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Jonathan Levine

Jonathan Levine

Department Head, Small Animal Clinical Sciences
Professor & Helen McWhorter Chair in Small Animal Clinical Sciences
Department of Small Animal Clinical Sciences
Contact
vscsdepthead@cvm.tamu.edu
9798452351
TAMU Mailstop: 4474

Research and Scholarly Interests

Spinal cord injury, in particular MR imaging and neuroprotection Neuro-oncology

EDUCATION

  • B.S., Cornell University, 1995
  • D.V.M., Cornell University , 2001
  • N/A, Colorado State University, 2002
  • N/A, Texas A&M/University of Missouri, 2005

CREDENTIALS

  • ACVIM (Neurology), start 2005, Board Certified
  • Texas Veterinary Medical License: 9993
  • Texas Veterinary Medical Specialty License: 0233-S
  • Neuroscience
  • Neurology
  • S C Kerwin, J M Levine, C M Budke, J F Griffin, C E Boudreau (2017). Putative Cerebral Microbleeds in Dogs Undergoing Magnetic Resonance Imaging of the Head: A Retrospective Study of Demographics, Clinical Associations, and Relationship to Case Outcome. JOURNAL OF VETERINARY INTERNAL MEDICINE. 4, 1140-1148
  • Jonathan M Levine, Noah D Cohen, Thomas M Fandel, Gwendolyn J Levine, Joseph Mankin, John F Griffin, Sharon C Kerwin, C Elizabeth Boudreau, Alpa Trivedi, Linda J Noble-Haeusslein (2017). Early Blockade of Matrix Metalloproteinases in Spinal-Cord-Injured Dogs Results in a Long-Term Increase in Bladder Compliance. JOURNAL OF NEUROTRAUMA.
  • Amanda E Masciarelli, John F Griffin, Geoffrey T Fosgate, Silke Hecht, Joseph M Mankin, Shannon P Holmes, Simon R Platt, Marc Kent, Theresa E Pancotto, Annie V Chen, Jonathan M Levine (2017). Evaluation of magnetic resonance imaging for the differentiation of inflammatory, neoplastic, and vascular intradural spinal cord diseases in the dog. VETERINARY RADIOLOGY & ULTRASOUND : THE OFFICIAL JOURNAL OF THE AMERICAN COLLEGE OF VETERINARY RADIOLOGY AND THE INTERNATIONAL VETERINARY RADIOLOGY ASSOCIATION. 4, 444-453
  • Sarah A Moore, Nicolas Granger, Natasha J Olby, Ingo Spitzbarth, Nick D Jeffery, Andrea Tipold, Yvette S Nout-Lomas, Ronaldo C da Costa, Veronika M Stein, Linda J Noble-Haeusslein, Andrew R Blight, Robert G Grossman, D Michele Basso, Jonathan M Levine (2017). Targeting Translational Successes through CANSORT-SCI: Using Pet Dogs To Identify Effective Treatments for Spinal Cord Injury. JOURNAL OF NEUROTRAUMA. 12, 2007-2018
  • Nick D Jeffery, Andrew K Barker, Cody J Alcott, Jon M Levine, Ilyssa Meren, Jane Wengert, Albert E Jergens, Jan S Suchodolski (2017). The Association of Specific Constituents of the Fecal Microbiota with Immune-Mediated Brain Disease in Dogs. PLOS ONE. 1,
  • Megan W Stout Steele, Amy W Hodshon, Andrew L Hopkins, Gaemia M Tracy, Noah D Cohen, Sharon C Kerwin, C Elizabeth Boudreau, William B Thomas, Joseph M Mankin, Jonathan M Levine (2016). Multi-Center Retrospective Evaluation of Screw and Polymethylmethacrylate Constructs for Atlantoaxial Fixation in Dogs. VETERINARY SURGERY : VS. 7, 909-915
  • Shelton GD, Rinz C, Levine JM, Minor K, Starr-Moss A, Clark LA (2014). Congenital myasthenia gravis in a family of Labrador retrievers is caused by a mutation in the COLQ gene
  • Griffin JF, Davis MC, Cohen ND, Young BY, Levine JM (2013). Evaluator agreeement and outcome associations in dogs with spinal cord injury caused by intervertebral disk herniation
  • Levine GJ, Cook JR, Kerwin SC, Mankin J, Griffin JF, Fosgate GT, Levine JM (2014). Relationships between cerebrospinal fluid characteristics, injury severity, and functional outcome in dogs with and without intervertebral disk herniation VET CLINI PATHOL.
