{"id":18704,"date":"2022-08-10T08:58:55","date_gmt":"2022-08-10T13:58:55","guid":{"rendered":"https:\/\/vetmed.tamu.edu\/news\/?p=18704"},"modified":"2022-09-16T10:35:30","modified_gmt":"2022-09-16T15:35:30","slug":"fracture-healing-down-syndrome","status":"publish","type":"post","link":"https:\/\/vetmed.tamu.edu\/news\/press-releases\/fracture-healing-down-syndrome\/","title":{"rendered":"Texas A&M Research Reveals Issues With Fracture Healing In People With Down Syndrome"},"content":{"rendered":"
\n
\"Sherman
Kirby Sherman and Dr. Larry Suva<\/small><\/figcaption><\/figure>\n<\/div>\n\n\n

New research from the Texas A&M School of Veterinary Medicine & Biomedical Sciences (VMBS) is the first to provide direct experimental evidence that people with Down syndrome (DS) may not heal from bone fractures.<\/p>\n\n\n\n

The recently published study<\/a>, led by Kirby Sherman, a Ph.D. candidate in the VMBS\u2019 Department of Veterinary Physiology & Pharmacology (VTPP)<\/a>, not only illuminates a previously unknown issue but also highlights a need for doctors to better address the issue of fracture healing in people with DS.<\/p>\n\n\n\n

DS, the most common birth defect<\/a> in the United States, alters human development and leads to a variety of clinical issues, which have included mental impairment, joint laxity, heart defects, sleep apnea<\/a>, and infertility<\/a>.<\/p>\n\n\n\n

Previous research also had indicated that bone density in people with DS is lower, which increases the likelihood of bone fracture. Scientists previously believed that the healing response to fractures would be different in people with DS, but to discover that fractures in DS would not heal \u201cwas incredible,\u201d Sherman said.<\/p>\n\n\n\n

\u201cScientists have been studying fractures for a long time in a lot of different species, and while healing might be slow in some cases, the vast majority of fractures do eventually heal in all species,\u201d Sherman said. \u201cIn our research, the fractures didn\u2019t heal at all.<\/p>\n\n\n\n

\u201cWhen bones heal, a soft callous made of cartilage, a sort of glue, will form on the bones and then connect the fractured ends back together; we call this bridging,\u201d said Sherman. \u201cIn Down syndrome models, the glue starts to form, but it\u2019s never able to bridge.\u201d<\/p>\n\n\n\n

This is alarming, the researchers assert, because a fracture not fully healing can have devastating health impacts, which is compounded for those with DS because of their pronounced bone density loss.<\/p>\n\n\n\n

\u201cBased on this, the risk of fractures is a major health concern for the Down syndrome community,\u201d Sherman said.<\/p>\n\n\n\n

\u201cA fracture not healing properly, what we call a non-union, can kill people, whether they have Down syndrome or not,\u201d said Dr. Larry Suva<\/a>, VTPP department head. \u201cIf this population really has a higher rate of non-union than the normal population, that\u2019s a big deal.\u201d<\/p>\n\n\n

\n
\"x-ray
While previous research has indicated that bone density in people with Down syndrome is lower, the VMBS’ recently published study was the first to provide direct experimental evidence that they may not heal from bone fractures at all.<\/small><\/figcaption><\/figure>\n<\/div>\n\n\n

According to Suva and Sherman, there are two primary reasons this issue has gone undetected until now; the first is that those with DS are living much longer than they used to.<\/p>\n\n\n\n

According to the Centers for Disease Control and Prevention (CDC), in 1960, people with DS had a life expectancy of just 10 years. By 2007, as more was learned and applied to offset the endocrine impacts of DS, the life expectancy increased to 47 years.<\/p>\n\n\n\n

\u201cWe\u2019ve known that bone mass is lower in this population, and the increased life expectancy of this population has allowed researchers to better understand the long-term implications of their lower bone mass,\u201d said Suva. \u201cToday, there are people with DS in their 20s and 30s who have bone mass and bone architecture consistent with someone in their 60s. They\u2019re active members of the community and they\u2019re playing sports. Obviously, that\u2019s great, but if they\u2019re at increased risk of bone fractures that won\u2019t heal, it\u2019s also a concern.\u201d<\/p>\n\n\n\n

The second reason this issue stayed undetected for so long is that specialized care for people with DS has not been a consideration by doctors and hospitals, which means that there wasn\u2019t data readily available to identify this issue.<\/p>\n\n\n\n

\u201cThere\u2019s not a medical code that identifies people with Down syndrome, so researchers have not had any kind of database they could use to gather statistics that support this kind of research,\u201d said Suva. \u201cDown syndrome support groups and family members don\u2019t want their loved ones or themselves singled out for having a disease. After all, they\u2019re normal people.<\/p>\n\n\n\n

\u201cAs a result, even with all of the fractures that get recorded every day in the United States, there\u2019s no way to identify which of those patients have Down syndrome and, therefore, no organized way to track their healing,\u201d Suva said.  <\/p>\n\n\n\n

The next steps in the research will involve trying to find that human data, focusing on the actual mechanisms preventing the healing of the fractures. Since nobody knew this was a problem, nobody was looking for solutions.<\/p>\n\n\n\n

In the meantime, with this new awareness of the problem, the researchers hope there will be more widespread adoption of measures to increase bone strength, more careful monitoring when fractures do occur, and that physicians and others will consider the bone health of people with DS.<\/p>\n\n\n\n

\u201cWe want physicians to say to patients, \u2018you\u2019re 17 years old; you can keep playing soccer and being active,\u2019\u201d said Suva. \u201cBut we also want them making sure these patients\u2019 diet and vitamin D levels are good, to do all of these things that are suggested for skeletal health. That\u2019s our goal.\u201d<\/p>\n\n\n\n

###<\/p>\n\n\n\n

For more information about the Texas A&M College of Veterinary Medicine & Biomedical Sciences, please visit our website at\u00a0<\/em>vetmed.tamu.edu<\/em><\/a>\u00a0or join us on\u00a0<\/em>Facebook<\/em><\/a>,\u00a0<\/em>Instagram<\/em><\/a>, and\u00a0<\/em>X<\/em><\/a>.<\/em><\/p>\n\n\n\n

Contact Information:<\/em><\/strong> Jennifer Gauntt, Director of VMBS Communications, Texas A&M College of Veterinary Medicine & Biomedical Sciences, <\/em>jgauntt@cvm.tamu.edu,<\/em><\/a> 979-862-4216<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

New research from the Texas A&M School of Veterinary Medicine & Biomedical Sciences (VMBS) is the first to provide direct experimental evidence that people with Down syndrome (DS) may not heal from bone fractures. The recently published study, led by Kirby Sherman, a Ph.D. candidate in the VMBS\u2019 Department of Veterinary Physiology & Pharmacology (VTPP), 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research from the Texas A&M School of Veterinary Medicine & Biomedical Sciences (VMBS) is the first to provide direct experimental evidence that people with Down syndrome (DS) may not heal from bone fractures. The recently published study, led by Kirby Sherman, a Ph.D. candidate in the VMBS\u2019 Department of Veterinary Physiology & Pharmacology (VTPP),…","_links":{"self":[{"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/posts\/18704","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/users\/269"}],"replies":[{"embeddable":true,"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/comments?post=18704"}],"version-history":[{"count":0,"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/posts\/18704\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/media\/18705"}],"wp:attachment":[{"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/media?parent=18704"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/categories?post=18704"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vetmed.tamu.edu\/news\/wp-json\/wp\/v2\/tags?post=18704"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}