we’re really thankful.”

With her three radiation doses now complete, Lady will return to her home at the Bill and Eva Williams Bear Habitat in Waco, a U.S. Department of Agriculture Certified Class C Zoo facility that provides Lady and her sister, Joy, with a natural environment full of enrichment.

“Joy and Lady are a beloved part of our community, and we’re just really grateful that we have excellent care and access to resources and the ability to care for them well,” Farquhar-Caddell said. “In some ways we see our bears as ambassadors for other American black bears. They have probably the largest platform any black bear has in the country, so we use it to educate the community and for important conservation efforts.”

Likewise, Lady’s case will educate veterinarians around the world on the use of stereotactic body radiation therapy and TomoTherapy to treat difficult tumors.

By focusing on her quality of life and finding an innovative way to treat her thymoma, Lady’s veterinarians and Baylor care team have taken a monumental step forward in the veterinary care of large exotic animals.

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Contact Information: Jennifer Gauntt, Interim Director of Communications, Texas A&M College of Veterinary Medicine & Biomedical Science; jgauntt@cvm.tamu.edu; 979-862-4216

Combating Pet Cancer

Cancer is a scary subject, especially when a loved one has been diagnosed. Because the first reactions and decisions can make a huge impact on treatment options and outcomes, it is important to be prepared and know what questions to ask first.

Dr. Brandan Wustefeld-Janssens, an assistant professor of surgical oncology at the Texas A&M College of Veterinary Medicine & Biomedical Sciences, uses his years of oncology experience to advise pet owners on the early steps of cancer detection and treatment.Dog

In order to get an early diagnosis, a pet with an unusual mass should be taken to a veterinarian as soon as possible. Pet owners should then be willing to do whatever is needed to ensure that a full diagnosis is made.

“Early detection and intervention can be the difference between a cure and a poor outcome, as well as the difference between a short, non-complex procedure or an expensive, extensive treatment protocol,” Wustefeld-Janssens said.

Once the mass is examined, the veterinarian will need to run tests to determine if it is cancerous and, if so, what stage of cancer is present. With fine-needle aspiration, a cheap but very effective test, a hollow needle removes cells from the mass that are then viewed under a microscope to see if the tumor is malignant or benign.

If the mass is determined to be cancerous, the pet owner can begin discussing treatment options with the veterinarian.

“Get as much information as you need to make an informed decision,” Wustefeld-Janssens said. “The most important aspect of all is finding a balance between being aggressive with treatment to increase the chances of a good outcome and maintaining a good quality of life.

“(At the Texas A&M Veterinary Medical Teaching Hospital) We have extensive discussions with owners about treatment options and costs that may be associated with those options,” he said.

While small, low-grade tumors may be cured with a minor, low-cost surgery, other tumors may need more extensive treatment plans. Some pets will need a combination of radiation, chemotherapy, and surgery to treat cancer, and the cost can build quickly.

Wustefeld-Janssens recommends that pet owners look into pet insurance or ask about payment plans to make the cost of cancer treatment more manageable.

One of the most important things to remember after a cancer diagnosis is to not lose hope.

“Our goal is always maintenance of a good quality of life so there may be little change to the daily routine, though some pets will be on chronic medication or need minor changes to exercise (regimens),” Wustefeld-Janssens said.

“As a group, we veterinarians are committed to supporting families and their pets through a diagnosis and treatment,” he said. “We have options and there is always something we can do.”

Pet Talk is a service of the College of Veterinary Medicine & Biomedical Sciences, Texas A&M University. Stories can be viewed on the web at vetmed.tamu.edu/news/pet-talk. Suggestions for future topics may be directed to editor@cvm.tamu.edu.