  • Bentley RT, Burcham GN, Heng HG, Levine JM, Longshore R, Carrera-Justiz S, Cameron S, Koft K, Miller MA (2014). A comparison of clinical, magnetic resonance imaging, and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes VET COMP ONCOL.
  • Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi A, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ (2014). Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs PLOS ONE., e96408
  • Taylor AR, Welsh J, Young C, Cohen ND, Levine GJ, Levine JM (2014). Inflammatory cytokines in cerberospinal fluid of dogs with acute spinal cord injury
  • Trivendi A, Fandel TM, Martinez AF, Zhang H, Levine JM, Noble-Haeusslein LJ (2013). Matrix metalloproteinase inhibitor, GM6001 improves bladder and locomotor function after moderate-severe contusion spinal cord injury in mice
  • Fandel TM, Trivendi A, Gimlin K, Zhang H, Levine JM, Martinez AF, Noble-Haeusslein LJ (2013). Acute treatment with the matrix maetalloproteinase inhibitor GM 6001 improves long-term locomotor and bladder function in a murine model of spinal cord injury
  • Jeffery ND, Levine JM, Olby NJ, Stein V (2013). Intervertebral disc degeneration in dogs: consequences, diagnosis, treatment, and future directions J VET INTERN MED. 27, 1318-1333
  • Van Wie EY, Fosgate GT, Mankin JM, Jeffery ND, Kerwin SC, Levine GJ, Greatting HH, Chen AV, Levine JM (2013). Prospectively recorded versus medical record-derived spinal cord injury scores in a cohort of dogs with intervertebral disk herniation J VET INTERN MED. 27, 1273-1277
  • Young BD, Fosgate GT, Holmes SP, Wolff CA, Chen-Allen AV, Kent M, Platt SR, Savage MY, Schatzberg SJ, Levine JM (2014). Evaluation of standard magnetic resonance characteristics used to differentiate neoplastic, inflammatory, and vascular brain lesions in dogs VET RADIOL ULTRASOUND. 55, 399-406
  • Cooper JJ, Schatzberg SJ, Verneau K, Summers B, Porter B, Sisso S, Young BD, Levine JM (2014). Necrotizing meningoencephalitis in atypical dog breeds: a case series and literature review J VET INTERN MED. 28, 198-203
  • Cooper JJ, Young BD, Griffin JF, Fosgate GT, Levine JM (2014). Comparison between noncontrast computed tomography and magnetic resonance imaging for detection and characterization of thoracolumbar myelopathy caused by intervertebral disk herniation in dogs VET RADIOL ULTRASOUND. 55, 182-189
  • Xu S, Wei J, Kong LY, Ling XY, Nduom E, Gabrusieeicz K, Doucette T, Yang Y, Yaghi NK, Fajt V, Levine JM, Qiao W, Li XG, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB (2014). Effect if miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma J NATL CANCER INST.
  • Mouradian-Darby AE, Young BD, Griffin JF, Mansell J, Levine JM (2014). Lymphocytic ganglioneuritis secondary to intervertebral disc extrusion in a dog J SMALL ANIM PRACT.
  • Taylor AR, Welsh J, Young C, Spoor E, Kerwin SC, Griffin JF, Levine GJ, Cohen ND, Levine JM (2014). Cerebrospinal fluid inflammatory cytokines and chemokines in naturally-occurring canine spinal cord injury J NEUROTRAUMA.
  • Barber RM, Li Q, Diniz PP, Porter BF, Breitschwerdt EB, Claiborne MK, Birkenheuer AJ, Levine JM, Levine GJ, Chandler K, Kenny P, Nghiem P, Wei S, Greene CE, Kent M, Platt SR, Greer K, Schatzberg SJ (2010). Evaluation of brain tissue or cerebrospinal fluid with broadly reactive polymerase chain reaction for Ehrlichia, Anaplasma, spotted fever group Rickettsia, Bartonella, and Borrelia species in canine neurological diseases (109 cases). J VET INTERN MED.. 2, 372-8
