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Brad Weeks

Brad Weeks

Professor Emeritus Department of Veterinary Pathobiology
Contact
BWEEKS@cvm.tamu.edu
9798450789
TAMU Mailstop: 4467

Research and Scholarly Interests

Diagnostic anatomic pathology; collaborative research of inflammatory and neoplastic gastrointestinal disease, and cardiovascular disease. Veterinary medical education, particularly general pathology.

EDUCATION

  • B.S., Oklahoma State University, 1979
  • D.V.M., Oklahoma State University, 1983
  • Ph.D., Kansas State University, 1988
  • Residency in Veterinary Pathology, Kansas State University, 1988

CREDENTIALS

  • Licensed to Practice Veterinary Medicine, KS
  • Professor, Dept. of Veterinary Pathobiology, , start 2012
  • Diplomate, American College of Veterinary Pathologists, (ACVP) , start 1990, Board Certified
  • Licensed to practice Veterinary Medicine, TX Individual License # 10969:, start 2008, Board Certified
  • Monk JM, Hou TY, Turk HF, Weeks B, Wu C, McMurray DN, Chapkin RS (2012). Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. PLOS ONE. 11,
  • Fan YY, Monk JM, Hou TY, Callway E, Vincent L, Weeks B, Yang P, Chapkin RS (2012). Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model. J LIPID RES. 7, 1287-95
  • Monk JM, Jia Q, Callaway E, Weeks B, Alaniz RC, McMurray DN, Chapkin RS (2012). Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice. J NUTR. 1, 117-24
  • Monk JM, Kim W, Callaway E, Turk HF, Foreman JE, Peters JM, He W, Weeks B, Alaniz RC, McMurray DN, Chapkin RS (2012). Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARδ in inflammation-induced colon carcinogenesis. AM J PHYSIOL GASTROINTEST LIVER PHYSIOL. 1,
  • Armstrong CM, Billimek AR, Allred KF, Sturino JM, Weeks BR, Allred CD (2013). A novel shift in estrogen receptor expression occurs as estradiol suppresses inflammation-associated colon tumor formation. ENDOCR RELAT CANCER. 4, 515-25
  • Carpenter BA, Gonzalez CJ, Jessen SL, Moore EJ, Thrapp AN, Weeks BR, Clubb FJ Jr (2013). A brief review of ventricular assist devices and a recommended protocol for pathology evaluations. CARDIOVASC PATHOL. 5, 408-15
  • Brown JS, Johnson MC, Sims WP, Boone LH, Swor TM, Weeks BR (2011). Oil Red O-positive lipid in peritoneal fluid from a horse with a rectal tear. VET CLIN PATHOL. 2, 265-9
  • Hilligas J, Van Wie E, Barr J, Russell KE, Perry AL, Weeks BR, Zhang S (2014). Vertebral osteomyelitis and multiple cutaneous lesions in a dog caused by Nocardia pseudobrasiliensis. J VET INTERN MED. 5, 1621-5
  • Jia Q, Ivanov I, Zlatev ZZ, Alaniz RC, Weeks BR, Callaway ES, Goldsby JS, Davidson LA, Fan YY, Zhou L, Lupton JR, McMurray DN, Chapkin RS (2011). Dietary fish oil and curcumin combine to modulate colonic cytokinetics and gene expression in dextran sodium sulphate-treated mice. BR J NUTR. 4, 519-29
  • Lentz EK, Cherla RP, Jaspers V, Weeks BR, Tesh VL (2010). Role of tumor necrosis factor alpha in disease using a mouse model of Shiga toxin-mediated renal damage. INFECT IMMUN. 9, 3689-99
  • Massuto DA, Hooper RN, Kneese EC, Johnson GA, Ing NH, Weeks BR, Jaeger LA (2010). Intrauterine infusion of latency-associated peptide (LAP) during early porcine pregnancy affects conceptus elongation and placental size. BIOL REPROD. 3, 534-42
