George Stoica
Professor Emeritus Department of Veterinary PathobiologyResearch and Scholarly Interests
Mechanism(s) of retro viral-induced neurodegeneration. Pathogenesis of brain and bone metastases of mammary gland tumors; application of flow cytometry in the study of tumors; lectin and immunohistochemistry; chemical carcinogenesis; animal models for retro virus-induced neoplasia. Genetic alterations in tumors of the nervous system, dog animal model. Investigating the mechanism of alpha-synuclein in neurodegeneration in a rat animal model. Application of non-invasive technologies in biomedical science. Use of molecular markers in non-invasive optical imaging technologies.
EDUCATION
- D.V.M., Institute of Agronomy, Yassy, Romania, 1966
- M.S., Ohio State University, 1981
- Ph.D., Michigan State University, 1984
CREDENTIALS
- Texas Veterinary Medical Specialty License: 0143-S
- Immunology
- Toxicology
- Cell Biology
- Genetics
- Imaging
- Oncology
- Virology
- Laboratory Animal Medicine
- Stoica George (2014). Potential role of alpha synuclein in the pathogenesis of neurodegeneration in a rat animal model
- Stoica G. (2015). Cancer Stem Cells: Current Status and Future Directions THE VETERINARY JPURNAL.
- Lungu G, Stoica G, Ambrus A. (2013). MicroRNA profiling and the role of microRNA-132 in neurodegeneration using a rat model. NEUROSCIENCE LETTERS 553., 153-158
- Xing Zhang, Veronica M. Chiu, George Stoica, James O. Schenk and Herbert H. Hill, Jr. (2014). Metabolic analysis of striatum tissue from Parkinson’s disease- like rats by ion mobility mass spectrometry (ESI-IMMS). ANAL CHEM. . 6, 3075-83
- Michael Empl, Sebastian Macke, Peter Winterhalter, Christina Puff, Stephanie Lapp, George Stoica, Wolfgang Baumgartner and Pablo Steinberg. (2014). The growth of the canine glioblastoma cell line D-GBM and the canine histiocytoma cell line DH82 is inhibited by the resveratrol oligomers hopeaphenol and r2-viniferin. VET COMP ONCOL. 2, 149-59
- Stoica G, Lungu G, Martini-Stoica H, Waghela S, Levine J, Smith R 3rd (2009). Identification of cancer stem cells in dog glioblastoma. VET PATHOL. 3, 391-406
- Stoica G, Levine J, Wolff J, Murphy K (2011). Canine astrocytic tumors: a comparative review. VET PATHOL. 1, 266-75
- Lungu G, Kuang X, Stoica G, Wong PK (2010). Monosodium luminol upregulates the expression of Bcl-2 and VEGF in retrovirus-infected mice through downregulation of corresponding miRNAs. ACTA VIROL. 1, 27-32
- Stoica G, Lungu G, Kim HT, Wong PK (2008). Up-regulation of pro-nerve growth factor, neurotrophin receptor p75, and sortilin is associated with retrovirus-induced spongiform encephalomyelopathy. BRAIN RES. 1208, 204-16
- Lungu G, Covaleda L, Mendes O, Martini-Stoica H, Stoica G (2008). FGF-1-induced matrix metalloproteinase-9 expression in breast cancer cells is mediated by increased activities of NF-kappaB and activating protein-1. MOL CARCINOG. 6, 424-35
- Mendes O, Kim HT, Lungu G, Stoica G (2007). MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. CLIN EXP METASTASIS. 5, 341-51
- Stoica G, Lungu G, Xie X, Abbott LC, Stoica HM, Jaques JT (2007). Inherited tertiary hypothyroidism in Sprague-Dawley rats. BRAIN RES. 1148, 205-16
- Mendes O, Kim HT, Stoica G (2005). Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. CLIN EXP METASTASIS. 3, 237-46
- Stoica G, Cohen N, Mendes O, Kim HT (2004). Use of immunohistochemical marker calretinin in the diagnosis of a diffuse malignant metastatic mesothelioma in an equine. J VET DIAGN INVEST. 3, 240-3
- Stoica G, Kim HT, Hall DG, Coates JR (2004). Morphology, immunohistochemistry, and genetic alterations in dog astrocytomas. VET PATHOL. 1, 10-9
- Guyer CL, Stoica G, Womack JE, Storts RW, Derr JN, Abbott LC (2002). A line of Berlin Druckrey IV rats proposed as a new model for human hereditary ataxia. IN VIVO. 4, 255-63
- Stoica G, Tasca SI, Kim HT (2001). Point mutation of neu oncogene in animal peripheral nerve sheath tumors. VET PATHOL. 6, 679-88
- Kim HT, Qiang W, Wong PK, Stoica G (2001). Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation. J NEUROVIROL. 5, 466-75
- Stoica G, Tasca SI, Wong PK (2000). Motor neuronal loss and neurofilament-ubiquitin alteration in MoMuLV-ts1 encephalopathy. ACTA NEUROPATHOL. 3, 238-44
- Stoica G, Barker R, Wu G, Lynn WS, Wong PK (1998). Quantitative variation of free amino acids in the central nervous system of MoMuLV-ts1-infected mice. IN VIVO. 4, 395-401
- Stoica G (1994). Sarcoma viruses containing the mos oncogene induce lesions resembling Kaposi's sarcoma. IN VIVO. 1, 43-7
- Tasca SI, Hoffman RJ, Stoica G (1993). Detection of Moloney murine sarcoma virus in tissues and cultured cells by the polymerase chain reaction. J VIROL METHODS. 3, 255-63
- Stoica G, Jacobs R, Koestner A, O'Leary M, Welsch C (1991). ENU-induced in vitro neoplastic transformation of rat mammary epithelial cells. ANTICANCER RES. 5, 1783-92
- Stein LS, Stoica G, Tilley R, Burghardt RC (1991). Rat ovarian granulosa cell culture: a model system for the study of cell-cell communication during multistep transformation. CANCER RES. 2, 696-706
- Stoica G, O'Leary M (1988). In vitro malignant transformation of in vivo ENU-induced rat ovarian Sertoli cell tumor (adenoma). J CANCER RES CLIN ONCOL. 2, 142-8
- George Stoica (2015). Cancer stem cell microenvironment in canine glioblastoma development: Animal model for human disease. Int. J PatholClinRes.
- George Stoica (2015). Cancer stem cell microenvironment in canine glioblastoma development:Animal model for human disease.
- George Stoica (2015). Cancer stem cell microenvironment in canine glioblastoma development: Animal model for human disease
- Ian Tizard*, Judith Ball, George Stoica, Susan Payne. (3095). THE PATHOGENESIS OF BORNAVIRAL DISEASE IN MAMMALS ANIMAL HEALTH RESEARCH REVIEWS. PUBLISHED, .