  • Dewey CW, Cerda-Gonzalez S, Levine JM, Badgley BL, Ducoté JM, Silver GM, Cooper JJ, Packer RA, Lavely JA (2009). Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy. J AM VET MED ASSOC.. 12, 1442-9
  • Schatzberg SJ, Li Q, Porter BF, Barber RM, Claiborne MK, Levine JM, Levine GJ, Israel SK, Young BD, Kiupel M, Greene C, Ruone S, Anderson L, Tong S (2009). Broadly reactive pan-paramyxovirus reverse transcription polymerase chain reaction and sequence analysis for the detection of Canine distemper virus in a case of canine meningoencephalitis of unknown etiology. J VET DIAGN INVEST.. 6, 844-9
  • Eagleson JS, Diaz J, Platt SR, Kent M, Levine JM, Sharp NJ, Schatzberg SJ (2009). Cervical vertebral malformation-malarticulation syndrome in the Bernese mountain dog: clinical and magnetic resonance imaging features. J SMALL ANIM PRACT.. 4, 186-93
  • Bergman RL, Levine JM, Coates JR, Bahr A, Hettlich BF, Kerwin SC (2008). Cervical spinal locking plate in combination with cortical ring allograft for a one level fusion in dogs with cervical spondylotic myelopathy. VET SURG.. 6, 530-6
  • Baltzer WI, McMichael MA, Hosgood GL, Kerwin SC, Levine JM, Steiner JM, Ruaux CG (2008). Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease. SPINE (PHILA PA 1976). 13, 1397-402
  • Baltzer WI, Calise DV, Levine JM, Shelton GD, Edwards JF, Steiner JM (2007). Dystrophin-deficient muscular dystrophy in a Weimaraner. J AM ANIM HOSP ASSOC.. 4, 227-32
  • Levine JM, Fitch RB (2003). Use of an ankle-foot orthosis in a dog with traumatic sciatic neuropathy. J SMALL ANIM PRACT.. 5, 236-8
  • Levine JM, Hillman RB, Erb HN, deLahunta A (2002). The influence of age on patellar reflex response in the dog. J VET INTERN MED.. 3, 244-6
  • Wolff CA, Holmes SP, Young BD, Chen AV, Kent M, Platt SR, Savage MY, Schatzberg SJ, Fosgate GT, Levine JM (2012). Magnetic resonance imaging for the differentiation of neoplastic, inflammatory, and cerebrovascular brain disease in dogs. J VET INTERN MED. 3, 589-97
  • Witsberger TH, Levine JM, Fosgate GT, Slater MR, Kerwin SC, Russell KE, Levine GJ (2012). Associations between cerebrospinal fluid biomarkers and long-term neurologic outcome in dogs with acute intervertebral disk herniation. J AM VET MED ASSOC. 5, 555-62
  • Fryer KJ, Levine JM, Peycke LE, Thompson JA, Cohen ND (2011). Incidence of postoperative seizures with and without levetiracetam pretreatment in dogs undergoing portosystemic shunt attenuation. J VET INTERN MED. 6, 1379-84
  • Blair WH, Levine JM, Kerwin SC, Spaulding KA, Young BD, Pool RR (2011). Imaging diagnosis-synovial myxoma of lumbar vertebrae articular process joint. VET RADIOL ULTRASOUND. 3, 309-12
  • Levine JM, Levine GJ, Porter BF, Topp K, Noble-Haeusslein LJ (2011). Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research. J NEUROTRAUMA. 4, 675-88
  • Cooper JJ, Young BD, Hoffman A, Bratton G, Hicks DG, Tidwell A, Levine JM (2010). Intracranial magnetic resonance imaging artifacts and pseudolesions in dogs and cats. VET RADIOL ULTRASOUND. 6, 587-95
  • Stoica G, Levine J, Wolff J, Murphy K (2011). Canine astrocytic tumors: a comparative review. VET PATHOL. 1, 266-75
  • Levine JM, Scrivani PV, Divers TJ, Furr M, Mayhew IJ, Reed S, Levine GJ, Foreman JH, Boudreau C, Credille BC, Tennent-Brown B, Cohen ND (2010). Multicenter case-control study of signalment, diagnostic features, and outcome associated with cervical vertebral malformation-malarticulation in horses. J AM VET MED ASSOC. 7, 812-22