  • Russell-Lodrigue KE, Andoh M, Poels MW, Shive HR, Weeks BR, Zhang GQ, Tersteeg C, Masegi T, Hotta A, Yamaguchi T, Fukushi H, Hirai K, McMurray DN, Samuel JE (2009). Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever. INFECT IMMUN. 12, 5640-50
  • Fan YY, Zhan Y, Aukema HM, Davidson LA, Zhou L, Callaway E, Tian Y, Weeks BR, Lupton JR, Toyokuni S, Chapkin RS (2009). Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice. J NUTR. 7, 1328-32
  • Andoh M, Zhang G, Russell-Lodrigue KE, Shive HR, Weeks BR, Samuel JE (2007). T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice. INFECT IMMUN. 7, 3245-55
  • Monk JM, Turk HF, Fan YY, Callaway E, Weeks B, Yang P, McMurray DN, Chapkin RS (2014). Antagonizing arachidonic acid-derived eicosanoids reduces inflammatory Th17 and Th1 cell-mediated inflammation and colitis severity. MEDIATORS INFLAMM. 2014, 917149
  • Turk HF, Monk JM, Fan YY, Callaway ES, Weeks B, Chapkin RS (2013). Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. AM J PHYSIOL CELL PHYSIOL. 9,
  • Jay CM1, Ruoff C2, Kumar P1, Maass H2, Spanhel B2, Miller M2, Arrington A2, Montalvo N2, Gresham V2, Rao DD1, Evans C, Wang Z, Brunicardi FC, Liu SH, Zhou G, Senzer N, Nemunaitis J, King L, Weeks B, Clubb FJ, Fossum TW, Maples PB. (2013). Assessment of intravenous pbi-shRNA PDX1 nanoparticle (OFHIRNA-PDX1) in yucatan swine. CANCER GENE THER.. 12, 683-9
  • A Roberts, K E Trainor, B Weeks, N Jackson, R W Troughton, C J Charles, M T Rademaker, I C Melton, I G Crozier, W Hafelfinger, D E Gutfinger, N L Eigler, W T Abraham, F J Clubb, Jr (2013). Integrated microscopy techniques for comprehensive pathology evaluation of an implantable left atrial pressure sensor J HISTOTECHNOL.. 1, 17
  • Christine T. McFarland, Yang-Yi Fan, Robert S. Chapkin, Bradley R. Weeks, David N. McMurray (2008). Dietary Polyunsaturated Fatty Acids Modulate Resistance to Mycobacterium tuberculosis in Guinea Pigs J NUTR.. 11, 2123
  • McFarland CT, Ly L, Jeevan A, Yamamoto T, Weeks B, Izzo A, McMurray D (2010). BCG vaccination in the cotton rat (Sigmodon hispidus) infected by the pulmonary route with virulent Mycobacterium tuberculosis. TUBERCULOSIS (EDINB). 4, 262-7
  • Nicolette Jackson, Kolsie Frazee, Anagha Phadke, Phillip B. Maples, Aaron Roberts, Bradley R. Weeks, Brett P. Giroir and Fred J. Clubb Jr. (2010). Stathmin I Bifunctional shRNA Effectiveness on Melanoma Progression. PROCEEDINGS, CPRIT (CANCER PREVENTION AND RESEARCH INSTITUTE OF TEXAS) CONFERENCE..
  • Cameron M Armstrong, Kimberly F Allred, Brad R Weeks, Robert S Chapkin, Clinton D Allred (2017). Estradiol Has Differential Effects on Acute Colonic Inflammation in the Presence and Absence of Estrogen Receptor β Expression DIGESTIVE DISEASES AND SCIENCES. 8, 1977
  • Herlihy SE, Brown ML, Pilling D, Weeks BR, Myers LK, Gomer RH (2015). Role of the Neutrophil Chemorepellent Soluble Dipeptidyl Peptidase IV in Decreasing Inflammation in a Murine Model of Arthritis. ARTHRITIS RHEUMATOLOGY.
  • Ritchie, Lauren E, Taddeo, Stella S, Weeks, Brad R, Lima, Florence, Bloomfield, Susan A, Azcarate-Peril, M Andrea, Zwart, Sara R, Smith, Scott M, Turner, Nancy D (2015). Space environmental factor impacts upon murine colon microbiota and mucosal homeostasis PLOS ONE. 6,
  • Herlihy, Sarah E, Brown, Monica L, Pilling, Darrell, Weeks, Brad R, Myers, Linda K, Gomer, Richard H (2015). Role of the Neutrophil Chemorepellent Soluble Dipeptidyl Peptidase IV in Decreasing Inflammation in a Murine Model of Arthritis ARTHRITIS & RHEUMATOLOGY. 10, 2634-2638