  • Levine GJ, Levine JM, Witsberger TH, Kerwin SC, Russell KE, Suchodolski J, Steiner J, Fosgate GT (2010). Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation. J VET INTERN MED. 4, 890-6
  • Cooper JJ, Levine JM, Young BD, Hicks DG, Hoffman A, Bratton G (2010). Imaging diagnosis--magnetic resonance imaging pseudolesion associated with the petrous temporal bone. VET RADIOL ULTRASOUND. 1, 39-41
  • Snyder K, Saunders AB, Levine JM, Clubb FJ (2010). Arrhythmias and elevated troponin I in a dog with steroid-responsive meningitis-arteritis. J AM ANIM HOSP ASSOC. 1, 61-5
  • Levine JM, Fosgate GT, Chen AV, Rushing R, Nghiem PP, Platt SR, Bagley RS, Kent M, Hicks DG, Young BD, Schatzberg SJ (2009). Magnetic resonance imaging in dogs with neurologic impairment due to acute thoracic and lumbar intervertebral disk herniation. J VET INTERN MED. 6, 1220-6
  • Israel SK, Levine JM, Kerwin SC, Levine GJ, Fosgate GT (2009). The relative sensitivity of computed tomography and myelography for identification of thoracolumbar intervertebral disk herniations in dogs. VET RADIOL ULTRASOUND. 3, 247-52
  • Griffin JF 4th, Young BD, Levine JM (2009). Imaging diagnosis--chronic canine distemper meningoencephalitis. VET RADIOL ULTRASOUND. 2, 182-4
  • Levine GJ, Levine JM, Budke CM, Kerwin SC, Au J, Vinayak A, Hettlich BF, Slater MR (2009). Description and repeatability of a newly developed spinal cord injury scale for dogs. PREV VET MED. 1-2, 121-7
  • Stoica G, Lungu G, Martini-Stoica H, Waghela S, Levine J, Smith R 3rd (2009). Identification of cancer stem cells in dog glioblastoma. VET PATHOL. 3, 391-406
  • Aloisio F, Levine JM, Edwards JF (2008). Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. J VET DIAGN INVEST. 6, 836-8
  • Levine JM, Ngheim PP, Levine GJ, Cohen ND (2008). Associations of sex, breed, and age with cervical vertebral compressive myelopathy in horses: 811 cases (1974-2007). J AM VET MED ASSOC. 9, 1453-8
  • Levine JM, Budke CM, Levine GJ, Kerwin SC, Hettlich BF, Slater MR (2008). Owner-perceived, weighted quality-of-life assessments in dogs with spinal cord injuries. J AM VET MED ASSOC. 6, 931-5
  • Budke CM, Levine JM, Kerwin SC, Levine GJ, Hettlich BF, Slater MR (2008). Evaluation of a questionnaire for obtaining owner-perceived, weighted quality-of-life assessments for dogs with spinal cord injuries. J AM VET MED ASSOC. 6, 925-30
  • Levine JM, Fosgate GT, Porter B, Schatzberg SJ, Greer K (2008). Epidemiology of necrotizing meningoencephalitis in Pug dogs. J VET INTERN MED. 4, 961-8
  • Griffin JF, Levine JM, Levine GJ, Fosgate GT (2008). Meningomyelitis in dogs: a retrospective review of 28 cases (1999 to 2007). J SMALL ANIM PRACT. 10, 509-17
  • Levine JM, Levine GJ, Boozer L, Schatzberg SJ, Platt SR, Kent M, Kerwin SC, Fosgate GT (2008). Adverse effects and outcome associated with dexamethasone administration in dogs with acute thoracolumbar intervertebral disk herniation: 161 cases (2000-2006). J AM VET MED ASSOC. 3, 411-7
  • Levine JM, Adam E, MacKay RJ, Walker MA, Frederick JD, Cohen ND (2007). Confirmed and presumptive cervical vertebral compressive myelopathy in older horses: a retrospective study (1992-2004). J VET INTERN MED. 4, 812-9
  • Levine JM, Levine GJ, Johnson SI, Kerwin SC, Hettlich BF, Fosgate GT (2007). Evaluation of the success of medical management for presumptive cervical intervertebral disk herniation in dogs. VET SURG. 5, 492-9
  • Levine JM, Levine GJ, Johnson SI, Kerwin SC, Hettlich BF, Fosgate GT (2007). Evaluation of the success of medical management for presumptive thoracolumbar intervertebral disk herniation in dogs. VET SURG. 5, 482-91
  • Levine GJ, Bissett WT, Cole RC, Janke JJ, Nunes J, Porter B, Levine JM (2006). Imaging diagnosis--bacterial diskospondylitis in a goat. VET RADIOL ULTRASOUND. 6, 585-8
  • Levine JM, Levine GJ, Kerwin SC, Hettlich BF, Fosgate GT (2006). Association between various physical factors and acute thoracolumbar intervertebral disk extrusion or protrusion in Dachshunds. J AM VET MED ASSOC. 3, 370-5
  • Levine JM, Ruaux CG, Bergman RL, Coates JR, Steiner JM, Williams DA (2006). Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease. AM J VET RES. 2, 283-7
  • Levine GJ, Levine JM, Walker MA, Pool RR, Fosgate GT (2006). Evaluation of the association between spondylosis deformans and clinical signs of intervertebral disk disease in dogs: 172 cases (1999-2000). J AM VET MED ASSOC. 1, 96-100
  • Levine JM, Bergman RL, Coates JR, Shelton GD (2005). Myasthenia gravis and hypothyroidism in a dog with meningomyelitis. J AM ANIM HOSP ASSOC. 4, 247-51
  • Thompson CA, Russell KE, Levine JM, Weeks BR (2003). Cerebrospinal fluid from a dog with neurologic collapse. VET CLIN PATHOL. 3, 143-6
  • Xu S, Wei J, Wang F, Kong LY, Ling XY, Nduom E, Gabrusiewicz K, Doucette T, Yang Y, Yaghi NK, Fajt V, Levine JM, Qiao W, Li XG, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB (2014). Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma. J NATL CANCER INST. 8,
  • Young BD, Mankin JM, Griffin JF, Fosgate GT, Fowler JL, Levine JM (2015). Comparison of two fat-suppressed magnetic resonance imaging pulse sequences to standard t2-weighted images for brain parenchymal contrast and lesion detection in dogs with inflammatory intracranial disease. VET RADIOL ULTRASOUND. 2, 204-11
  • Griffin JF, Davis MC, Ji JX, Cohen ND, Young BD, Levine JM (2015). Quantitative magnetic resonance imaging in a naturally occurring canine model of spinal cord injury. SPINAL CORD. 4, 278-84
  • Rissi DR, Levine JM, Eden KB, Watson VE, Griffin JF, Edwards JF, Porter BF (2015). Cerebral oligodendroglioma mimicking intraventricular neoplasia in 3 dogs J VET DIAGN INVEST.
  • Mouradian-Darby AE, Young BD, Griffin JF, Mansell J, Levine JM (2014). Lynphocytic ganglioneuritis secondary to intervertebral disc extrusion in a dog J SMALL ANIM PRACT.
  • Anderson KM, Welsh CJ, Young C, Levine GJ, Kerwin SC, Boudreau CE, Reyes I, Mondragon A, Griffin JF 4th, Cohen ND, Levine JM (2015). Acute Phase Proteins in Cerebrospinal Fluid from Dogs with Naturally-Occurring Spinal Cord Injury. J NEUROTRAUMA.
  • Li P, Yu X, Griffin J, Levine JM, Ji J (2015). High-resolution MRI of spinal cords by compressive sensing parallel imaging IEEE ENG MED BIOL SOC.
  • Jeffery ND, Baker A, Alcott, Hu HZ, Kraus K, Scanlin E, Granger N, Levine JM (2015). Prospective cohort study to analyze physical and temporal prognostic factors associated with recovery from paraplegia in dogs that have lost deep pain perception J AM VET MED ASSOC.
  • aylor AR, Young BD, Levine GJ, Eden K, Corapi W, Rossmeisl JH, Levine JM (2015). Magnetic resonance imaging and clinical features of dogs with central nervous system aspergillosis J VET INTERN MED., 1556-1563
  • Kuhlman GM, Taylor AR, Griffin JF, Thieman KT, Cook AK, Levine JM (2016). Application of a frameless computed tomography-guided stereotactic biopsy system for the collection of nasal biopsies in dogs: 5 cases (2012-2014) J AM VET MED ASSOC., 929-934
  • Russell RL, Levine JM, Jeffery ND, Mondragon A, Lee B, Boudreau CE, Welsh CJ, Levine GJ (2016). Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury BMC NEUROSCI., 31

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