  • Davidson, Laurie A, Callaway, Evelyn S, Kim, Eunjoo, Weeks, Brad R, Fan, Yang-Yi, Allred, Clinton D, Chapkin, Robert S (2015). Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer CANCER RESEARCH. 24, 5392-5397
  • Kim, Eunjoo, Davidson, Laurie A, Zoh, Roger S, Hensel, Martha E, Patil, Bhimanagouda S, Jayaprakasha, Guddadarangavvanahally K, Callaway, Evelyn S, Allred, Clinton D, Turner, Nancy D, Weeks, Brad R, Chapkin Robert S. (2016). Homeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogen CARCINOGENESIS. 2, 206-214
  • Jessen, Staci L, Masse, Andrew M, Carpenter, Mallory D, Clubb Jr, Fred J, Weeks, Brad R (2016). A Method for Creating Artificial Thrombi In Vitro Using a Rotating Mechanical Surface ASAIO JOURNAL. 3, 252-260
  • Whitfield-Cargile, Canaan M, Cohen, Noah D, Chapkin, Robert S, Weeks, Brad R, Davidson, Laurie A, Goldsby, Jennifer S, Hunt, Carrie L, Steinmeyer, Shelby H, Menon, Rani, Suchodolski, Jan S (2016). The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy GUT MICROBES., 1-16
  • S. L. Jessen, J. D. Horn, A. C. Caruso, F. J. Clubb, Jr., B. R.Weeks (2016). Computational Evaluation of Thrombosis Risk After Ventricular Remodeling with Long-term Mechanical Support ASAIO JOURNAL (JOURNAL OF THE AMERICAN ASSOCIATION FOR ARTIFICIAL INTERNAL ORGANS).
  • A. V. Nguyen, M. T. O’Brien, B. R. Weeks, F. J. Clubb. Jr (2016). Optimized Rapid Electrolytic Processing of Nitinol Wire Components within Tissue for Paraffin Embedded Histology ASAIO JOURNAL (JOURNAL OF THE AMERICAN ASSOCIATION FOR ARTIFICIAL INTERNAL ORGANS.
  • M.T. O’Brien, N.D. Jackson, T. Lancon, H.R. Smith, F.J. Clubb, and B. Weeks. (2014). Advanced Pathologic Analysis of a Feline Microchip-Associated Fibrosarcoma. VETERINARY PATHOLOGY.
  • Eunjoo Kim, Laurie A Davidson, Roger S Zoh, Martha E Hensel, Michael L Salinas, Bhimanagouda S Patil, Guddadarangavvanahally K Jayaprakasha, Evelyn S Callaway, Clinton D Allred, Nancy D Turner, Brad R Weeks, Robert S Chapkin (2016). Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk CELL DEATH & DISEASE (NATURE PUBLISHING GROUP). doi:10.1038/cddis.2016.269, e2460
  • Lauren E Ritchie, Stella S Taddeo, Brad R Weeks, Raymond J Carroll, Linda Dykes, Lloyd W Rooney, Nancy D Turner (2017). Impact of novel sorghum bran diets on DSS-induced colitis NUTRIENTS. 1, 330
  • AM Ginn, SL Lee, MT O’Brien, BR Weeks, FJ Clubb, Jr (2017). A Method to Increase PLA Scaffold Radiopacity Within Cardiac Vessels. Poster Presentation at ASAIO National Meeting. ASAIO JOURNAL (JOURNAL OF THE AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS).
  • KT Ortiz, SL Jessen, FJ Clubb Jr., CN Kaulfus, BR Weeks. (2017). Method for Creating In Vitro Thrombi for Bench-testing of Cardiovascular Medical Devices. Poster Presentation. PROCEEDINGS OF NATIONAL VETERINARY SCHOLARS SYMPOSIUM.
  • Canaan Whitfield-Cargile, Noah Cohen, Kejun He, Ivan Ivanov, Jennifer Goldsby, Ana Chamoun-Emanuelli, Brad Weeks, Laurie Davidson, and Robert Chapkin . (2017). The non-invasive exfoliated transcriptome (exfoliome) reflects the tissue-level transcriptome in a mouse model of NSAID enteropathy. SCIENTIFIC REPORTS (NATURE PUBLISHING GROUP). DOI:10.1038/s41598-017-13999-5

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